Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name Suz12P1
Plot displaying the genomic locations of a retrocopy (in chrX) and its respective parental gene (in chr11). Each line represents a retrocopy.
Species Mus musculus
Coordinates chrX:77452221-77454594  UCSC
Strand +
Parental Sequence NM_001163018.1
Parental seq. overlap 2079 bp
Parental seq. overlap (%) 47.9%
Genomic Region Intergenic
Retrocopy Summary Suz12P1, located on chrX:77452221-77454594, is a retrocopy of the parental gene Suz12. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name Suz12
Full Name SUZ12 polycomb repressive complex 2 subunit
Also known as 2610028O16Rik|D11Ertd530e|mKIAA0160
Coordinate chr11:79883932-79924949
Strand +
Gene summary This gene encodes a core component of the polycomb repressive complex 2 (PRC2) that also includes, at least, embryonic ectoderm development protein (EED) and enhancer of zeste homolog 1 or 2 (EZH1 or EZH2). Through the methyltransferase activity of EZH1 or EZH2, the PRC2 complex methylates Lys9 and Lys27 of histone 3 and Lys26 of histone 1, leading to recruitment of the PRC1 complex, histone 2A ubiquitylation and transcriptional repression of the target genes. This gene product is essential for the activity and integrity of the PRC2 complex, and is required for X chromosome inactivation, stem cell maintenance and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]

Homology

Species Scientific Name Retrocopy
Human Homo sapiens Without Homology
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>Suz12P1
ATAAAACTCTGCCAAAGCAGATTTGTCTTCAATTATGTATATCATCCAAAAGGTGCTAGGATAGGTGTTCCTATCAATAAGTGTTATGATAGCTCCTATGCAGAAAATCTTCAGGACATACATCGCCAACCTAGATTTGCTTTTAGTTGAAATGGACCAGTTAAGAgaacacatatcacatacatccTTGTGTGCAGGCCAAAACGAACAAAAGCAAGCATGTCAGAGTTTCTTGAATCTGAAATGGAGAAGTAGAACAGCAAAGAACATACAGTAGTGGCCACAATCATTTTTATTTCCACAGTAGTACTTGTCTGCCTCTTCAGCCACAAGAAACAGAAGTAGACAATGAAGATGAGAAAGATCCAGAATGGCTgagatttaacaaattgaattttttttgatatgaaggaagaagagaacgAAGTAAAGAAACTGTGGTATCTCTATGTCATGAAGCATTGATTTATTGTTGACAATCAAATGAATCATGCCTGTATGCTGTTTGTAGAAAATTGTAGACAGAAAATAATTAAGAATTTATGTCGAAATTTTATGCTCATCTAGTCAGAATGCTTGACTTTAATCTTACTACCATAATGTCAATAGATAAAGCTCTTACCAAACTCCAAGAAATGCAGCAAAACGAGAAAAAGGAGAATCTGTGGCCCCTGCAAATGAAGAAATAGCTGAGGAACAAAATGGGACAGCAAATGGATTCAGTGAAACTAACTCAAAAGGGAAAGCTTTGGAAACTGACGGTTTCTCAAGGGTTCCACGATAGAGCAAGAACAAAAACTGAGAACTTGCCCGTGTTGTGGATACATACTGAAGTTGCTTCTAGGGAATTCAGCCTCTAGGATGAGTTTTGGTTttaagttattttgtttttaatcatggaTTAGAAACAGGCAGTGTTAGATGATGTCATTGATTTCAGCACGGAGGTTCTGTGGGTCTGCTTTGCTTCTTGTCCTCACGTGCTTATCAGCTTTAGTGATGTCCTCAATTTGGTTTTAGCCTGAAAAGCAGTTTTTCAAATAGTTAATTTTCCTTAGCTATAATAGtcatcatttttaaatatattgggTTAATCTTGAAGTTTTACACCTAAATTTTAATGCCTGTCTCACTTGTGACTGTTTTTCTGCTTTGTAATTATGAGACATTTTCTGGGAAAGGAAGGTTGGGATATTATGCTGTCCTAGAGATGGAGAATTTTTGTGAAATTATTCCATTGCCACTTTCCCCCAAACTTTGACCCTTGATTCAGTAATCACTTATGCATTTGGGATGAGCagttacaaagcaagttctgCATCAGTTCTGTTACAAGTTTAAAACAGCATCAGTTGATCTCCTCCTGTTGGAGGTGATGTGACCTTTCCATGCAGCCATGCAGTGCCATGCTCACTGATggaagttacttttttttttcaagtgactGGTTTTCATGTTCGTTTTTTCCCAATTtagttttttaattgaatatgttcttaggttttctattttcattagGTGATCCCATGAGAAATTGTTCTGTGTACATCTTTTGCACTAGGATGGTAAAGCAAGATTTAAAAGATGCCACTTTGTGGGGGAAGGGTGCCAGAAGATGTCACACCTTGTATCCTTTGTGATGTCCTTCTTGATTAGAATATCCATACAGATAAGTTGATTTGAATTGTTGTGAGCAATTTTCCCTGTGTTCTGTGTTTTATGCACATAttcatgtttggttttttttccagtgGAAAGTCGTTTCACTACTGGCATATTAATAAATAAGCACGGATGGGTTTTTATTCCAGCTCCAAGCACATCAATAACATCATCTCAATCttttttattatcctttaaagataTTACATGTTCTTTATTTATAAAGGATCAGTGTTCCTGTAAatacttgtatttttaaaattttaatttcatttcaccACCATCAGATACACTTCCCTGTTTTGTTTAGTAAAGGGATATAAGCATTCTCATGGTGTcttcagagattaaaaaaaaatgtaaatattgatttcgcTGGTCTTTACAATGTGTTTAACTGTGAGGCTATATAATAGTGTGGATGAGACTTGTCATCCAGTATTAAGTACTTAGTTACTGATTTTTgtgttaaaaataagaaagagggaGGCTGTAGTTTTCATTGTAGGCTCTCTACCTGGTAAACTCTGCTCATGAGTTCACTGAACTCTAATTTTGCCTCTGGGTAGTGGAATCTGAGCATTTCTCCTGGGCTTTAATTTAATAGTTatgcacatatgtaaaaaaaaagattattttaggGAAGATGTAGGTATAGAATTATTGCTTAAGccatttctt
>NM_001163018.1
