Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name Ess2P2
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Plot displaying the genomic locations of a retrocopy (in chr3) and its respective parental gene (in chr16). Each line represents a retrocopy.
Species Mus musculus
Coordinates chr3:139822210-139823689  UCSC
Strand -
Parental Sequence NM_022408.2
Parental seq. overlap 1311 bp
Parental seq. overlap (%) 46.3%
Genomic Region Intergenic
Retrocopy Summary Ess2P2, located on chr3:139822210-139823689, is a retrocopy of the parental gene Ess2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name Ess2
Full Name ess-2 splicing factor
Also known as D16H22S1269E|Dgcr1|Dgcr14|Dgsi|ES2|Es2el
Coordinate chr16:17718573-17729212
Strand -
Gene summary The human ortholog of this gene is located within the minimal DGS critical region (MDGCR) thought to contain the gene(s) responsible for a group of developmental disorders. These disorders include DiGeorge syndrome, velocardiofacial syndrome, conotruncal anomaly face syndrome, and some familial or sporadic conotruncal cardiac defects which have been associated with microdeletion of human chromosome band 22q11.2. The encoded protein localizes to the nucleus, and the orthologous protein in humans co-purifies with C complex spliceosomes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Human Homo sapiens Without Homology
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

AdiposeHeart AtriumBone MarrowBreast Mammary TissueBrain CerebellumBrain CortexColonEsophagusSkin Hair FollicleHeartHeart VentricleBrain HypothalamusKidneyLiverBrain MidbrainOvaryPancreasBrain PonsKidney CortexEye RetinaMuscle SkeletalSkinSmall IntestineBrain Spinal CordSpleenTestisBrain ThalamusThymusTrachea012
log10(TPM+1)

