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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name Chchd4P2
Plot displaying the genomic locations of a retrocopy (in chrX) and its respective parental gene (in chr6). Each line represents a retrocopy.
Species Mus musculus
Coordinates chrX:93012370-93012587  UCSC
Strand +
Parental Sequence NM_133928.2
Parental seq. overlap 183 bp
Parental seq. overlap (%) 14.7%
Genomic Region Intergenic
Retrocopy Summary Chchd4P2, located on chrX:93012370-93012587, is a retrocopy of the parental gene Chchd4. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name Chchd4
Full Name coiled-coil-helix-coiled-coil-helix domain containing 4
Also known as 2410012P20Rik|2810014D17Rik
Coordinate chr6:91441258-91450405
Strand -
Gene summary Predicted to enable protein-disulfide reductase activity. Involved in mitochondrial respiratory chain complex assembly. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; mitochondrial DNA repair; and regulation of protein export from nucleus. Located in mitochondrion. Orthologous to human CHCHD4 (coiled-coil-helix-coiled-coil-helix domain containing 4). [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Rat Rattus norvegicus Chchd4P3
Chinese hamster Cricetulus griseus Chchd4_1P3
Human Homo sapiens Without Homology
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>Chchd4P2
GTATTCGTGACCAAAGAAGACCACGAAAGTCCCAGCAATGCCGAGCTGGTGGTTGACGAGCCCAATGATCCCCATGCAGAGTATGGACTGATACTGCCAAGTGGCAGCATTAACTGGAATTGCCCGTGCCTTGGAGGAATGGCCAGCGGCCCCTGTGGAGAACACTTCAAGTCTGCCTTTTCCTGCTTCCACCACAGCACCGAAGAAGTCAAGGGGTC
>NM_133928.2
GGCGAGGGAGGTCACGGCGAGAAGGTGTATCCGCTCCAGCCGCGCCCGCTGCCTCTGCGAGCTGCAGAGGACTGTCGGGAACAACCATGTCCTACTGCCGGCAGGAAGGGAAGGATCGGATCATATTTGTGACCAAAGAAGACCATGAAACTCCTAGCAGTGCCGAGCTGGTAGCTGATGACCCCAATGATCCCTATGAGGAGCACGGGTTGATACTGCCTAACGGAGATATTAACTGGAATTGTCCATGTCTTGGGGGAATGGCCAGCGGCCCCTGTGGGGAGCAGTTCAAGTCTGCCTTCTCCTGCTTCCACTACAGCACAGAGGATATCAAGGGGTCAGACTGTATAGACCAGTTCCGGGCCATGCAAGAGTGCATGCAGAAGTACCCGGACCTCTATCCCcaagacgaggaggaggaagaggaggcaaagCCAGTGGAGCCGGTGGAGGAGACAGCTGACACTAAGGTCTCTGCAGCCAAAGAGCAAGGGACAAGCTCTTGAAGGCCACATGGCTGCCACTCACCATGGGACTTTCTGTACAATGCCTTTTGGTCACTTTTGTGAAAGTTCTTTCCCTCTGTGCACTGTAATATAcaaaataacttattttaatGATCAGGGGTCTTGGCCGTATACACTGAAGAAAAGGgcgtgtgtgcacctgtgtccTGCATAAACCTGTCCTTAAACATTAGTCCACTCCTGGATGTACTACTCTGTGATTGCCCTGGATTTTGCCACTTTGAAATAATGTGTTGAGACTTCTCAGCAACCAAAAGTTGTTACTCAGGAAAGTTTATCGTGAGAAAGCTGATCTATTCTGATCCATTTTGGTATCCCTTTTGGTAGATTTTACACCTCTTTTGGAAATTAAGTAAATAGATGCCAAAACTCCTTTAAGAGTGGGTCCATTCCTACTGGAAGAGGCTGGTGGTCAGGTGCTTGCTGGAGTACATGGGGCTGCTGCCTCGTTCCCGACAGCTAATTGTCTGTTTGCTGTCCAGGCTCCAGTGCCTACAGCTGCAGGGTGGCATTGGATCCTGTGACTCCCGGTCCTTCCTAAGTGAAAGGATGGGCTGGGTTTGCAGTTTATTGTTTTGCTGTTCTAAGAGCCCTGGTTTGGGGCCCATGTTCACTCAGTTGTGATATTGAGGTGGGGACCTAGCTGCTTCCAGAGCAGAAGCCAACAGAGGAATGTCTGAATGAAGTACtcaattaaaaagaaaccatTTCTATCTGA

Publications

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