Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name Ddb1P1
Plot displaying the genomic locations of a retrocopy (in chr8) and its respective parental gene (in chr19). Each line represents a retrocopy.
Species Mus musculus
Coordinates chr8:101165387-101166862  UCSC
Strand +
Parental Sequence NM_015735.2
Parental seq. overlap 725 bp
Parental seq. overlap (%) 17.2%
Genomic Region Intergenic
Retrocopy Summary Ddb1P1, located on chr8:101165387-101166862, is a retrocopy of the parental gene Ddb1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name Ddb1
Full Name damage specific DNA binding protein 1
Also known as 127kDa|p127-Ddb1
Coordinate chr19:10582932-10607192
Strand +
Gene summary Predicted to enable several functions, including WD40-repeat domain binding activity; cullin family protein binding activity; and damaged DNA binding activity. Involved in cellular protein metabolic process; positive regulation of gluconeogenesis; and regulation of circadian rhythm. Acts upstream of or within Wnt signaling pathway and negative regulation of apoptotic process. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of Cul4A-RING E3 ubiquitin ligase complex and Cul4B-RING E3 ubiquitin ligase complex. Predicted to be active in nucleus and site of double-strand break. Is expressed in several structures, including liver; lung; otocyst; spermatocyte; and spleen. Orthologous to human DDB1 (damage specific DNA binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Human Homo sapiens Without Homology
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>Ddb1P1
GGGAGATCCTTTCACACTGAGGGAAAGACAGAACTAGCCACAGGCTTCTTAGGTGGTAACCTGATTGACAGTTTCCAAGATTATCAGCCTTCCAAAGATGCAGGAGTTTGTGGCAAATTTGCTGTATGATGATGGCAGTGGTATGAAGCAGAAAGCAACTGCATATGACCCCATCAAAGTCGTGGAGGCGCTAACTCCAATCCATTAGCCAAGGACAGGATCTCTTTCCCTGACCCTCCCTAAAGGTTCTGCGCTCTtattctctcctccctttccaacCCTTATTTTCTTGGCATAGGAGGCTTTCCCCTAAGCCACCTACCCGTGGAGCCACAGCTGACTGGTGTGGAAAcaggactttttttaaaaaattaatcAGTTCACTAGCGACCTAGGAATGGGCTGAAATTTGGAAACGGGTgaaatattttctgccttgattctAACCACCCATCACCTTACACCACCAAGCCTTGAATGGTGCTGCCAGTTGGCCCCTCCTGTGGAGGACTTTTGTCACTCTTCTGCCAAGAAACAGCTCTGTGCACTTTTATGTGATACCTCACACTTGTGCTTTGTTCTATACTATCTTATGTAGGGAGAGGGTAATTAGGgcttcattttcttaagagcttccttttgctttcttctcttgcctCTGAGAACATCAGCCTGTAGGTCTGTCAAGCTATGGACTGCTTGAGTGGAAACCTGGGATGGTAGATAATTCCGAAGCCATAGCCCTTTTGTCTCAGAGAACTACTTTCTTCCCAGAGGAGGTGGCCCTGTGAATTGGTTGTTAGTGTCTGAATTTTACCAAATACAGTAGAatcta
