Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name Akt2P1
Plot displaying the genomic locations of a retrocopy (in chr11) and its respective parental gene (in chr7). Each line represents a retrocopy.
Species Mus musculus
Coordinates chr11:16464267-16467316  UCSC
Strand +
Parental Sequence NM_001110208.2
Parental seq. overlap 2967 bp
Parental seq. overlap (%) 65.1%
Genomic Region Intergenic
Retrocopy Summary Akt2P1, located on chr11:16464267-16467316, is a retrocopy of the parental gene Akt2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name Akt2
Full Name thymoma viral proto-oncogene 2
Also known as 2410016A19Rik|PKB|PKBbeta
Coordinate chr7:27290977-27340251
Strand +
Gene summary Enables protein serine/threonine kinase activity. Involved in several processes, including cellular response to insulin stimulus; intracellular protein transmembrane transport; and positive regulation of transport. Acts upstream of or within with a negative effect on protein localization to nucleus. Acts upstream of or within several processes, including activation of GTPase activity; cellular response to high light intensity; and peripheral nervous system myelin maintenance. Located in cell cortex and ruffle membrane. Is expressed in several structures, including brown fat; central nervous system; genitourinary system; retina; and spleen. Used to study polycystic ovary syndrome and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in glucose metabolism disease (multiple); high grade glioma; hypoinsulinemic hypoglycemia with hemihypertrophy; and reproductive organ cancer (multiple). Orthologous to human AKT2 (AKT serine/threonine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Human Homo sapiens Without Homology
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>Akt2P1
TGGGGGGCCCGCGCTGCGCGAGCTGTTGGGCCTGACTCTGAGAAGGCGTCGCAGATGCCAGCACTGCCGCTGTTGCTGCTGCCAGTTCATAAATAAGGAGCGGGAATGAGCTCAGCGTGGCGATGGGCGGGGGTAGAGCCCGGCCGGAGAGGCTGGGCGGCGGCCGGTGACAGACGATACTGTGATACTGTATCCGAGGAGCCTCCTGCATGTCCTGCTGCCCTGAGCTCGCTCAAGCTAGGTGACAGCGTGTGAATGCTGCCACCATGAATGAGGTATCTGTCATCAAAGAAGGCTGGCTCCACAAACGTGGTGAATACATCAAGACCTGGAGGCCACGGTACTTCCTTCTGAAGAGTGATGGATCTTTCATTGGGTATAAGGAGAGGCCCGAGTCCCCTGACCAgaccttaccccccccccccaacaatttCTCTGTAGCAGAATGCCAGCTGATGAAGACTGAGAGGCCACGACCCAACACCTTTGTCATACGCTGCCTGCAGTGGACCACAGTCATCGAGAGGACCTTCCATGTAGACTCTCCAGATGAGAGGGAAGAGTGAATGCGGGCTATCCAGATGGTCGCCAACAGTCTGAAGCAGCGGGGCCCAGGTGAGGACGCCATGGATTACAAGTGTGGCTCCCCCAGTGACTCTTCCACATCTGAGATGATGGAGGTAGCTGTCAACAAGGCACGGGCCAAAGTGACCATGAATGACTTCGATTATCTCAAACTCCTCGGCAAGGGCACCTTCGGCAAGGTCATTTTGGTTCGAGAGAAGGCCACTGGCCGCTATTATGCCATGAAGATCCTGCGCAAGGAGGTCATCATTGCGAAGGATGAAGTCGCCCACACAGTCACAGAGAGCCGGGTTCTGCAGAATACCAGGCACCCCTTCCTTACAGCCCTCAAGTATGCCTTCCAGACCCATGACCGCCTGTGCTTTGTGATGGAGTATGCCAACGGGGGTGAGCTGTTTTTCCACCTCTCTCGGGAGCGAGTCTTCACGGAGGATCGGGCGCGCTTTTACGGAGCAGAGATTGTGTCAGCTCTGGAGTATTTGCACTCGAGAGATGTGGTGTACCGTGACATCAAGCTGGAAAACCTTATGTTGGACAAAGATGGCCACATCAAGATCACTGACTTTGGCTTGTGCAAAGAGGGCATCAGTGATGGAGCCACCATGAAAACCTTCTGTGGTACCCCGGAGTACTTGGCGCCTGAGGTGCTAGAGGACAATGACTATGGGCGCGCAGTGGACTGGTGGGGGCTGTGTGTGGTCATGTATGAGATGATGTGTGGCCGCCTGCCATTCTACAACCAGGACCACGAGCGCCTCTTTGAGCTCATCCTTATGGAGGAGATCCGCTTCCCGCGCACACTCGGGCCAGAGGCCAAGTCCCTGCTGGCTGGGCTGCTGAAGAAGGACCCAAAGCAGAGGCTCGGCGGAGGTCCCAGTGATGCGAAGGAGGTGATGGAGCATAGGTTCTTCCTCAGCATCAACTGGCAGGACGTGGTACAGAAAAAGCTCCTGCCACCCTTCAAACCTCAGGTCACTTCAGAAGTGAACACAAGGTACTTTGATGAGGAGTTCACCGCCCAGTCCATCACAATCACACCCCCAGACCGATATGACAGCCTGGATCCGCTGGAACTGGACCAGCGGACGCACTTCCCCCAGTTCTCCTACTCAGCCAGCATCCGAGAGTGAGCAGCCCTCTGCCACCACAGGACACAAGCATGGCCGTCATCCACTGCCTgggtggctttctttattttgcCTTTTGGTTTGTgttcccttccctgtcccctcatcCCAAATCCAGTTTCTTCTTCAGTTCTTGCTCAGACTTAGTGGTCCTGGCGGCCCTCTCCTCTGGGCTCCCCTCTGTTTCAGGTGAGCGCTGGGGACCTGCCCAGGGACAGGCTGTTGGGAGGATGGAGAGTGAGGTCATTCCTCACCACCAGCCTCCAAGAGGGTGAAGTGGAGAGCCATGGGGTCACATGGATTTGGAGGCACGCCAGCGGAGGACACATCTAGAAGTTCCCCTCACTCCCAGCACCTCAGCTGCCTTCCATGCTGTCCTCTGGGCAATCTTATCTGCTGCCACCCCACCTGGGGCACAAAAGCAGTAATGTccagggacaggcagaagcctTTGGAAGCTGAGGGGTCTGGGTTTGCTTCTATGGAGAATGGATCTTCAAGGGGGATCCAGGAGCAGGAgctgccttccccttcctccaaAGCTACTCTCTTGATTCTCAATAAAGCAGGAGGAATGTTCGGGGGCAGCCCTCCTGCCCACAGCCCAGTGCCTTACCAGGGCTTCCTTCTAGCCAGCCTTGCCTCCCGCTCGGCCCCTTTGGATGGCTCCGTTCTCTGCCTGGGGCAGAGGGAAGCCAACCTTGGCTGTTACACATCTCACACGAAGACAGTATTGGGCCCCTTGGACTTGACTGGGGTCTGAGGGGACAGAGATGGGGATAGGTGTCTGATACACAATGGGGTGGAGTCTGCCTCATCTCCAGGGCCCCTGTTCTGGAGCCTTAAAGTGAATGTTTGAGTTAGAGTTGTGTCAGTGCTGTGGGTGCGGGTGTGCACCCTGACCTAGCAGTGAGCATCCCAGGCTACTGGGATGCTGGTGCCCACAGCTGTATGCAGCACTTGTGTGAGTGGGCTCAGGCTCAGCCCCAGCCTGAGTGTTTGATCCCACGGGGTGCAGTGAGTGCAGGCGATGTGCCTGCTGCTCTGGCCATGTCTCTCCCTCCTCAATAGCTCTGGGTTTTTGGAAATGAGTTCTCCTGGTTTTGCTCTCCCACCACACCCCCAGAATAGGTGGATTTCAGAAAGGCAGTAGGGTGGGGTGGTTGGGATGGTTATGGGGGGTCATCTGTTTtttactttgtatgtgtgtatgtttatctgAGAGTTTTCGCCCATCCCTGCTGGCCTTTCCTTACTCCTCGTATTTGTACGGTACAAGCAATAAAGACACTCATTtcagaccagg
>NM_001110208.2
TGCCTCCTAGTTCCTGCGCTTGCGGTCTGATGTTTTCTGAGGCCATTCCCTTGGTCTACTACGTCAGTTCCTGTTTGTGGCTGGAAAAGGCGGTATTTCCGGCCAGCGGGTGGGAGGGGGCTGtgagtgggggctgggggctggggggagggggcgggggggccCGCGCTGCGCGAGCCGTTGGGCCTGACTCCGAGAAGGCGTCGCCGCCGCCAGCACTGCCGCCGTTGCTGCCGCCAGTTCATAAATAAGGAGCGGGAACGAGCTCAGCGTGGCGATGGGCGGGGGTAGAGCCCGGCCGGAGAGGCTGGGCGGCCGCCGGTGACAGACGATACTGTATCCGAGGAGCCTCCTGCATGTCCTGCTGCCCTGAGCTCACTCAAGCTAGGTGACAGCGTGTGAATGCTGCCACCATGAATGAGGTATCTGTCATCAAAGAAGGCTGGCTCCACAAACGTGGTGAATACATCAAGACCTGGAGGCCACGGTACTTCCTTCTGAAGAGTGATGGATCTTTCATTGGGTATAAGGAGAGGCCCGAGGCCCCTGACCAGACCTTACCCCCCCTGAACAATTTCTCTGTAGCAGAATGCCAGCTGATGAAGACTGAGAGGCCACGACCCAACACCTTTGTCATACGCTGCCTGCAGTGGACCACAGTCATCGAGAGGACCTTCCATGTAGACTCTCCAGATGAGAGGGAAGAGTGGATGCGGGCTATCCAGATGGTCGCCAACAGTCTGAAGCAGCGGGGCCCAGGTGAGGACGCCATGGATTACAAGTGTGGCTCCCCCAGTGACTCTTCCACATCTGAGATGATGGAGGTAGCTGTCAACAAGGCACGGGCCAAAGTGACCATGAATGACTTCGATTATCTCAAACTCCTCGGCAAGGGCACCTTCGGCAAGGTCATTCTGGTTCGAGAGAAGGCCACTGGCCGCTATTATGCCATGAAGATCCTGCGCAAGGAGGTCATCATTGCAAAGGATGAAGTCGCCCACACAGTCACAGAGAGCCGGGTTCTGCAGAATACCAGGCACCCCTTCCTTACAGCCCTCAAGTATGCCTTCCAGACCCATGACCGCCTATGCTTTGTGATGGAGTATGCCAACGGGGGTGAGCTGTTTTTCCACCTCTCTCGGGAGCGAGTCTTCACGGAGGATCGGGCGCGCTTTTATGGAGCAGAGATTGTGTCAGCTCTGGAGTATTTGCACTCGAGAGATGTGGTGTACCGTGACATCAAGcTGGAAAACCTTATGTTGGACAAAGATGGCCACATCAAGATCACTGACTTTGGCTTGTGCAAAGAGGGCATCAGTGATGGAGCCACCATGAAAACCTTCTGTGGTACCCCGGAGTACTTGGCGCCTGAGgTGCTAGAGGACAATGACTATGGGCGAGCAGTGGACTGGTGGGGGCTGGGTGTGGTCATGTATGAGATGATGTGTGGCCGCCTGCCATTCTACAACCAGGACCACGAGCGCCTCTTTGAGCTCATTCTTATGGAGGAGATCCGCTTCCCGCGCACACTCGGGCCAGAGGCCAAGTCCCTGCTGGCTGGACTGCTGAAGAAGGACCCAAAGCAGAGGCTCGGCGGAGGTCCCAGTGATGCGAAGGAGGTCATGGAGCATAGATTCTTCCTCAGCATCAACTGGCAGGACGTGGTACAGAAAAAGCTCCTGCCACCCTTCAAACCTCAGGTCACTTCAGAAGTGGACACAAGGTACTTTGATGACGAGTTCACCGCCCAGTCCATCACAATCACACCCCCAGACCGATATGACAGCCTGGACCCGCTGGAACTGGACCAGCGGACGCACTTCCCCCAGTTCTCCTACTCAGCCAGCATCCGAGAGTGAGCAGCCCTCTGCCACCACAGGACACAAGCATGGCCGTCATCCACTGCCTgggtggctttttaaaaaaaaaactttattttgcCTTTTGGTTTGTgttcccttccctgtcccctcatcCCAAATCCAGTTTCTTCTTCAGTCCTTGCTCAGACTTAGTGGTCCTGGCGGCCCTCTCCTCTGGGCTCCCCTCTGTTCCAGGTGAGCGCTGGGGACCGCCCAGGGACAGGCTGTTGGGAGGATGGAGAGTGAGGTCATTCCTCACCACTAGCCTCCAAGAGGGTGAAGTGGGGAGCCATGGGGTCACATGGATTTGGAGGCACGCCAGCGGAGGACACATCTAGAAGTTCCCCTCACTCCCAGCACCTCAGCTGCCTTCCATGCTGTCCTCTGGGCAATCTTATCTGCTGCCACCCCACCTGGGGCACAAAAGCAGTAATGTccagggacaggcagaagcctTTGGAAGCTGAGGGGTCTGGGTTTGCTTCTATGGAGAATGGATCTTCAAGGGGGATCCAGGAGCAGGagctgccttcctcttcctcccaagctACTCTCTTGATTCTCAATAAAGCAGGAGGAATGTTCGGGGGCAGCCCTCCTGCCCACAGCCCAGTGCCTTACCAGGGCTTCCTTCTAGCCAGCCTTGCCTCCCGCTCGGCCCCTTTGGATGGCTCCGTTCTCTGCCTGGGGCAGAGGGAAGCCAACCTTGGCTGTTACACATCTCACACCAAGACAGTATTGGGCCCCTTGGACTTGACTGGGGTCTGAGGGGACAGAGATGGGGATAGGTGTCTGATACACAATGGGGTGGAGTCTGCCTCATCTCCAGGGCACCTGTTCTGGAGCCTTAAAGTGAATGTTTGAGTTAGAGTTGTGTCAGTGCTGTGGGTGCGGGTGTGCACCTGACCTAGCAGTGAGCATCCCAGGCTCCTGGGATGCTGGTGCCCACAGCTGTATGCAGCACTTGTGTGAGTGGGCTCAGGCTCAGCCCCAGCCTGAGTGTTTGATCCCACGGGGTGCAGTGAGTGCAGGCGATGTGCCTGCTGCTCTGGCCATGTCTCTCCCTCCTCAATAGCTCTGGGTTTTTGGAAATGAGTTCTCCTGGTTTTGCTCTCCCACCACACCCCCAGAATAGGTGGATTTCAGAAAGGCAGTAGGGTGGGGTGGTTGGGATGGTTATGGGGGTCATCTGTTTtttactttgtatgtgtgtatgtttatctgAGAGTTTTCGCCCATCCCTGCTGGCCTTTCCTTACTCCTCGTATTTGTACGGTACAAGCAATAAAGACACTCATTTCAGACCAGGGCCCAGTCCACATTTCCTTAGCCACCCCTTCTGTCCTGGTACTGGAGTGCCAGAGTAGCATGCACCATTTATTACCTGCTCTGCCTTATTCTGAGGTCCATGGAGCCATGGGGATGGAAGAGATGGCCGTGAGAAAGTGGGTGGTGGATCCCGGCTGCAGAGAGCGGCGCTGCAGAGGAAAAGGTGGCTGGGTGGTTTCTGTTGGGTAGGGATGGCTCGGACCCTTAGAAGCTGCCAGATTGGGGGCAGCAGTGCTGAGCGGCTCTAAACAGGAAGCACGAGCGCTGTGGCAGCAGAGGGGTGGTTCATTCACTTGGCCTCTGAGCCCTAAACAGCTTCTGTGTGGAACCAGGAAGCCTTAGTGTCCCCAAATGCCATCATAAAATCTGTGACTTAACAGGGCTTGTGACTCCCAGCAGGAACACCCGGACATTTGATTACAGCTGCACTGGTCTAGGACTGAACCCCATGCTGAACCTGTGGGTTGTGGGGCTCACTGGGGTACTTGCTCCTTTCCCATACCCAGGTGCCAGGCACACAGGGCCTGGTGCAGATGGATTTGTTCCAGGATTTACTAGAAGACGGGGCACCACAAGCATGGCGATCTGAGAACTGGAAAGCGGGCTGTGGGAAAGCAAGGCCAGTTTAGACACCTGTCCCAACTGCAGAGAAGACTGCGTGCGGCCCAGGTTGGGTGTCCCGTAGCTCTGATAGGAgaaggtggagccttgctggggTGTTAGAGTTCACTGTAGTCTTTCACTCTAgcctaggaaaaagaaaaatgctttgcATTCCCCTGTCACAGCACCTCAGTCACCTTGTGTGACTCATCTCCCAGCAGGACACGTTCCTGCCTACCTCTGGTTTTCAGCAGCTCCGCGAAAggagctcacagtcagctgttccTGTAGTGAACACACGTGTCTACGCTGCTTAGTGTGAGGGACAAAGTTTTCATAAAAGTTTTCACTGGAATCCTTTACAAGGCTCACTTCAAACATTTCACAAGGTTTTGTTTCTCCCCAATCTGTGTGTTTATAAGAGCATCAGGGAGAAGTGAGCCCCCACAACCCAGGCTGCAGTGGCATCACTGTGCACTTTGCCATGAACCCTTGGCCTGCCTTTTGTGCATCCCTCATTCTTGCCAGCTGCAGCCGTGCCTGGGCTATGCCCCTTTGCCACCATACCTTAGGAATTTTGCAGATGTCCTCAGTCTGCTGGGTCCTTGAGGAAATGAGACTTGGGTATCAGGGGACTCTGTGGCCTTGTGGTCCCAGTTGCTTCACAAGGCTGCATGGGCGTGTACCTTCCATCACTAAGATCTGCTATCATCAGTGCtgtaatcaaaaataaaaataaggctcCATCTT

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