Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name XiapP1
Plot displaying the genomic locations of a retrocopy (in chr7) and its respective parental gene (in chrX). Each line represents a retrocopy.
Species Mus musculus
Coordinates chr7:38306078-38306727  UCSC
Strand +
Parental Sequence NM_001301641.1
Parental seq. overlap 594 bp
Parental seq. overlap (%) 9.2%
Genomic Region Intragenic (R3hdm1)
Retrocopy Summary XiapP1, located on chr7:38306078-38306727, is a retrocopy of the parental gene Xiap. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name Xiap
Full Name X-linked inhibitor of apoptosis
Also known as 1110015C02Rik|Aipa|Api3|Birc4|IAP3|ILP-1|MIHA
Coordinate chrX:41148483-41198541
Strand +
Gene summary The protein encoded by this gene is a member of the inhibitor of apoptosis (IAP) family of proteins. While first identified for its role in blocking apoptosis, this protein modulates many other signaling processes including nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) pathways and inflammatory responses. This protein blocks apoptosis by binding and inhibiting target caspases after they have been activated. Binding occurs to some, but not all, caspases. This protein has several conserved regions, including baculoviral IAP repeat (BIR) motifs and a RING finger E3 ligase domain. In humans, mutations in this gene are linked to immunodeficiency in X-linked lymphoproliferative syndrome type-2 (XLP-2). A pseudogene of this gene is found on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]

Homology

Species Scientific Name Retrocopy
Human Homo sapiens Without Homology
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>XiapP1
ttacgcAGGATGAGTCAAGTGAAACTTCATTGCAGAAAGACATTAGTACTGAAGAACAGGTAAGGTGCCTACGAGGGGAGAAGCTTTGCAAAATCTGTATGGATATTGCTGtcatttttgttctttgtggACATCTGGTCACCTGTAAACAGTGTGCTGAAGCGGTAGACAAATGTCCCATGTGCTACACAGTCATTATGTTCAAGCAAAACATGTTTATGTCTTAGTCCAGCACCACATGTTATGTTCTTCTTGCTCTAATTGAATGTGTGATGTGAGCGAACGTTAAGTAATGTGCCTTGCATTCCATTAGCATCTGCTGTTTCCAAATGGAGACAAATCTTAACAGCACTGTTTTGGTCTAAACATTCAATTTCTGGATCTTTCAGGTTATCAGCTGTACCCTTTATCCAATGTTTTACTCGATTTAAGCCTTAGACAAACAAGCATTTTATAACTTTTCACATGTATATTTGTAGTACACTGACTTGATGTCTATTTTTCATGCCTTTTGCATAAGCTAACAAATGGAGTATTCTGTATAAGCATGGAGATGTGATGTAATCTGCCCAATCGCTTTAATTTGCTTATTGTAAACAGGGAAAGAACTGTTCCTCACTGCTGGGAGAATAAAGATTGTTTTAGAtgct