Related Sequence

>Ess2P2
GCGGGTCCTGAATGAAGAAGAGTACattgagggacttcagacagtcATCCAAAGAGACTTCTTCCCTGATGTGGAGAAGCTACAGGCACAGAAGGAATGCTGAGGAAAATGGAGATTTGGAGCGCATGTGCCAGATTGCCATCAAGTTTGACTCTGCCCTGGACAAGATATCTCGGAAACCTACACCACCCTATGTTACTCCAGCCACCTTTGAAACTCCTGAGGTATACCTGGGCTCTGGTGTGCTGGGTAGCAAGCCCCAGCCCCAGGGCCGAGACCTAGATGACAGATCAGCTGGAGATGAGAAGCAGGAGCCACTGCCCACCCTGGATGTCTACTTGAGCCACTACACAAGCGAGGACAACGCCGTATTCCAGAAGATCATGGAAGTGGCTAAGGGAAAAAGCCATGCCCACCATATTTGGCTCTACCAGGCTGAGGAGGAATTTGAGAAGCGACAGAAAGATAATCTTGAAAACCCATCAGCAGAAACTAAGCCATTGAGAATAGTCGGGCTGGAGTGGAATCCTGGAAGTACAAGGCCAAGAATTCTCTCATGTACTATCCCAAGGGTGTGCCTGATATCAAACAGTTGTTCAAGGAGCCGCTTCAGGTAGTACATAAGAACACACGTTTCCTCCAGGACCCCTTCAGTCAGGTTCTGAGCAAATCCCAGCTTCAGCAAGCAGCTGCCCTCAATGCTCAGCACAAACTGGGCAATGTTGGCCCAGATGGCAAGGAACTCATTCCCCAGGAGTCCCCCAGAGTGAATGGCTTTGGATTCGTTGCCACTCCTTCCCCTGCTCCTGGTATGAATGAGTCCCCACTGATGGTGTGGGGACAGGTTGAGAACACACCCCTGCTAATCGAAGGGTCCGAGAGCCCCTATGTGGACAGGACACTGGGACCCGTGTTCAAGATCTCAGAGCCAGGACCCAGGGAGCGTCTGGGACTGAAGATAGCCAATGAAGCAGCTGCCAAAAACCGGGCCATGAAGCATAAAGCATTGCAGAGAGTTACAGGGAACTTGACCAGTCTTACTCGCAAAGGCCTGAGCccagccatgtccccagccctaCATCGCCCCGTAAGCAGGACAGCAAGCAGGTATACAGATCTTGCCCTGTGGGCCAGCCATACACCATCCCCAGCATGCTCTACCCACCTCAAGAACCCAACTGCTGGGCCGCAGACACCCACAAGCATCCCAGCCCTAACAGGTACACCCCTCACACAGGATCCAGCCTCTATCACAGACAACCTGCTGCAGTTTCCCCGCCCGGCACAAAGCTTCAGACTTCTTTTAGAGCCAGGCCTGGCTGGACTTGTGGATGTTTTGTGCGATACTTTGTGGAGCATCTGGGGGCAGTTTCTACTCCTCAGAGGACTCCAGGCCTTGGAGACCCAGACCACGGGCAGTTGACTATTACAGGAACCACAAGTATATAGTGCTGTGCCAGTGGCCAGGTTGGCACATTAT
>NM_022408.2
GTTGGAGCGGTGCAGACGCCGCCCGAGCGATTCTGGGATAGCGATGGGGACGCCCGGGACCTCGGCGGGTGCTCTGTTTCTGTCCTCCGCGTCCGCGCCCTCAAGGAAGCGCGCggctggggaggctggagaggccGGAGTTGCGAGAAGCAGGCAGCGGGTCCTGGATGAAGAAGAGTACATCGAGGGACTTCAGACAGTTATCCAGAGAGACTTCTTCCCTGATGTGGAGAAGCTACAGGCACAGAAGGAGTACCTGGAGGCCGAGGAAAACGGAGATTTGGAGCGCATGCGCCAGATTGCCATCAAGTTTGGCTCTGCCCTGGGCAAGATATCTCGGGAACCTCCACCACCCTATGTTACTCCAGCCACCTTTGAAACTCCTGAGGTACACCCAGGCTCTGCTGTGCTGGGCAACAAGCCCCGGCCCCAGGGCCGAGACCTAGATGATGcaggagaggctggagaggaagaggagaaggagccaCTGCCCAGCCTGGATGTCTTCTTGAGCCAGTACACAAGTGAGGACAATGCCTCCTTCCAGGAGATCATGGAGGTGGCCAAGGAAAAAAGCCATGCACGGCACGCGTGGCTCTACCAGGCTGAGGAGGAATTTGAGAAGCGACAGAAAGATAATCTTGAACTCCCATCGGCAGAGCATCAAGCCATTGAGAGCAGTCAGGCTGGAGTGGAGACCTGGAAGTACAAGGCCAAGAACTCTCTCATGTACTATCCCGAGGGTGTCCCTGATGAAGAGCAGTTGTTTAAGAAGCCGAGACAGATAGTACATAAGAACACACGTTTCCTCCGAGATCCCTTCAGTCAGGCTTTGAGCAGGTCCCAGCTTCAGCAGGCGGCTGCCCTCAATGCCCAGcaCAAACAGGGCAAGGTCGGCCCTGACGGCAAGGAACTCATTCCCCAGGAGTCCCCCAGAGTGGGCGGCTTTGGATTTGTTGCcactccttctcctgctcctgGTGTGAATGAGTCCCCACTGATGACATGGGGAGAGGTTGAGAACACGCCCCTGCGAGTAGAAGGATCCGAGAGCCCCTATGTGGACAGGACACCTGGACCCACATTCAAGATCTTGGAGCCAGGACGCAGGGAGCGTCTGGGCCTGAAGATGGCCAATGAAGCGGCTGCCAAAAACCGGGCGAAGAAGCAGGAAGCGTTGCGGAGAGTTACAGAGAACTTGGCCAGTCTTACTCCCAAAGGCTTGAGCccagccatgtccccagccctaCAGCGCCTCGTAAGCAGGACAGCCAGCAAGTACACAGATCGTGCCCTGCGGGCCAGCTATACACCATCCCCAGCacgatcttcccacctcaagaccCCAGCTGGTGGGCCGCAGACACCCACAAGCACTCCAGCCCCTGGGTCTGCTACACGCACACCCCTCACACAGGACCCAGCCTCCATCACAGACAACCTGCTGCAGCTCCCTGCCCGACGCAAAGCTTCAGACTTCTTTTAGAGCCAGGCCTGACTGGACCTGTGGATGTTTTGTGGAACACTTTGTGGAGCATCTAGGGCAGCTTTCTACCACTCAGAGGATTCCAGGCCTTGGAGACACAGACCACAGTTGATTATTCCAGGAGCCACAAATATCTAGTGTTGTTCCCGTGGCCAGGTTGGCACATTACGCGGACCAGTCCCTTGGAAGTACAGCGTTGGTGCTGTTCCCAGGGCCCTGCTGAAATGCCTTCTAGCTAACCCCCAATTGAATCCTCATTAAAGAACACCTGGAACTGTCTGGCCAGGCTGCTGATCCATGTCCTGGGGCCCACGTGGGTGTCTCAGGGTTGGAAGCAAGGGGTGCTGGGGAGCTGCCTTCTATGCTGAGATCACCCCCCGAGCCTCCCACTGTAAAGGATACCACAGACCCCAAAAGTGGAGCCATTGAGCTTGTGGGCCTCCTAGTCAGAGCTGGCCATTCGGTTTGTTGGTTCTGGGCTTTCGTATCAGGTGTCTTCATATCAGGCTCACCAGGACCAGTTCTCTTCCTGTGACTCGAACCAGTACCTCCCAGCAACCTGGctgcctccctgtcctcctcTCTGCTTGACCCACTGTTCTTCAGCTCTGCCTGCTGGACTCTGCTGAGACACCAGCTTTACCTCAGCCTGAGCTGTACTATGAAAAGAAAGAGTGCAGGCTCCCTGCAAACATGCAAATGCCATGCGCACCAGCAACTAAGAGTAACTAGTCCTCAGGTGACTAGAGGCCAGCTACGCCTGTTAGCCTGTGCCTACAGAGAGCTGAAGGGTCCCTTCTCGGCCTAACAGAGTCAAAAACTATGACCTAATTCCCCAGCCTACGTACGGTTTTCAGGCCACAAGTGGCATCCTATGGCCGGCCCTATGTTAAGGGCAGCCTTAAGCACACCAGACTTTTCTGACACCTGGGTCTTGCTTTGATTGCATGAGAGCCACCTTTTCTAGTCTGCTGGCATTGGGCCTCTGAGGCGGGGTTGGGTACCTTCCTCCTTGGGCCTCATACTACTTAGTTTTTGTCAGTTTGACAGaagctagaatcacctgggaagaaggaacctcaattgaattACCTCTCATCAGATGGGCTTGACGGCATGTCTGCAGGCATTTTCTTGATCGTCAATCGATGTAGGAGGGCAGTGGTCTTGGGTTGAGTCAGAAAGCCTGGGAGGAAACTAGAGAGGAAGCCAGCCAGGACGTGACACTCCTTCATggtgtctgcttcagctcctaCTTGAGgtcctgctctggcttccctcagtgatggactgtgatggaaagtgtgagctgaataaacccattTCCTCCCTTAA

Publications

PMID - Link Title
No publications available for this retrocopy