Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

Advanced Search

Summary

Retrocopy Name Usf1P2
Plot displaying the genomic locations of a retrocopy (in chrX) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Mus musculus
Coordinates chrX:108163833-108165310  UCSC
Strand -
Parental Sequence NM_001305678.1
Parental seq. overlap 1323 bp
Parental seq. overlap (%) 75.1%
Genomic Region Intragenic (Sh3bgrl)
Retrocopy Summary Usf1P2, located on chrX:108163833-108165310, is a retrocopy of the parental gene Usf1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name Usf1
Full Name upstream transcription factor 1
Also known as bHLHb11
Coordinate chr1:171238875-171246327
Strand +
Gene summary This protein encoded by this gene is a member of the basic-Helix-Hoop-Helix-Leucine zipper (bHLH-LZ) family and encodes a protein that can act as a transcription factor. Studies indicate that the basic region interacts with DNA at E-Box motifs, while the helix-loop-helix and leucine zipper domains are involved in dimerization with different partners. This protein is involved in a wide array of biological pathways, including cell cycle regulation, immune response, and responses to ultraviolet radiation. Mice lacking most of the coding exons of this gene often lacked both whiskers and nasal fur, and were prone to epileptic seizures, while mice lacking both this gene and another family member, Usf2, displayed embryonic lethality (PMID:9520440). Mutations in the human ortholog of this gene have been associated with Familial Combined Hyperlipidemia (FCHL) in humans. Pseudogenes of this gene are found on chromosome 11 and the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]