>NM_015735.2
AGCAGCCACGGAGTTGGCTGCGTGAGGGTGGGGGTTCTCAGTCTCTTCGCTCGCGCCCGTCTCTCTATCGTCGCTCTAGGCGCCCCACGGGCCAACCCAAGGCCTCAATATGTCGTACAACTACGTCGTAACGGCGCAGAAGCCTACTGCAGTGAACGGCTGTGTGACCGGACACTTTACTTCAGCGGAAGATCTGAACCTGTTGATTGCTAAAAACACAAGATTAGAGATCTATGTGGTCACTGCGGAGGGTCTTCGGCCAGTCAAAGAGGTGGGAATGTACGGGAAGATTGCAGTCATGGAGCTCTTCAGGCCCAAGGGGGAGAGCAAAGACCTGCTGTTCATCTTGACTGCTAAATACAATGCCTGTATCTTGGAGTATAAGCAGAGTGGCGAAAGCATTGACATCATTACAAGAGCCCATGGCAATGTCCAGgaCCGCATTGGTCGCCCCTCGGAGACTGGCATCATTGGCATCATTGACCCTGAGTGCCGTATGATTGGCCTTCGACTCTACGATGGCCTTTTCAAGGTCATTCCACTAGACCGAGACAATAAAGAGCTCAAGGCCTTTAACATCCGCCTAGAGGAACTGCACGTCATTGATGTCAAGTTCCTGTATGGTTGTCAAGCACCTACCATTTGCTTTGTCTACCAGGATCCTCAGGGGCGGCATGTGAAAACCTATGAGGTGTCTCTTCGAGAGAAGGAGTTCAACAAGGGCCCTTGGAAACAGGAGAATGTAGAAGCCGAAGCTTCAATGGTGATAGCAGTCCCAGAGCCTTTTGGAGGTGCCATCATCATTGGACAGGAATCAATCACCTATCATAACGGTGATAAATACCTGGCAATTGCTCCTCCTATCATTAAGCAAAGCACTATTGTGTGCCATAACCGGGTGGATCCTAATGGCTCGCGGTACCTTCTGGGAGATATGGAGGGACGGCTTTTCATGCTGCTCTTAGAGAAGGAGGAGCAGATGGATGGCACTGTCACCCTCAAGGACCTTCGAGTGGAACTCCTCGGAGAGACCTCCATTGCTGAGTGCCTAACTTATCTTGATAATGGTGTTGTATTTGTCGGGTCTCGCCTAGGTGACTCCCAGCTCGTAAAGctCAATGTCGACAGCAACGAACAAGGCTCCTATGTAGTGGCCATGGAAACCTTTACCAATTTAGGACCcattgtggatatgtgtgtggtgGACCTGGAGAGGCAGGGACAGGGTCAGCTGGTCACTTGCTCTGGAGCTTTCAAGGAAGGTTCCTTGCGGATCATCCGGAACGGCATTGGAATCCATGAGCATGCCAGCATTGACTTACCAGGCATCAAAGGTTTATGGCCTCTGCGCTCTGACCCCGGTCGGGAGACGGATGACACTTTGGTGCTCTCTTTTGTGGGCCAGACAAGAGTTCTCATGCTAAAcggagaggaagtggaagagaCAGAACTGATGGGCTTTGTGGACGATCAGCAGACTTTCTTTTGTGGCAACGTGGCTCATCAGCAACTTATCCAGATCACCTCAGCATCTGTGAGGTTGGTGTCTCAAGAGCCCAAAGCTTTGGTCAGCGAGTGGAAAGAGCCTCAGGGCAAGAACATCAGTGTGGCCTCCTGTAACAGCAGCCAGGTGGTTGTTGCCGTGGGAAGGGCACTATATTACCTTCAGATCCACCCTCAGGAGCTCCGGCAAATCAGCCACACAGAGATGGAACATGAAGTGGCATGCTTGGATATCACCCCATTAGGGGACAGCAATGGCCTCTCCCCACTTTGTGCCATTGGACTTTGGACAGACATCTCAGCTCGTATCCTGAAGCTCCCATCCTTTGAACTACTACACAAGGAGATGCTGGGTGGAGAGATCATTCCTCGATCCATCCTGATGACCACTTTTGAGAGTAGCCACTACCTCCTTTGTGCCTTGGGAGATGGGGCTCTTTTCTACTTTGGGCTCAACATCGAGACAGGTTTACTGAGTGACCGTAAAAAGGTGACTTTGGGCACCCAGCCCACGGTGTTGAGGACATTCCGTTCTCTTTCTACCACCAACGTCTTTGCTTGCTCTGACCGGCCCACTGTCATCTATAGCAGCAATCACAAGTTGGTCTTCTCCAATGTCAACCTCAAGGAGGTGAACTATATGTGTCCTCTCAACTCAGATGGCTATCCTGACAGTCTGGCATTGGCCAATAACAGCACTCTCACCATTGGCACCATCGATGAGATCCAGAAGCTCCATATTCGCACAGTTCCCCTCTATGAGTCTCCCAGGAAGATCTGCTATCAGGAAGTGTCTCAGTGCTTTGGGGTCCTTTCCAGCCGCATTGAAGTCCAAGATAGCAGTGGAGGCACTACTGCTTTGAGGCCCAGTGCCAGCACCCAGGCCCTGTCCAGCAGCGTCAGCTCCAGCAAACTTTTCTCCAGCAGTACGGCTCCTCACGAGACCTCCTTTGGAGAAGAAGTGGAGGTGCACAACCTCCTCATCATTGACCAGCACACCTTTGAAGtGCTTCACGCCCATCAGTTTCTACAAAACGAGTATGCCCTCAGCCTGGTCTCCTGCAAGTTGGGTAAAGACCCCAACACTTACTTCATTGTGGGCACAGCCATGGTATATCCTGAAGAGGCAGAGCCCAAGCAGGGTCGTATTGTGGTCTTCCAGTATTCAGATGgaAAACTACAGACTGTGGCTGAAAAGGAAGTAAAAGGAGCTGTGTACTCTATGGTGGAGTTTAATGGGAAGCTGCTTGCCAGCATCAATAGCACGGTGCGGCTCTATGAGTGGACCACAGAAAAGGAGCTTCGCACTGAGTGTAATCACTACAACAACATCATGGCCCTGTACCTGAAGACCAAGGGCGACTTCATCCTGGTGGGCGACCTCATGCGCTCAGTGCTGCTGCTTGCCTACAAGCCTATGGAAGGAAACTTTGAAGAGaTTGCCCGAGACTTTAATCCCAACTGGATGAGTGCAGTGGAGATCTTGGATGATGACAATTTTCTGGGAGCTGAAAATGCCTTTAACTTGTTTGTGTGTCAGAAGGACAGTGCTGCCACCACTGATGAGGAGCGGCAGCACCTACAGGAGGTTGGTCTCTTCCACCTGGGCGAGTTTGTCAATGTGTTCTGCCATGGCTCCCTAGTTATGCAGAATCTGGGCGAGGCTTCTACCCCTACACAGGGCTCGGTGCTCTTTGGCACAGTCAACGGCATGATAGGGCTGGTGACCTCGCTGTCAGAGAGCTGGTATAACCTCCTGTTGGACATGCAGAACCGACTCAATAAGGTCATCAAAAGCGTGGGCAAGATTGAGCACTCCTTCTGGAGATCCTTTCACACTGAGCGAAAGACAGAACCAGCCACAGGCTTCATCGATGGTGATCTGATTGAAAGTTTCCTAGATATCAGCCGCCCTAAGATGCAGGAGGTTGTGGCAAACTTGCAGTATGATGATGGCAGTGGTATGAAGCGGGAGGCAACTGCAGATGACCTCATCAAAGTCGTGGAGGAGCTAACTCGGATCCATTAGCCAAGGACAGGATCTCTTTTCCTGACCCTCCCTAAAGGCGTTGCCCTCCTATCCTCCCCTCCCTTGCCCACCCTTGTTTTCTTGGCATGGGAGGCTTTTCCCTAAGCCACCTGCCCCTAGAGCCACAGCTGACCTGTGTGGAAACAGGGCTTTTTATAACTAAAACCAGTTCACTAGAGACCTAGGAATGGGCTGGGCTGAAAGTGAAATATTTTCTCCCTGGATTTTTACCAGCCATCACCTTGGACCACCAAGCCTTGAATGGTGTTGCCAGTTGGCTCCTCCTGGGGAGGACTTTTGTCACTCTTCAGCCAAGAAGCAGctctgtgcacctgtgtgtgatACCTCACACTCGTGCTTTGTCCTCCACTGTCTATGTAGGTTGTGGGTGTGGGGAGGTTGAGGTAGAGGGAAGAGGGTCGAGAGGGTTCCACTGTCTTGAGAGcttccttttgctttcttctcttgcctCTGAGAACATCAGCCTGGAGGCCTGTCAGGCTACGGGCTGCCTGAGTGGAAACCTGGGATGGTGGAGAATTCCCAAGCCACAGCCCTTTTGTCTCGGGGAACTCCCTTCTTCACAGAGAAGGAGGTGGGGGCTGTGAATTGGTTGTTAGTTTCTGAATTTTACCAAATAAAGTAGAATCTAAGAAGAAACTCTTA

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