>NM_001301641.1
ATATGCTAATGAAGACTCGGGTGAAAAAAATGAATTGCTTAGTTATATTGCAGACTTTGGACTGGTGTCTTCATCCTTGTCTAGAATTCCTGCAGTTAGTTGTATTGCTGTGGTAGGGGGTCTAAAGATTCTACATACAGTGATACACATTTGGAATTTTTGTACTTGGCAAATTGAGGCAGGAAGCTAACGTTTTCCAGAACGGCCTGGGCTGCTTTTGAGAGCTCCGATCTCAGAGAAGAAGCACTAAAAGATGAATATGAAAAGGTGGACAAGTCCTATTTTCCAGAGAAGATGACTTTTAACAGTTTTGAAGGAACTAGAACTTTTGTACTTGCAGACACCAATAAGGATGAAGAATTTGTAGAAGAGTTTAATAGATTAAAAACATTTGCTAACTTCCCAAGTAGTAGTCCTGTTTCAGCATCAACATTGGCGCGAGCTGGGTTTCTTTATACCGGTGAAGGAGACACCGTGCAATGTTTCAGTTGTCATGCGGCAATAGATAGATGGCAGTATGGAGACTCAGCTGTTGGAAGACACAGGAGAATATCCCCAAATTGCAGATTTATcaatggtttttattttgaaaatggtgCTGCACAGTCTACAAATCCTGGTATCCAAAATGGCCAGTACAAATCTGAAAACTGTGTGGGAAATAGAAATCCTTTTGCCCCTGACAGGCCACCTGAGACTCATGCTGATTATCTCTTGAGAACTGGACAGGTTGTAGATATTTCAGACACCATATACCCGAGGAACCCTGCCATGTGTAGTGAAGAAGCCAGATTGAAGTCATTTCAGAACTGGCCGGACTATGCTCATTTAACCCCCAGAGAGTTAGCTAGTGCTGGCCTCTACTACACAGGGGCTGATGATCAAGTGCAATGCTTTTGTTGTGGGGGAAAACTGAAaaattgggaaccctgtgatcgtGCCTGGTCAGAACACAGGAGACACTTTCCcaattgcttttttgttttgggcCGGAACGTTAATGTTCGAAGTGAATCTGGTGTGAGTTCTGATAGGAATTTCCCAAATTCAACAAACTCTCCAAGAAATCCAGCCATGGCAGAATATGAAGCACGGATCGTTACTTTTGGAACATGGACATCCTCAGTTAACAAGGAGCAGCTTGCAAGAGCTGGATTTTATGCTTTAGGTGAAGGCGATAAAGTGAAGTGCTTTCACTGTGGAGGAGGGCTCACGGATTGGAAGCCAAGTGAAGACCCTTGGGAACAGCATGCGAAGTGGTACCCAGGGTGCAAATACCTATTGGATGAGAAGGGgcaagaatatataaataatattcattTAACCCATTCACTTGAGGAATCTTTGGGAAGAACTGCTGAAAAAACACCATCGCTAACTAAAAAAATCGATGATACCATCTTCCAGAATCCTATGGTGCAAGAAGCTATACGAATGGGATTTAGCTTCAAGGACATTAAGaaaacaatggaagaaaaaatCCAAACATCCGGGAGCAGCTATCTATCACTTGAGGTCCTGATTGCAGATCTTGTGAGTGCTCAGAAAGATAATACGGAGGATGAGTCAAGTCAAACTTCATTGCAGAAAGACATTAGTACTGAAGAGCAGCTAAGGCGCCTACAAGAGGAGAAGCTTTGCAAAATCTGTATGGATAGAAATATTGCTATCGTTTTTGTTCCTTGTGGACATCTGGTCACTTGTAAACAGTGTGCAGAAGCAGTTGACAAATGTCCCATGTGCTACACCGTCATTACGTTCAAGCAAAAAATTTTTATGTCTTAGTGGGGCACCACATGTTATGTTCTTCTTGCTCTAATTGAATGTGTGATGGGAGCGAACTTTAAGTAATCTGCATTGCATTCCATTAGCATCTGCTGTTTCCAAATGGAGACCAATGCTAACAGCACTGTTTCCGTCTAAACATTCAATTTCTGGATCTTTCGAGTTATCAGCTGTATCATTTAGCCAGTGTTTTACTCGATTGAAACCTTAGACAGAGAAGCATTTTATAGCTTTTCACATGTATATTGGTAGTACACTGACTTGATTTCTATATGTAAGTGAATTCATCACCTGCATGTTTCATGCCTTTTGCATAAGCTTAACAAATGGAGTGTTCTGTATAAGCATGGAGATGTGATGGAATCTGCCCAATGACTTTAATTGGCTTATTGTAAACACGGAAAGAACTGCCCCACGCTGCTGGGAGGATAAAGATTGTTTTAGATGCTCACTTCTGTGTTTTAGGATTCtgcccatttacttggaatttatTGGAGTTATAAATGTACTTATATGAGTATTTTTAAGTGATTTCGTCATCTCCTAAAAGATATTGAATGGTAGACTACCATCTAACCAGCATGTACTGACATGGAAAGGCAACACAGATATAgttaagtgtaaaatacaaatggCAAAACACTGTATCTAGTTGGAGCCAAATCAGCTTGTGTGTATTTTGTATCTGTACAGGACAAAAAGGTTTGAAAATATAAGTATCACActcttaaatgtattttttcttcagggggtggggggtgggtctTAGAGGGGCTTATAGAGcccttcactttattttttcatttttttctgtttaaaggTTTTATAAGTATGTATTACTTTTATAATCAGAGTTCTTAGTAAATATGTTGCTGATTTAAAGGCTTAGGCATGTTCAAACGTCTGCAAAACTACTTATCGCTCAGTTTTAGTTTTTCTAATCCAGGAAGGCAGGCCAGTTAACTTTTCTGGTGCCAATGTgaactttaaatgtttttattttacctgCTTTGTGGATGAAAAATATTTCTGAGTGGTAGTTTTCTGACAGGTAGATCATGTCTTTTTATCTTGTTTCAAAATaactatttctgattttgtaaaatgaaatataaaatatgtctCAGATCTTCCAATTAATTAGTAAGGATTCACCCTTAATCCTTGCTAGTTGAAGCCTGCCTAAGTCACTTTACTAAAAGATCTTTGTTAACCCAGTATTGTAACCATCTGTCCGCTTACGTAGGTAAATGTAGACGCCTGGTGTATATGGCTTGTAGTTTTAGTGTTGGCTCTCCGTGTTGAGATTCTTTCTCAGTGTCATTCTGTGTCCTACAAGTTTCATGTAGGTTTCGATGTTAGGATGGTTAAGATGTATATAGTACAAAATGTTCAGTCTTtgattgttttatgtttgtttgttttcatgactAGTAATGGTAGtggatactttaaaaatattttctgaagatCCTTAAAACCTTGGAAATTGTAACATACTGAGAAGAGTGGTTGTTTGAATATTTTTAACAACTTGTATAAGTCAATATGAATACAATCAAAAGCTAAAGTGCTTCATAGAACACGGGATTTACCTTAAGTAATTATCATGAGAGACCTCTTGTAAAGACTGGTCTATTTTACTACAGAGAACAGTTTGAGAGTGAAACTGTTACAATTTAGactttttgttgtattttctaaGAGAAAGAGTATTGTTAGGTTCTCCTAACCTCTGTTGACTACTATGGTAAGTGATGTTATTTTAATTGCAAATTTAAATAGAAACCAACAGAATTAAGTAactgactgtctctctctctctctctctctctgtcttcttcatgAAAATCCTTAGTTCTGTATACTGCCTTCTGCTTAGATTTAGTTATATGATCATTAGGTTACATTTGATCTAAGTTGACTAAGATTTCAATTTcaatttatatttcaagcattCTGCCAgggaatagttttaaaaattgtttccaaGGCACTTCAGGTACAAGTCATATAGGTAGTTTGTTTAATCTAGTCCTTAGCCTAGGACTCAAGGACTGAATGTTTTCAAATAACACTTTTCTTGTTCTCAGAGCCTCAGTTCATTAAAACTCTTTTAAAACCTGTGTGCTGAGAGTTAAGCAAGACCTCTTTTCTTGTCTTCATGAGTTGCGAAATTGAATTCATGGAGCTGatgtggctaacaagtttattttAGGAATTGTTTAGAAAATGCTGTTGCTTCGGGTTCTTAAAATCACAGCACTCCAACTCTAATCAAATTATTGGAGACTTAGCAGAGCTGGTCTGAaatcacactaaaaaaaaaaaggtactggATCCTTTCCAGTATGGTTGTGTAAAAAATGGTCACTCGGAAGGTCACAGAATAACCGGCTCTGAATCACCACCCCTGAGAGAGTTCAGTGTCTGCGTGCTGATGGTCTTTTGCTGTATAAAGTTCATTCTAGAATTTTGAAGTAACCACCCGTTTTACTACATATTAGTCATGTGAATTTTGAAGTTATTTTGTAATAGTTACTTTCATTTGTTATTTACTGTGTTGATCaagatgtgtgtgagtgtttagcATTTATTAAAGTATTGTCTTTCCTCCTAGACTTTTGCCTCTTCCTGTAGTTAGGGGTAGAGGTGAGGTGAGTGGAGTGACTACAATGTGATTCGCTGGGGTAGGACAGTTTGTTGTCTTGTTAGTCACAGTGTGTtgctctgttttttattttagtaagaTTTATATTTTGAGCTCTCTGAATGGAAAGTGCCACTGCAACCTTAGCTGCATGCATTGTTCCCATTAGACCTAAGTCTTCCTGGACTTCTGAGTCCCCAGATACTGgataaaggaagaggagagatggaGTAGCCTGTCTGTCACTGCTATGAGAGAAGCAAGAAAGTGGGTAGAGAAATACTTCACATTTTAGTCacatcttctctttttaaaaaggtagCCATCAGTGAAGGAAAGAACTAGTCAAAAATAGGCTTGAcaacctgaattcagatccccagaacggGCATAAAAGCAGCCAGGTCATGGttagtgcactcctttaatcccagcatttgggaggcaggggtagaCATATctgggtttgaagccagcctgatctacagagtgagttccaggacagggaacCCTGtcttattcataaaagaaaacaaaacaaacaaaaagctgagCGCACTAGCCcaagcacctgtaatcccagaatgcCTACATGAAACAGGAAGTAGCTAGGAGAATGCCCCAAAGCTCATGGTCAGTTAATGGCTTATGTATTAATGAAGAGGCACCATGGTAAACAAAGTGGGAAGGTGAGAGCCCACCAACATCCACAAGTTATCTGCTGCCTCCACACATGTAACATGGCAGGTAACCACTTAcacccagacacatacacaaaagagaGAAGACCAAGAGTGTTAACACAAGAACATCTTATATACTCTTAAGTGTTAACTCTCATCCTACAACTTAGAATCCTCCATGGCTTTGTCTTGATGGAAGATCTTAGACTAAAGCTTAAAAGAGGCCCAGAACTATTactcagttaagagtacttgctgctttttcagaggacttaggttcagttcccagcacccacatggacaAAGACACATGTAgctctggtgccctcttttggccttcaggggtgcatgcatgtgtgtatacatacacagtcatacacaagtacacataaaataaaagtaatcttTAAAGCTTAAATGAAACTCTTTATGTTAACTTTTACTCActattatttgtttctctggatgcTTCTTGTAACAAAGCTATAAATTGTAATAAATAGTTCaaccctttaaaaatatttaaattacctTTTCAAAAATTAGAGAAAGTATTCTTACTAAATTCAGTCGAATTTTTTCCAATAGAAACAGTCAACTTATTACCATCTTAATATTTTAGTTTGGCTCTGAAACATTTAGTGCAATGTAGATTTCTTCCTTATATAATAAAATCACTGACTATCAGAGCTAGAAATGACCTTAGAAAGTCACTTAttcacactaccaccaccaccttcaTTTTATTGTTGAGGCAACTTAAAGGAAAGGTGATTGGCCCGAAGCTATATAGCTGATTAGTGATAGATTCCTTACTGGAAGTCTCAGGTGTTTGTCAACTCTTCATTCTATTACACTCTTATCAGGGCACAGTAAGTGGTGCTTTGTAGTTTCTACAGTAAGACGGTTGCTGATACTTTCAAATTAAACAATATGACAGTAATGCTTGAGTGGTAAAGTTCTCTTTTGGAGGCTGAAATTTGCAGATGTGAGTACAGCTGTTTGGCATTTACTATGTGCTTATGTATTATTAATGAGCATTTAAGATTACTCTGTAAGTATATTTTATCACTGTCTATACTTACCAACAAATTTGCATTTTGATGTAATAATGGCTTTCGTGTAATTTCTGTTTTGGCATTTTTGTTATactttacctgaaaaaaaaaaagaccaattcTTTTGTCATGTGTTGTACTATATTTGTGAATATAATTTTATGACTCGTTTATGGAAACTCCTTTATGGAATTGCTTTCTGCTCTATAATCTGTCATTTGTTGTAGATTAAAGCTTATTTTTCTGTGAATAAGACTTATTCAATAAAGCActattctttaaaatgtta

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