Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name Tsg101P1
Plot displaying the genomic locations of a retrocopy (in chr15) and its respective parental gene (in chr7). Each line represents a retrocopy.
Species Mus musculus
Coordinates chr15:62852486-62853907  UCSC
Strand +
Parental Sequence NM_021884.4
Parental seq. overlap 1397 bp
Parental seq. overlap (%) 71.7%
Genomic Region Intergenic
Retrocopy Summary Tsg101P1, located on chr15:62852486-62853907, is a retrocopy of the parental gene Tsg101. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name Tsg101
Full Name tumor susceptibility gene 101
Also known as CC2
Coordinate chr7:46538697-46569717
Strand -
Gene summary Enables transcription corepressor activity. Involved in exosomal secretion; positive regulation of ubiquitin-dependent endocytosis; and viral budding. Acts upstream of or within several processes, including keratinocyte differentiation; negative regulation of transcription by RNA polymerase II; and regulation of cell growth. Located in cytoplasm and extracellular exosome. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system gland; limb; and nervous system. Human ortholog(s) of this gene implicated in breast cancer; breast carcinoma; cervix carcinoma; endometrial adenocarcinoma; and prostate cancer. Orthologous to human TSG101 (tumor susceptibility 101). [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Human Homo sapiens Without Homology
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>Tsg101P1
TGGAGCGCGCCATGGCAGTGTCTGAGAGTCAGCTGAAGAAGATGATGTCCAAGTACAAATACAGAGATCTAACTGTCCGTCAAACTGTCAATGTCATCGCTATGTACAAAGATCTCAAACCTGTATTGGATTCATGTTTTTAATGATGGCAGTTCCAGGGAGCTGGTGAACCTCACTGGTACAATCCCAGTGTGTTATCGaggtaatatatataatattccaATATGCCTGTGGCTGCTGGACACATATATAACCCCCCCATCTGTTTTGTTAAGCCTACTAGTTCAATGACTATTAAAACAGGAAAGCATGTGGATGCAAATGGGAAAATCTACCTACCTTATCTACATGACTGGAAACATCCACAGTCAGAGTTGCTGGAGCTTATTCAAATCATGATTGTGATATTTGGAGAGGAGCCTCCAGTGTTCTCCCGGCCTACTGTTTCTGCATCCTACCCACCATACACAGCAACAGGGCCACCAAATACCTCCTACATGCCAGGCATGCCAAGTGGAATCTCTGCATATCCATCTGGATACCCTCCCAACCCCAGTGGTTATCCTGGCTGTCCTTACCCACCTGCTGGCCCATACCCTGCCACAACAAGCTCACAGTACCCTTCCCAGCCTCCTGTGACCACTGTTGGTCCCAGCAGAGATGGCACAATCAGTGAGGACACTATCCAAGCATCTCTCATCTCAGCAGTCAGTGACAAACTGAGATGGTGGATGAAGGAGGAAATGGATGGTGCCCAGGCAGAGCTTAATGCCTTGAAACGAACAGAGGAAGATCTGAAAAAAGGCCACCAGAAACTGGAAGAGATGGTCACCCGCTTAGATCAAGAAGTAGCTGAAGTTGATAAAAACATAGAACTTTTGAAAAAGAAGGATGAAGAACTAAGTCCTGCTctggagaaaatggaaaatcaaTCTGAAAATAATGATATTGATGAAGTTATCATTCCCACAGCCCCACTGTATAAACAGATTCTAAATCTGTACGCAGAGGAAAATGCTATTGAAGACACTATCTTTTACCTTGGAGAAGCTTTGCGGTGGGGAGTAATAGACCTGGATGTGTTCCTGAAGCACTTCAGCCTCCTGTCCCTTAAACAGTTCCAGCTAAGGGCACTAATACAAAAGGCAAGGAAGACTGCGGGCCTTAGTGACCTCTACTGACGTGTGCTGTCAGCTGGAGACTGACCTCTCCGTAaagcattcttttcttcttctttttctcatcaGTAGAACCCACAATAAGTTATTGCAGTTTATCACTCAAGtgttaaatattttgaatcaataatatattttctgtttcctttgggTAAAAACTGGCTTTTATTAATTCACTTTCTACCCTCTGTaagtgtctgtgctgtgctgggacTGACTGGGCTAAATAAAATTTGttgcataa
>NM_021884.4
CGGCTTCCTGCTTCGCAGGggcggggcggcggcggcggcgattGTCTGGCGGCCTGGGGCGGCCCCGTGGCGCCTACCCTCTGCCTGTGGGGACGGAGGAGCGCGCCATGGCGGTGTCCGAGAGTCAGCTGAAGAAGATGATGTCCAAGTACAAATATAGAGATCTAACCGTCCGTCAAACTGTCAATGTCATCGCTATGTACAAAGATCTCAAACCTGTATTGGATTCATATGTTTTTAATGATGGCAGTTCCAGGGAGCTGGTGAACCTCACTGGTACAATCCCAGTGCGTTATCGAGgtaatatatataatattccaATATGCCTGTGGCTGCTGGACACATACCCATATAACCCCCCTATCTGTTTTGTTAAGCCTACTAGTTCAATGACTATTAAAACAGGAAAGCATGTGGATGCAAATGGGAAAATCTACCTACCTTATCTACATGACTGGAAACATCCACGGTCAGAGTTGCTGGAGCTTATTCAAATCATGATTGTGATATTTGGAGAGGAGCCTCCAGTGTTCTCCCGGCCTACTGTTTCTGCATCCTACCCACCATACACAGCAACAGGGCCACCAAATAccTCCTACATGCCAGGCATGCCAAGTGGAATCTCTGCATATCCATCTGGATACCCTCCCAACCCCAGTGGTTATCCTGGCTGTCCTTACCCACCTGCTGGCCCATACCCTGCCACAACAAGCTCACAGTACCCTTCCCAGCCTCCTGTGACCACTGTTGGTCCCAGCAGAGATGGCACAATCAGTGAGGACACTATCCGTGCATCTCTCATCTCAGCAGTCAGTGACAAACTGAGATGGCGGATGAAGGAGGAAATGGATGGTGCCCAGGCAGAGCTTAATGCCTTGAAACGAACAGAGGAAGATCTGAAAAAAGGCCACCAGAAACTGGAAGAGATGGTCACCCGCTTAGATCAAGAAGTAGCTGAAGTTGATAAAAACATAGAACTTTTGAAAAAGAAGGATGAAGAACTAAGTTCTGCTctggagaaaatggaaaatcaaTCTGAAAATAATGATATTGATGAAGTTATCATTCCCACAGCCCCACTGTATAAACAGATTCTAAATCTGTATGCAGAGGAAAATGCTATTGAAGACACTATCTTTTACCTTGGAGAAGCTTTGCGGCGGGGAGTCATAGACCTGGATGTGTTCCTGAAACACGTCCGCCTCCTGTCCCGTAAACAGTTCCAGCTAAGGGCACTAATGCAAAAGGCAAGGAAGACTGCGGGCCTTAGTGACCTCTACTGACATGTGCTGTCAGCTGGAGACCGACCTCTCCGTAaagcattcttttcttcttctttttctcatcaGTAGAACCCACAATAAGTTATTGCAGTTTATCATTCAAGtgttaaatattttgaatcaataatatattttctgtttcctttgggTAAAAACTGGCTTTTATTAATGCACTTTCTACCCTCTGTAAgcgtctgtgctgtgctgggacTGACTGGGCTAAATAAAATTTGTTgcataatttttctctttcttggacTTGAGATAAGATGCACAAAAGAAGCCTGGCTTCTCATTAATAAACAAGGCACAGTGTTCATCTTAAGTTGCAGTTCAGTATTCTGTAGGTTAAAGATAAGTTCCCTTTAGTGTAGAATGTCATGCAGAGAAATGTATATATTGGAGGATATGTTTATTTCATTCTAGAACCAACTGAACCATGGTTCAAAACTTTTTTAATCAAGAATTCAATTCCCGCCATTTgcattaggcagctcacaactgtattcTAGCTTTGGGGATCCAATattgtcttctggtctctgtggccactacactcatatgtacatagacatagatacatactttaaaaaaaaaaaaaaacttgggaaAATGTAGTAAGACtgtttcaaataaacaaacactgaGCATGCTGGGTGATTTAAA

Publications

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