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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name Eif3fP1
Plot displaying the genomic locations of a retrocopy (in chr11) and its respective parental gene (in chr7). Each line represents a retrocopy.
Species Mus musculus
Coordinates chr11:27001685-27001953  UCSC
Strand +
Parental Sequence NM_025344.2
Parental seq. overlap 245 bp
Parental seq. overlap (%) 16.3%
Genomic Region Intergenic
Retrocopy Summary Eif3fP1, located on chr11:27001685-27001953, is a retrocopy of the parental gene Eif3f. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name Eif3f
Full Name eukaryotic translation initiation factor 3, subunit F
Also known as 0610037M02Rik|Eif3s5
Coordinate chr7:108533622-108541149
Strand +
Gene summary Enables thiol-dependent deubiquitinase and translation initiation factor binding activity. Contributes to translation initiation factor activity. Involved in protein deubiquitination and translational initiation. Part of eukaryotic translation initiation factor 3 complex, eIF3m. Is expressed in genitourinary system. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human EIF3F (eukaryotic translation initiation factor 3 subunit F). [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Human Homo sapiens Without Homology
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>Eif3fP1
TCTCTAAGCACTGTATTGCAGTATGCTGAGGATGTGCTGTCTGGGAAAGTGTCTGCTGCCAACACGGTAGGCCACTTCTTGATAAGCCTTGTCAACCAAGTACCAAAGATAGTTATTGATGACTTTGAGATCATGCTCAACAGCCACATCAATGACCTGCTGCTGGTGACCTACCTGGTCTATCTCATCCAGTCACAGATTTCTATCAACAAGAAACTTGTAAACCAATGAATCAGACCCAAGAGGCACTTGTGCTGGTTGAGGTTTTC
>NM_025344.2
ctctctttctcggcAAGATGGCTTCTCCGGCCGTACCGGCTAATGTCCCTCCTGCCACTGCAGCCGCAGCCCCGGCGCCGGTCGTCACCGCAGCCCCGGCTTCAGCCCCGACCCCATCCACGCCAGCTCCGACACCGGCTGCGACTCCCGCTGCGTCCCCGGCGCCCGTCTCGTCTGATCCTGCTGTAGCTGCGCCTGCAGCCCCGGGCCAGACCCCAGCCTCCGCGCCAGCCCCAGCGCAGACGCCGGCGCCTTCGCAGCCCGGGCCCGCCCTCCCGGGGCCTTTCCCGGGCGGCCGCGTGGTCAGGCTACACCCCGTCATTTTGGCCTCGATCGTGGACAGCTACGAACGCCGCAACGAGGGAGCTGCCCGAGTTATTGGAACCCTGTTGGgaactgtTGACAAGCACTCGGTAGAAGTCACCAACTGCTTTTCGGTGCCACACAATGAGTCAGAAGATGAAGTGGCTGTTGACATGGAATTTGCTAAGAATATGTATGAATTACATAAAAAAGTCTCCCCAAATGAGCTCATCCTAGGCTGGTATGCCACAGGCCATGACATCACAGAACACTCAGTGCTGATCCATGAGTACTACAGCAGGGAGGCCCCGAACCCCATTCACCTCACGGTGGACACAGGTCTCCAGCATGGGCGCATGAGCATCAAGGCCTATGTCAGcACTTTAATGGGTGTCCCTGGGAGGACCATGGGAGTGATGTTCACACCTCTCACAGTGAAGTACGCGTATTATGACACTGAACGCATTGGAGTTGACCTCATCATGAAGACGTGTTTTAGCCCCAACCGGGTGATTGGACTCTCAAGTGACTTACAACAAGTGGGAGGGGCCTCAGCTCGCATCCAGGATGCTCTAAGCACTGTATTACAGTATGCTGAGGATGTGCTGTCTGGGAAAGTGTCTGCTGACAACACGGTGGGCCGCTTCTTGATGAGCCTTGTCAACCAAGTACCCAAGATAGTTCCTGATGACTTTGAGACCATGCTCAACAGCAACATCAATGACCTGCTGATGGTGACCTACCTGGCCAATCTCACCCAGTCACAGATTGCCCTCAACGAGAAACTTGTAAACCTGTGAATGAGCCCCAAGAGGCACTTGTGCTGGTCGAGGTTTTCACCACAGGGCTGAGACCGAAGTGGAGGCAAAGGGTTTCTTTGTGGTCTTGAGTCACGGtgactcagtcagctgcttgtgaCTCCAAATAAACATAGCTTACCTTTTGTAAATGAACTTTATCTGATGCGAGTTTATTGTCGGCCAGGAGAAAGAAGCATGTTCCTGAACTCGCACGGAAGCCAGGGAGTGGGCACTGTGGGGAGAAGCTGGTTATGTTGGCATGACTCACCCACAGTGGCTGCTCCCACAGCCTAGGCTGCGGTAGTGTCACCCAGCCCCACACCAAGCAGCTTTTTCTTGGCACAGTGGTTTACAGtgatacttttttcttcttctaacttAGGATAATAGCAAATGGAATCTCC

Publications

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