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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name Hsd17b10P1
Plot displaying the genomic locations of a retrocopy (in chr5) and its respective parental gene (in chrX). Each line represents a retrocopy.
Species Mus musculus
Coordinates chr5:107992318-107992488  UCSC
Strand +
Parental Sequence NM_016763.2
Parental seq. overlap 150 bp
Parental seq. overlap (%) 16.4%
Genomic Region Intragenic (Evi5)
Retrocopy Summary Hsd17b10P1, located on chr5:107992318-107992488, is a retrocopy of the parental gene Hsd17b10. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name Hsd17b10
Full Name hydroxysteroid (17-beta) dehydrogenase 10
Also known as 17bHSD10|Ads9|ERAB|Hadh2|MHBD
Coordinate chrX:150784892-150787438
Strand +
Gene summary Predicted to enable several functions, including amyloid-beta binding activity; estrogen receptor binding activity; and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be involved in several processes, including carboxylic acid metabolic process; cellular hormone metabolic process; and mitochondrial tRNA processing. Predicted to act upstream of or within steroid metabolic process and tRNA processing. Located in endoplasmic reticulum and mitochondrial nucleoid. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in chromosome Xp11.22 duplication syndrome; pheochromocytoma; and syndromic X-linked intellectual disability type 10. Orthologous to human HSD17B10 (hydroxysteroid 17-beta dehydrogenase 10). [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Human Homo sapiens Without Homology
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>Hsd17b10P1
TCACTTGCAATGTGATCTGTCAGGTTGCTAGTGAGATGGGTCAGAATGAACCCAGCCAGGGAGGCCAACATGGAGTTAATAACACTGTCAGTGAGGCTGCCTTTGAGGGACAGGTTGGACAAGCTGCACACCCTGCATCCAAAGAGGCACAGTGTCCACGACACTGCCCAT
>NM_016763.2
GGCTTGTGCAAGATGGCTGCGGCAGTTCGGAGCGTGAAGGGCTTGGTCGCGGTAGTAACTGGAGGAGCCTCGGGCCTTGGCCTAGCTACGGCCAAAAGACTGGTGGGACAAGGGGCCACAGCTGTACTTCTGGATGTACCTGACTCAGAGGGTGAAGCCCAAGCCAAGAAGTTAGGAGAAAGCTGCATATTTGCCCCAGCAAATGTGACCTCTGAGAAGGAGATACAAGCAGCTTTGACTCTAGCAAAAGAAAAGTTTGGCCGTATAGATGTGGCTGTCAACTGTGCAGGTATTGCAGTGGCCATTAAGACATACCACCAAAAGAAGAACAAGATCCATACTTTGGAGGACTTCCAGCGGGTTATCAATGTGAATCTTATAGGCACTTTCAATGTGATCCGCCtggttgctggggagatgggCCAGAATGAACCAGACCAGGGAGGCCAACGTGGAGTTATCATTAACACTGCCAGTGTGGCTGCCTTTGAGGGCCAGGTTGGACAAGCTGCATACTCTGCATCCAAAGGGGGCATAGTGGGCATGACACTGCCCATTGCTCGAGATCTGGCTCCTACAGGCATCCGTGTGGTAACAATTGCTCCAGGTTTGTTTGCCACCCCACTGCTTACCACCCTTCCAGAGAAAGTGCGAAACTTCTTGGCCAGCCAGGTACCCTTCCCCAGCCGACTAGGTGACCCCGCTGAATATGCTCATCTGGTACAGACCATAATCGAGAACCCATTCTTGAATGGAGAGGTCATCCGGCTGGATGGGGCCATTCGAATGCAGCCTTAAAGGGCCAAGGCAGGAGAAACACCAGCTCCTTTTCAATTTGAAGGAAAGCTAACAGCCACTTTGTAACTCTGCTCCACTCACCCTCGGTGCCTAATAAATTCTCAAACTTCCAA

Publications

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