Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

Advanced Search

Summary

Retrocopy Name Plk1P1
Plot displaying the genomic locations of a retrocopy (in chr5) and its respective parental gene (in chr7). Each line represents a retrocopy.
Species Mus musculus
Coordinates chr5:35711478-35713596  UCSC
Strand +
Parental Sequence NM_011121.4
Parental seq. overlap 2010 bp
Parental seq. overlap (%) 90.6%
Genomic Region Intragenic (Trmt44)
Retrocopy Summary Plk1P1, located on chr5:35711478-35713596, is a retrocopy of the parental gene Plk1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name Plk1
Full Name polo like kinase 1
Also known as Plk|STPK13
Coordinate chr7:121758658-121769107
Strand +
Gene summary The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and may play a role in DNA replication during S phase. This gene is expressed in all embryonic tissues, but restricted to thymus and ovaries in adult tissues. Homozygous knockout mice were embryonic lethal, suggesting that this gene is important for early embryonic development. This gene is thought to be a potential oncogene because it is overexpressed in a variety of tumors and tumor cell lines. Depletion of this protein in cancer cells has been shown to inhibit cell proliferation and suppress oncogenic transformation; hence, it is a target for cancer therapy. [provided by RefSeq, Sep 2015]

Homology

Species Scientific Name Retrocopy
Human Homo sapiens Without Homology
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>Plk1P1
GAGGACCCTCTCCACCGACTCAGCCAGGTTCGTGGAGCAACTTCGGCATCATGAATGCAGTGGCCAAAGCTGGAAAGCTGGCTCGAGCACCAACCGACCTCGGGAAAGGTGGGGTCCTGGGAGATGCAGCTCCCAGTGCCCCAGTGGCTGCCCCACTGGCGAAAGAAATTCTGGAGGTCCTAGTGGACCCACGCAGCCGGAGGCAGTATATACAGGGGCGCTTTCTGGGTAAAGGAGGCTTCAGCAAATGCTTCGAGATCTCAGATACAGACACAAAAGAGGTGTTAGCAGGCAAGATCGTGCCTAAGTCTTTGCTGCTCAAGCCCCACCAGAAGGAGATGTCTATGGATCTCAATTCACCACAGCCTCGCACACCAACACTTTGTAGGCTTCCATGACTTTTTCCAGGACAGCGACTTTGTGCTTGTAGTTTTGGAGCTGTCGAAGGAGGTCCTTCCTGGAGCTGCACACGAGGAGGAAGGCACTGACAGCGCCTGAGGCCCGCTACTACTGTGACAGATAGTCCTGGGCTGCCAGTACCTGCACCGCAATCAGGTCATTCACAGGGACCTCAAGCTGGGCAACCTCTTCCTGAACGAGGATCTGGAGGTGAAAATAGGGGATTTTGGCCTGGCAACCAAAGTGGAATATGAAGGGAAATGAAAGAAGACCTTGTGTGGCACTCCTAACTACATAGCTCCTGAGGTGCTGAGCAAGAAGGGACACAGGTGGATGTGTGGTCCATTGGATTAATCATGTATACCTTGCTAGTGGGCAAGCCACCCTTTGAGACCTCAGGCCTAAAAGAGTCCTACCTCCAGatcaagaaaaatgaatacaGTATTCCCGAGCACATCAACCCAGTGGCCGCCTCCCTCATCCAGAAGATGCTTCAGACAGACCCCACTGCCCGCCCCACCATTCACGAGTCGCTCAGTGACGAGTTCTTCACTTCGGGCTACATCCCCACCTGTCTCCCTATTACCTGCCTCACCATCCCAACAAGGTTTTCAATCGCTCCCAGCAGCCTGGACCCCAGCAACAGGAAGCCTCTCAAAGTCCTCAATAAAAGCGTGGAGAACCCCCTGCCTGACCGTCccggggagaaagaggaaccagtGGTCCGGGAGACAGATGAGGCCATTGAGTGCCACCTTAGTGACTTGCTACAGCAGCTGACCAGTGTCAACGCCTCCAAGCCCTCGAAGCGTGGGCTGGTGCGGCAAGAGGAGGCTGAGGATCCTGCCTGCATCCACATCTTCTGGGTCAGCAAGTGGGTAGACTATTCGGACAAGTATGGCCTTGGGTATTAGCTGTGTGACAACAGTGTGGGGGTGCTTTTTAGTGACTCAACATGCCTCATTCTCTACAATGACGGGGACAGCCTGCAGTACATAGAGCGTGATGGCATGGAGTCCTACCTTACTGTGAGCTCCTATCCCAATTCCTTGATGAAGAAGATCACTCTCCTCAACTATTTCCGCAATTATGTGAGTGAACACCTGCTGAAGGCAGGAGCCAACATCACACCCCGGGAAGGTGACAAGCTGGCCCGGCTGCCCTACCTACGAATGTGGTTCCAAACGTGCAGCGCCATCATCCTGCACCTCAGCAACGGCACTGTGCAGATTAACTTCTTCCAGGACCAACCAAACTTATCCTGTGCCCCCTGATGGCAGCGGTGACCTACATCAACGAGGAACTTCCAAACGTATGCCTGAGCCTCCTGGAGGAGTATGGCTGCTACAAGGCCAGCTGCCTCTGCTACACCCGCCTGCACCATGGTAGACAAGCTGCTGAGCTTGCGCTCTGCCAGCAACCGCCTCAAGGCCTCCTAGGTCTCTCTTCTTTGGACTGATGCCCCTTCACTCTGCTAGCTCTGAGCCTGCACTGTGGGGTCCTGGGGGCTGCTGTTCAGTGCCCCTGGCCCTGGGGGCTGGGCAGGAGCAGGGCCCCCTTTGAAGGGGTTGCTATAAGTTATTTTGTACATGTCTGGGTGTGGGTTTACATCCGCTTCCCTGTCCTCACTCGGCCCATTGTATGAATTGTATAAATATTTCTATTAAATTGGGACTGTTCTTTTCTTagctttatatatattaaaatatgtacatctctc
>NM_011121.4
GCAGGCCCTTGTAACGTTCCCAGCGCCGCGTTTGAATTCGGGGAGGAGCGGAGCAGAGCAGGACCCTCTGCACCGACTCAGCCAGGTTCGTGGAGCAACTTCGGCATCATGAATGCAGCGGCCAAAGCTGGAAAGCTGGCTCGAGCACCAGCCGACCTCGGGAAAGGTGGGGTTCCGGGAGATGCAGTTCCCGGTGCCCCAGTGGCCGCCCCGCTGGCGAAAGAAATTCCGGAGGTCCTAGTGGACCCACGCAGCCGGCGGCAGTATGTACGGGGGCGCTTTCTGGGTAAAGGAGGCTTCGCCAAATGCTTCGAGATCTCAGACGCAGACACAAAAGAGGTGTTCGCAGGCAAGATCGTGCCTAAGTCTTTGCTGCTCAAGCCCCACCAGAAGGAGAAGATGTCTATGGAGATCTCAATTCACCGCAGCCTAGCACACCAACACGTCGTAGGCTTCCATGACTTTTTTGAGGACAGCGACTTTGTATTTGTAGTTTTGGAGCTCTGTCGCAGGAGGtCCCTCCTGGAGCTGCACAAGAGGAGGAAGGCACTGACCGAGCCTGAGGCCCGCTACTACCTGCGACAGATAGTCCTGGGCTGCCAGTACCTGCACCGCAATCAGGTCATTCACAGGGACCTCAAGCTGGGCAACCTCTTCCTGAACGAGGATCTGGAGGTGAAAATAGGGGATTTTGGCTTGGCAACCAAAGTGGAATATGAAGGGGAACGAAAGAAGACCTTGTGTGGCACTCCTAACTACATAGCTCCTGAGGTGCTGAGCAAGAAGGGACACAGTTTTGAGGTGGATGTGTGGTCCATTGGGTGCATCATGTATACCTTGCTAGTGGGCAAGCCTCCCTTTGAGACCTCGTGCCTAAAAGAGACCTACCTCCGGatcaagaaaaatgaatacaGTATTCCCAAGCACATCAACCCAGTGGCCGCCTCCCTCATCCAGAAGATGCTTCAGACAGACCCCACTGCCCGCCCCACCATTCACGAGTTGCTCAATGACGAGTTCTTCACTTCTGGCTACATCCCCGCCCGTCTCCCTATTACCTGCCTCACCATCCCACCAAGGTTTTCAATCGCTCCCAGCAGCCTGGACCCCAGCAGCAGGAAACCTCTCAAAGTCCTCAATAAAGGTGTGGAGAACCCCCTGCCTGACCGTCCCCGGGAGAAAGAGGAACCGGTGGTCCGGGAGACAAATGAGGCCATTGAGTGCCACCTTAGTGACTTGCTACAGCAGCTGACCAGTGTCAACGCCTCCAAGCCCTCGGAGCGCGGGCTGGTGCGGCAAGAGGAGGCTGAGGATCCTGCCTGCATCCCCATCTTCTGGGTCAGCAAGTGGGTGGACTATTCGGACAAGTATGGCCTTGGGTATCAGCTGTGTGACAACAGTGTGGGGGTGCTTTTTAATGACTCAACACGCCTGATTCTCTACAATGACGGGGACAGCCTGCAGTACATAGAGCGTGATGGCACGGAGTCCTATCTCACTGTGAGCTCCCATCCCAATTCCTTGATGAAGAAGATCACTCTCCTCAACTATTTCCGCAATTACATGAGTGAGCACCTGCTGAAGGCAGGGGCCAACATCACACCCCGGGAAGGCGACGAGCTGGCCCGGCTGCCCTACCTACGAACGTGGTTCCGCACACGCAGCGCCATCATCCTGCACCTCAGCAACGGCACCGTGCAGATTAACTTCTTCCAGGACCACACCAAACTTATCCTGTGCCCCCTGATGGCAGCGGTGACCTACATCAACGAGAAGAGGGACTTCCAAACGTACCGCCTGAGCCTCCTGGAGGAGTATGGCTGCTGCAAGGAGCTGGCCAGCCGCCTCCGCTACGCCCGCACCATGGTAGACAAGCTGCTGAGCTCGCGCTCCGCCAGCAACCGCCTCAAGGCCTCCTAGGTCTCTCTCCTTCGGACTGGTGCCCCTTCACTCTGCTAGCTCTGAGCCTGCACTGTAGGCTCCTGGGGGCTGCTGTTCAGTGCCCCTGGCCCTGGGGGCTGGGCAGGAGCAGGGCCCCCTTTGAAGGGGTTGCTGTGTGTAAGTTATTTTGTACATGTCTGGGTGTGGGTTTACATCTGCTTCCCTGCCCTCGCTCAGCCCACTGTATGAATTGTATAAATGTTTCTATTAAATTGGGACTGCTCTTTCCTTagctttatatatattaaaatgtgtacatctctctctctcttt

Publications

PMID - Link Title