CCGAAGCGGAGCGGGGCTCGGaggagacactttttttttttcctccctccttccctcctctcctcctcccttcccttcccctctcctcccctctctcctccttcccccctcggTCCGCTGGAGCCTGCTGGGGCGAGCGGTTGGTGTAGCAGGCGCGCTCACTCTCCGGGGCCGCCCGGCGGGTAGCTGGCGGGGGGAGGAGGCAGGAACCGCGATGGCGCCTCAGAAGCACggcggtgggggagggggcggctCGGGGCCCAGCGCGGGGTCCGGGGGAGGCGGCTTCGGGGGttcggcggcggcggtggcggcggcggcttCGGGCGGCAAATCCGGCGGCGGGGGCTGTGGAGGCGGCGGCAGTTACTCGGCCTCCTCCTCCTCGGCGGcggccgcggcggcggcggcgggggccGCGGTGTTGCCGGTGAAGAAGCCGAAAATGGAGCACGTCCAGGCTGACCACGAGCTTTTCCTCCAGGCCTTTGAGAAACCAACACAGATATATAGATTTCTTCGAACTCGAAATCTTATCGCAccAATATTTTTGCACAGAACTCTTACTTACATGTCTCATCGAAATTCCAGAACAAGCATCAAAAGcttGTCTGCACATTTGCAACTTACATTTACCGGTTTCTTCCACAAAAATGATAAGCCATCACAAAActcagaaaatgaacaaaattctGTTACCCTGGAAGTCCTGCTTGTGAAAGTTTGCCACAAAAAAAGGAAGGATGTAAGTTGTCCAATAAGACAAGTCCCTACTGGTAAAAAGCAGGTGCCTTTGAATCCTGACCTCaatcaaacaaaaccaggaaatttTCCATCCCTGGCAGTTTCCAGTAATGAATTTGAACCTAGTAACAGCCATATGGTGAAGTCCTACTCGTTGCTGTTTAGAGTAACTCGTCCAGGAAGAAGAGAATTTAATGGAATGATTAATGGAGAAACCAATGAAAATATTGATGTCAGTGAAGAACTTCCAGCCAGAAGAAAACGAAATCGCGAAGATGGAGAAAAGACATTTGTTGCACAAATGACAGTTTTTGACAAAAACAGGCGTTTACAGCTTTTAGATGGGGAATATGAAGTGGCCATGCAGGAAATGGAAGAATGTCCAATAAGTAAGAAAAGAGCAACATGGGAGACAATTCTTGATGGGAAGAGGCTGCCTCCatttgagacattttctcaggGACCTACATTACAATTTACTCTTCGATGGACAGGAGAAACCAACGATAAGTCTACAGCTCCTGTTGCCAAGCCTCTTGCCACTAGAAATTCAGAGAGCCTTCATCAGGAAAATAAGCCTGGTTCTGTTAAACCTGCACAAACTATTGCTGTTAAGGAGACGCTGACTACAGAGCtgcaaacaagaaaagaaaaggataatTCAAATGAAAGTCGCCAGAAGTTAAGAATATTTTATCAGttcctTTATAACAATAATACAAGACAACAGACAGAAGCCAGAGACGACCTGCACTGCCCGTGGTGCACTCTGAACTGCCGTAAACTGTATAGCTTACTCAAACATCTAAAGCTCTGCCACAGCAGGTTCATCTTCAATTACGTAtatCATCCAAAAGGTGCTAGGATAGATGTTTCAATCAATGAGTGTTATGATGGCTCCTATGCAGGAAATCCTCAGGATATACATCGCCAACCTGGATTTGCTTTTAGTCGAAATGGACCGGTAAAGAGAACACCTATCACACATATTCTTGTTTGCAGgccaaaaagaacaaaagcaagcatGTCGGAGTTTCTTGAATCTGAAGATGGAGAAGTGGAGCAGCAGAGAACATACAGCAGTGGCCACAATCGTCTCTATTTCCACAGTGATACCTGCTTACCTCTTCGGCCACAAGAAATGGAAGTAGATAGTGAAGATGAGAAAGATCCAGAATGGCTGAGAGAAAAAACCATTACTcaaATTGAAGAATTTTCTGATGtgaatgaaggagagaaagaagtgaTGAAGCTGTGGAACCTCCATGTCATGAAGCATGGATTTATTGCTGACAATCAAATGAATCATGCCTGTATGCTGTTTGTAGAAAATTATGGACAGAAAATAATTAAGAAGAATTTATGTCGAAACTTCATGCTTCATCTAGTCAGCATGCATGACTTTAATCTTATTAGCATAATGTCAATAGATAAAGCTGTTACCAAGCTCCGAGAAATGCAGCAAAAACTAGAAAAAGGAGAATCTGCGACCCCTTCAAATGAAGAAATAGCTGAGGAACAAAATGGAACAGCAAATGGATTCAGTGAAACTAACTCAAAAGAGAAAGCTTTGGAAACTGACGGTGTCTCAGGGGTTCCAAAACAGAGCAAGAAACAAAAACTCTGAGAACTTGCCCCATGTTTTGAACAGACACTGAAGTTGCTTCTAGGGAATTCAGCCTCTAGGAAGAGTTTTGGTTTTAGGTTGTTTGGCTTTTAATCATGGATTGGGAACAGGCAGTGTTCGATGATGTCATTGATTTCAGCACGGAGGTTCTGTGGGTCTGCTTGGCTGCTTCTCCTCACGTGCTTATCAACTTTAGTGATGTCCTCAATTTGGTTTTAGCCTGAAAAGCAGTTTTTCAAATAGTTAATTTTTTCTTAGCTATGACACACATCTTATTAAATATATTGGGTTAATCTAGAAATTTCACACCTAAATTTTAATGCTTATTTCATTTGTGACTTTTTCTGCTTTGTAATTATGAGACATTTTCTGGGAAAGGGATGTTGGGATGTTATGCTGTCTTAGAGATGGAGAATTTTTGTGAAATTGTTACTTACATTGCCACTTTCCCCCAAACGTTGACCCTTGATTCAGAAATCATGCATCTGGGATGAGAagttacaaagcaagttctgCATCAGTTGTGTTACAAGTTCAAAACAGCACCAGTTGGTCTCCTGTCGGAGGCAGTGTGACTGCCTTCCATGCAGCCATGCAGTGCCGTCCCGTGCGCACTGAGGGAGCTCGCTGTTCCTTTTCAAGTGAATGGTTTTAGTGCTTGTTTTCCCAGTTTAGGTTTTTACTTGAACATGTTTttagtttttccttttaattagGTAACCCCATGGGAAATTGTTCTGTGCACGTCTTTTGCACTAGGATGGTAAAGCAAGAGAAACAGTTGGAGATTCAGAAGATGCCACTGTGGGGAGGGTGTCTCTGAGTGTAAACCAGAAGATGTCACACCTTGTTTCCTTTGTGACATCCTTCTTGATTAGAATATCCATACAGATAAGCTGACTTGAATTGTTGTGAGCAATTTTCCCTGTGTTCTGTGTTTTATGCACATATTCGTGGTTGGGTTTTCTCCAACAGAAAGTGGTTTCACTACTGGCACGGATAGCTTTTTATTCCAGCTCCAAGCACTGTGGTTGAATAACATCACCTCAattttttattatcctttaaagatattgcattttcatattctttatttATAAAGGATCAATGCTGCTGTAAATActggtatttttaatgttttaatttcatTCCACCACCATCAGATGCAGTTCCCTGTTTTGTTTGGTTAAGGGACATAAGCTTTCTCATGGTGTCTTCAGAGATTTATAAGTGTAAATACTGATTTGGCTGGTCTTTATGATGTGTTTAACTGTGAGGCTATTTAAATAGTGTGGATGTGACTTGTCATCCAGTATTAAGTTCTTAGTTACTGGtttttgtgttaaaaaaaaataagaaagagggaAGCTGCAGTTTTCGTTGTAGGCTCCCTAGCTGGTAAACTCTCCTCACGAGTTCACTGAACTCTGATTTTTGCCTCTGGGTAGTGGGTTCTGAGCATTTCTCCTGGGCTTTAATTTGCTAAagctgtgcacatatgtaaaaatcaaaaaaatagattattttaggGAAGATGTAGGTGTAGAATTATTGCTTATGTCATTTCTTAAAGCAGTTATGCTCTTAATGCTTAAAAGAAGGCTAGCATTGTTTGCACAAAAAATTGGTGATTTCCCTCCCCTGAACAGTAATGAAATTACTTCTGTTGAGTAAACTTTTTATGTCATCTTATAATAAAAGCTAAAAATGCCCTTTGGttctatttataaaaaaaaaaaagcttttctatATGTACCCTTGAAAACAGATTTTGAAGAAATCATGTAAGATGATAAAGCATTTGAATGGTACAATAGATgtaaaaaaattcagtttaaaagaaacgtttgtttttacattaaatGTTTATTTGAAATCAAATGATTTTGTACATAAAGTTCAATAATATAAAGCTGTCTTCTGCTTTTCTTCA

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