Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

Advanced Search

Summary

Retrocopy Name Mapk3P3
Plot displaying the genomic locations of a retrocopy (in chrX) and its respective parental gene (in chr7). Each line represents a retrocopy.
Species Mus musculus
Coordinates chrX:125518972-125520115  UCSC
Strand -
Parental Sequence NM_011952.2
Parental seq. overlap 1051 bp
Parental seq. overlap (%) 59.3%
Genomic Region Intergenic
Retrocopy Summary Mapk3P3, located on chrX:125518972-125520115, is a retrocopy of the parental gene Mapk3. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name Mapk3
Full Name mitogen-activated protein kinase 3
Also known as Erk-1|Erk1|Ert2|Esrk1|Mnk1|Mtap2k|Prkm3|p44|p44erk1|p44mapk
Coordinate chr7:126358798-126364988
Strand +
Gene summary Enables MAP kinase activity; MAP kinase kinase activity; and phosphotyrosine residue binding activity. Involved in several processes, including negative regulation of apolipoprotein binding activity; regulation of DNA-binding transcription factor activity; and sensory perception of pain. Acts upstream of or within several processes, including Bergmann glial cell differentiation; ERK1 and ERK2 cascade; and animal organ development. Located in cytosol; nucleus; and pseudopodium. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in colon adenocarcinoma; colorectal adenocarcinoma; endometrial adenocarcinoma; pancreatic ductal carcinoma; and pulmonary hypertension. Orthologous to human MAPK3 (mitogen-activated protein kinase 3). [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Human Homo sapiens Without Homology
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>Mapk3P3
CTTTCTCACGGAGTACGTGGCCACACGCTGGTACTGAGCGCCAGAGATCATGCTTATCTCCAAAGGCTACACCAAATCCATTGACATCTGGTCTGTGGGCTTCATTCTGGCTGAGATGCTCTCCTAAACGGCCCATCTTCCCTGGTAAGCACTACCTGGAACAGCTCAACCACATTCTATGTATTCTGTGTTCCCCATCCCAGCAGGACCTTAATTGCATCATTAACATGAAGGCCCGAAACTACCTACAGTCTCTGCCCTCTAAAACCAAGGTGGCTTGGGCCAAGCTCTTTCATACATCTGACTCTAAAGCTCTTGACCTGATGGACTGGATGCTAACCTTCAACCGAAACAAGTGCATCACAGTACAGGAAGCACTGGCTCACCCTTACAGTACTATGATCCTACAGATGAGCCAGTGGCTGAGGAGTTGTTCACCTTCCACATGGCGCTGGGCAATCTCCCCAAGGAGCGGCTGAAGGAACTGATCTTCCAAGATATGGACCACTTCCAGCCAGAGGCTGCAGAGGGCCCCTAACAAGAACAGACACCCCTGTCCTTTTGGACCTGGTCCTGCTTCTACCTGCTCCTTCTCTGCAGATTGTTAGAAAGTGAACTTTGCTCAACCCTTCCCCGGCCGCCCAGGCTGGACCAAGGGTAGGTCTGGCTACCTTCTCTCACTTTGCAGGGGTCTCCTGCTTCAAGCAGGCTTCTCCCACGCAATCCCCTGCCCCACCTCCCCATAGCCTGAGTGATGAGGTGGCCCCAGAGTTGATCTCTGCTGCTGTGTCTTTGTCTACCTTTGCTAGACCTGGCTCTGGTAGACTGTTCTGGAATGGAGGGGCTATGATCGCCCTAGGACCTGTGCTTCGGAGGGGTGGAGGGCACTGAGTAGGGCTCTGCCCTATTTATCTTGTTGGAACCCCACCCCATTTTTCCTGACAGAACATTCCTAAGTTTCAAGGGCTAGTTTCTCTGAGGAGCCCAGACCTAACCCTCTCCCTCTCAAGCTGCCACATGTAACACCCTTGCTGCTTCTGTGAGTGGGTGATTtgatgtgggggtggggctcgTGGAGAGCCGGTGCTCCTCCTCACCTCCCAGTACCtatatctaataaagaaatatagaaatgtgtatatga
>NM_011952.2
GGGAGGCGGGAGGAGTGGagatggcggcggcggcggcggctccggggggcgggggcggggagcCCAGGGGAACTGCTGGGGTCGTCCCGGTGGTCCccggggaggtggaggtggtgaaGGGGCAGCCATTCGATGTGGGCCCACGCTACACGCAGCTGCAGTACATCGGCGAGGGCGCGTACGGCATGGTCAGCTCAGCTTATGACCACGTGCGCAAGACCAGAGTGGCCATCAAGAAGATCAGCCCCTTTGAGCATCAAACCTACTGTCAGCGCACGCTGAGGGAGATCCAGATCTTGCTGCGATTCCGCCATGAGAATGTTATAGGCATCCGAGACATCCTCAGAGCGCCCACCCTGGAAGCCATGAGAGATGTTTACATTGTTCAGGACCTCATGGAGACAGACCTGTACAAGCTGCTTAAAAGCCAGCAGCTGAGCAATGACCACATCTGCTACTTCCTCTACCAGATCCTCCGGGGCCTCAAGTATATACACTCAGCCAATGTGCTGCACCGGGACCTGAAGCCTTCCAATCTGCTTATCAACACCACCTGCGACCTTAAGaTCTGTGATTTTGGCCTGGCCCGGATTGCTGACCCTGAGCACGACCACACTGGCTTTCTGACGGAGTATGTGGCCACACGCTGGTACCGAGCCCCAGAGATCATGCTTAATTCCAAGGGCTACACCAAATCCATCGACATCTGGTCTGTGGGCTGCATTCTGGCTGAGATGCTCTCCAACCGGCCCATCTTCCCCGGCAAGCACTACCTGGACCAGCTCAACCACATTCTAGGTATCTTGGGTTCCCCATCCCAGGAGGACCTTAATTGCATCATTAACATGAAGGCCCGAAACTACCTGCAGTCTCTGCCCTCGAAAACCAAGGTGGCTTGGGCCAAGCTCTTTCCTAAATCTGACTCCAAAGCTCTTGACCTGCTGGACCGGATGTTAACCTTCAACCCAAACAAGCGCATCACAGTAGAGGAAGCGCTGGCTCACCCTTACCTGGAACAGTACTACGATCCGACAGATGAGCCAGTGGCCGAGGAGCCATTCACCTTCGACATGGAGCTGGATGACCTCCCCAAGGAGCGGCTGAAGGAGTTGATCTTCCAGGAGACAGCCCGCTTCCAGCCAGGGGCGCCAGAGGGCCCCTAACAAGAACAGACACCcctgtccttttggatctgGTCCTGCTCCTACCTGCTCCTTCTCTGCAGATTGTTAGAAAGTGAACTTTGCTCAACCCAGACCCCGGCAGCCCAGGCTGGACCAAGGGTGGGCCTGGCCACCTTCTCTCACTTTGCTGGGGTCTCCTGCTTCAAGCAGGCTTCTCCCACTCCAATCCCCTGCCCCATCTCCCCATAGCCTGAGTGATGAGGTGGCCCCAGAGCTGATCTCTGCTGCTGTGTCTTTATCTACCCTTGCTAGCCCCGGCTCTGGTAGACCGTTCTGGAATGGAGGGGCTATGATCGTCCTAGGACCTGTGCTACGGAGGGGTGGAGGGCACTGAGTAGGGCTCTGCCCTATTCATCTTGTTGGAACCCCACCCCATTTTCCCTGACAGAACATTCCTAAGTCTCAAGGGCTAGTTTCCCTGAGGAGCCCAGGCCTaaccctctctctctcaagctGCCACATGTAACGCCcttgctgcttctgtgtgtgGGTGATTGGATGTGGGGGTGGGGCCCGTGGAGAGCCGgtgcccctccccatctccccgtGCCTGtatctaatatataaatatagagatGTGTATATGga

Publications

PMID - Link Title