Homology

Species Scientific Name Retrocopy
Human Homo sapiens Without Homology
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>Usf1P2
ATGAGCCCCCTCACAGAGATttgatggggcagcagaaaacaGCTGAAACCCAAGAGGGGACAGTGCAGATTCAGAAAGGTGTGGTGGCTGACCCAACTAGTGTAGCTATTGCCAGCATCCAATCAGCTGCCACTTTCTCCGACCCCAATGTCAAGTGATGTTCAGGGTGATCCAGGTGTCTGAAGGGCAGCTGGATGGCCAGACAGAGGACTGAGCCACCATCAGTCGTTACCCTGCCACTCAGTCACCCAGGCAGTGATCCAGGGAGCTATCACCAGTGAAGATTGCTTTGACACGGAGGGAGCAGCTGCTGAGACACATTATACGTATTTCCCCAGCACCACAGTGGGAGATGGGTCAGAGGGTACCACATCTGGGAGTACAACAGCTGTTATTACCATCCAGGGCTCAAAGGCATTACTGGGGCAGGCAACCCCGCCCACCACCACGGGGTCCATTCTTTGTGATGATGTCACCACACGAAGTATTGCAGGGAGGGAGCCAGCGATCAATTGCCCCCAGGACGCACCCTTATTCCCCGAAGTCAGCAGCTCCCAGGACAACTGAGATGAGAAACTGAGAGCTCAACATAACGAAGTGGGGCACAGCCGCTGGGACAAGATCAACAACTGAATTATACAGCTGTCCAAATCGCCCCAGACTGCTTCTCTGGAGAGCATCAAGTCTGGCCAGAGTAAAGGTGCAATGCTGTCCAAAGCCTGTGATTATATCCAGGAGCTGCAGCAAAGCAATCACTAGTTGTCTGAAGAGCTGCAGGGGTTAGATCAATTGCACCTGGACAATGATGTGCTTCGgcaacaggtagaagaccttaaaaacaAGAACGTGCTACTACGGCCTCTGTTATGGACTAGAGATTGTCATCAAGAAAGACAGCAACTAACTCTGGGGACTCAGCGGCTTTGGGCCAAGAACTGCAGATCGGCTAGGAGCAACAGGCTAAACCCATGGCCCTCTCCTTCACTGCCGACTTCTGGCATGGGACTCAGGGGAGTTTGGCAAGTGTGTTTTCCCCGTGGCATGGCAGGCTGCAGTGAGTGGTGTGAAGCACAGTGTGGACGTGCATCAACAGCCTTGCCTGCTCCCGCCTCACAGTCCCCGAGCTTGGTGTTCCTTCGGCACCTGGCATGTGCTGTCTTCTTGGTGGACACTGGACACATTAATCTGGGCTTGCTTAGAGTGCCTGGGAGAGGGTCTGTGGGCCTAGTACTTCCACTGGTTCCTTTCTCTGGAGCAGAAGTTAAGATAAACACCTGAGTACTCTGGGGAGCAGGCTTCCTCAAGAGGTTGGAAAGGATGCTAGCTGGCTGCTATCCCAGGAATAGGAGAGGGGCCAGTGAGCAGCTGAGGCCTCCACAGAAGGTTCTGGAGCCAGGGAGAATTATAGGCAGGGGCGGATTCACTGAGAGCCTTCCCTGTTCTGGGGatggttctttttatttctttacttcttttta
>NM_001305678.1
ACACTTCCGCCCCTCACCAACATGGCCGCAGGCTGGGACTGCGCATGAGCAGCTGTCTATGGAGAGACCTAGATCCAAAGACGGAGAAGGCTGCCGGGGGAAATCGGCGACTGAAGCGGCCTGGCCCGGACTTAGCATTCAGGCCTTTGAGTTGGGAGATACAAAGTCCTCCGAAAAAAGACCGGCGCCTCGGATGAGCCCCCTCACAGAGAGATGAAGGGGCAGCAGAAAACAGCTGAAACCGAAGAGGGAACAGTGCAGATTCAGGAAGGCGCAGTGGCTACTGGAGAGGACCCAACTAGTGTAGCTATCGCCAGCATCCAGTCAGCTGCCACTTTTCCTGACCCCAACGTCAAGTGATGTACAGGGTGATCCAGGTGTCAGAGGGGCAGCTGGATGGCCAGACAGAGGGCTCTGGCGCCATCAGTGGTTACCCTGCCACTCAGTCTATGACCCAGGCAGTGATCCAGGGAGCTTTCACCAGTGACGATGCCGTTGACACGGAGGGAGCAGCTGCTGAGACACATTATACATATTTCCCCAGCACCGCAGTGGGAGATGGGTCAGGGGGTACCACATCTGGGAGTACTACAGCTGTTGTTACCACCCAGGGCTCAGAGGCACTACTGGGGCAGGCAACCCCGCCCAGCACAGGTCAATTCTTTGTGATGATGTCACCACAAGAAGTATTGCAGGGAGGGAGCCAGCGATCGATTGCCCCCAGGACCCACCCTTATTCCCCGAAGTCAGAGGCTCCCAGGACAACTCGAGATGAGAAACGGAGGGCTCAACATAACGAAGTGGAGCGCCGCCGCCGGGACAAGATCAACAACTGGATTGTACAGCTGTCCAAAATCATCCCAGACTGCTCTATGGAGAGCACCAAGTCTGGCCAGAGTAAAGGTGGAATCCTGTCCAAAGCCTGTGATTATATCCAGGAGCTGCGGCAGAGCAACCACCGGCTGTCTGAAGAGCTGCAGGGGTTAGATCAGTTGCAGCTGGACAACGATGTGCTCCGGCAACAGGTGGAAGATCTCAAGAACAAGAACCTGCTCCTGCGAGCTCAGCTTCGGCACCACGGACTCGAGGTCGTCATCAAGAATGACAGCAACTAACTCTGGGGACTCAGGGGCTTTGGGCCAAGGACTGCAGCCGGCCCAGGAGCAACAGGCTAACCCCATGCCCCTCTCCTTCACTGCCTCCTCTGGCATGGGACTCGGGGGAGTTTGGCAAGTGTGTTTTTGAACTGAGGCCCTGTGGCGTGGCAGTCTGCAGTGAGTGGTGTGAAACAAACAGTGTGGGCGTGCACTGACAGCCCGGCCTGCTCCCTCTGTGCAGTCCCCGGGTCTGGTGCGCCTTCGGCACACTGCATGTGCTGTCTCCTTGCTGGACACTGGACACACTGAATCTGGGCTTGCCGTGTGCTCGCTTGGAGTGCCTGAGAGAGGGACTGCGGGCCTAGTACTTCCACtggctcttcctttctctggaGCAGAAGTTAAGATGCGTACCTGAGTACTCTGGGAAGCAGGCTTACTCAAGAGGTGGGAAAGGATGCTAGCTGGCTGCTATCCCAGGAGTAGAAGGGGGCCCAATGAGCAGCCGAGGCCCCTACGGAAGGCTCTGGAGCCAGGGAGAACTGTAGGCAGGGGTGGGTTCACTGAGAGCCTTCCCTGCTCCAGGGATgggtctttttatttctttccttttttttttttttttttttttaaagataaaattgttTAGAGCCACA

Publications

PMID - Link Title