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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name Anxa1P1
Plot displaying the genomic locations of a retrocopy (in chrX) and its respective parental gene (in chr19). Each line represents a retrocopy.
Species Mus musculus
Coordinates chrX:36767407-36767740  UCSC
Strand +
Parental Sequence NM_010730.2
Parental seq. overlap 279 bp
Parental seq. overlap (%) 19.9%
Genomic Region Intergenic
Retrocopy Summary Anxa1P1, located on chrX:36767407-36767740, is a retrocopy of the parental gene Anxa1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name Anxa1
Full Name annexin A1
Also known as Anx-1|Anx-A1|C430014K04Rik|Lpc-1|Lpc1
Coordinate chr19:20350798-20368035
Strand -
Gene summary Predicted to enable several functions, including calcium-dependent phospholipid binding activity; double-stranded DNA helicase activity; and phospholipase A2 inhibitor activity. Predicted to contribute to single-stranded RNA binding activity. Involved in several processes, including myoblast migration involved in skeletal muscle regeneration; neutrophil homeostasis; and positive regulation of neutrophil apoptotic process. Acts upstream of or within several processes, including arachidonic acid secretion; positive regulation of G1/S transition of mitotic cell cycle; and regulation of cell population proliferation. Located in several cellular components, including apical plasma membrane; lateral plasma membrane; and sarcolemma. Is expressed in several structures, including alimentary system; central nervous system; respiratory system; skeleton; and skin. Human ortholog(s) of this gene implicated in brain ischemia and pancreatic cancer. Orthologous to human ANXA1 (annexin A1). [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Human Homo sapiens Without Homology
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>Anxa1P1
AATTTTACCAGAAGAAGTATGGACTTTCTCATTGCAGAGCCTTTCACAATGAAAGCAAAGGAAATTATGAAAAAATCCTGGTGGCTGTGTGGTACAAATTAGAAGTCCCCACTGCTCTGCAAGATTATGAGGAGAACATCTCTTATCTGCTCTTTTCCTTCTATCACCATAGGCTTAGTAGGAAAGTTGCTTTAGCACATAGTCCAATTATCTCCTTGAAATAATATAGCGTATTAATACATTTTACATCATACCTCAGTACAATAGAGAAATTCTTGTTGTGTTACTTATGTTTATTCTAAATTATAAATCCCTATAAGCAAGTCACTTTGGT
>NM_010730.2
GTCTGAAACCATCTGAGCAGAGTCTCTCTTCAGTCCCCGGGAAGACAAGCAAATACAAAGATACTTCTCTAAAAATGGCAATGGTATCAGAATTCCTCAAGCAGGCCCGTTTTCTTGAAAATCAAGAACAGGAATATGTTCAAGCTGTAAAATCATACAAAGGTGGTCCTGGGTCAGCAGTGAGCCCCTACCCTTCCTTCAATGTATCCTCGGATGTTGCTGCCTTGCACAAAGCTATCATGGTTAAAGGTGTGGATGAAGCAACCATCATTGACATTCTTACCAAGAGGACCAATGCTCAGCGCCAGCAGATCAAGGCCGCGTACTTACAGGAGAATGGAAAGccctTGGATGAAGTCTTGAGAAAAGCCCTTACAGGCCACCTGGAGGAGGTTGTTTTGGCTATGCTAAAAACTCCAGCTCAGTTTGATGCAGATGAACTCCGTGGTGCCATGAAGgGACTTGGAACAGATGAAGACACTCTCATTGAGATTTTGACAACAAGATCTAACGAACAAATCAGAGAGATTAATAGAGTCTACAGAGAAGAGCTGAAAAGAGATCTGGCCAAAGACATCACTTCAGATACATCTGGAGACTTTCGGAAAGCCTTGCTTGCTCTTGCCAAGGGTGACCGTTGTCAGGACTTGAGTGTGAATCAAGATTTGGCTGATACAGATGCCAGGGCTTTGTATGAagctggagaaaggagaaaggggacagACGTGAACGTCTTCACCACAATTCTGACCAGCAGGAGCTTTCCTCATCTTCGCAGAGTGTTTCAGAATTACGGAAAGTACAGTCAACATGACATGAACAAAGCTCTGGATCTGGAACTGAAGGGTGACATTGAGAAgtgcctcacaaccatcgTGAAGTGTGCCACCAGCACTCCAGCTTTCTTTGCCGAGAAGCTGTACGAAGCCATGAAGGGTGCCGGAACTCGCCATAAGGCATTGATCAGGATTATGGTCTCCCGTTCGGAAATTGACATGAATGAAATCAAAGTATTTTACCAGAAGAAGTATGGAATCTCTCTTTGCCAAGCCATCCTGGATGAAACCAAAGGAGACTATGAAAAAATCCTGGTGGCTCTGTGTGGTGGAAACTAGACATCCCAACTATTCTGCAAGGTTCTGAGGAGAATGTCTCTTAGCTGTTTTCCTTCGATGGCATGGGCTTAAGTAGGAAAGTTGCTTTGGCAGATAAGTCTAATTACCTGCTTTGAATAATATAGCCTATAAATAGATTTTACATCATTACTCTGTACAATAGAGAAATACTTGTTTTGTTAATTATGTTTATCCCAAATTATAAAGCCCCATAAGCAAGTCACTTTGGTACCATTCCTGAGAAAGaagtttacatataataaaataaaacaattttata

Publications

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