Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name Eif4g1P1
Plot displaying the genomic locations of a retrocopy (in chr2) and its respective parental gene (in chr16). Each line represents a retrocopy.
Species Mus musculus
Coordinates chr2:55665658-55666757  UCSC
Strand +
Parental Sequence NM_001304432.1
Parental seq. overlap 902 bp
Parental seq. overlap (%) 16.7%
Genomic Region Intergenic
Retrocopy Summary Eif4g1P1, located on chr2:55665658-55666757, is a retrocopy of the parental gene Eif4g1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name Eif4g1
Full Name eukaryotic translation initiation factor 4, gamma 1
Also known as E030015G23Rik|eIF-4-gamma 1|eIF-4G 1|eIF-4G1|eIF4GI
Coordinate chr16:20491446-20511633
Strand +
Gene summary This gene encodes a member of the eukaryotic translation initiation factors (eIF) that play important roles in translation initiation by mediating recruitment of additional initiation factors and providing a scaffold for ribosome/mRNA-bridging. Along with eIF4A and eIF4E, the encoded protein forms the eIF4F complex that bridges the 5' UTR with the polyadenylated 3' UTR resulting in mRNA circularization, enhanced translation initiation and mRNA stability. Through its association with eIF3, the encoded protein mediates recruitment of the 43S pre-initiation complex to mRNA. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes for this gene have been identified on chromosomes 2 and 13. [provided by RefSeq, Jan 2015]

Homology

Species Scientific Name Retrocopy
Human Homo sapiens Without Homology
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>Eif4g1P1
TTCTGTGGATGAGGTGGAGAAGAAATCTAAGGCCATCATTGAGGAATATCCCCATATCAATGGCATGAAGGAGGCAGTACAGTGTGTCCAGGAGCCTAGCTTCACCCTCCTTGCTCTTCATCTTTATATGGCTCAGCATCAAGTCCACGCTGGAGCATAGTACCATTGCTTGTGAGCATAAGGGACAACTGCAGTACTAACTGCTCTCTAATGCTCAGTACTATCAATGGTTGTATGAAACACTAGAATAGGCTGAGGACCTGGAAATTGATATCCCTCATGTATGGCTTTACTTGACAAAACTGATAACACCTATTATCCAGGAAGATGGGGTGCCCACCGGAAAGCCTCAGAGACCCATGGGCAAAGCTACTTCTTTGTTGCAGGAGATCCTGGGTCTCTTATGTCAGAGCAAGGATGCCAAAAAGGCGAGGATGCTGTGGTAAGAGGCTGGGCTGAACTGGAGGGAATTTCTAGCAGAGGGCCAAGACATTGGCTCATTTGTGGCTGAAAAGAAGGTGGAATATACCTTGGGAGAAGAATGAagctcctggccagaggacaCTTGCCTTCAAGGAGCTTCTTACGTAGCTAAGGAAGCTGCTAAAAGATGGCGGCAGTAATCAGCGTGGGTTTGACTGGATAGAGGCCAACCTGAATGAGCAGCAGATAGCATTGAATACATTAGTTCGAGCCCTCTTGACAAATGACCTTAGAACAGCCTGCCAGCCTGCTTTGAATGTTCTTCGATGCTCTATAAGATGAGGACATGGTGAAGGAAGACGCCCTCTAcagctggaagagcagcaaggacCCTGCtgaagagcagggcaggggtgtgGCCCTTAAATCTCTCATAGCATTCTTCAATTAGCTTCTGGAGCTGCAGACGACTAGTCTGGTCACAACTGATGGCAAGTGGGGCAGGGGACTTGGATATTTGGATAGCTTCGCCAGCCAGCCGCCTGGACTGGagggggTATTCTGccaagtgtctctctc
>NM_001304432.1
GCCCTCTGCGCCGGTCACGTGGGGCGCTGGCTGCGCCTGCGGAGAAGCGGTGGCCGCCGAGCGGGATCTGTGCGGGGAGCCGGAAATGGTTGTGGACTACGTCTGTGCGGCTGCGTGGGGCTCGGCCGCGCGGACTGAAGGAGACTGAAGGTGCTGGGGGGACCCTAATGTGGCACCAAATGAAATGAACAAAGCTCCCCAGCCCACAGGCCCCCCACCCGCCAGGTCCCCTGGACTCCCACAGCCAGCGTTTCCCCCGGGGCAGACTGCACCGGTGGTGTTTAGCACGCCTCAAGCGACACAAATGAACACGCCTTCTCAGCCCCGCCAGCACTTCTACCCTAGCCGGGCCCAGCCCCCTAGCAGTGCAGCCTCCCGAGTGCAGAGTGCAGCCCCTGCCCGTCCTGGCCCAGCTCCCCATGTCTACCCTGCTGGATCCCAAGTAATGATGATCCCTTCCCAGATCTCCTACTCAGCCTCCCAAGGAGCCTACTATATCCCTGGACAGGGGCGTTCCACATATGTTGTCCCAACACAGCAGTACCCTGTGCAGCCAGGAGCCCCAGGCTTCTATCCAGGTGCAAGCCCTACCGAGTTTGGGACCTATGCTGGAGCCTATTACCCAGCCCAAGGTGTGCAGCAGTTTCCTGCTAGTGTGGCTCCTGCCCCAGTTTTGATGAACCAGCCACCCCAGATTGCTCCTAAGAGGGAACGGAAAACTATCCGAATTCGAGACCCAAACCAAGGAGGGAAGGATATCACAGAAGAGATCATGTCTGGGGCCCGCACTGCCTCCACACCCACTCCTCCCCAGACGGGAGGCAGTCTGGAGCCTCAACCCAATGGGGAGTCGCCTCAGGTTGCTGTCATTATCCGGCCAGATGACCGGTCGCAGGGAGCAGCCATTGGGGGGCGGCCAGGACTGCCTGGCCCAGAGCATAGCCCTGGCACAGAATCTCAGCCTTCGTCGCCTTCTCCAACCCCATCACCACCCCCAATTTTGGAGCCGGGGTCTGAGTCTAATCTTGGAGTCCTCTCTATTCCTGGGGACACTATGACAACAGGGATGATACCAATGTCTGTAGAAGAATCGACCCCTATCTCTTGTGAAACTGGGGAGCCGTATTGCCTCTCTCCAGAACCCACTCTTGCCGAACCCATACTGGAAGTAGAAGTGACACTCAGCAAACCCATTCCAGAATCTGAGTTCTCTTCCAGTCCTCTCCAGGTTTCCACGGCCCTGGTGCCTCACAAGGTTGAAACTCATGAGCCCAATGGCGTGATCCCATCTGAGGATCTGGAACCAGAGGTGGAGTCAAGCACAGAGCCAGCTCCTCCCCCTCTATCACCTTGTGCTTCTGAATCGCTCGTGCCCATTGCTCCAACTGCCCAGCCTGAGGAACTGCTCAACGGAGCCCCCTCACCACCAGCTGTGGATTTAAGCCCAGTCAGTGAGCCAGAGGAACAGGCCAAGAAGGTTTCATCAGCAGCACTGGCCAGCATTCTCTCTCCTGCTCCACCTGTGGCTCCTTCAGATACTTCTCCTGCTcaggaggaagaaatggaagaagatgaCGATGACGAAGAaggtggagaagctgagagtgagaagggaggagaggacgtCCCCCTTGACAGTACTCCTGTCCCAGCCCAGCTGTCTCAGAATTTAGAGGTGGCAGCAGCTACCCAGGtGGCAGTGTCTGTGCCAAAGAGGAGACGGAAAATTAAAGAGCTAAATAAGAAGGAGGCTGTAGGAGACCTTCTAGATGCCTTCAAGGAGGTGGACCCAGCAGTACCAGAGGTAGAGAATCAGCCTCCCACTGGCAGCAACCCAAGCCCAGAGTCTGAGGGCAGCATGGTGCCCACACAGcctgaggaaacagaagaaacCTGGGACTCTAAGGAAGACAAAATTCATAATGCTGAGAACATCCAGCCTGGGGAGCAGAAGTATGAGTACAAGTCAGATCAGTGGAAGCCTCTAAACCTTGAAGAAAAGAAGCGTTATGACAGAGAATTCCTGCTGGGCTTTCAGTTCATCTTTGCCagcatgcagaagccagaaggaTTGCCCCATATCACTGATGTGGTGCTGGACAAGGCCAATAAAACACCACTTCGGCAACTGGATCCCTCCAGACTACCTGGCATAAACTGTGGCCCAGATTTCACTCCATCTTTTGCCAATCTTGGCCGACCAGCCCTCAGCAACCGTGGGCCCCCGAGGGGTGGGCCAGGTGGGGAGCTGCCCCGAGGGCCGgctggcctgggacccaGGCGCTCTCAGCAGGGCCCACGAAAGGAAACTCGCAAGATCATTTCCTCAGTGATAATGACTGAAgacataaaactaaataaagcAGAGAAGGCTTGGAAACCCAGTAGCAAACGGACAGCAGCTGATAAGGATCGAGGGGAAGAGGATGCTGATGGAAGCAAGACCCAGGACCTGTTCCGCAGGGTACGCTCCATCCTGAATAAGCTGACACCCCAGATGTTTCAGCAGCTGATGAAGCAGGTGACACAGCTGGCCATTGACACGGAGGAACGCCTCAAAGGAGTTATTGACCTCATCTTTGAGAAAGCCATTTCAGAGCCCAACTTCTCTGTGGCTTATGCCAACATGTGCCGCTGCCTCATGGCGCTGAAAGTGCCCACTACAGAAAAGCCAACAGTAACTGTGAATTTTCGAAAACTGTTGTTAAATCGGTGCCAGAAGGAATTTGAGAAAGACAAAGATGATGATGAAGTttttgaaaaaaagcaaaaagagatGGATGAAGCTGCTACGGCAGAAGAACGGGGACGCCTGAAAGAAGAGCTAGAAGAAGCCCGGGACATAGCTAGGCGGCGCTCTTTAGGGAATATCAAGTTTATTGGAGAGTTATTCAAGTTGAAGATGTTAACAGAAGCAATAATGCATGACTGTGTGGTCAAGCTACTTAAGAACCATGATGAGGAGTCCCTGGAATGCCTCTGCCGCCTCCTCACCACTATAGGCAAAGACCTGGACTTTGCAAAAGCCAAGCCTCGAATGGATCAGTATTTCAACCAAATGgaaaaaatcattaaagaaaagaagACCTCATCTCGCATCCGTTTTATGCTGCAGGATGTACTCGATCTGCGGCAGAGTAATTGGGTGCCACGCCGAGGGGATCAGGGTCCTAAGACTATTGATCAAATTCACAAGGAGGCTGAGATGGAAGAGCACCGAGAACATATTAAAGTACAGCAGCTCATGGCCAAGGGCAGCGACAAACGTCGGGGTGGCCCTCCAGGCCCGCCTATCAATGATGGTGGCTGGAATACAGTCCCCATTAGCAAAGGCAGTCGCCCCATTGACACCTCACGGCTCACCAAGATCACAAAGCCTGGTTCCATTGATTCTAACAACCAGCTTTTTGCACCTGGAGGACGACTGAGTTGGGGCAAGGGCAGCAGTGGGGGCTCAGGAGCCAAGCCCTCAGACACAGCATCGGAAGCTACTCGTCCAGCTACCTTGAATCGCTTTTCTGCTCTTCAACAAACATTACCCGCAGAGAACACAGATAACAGACGTGTTGTACAGAGGAGTAGCTTGAGCCGGGAACGAGGTGAGAAAGCTGGGGACCGGGGAGACCGACTAGAGCGGAGTGAGCGGGGAGGTGACCGTGGGGACCGACTTGATCGTGCCAGAACACCTGCCACCAAGCGAAGTTTTAGCAAAGAAGTGGAGGAGCGAAGTAGAGAGCGGCCATCCCAGCCTGAGGGACTCCGCAAGGCAGCTAGCCTCACAGAGGATCGTGGTCGGGATCCTgTGAAGCGGGAAGCCACTCTACCTCCAGTGAGCCCTCCAAAGGCTGCGCTGTCTGTGGATGAGGTGGAGAAGAAATCTAAGGCCATCATTGAGGAATATCTCCATCTCAATGACATGAAGGAGGCAGTACAGTGTGTCCAGGAGCTGGCTTCACCCTCCTTGCTCTTCATCTTCGTACGGCTTGGTATCGAGTCCACGCTGGAGCGTAGTACCATTGCTCGTGAGCATATGGGGCGACTACTGCACCAACTGCTCTGTGCGGGGCACCTCTCTACTGCCCAGTACTATCAAGGGCTGTATGAAACACTAGAATTGGCTGAGGACATGGAAATTGATATCCCTCATGTATGGCTTTACCTGGCAGAACTGATTACACCTATTCTCCAGGAAGATGGGGTGCCCATGGGAGAGCTCTTCAGGGAAATTACGAAGCCTCTGAGACCCATGGGCAAAGCTACTTCTTTATTGCTGGAGATCCTGGGTCTCTTATGCAAGAGCATGGGTCCCAAAAAGGTGGGGATGCTGTGGCGAGAGGCTGGGCTGAGCTGGAGGGAATTTCTAGCAGAGGGCCAAGACGTTGGCTCATTTGTGGCTGAAAAGAAGGTGGAATATACCTTGGGAGAAGAATCTGAagctcctggccagaggacaCTTGCCTTTGAGGAGCTTCGTAGGCAGCTAGAGAAGCTGCTGAAGGACGGCGGCAGTAATCAGCGTGTGTTCGACTGGATAGACGCCAACCTAAATGAGCAGCAGATAGCATCCAATACATTAGTTCGAGCCCTCATGACAACTGTCTGTTATTCTGCAATTATCTtTGAGACTCCTCTCCGAGTGGATGTTCAAGTGTTGAAAGTGCGAGCAAGACTGCTGCAGAAATACCTGTGTGATGAGCAGAAGGAGCTACAAGCACTCTATGCTCTCCAGGCCCTTGTAGTGACCTTAGAACAGCCTGCCAACCTGCTTCGGATGTTCTTTGATGCTCTATATGATGAGGACGTGGTGAAGGAAGACGCCTTCTACAGCTGGGAGAGCAGCAAGGATCCTGCTGAACAGCAGGGCAAGGGTGTGGCCCTTAAATCTGTCACAGCATTCTTCAATTGGCTTCGTGAGGCTGAGGACGAGGAGTCTGATCACAACTGATGGCGGGTGGGGCAGGGGACTTGGAGCCATGGACACGTGGATGGCCCAGCCAGCCAGCCGCCTGGACTGCAGGGGGGCGGCAGCAGCAGTGGCGGCAGTGGCAGTGGGTGCCTGTAGTGCGATGTGTCTTGAGCTAATAAAGTGGCTGATGAGGCAGGATGGCTTGGGGCTGCCTgggccccccccccctccaggatGCTGCCAagtgtctctctcctccccccaggGCACAGAGATATATATAAAGTCTTGAAATTTGGTGTGTCTTTGCGGGGGGAAGGGCACTACCGCCTGCCTCTAGggtccttttttattttctgaaatcaCTCTTGGGACTGCCGTCCTCGCTGCTGGGGGCATATGCCCCAGCCCCTGCACCACCCCTGCTGCTGCCTGGGCAGGGGAAAGGGGGGGGCACGGTGCCTGTAATTATTAAACATGAATTCAATTAA

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