Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name Rac1P3
Plot displaying the genomic locations of a retrocopy (in chr15) and its respective parental gene (in chr5). Each line represents a retrocopy.
Species Mus musculus
Coordinates chr15:93310626-93312128  UCSC
Strand +
Parental Sequence NM_009007.2
Parental seq. overlap 1270 bp
Parental seq. overlap (%) 55.3%
Genomic Region Intragenic (Pphln1)
Retrocopy Summary Rac1P3, located on chr15:93310626-93312128, is a retrocopy of the parental gene Rac1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name Rac1
Full Name Rac family small GTPase 1
Also known as D5Ertd559e
Coordinate chr5:143491236-143513786
Strand -
Gene summary Enables GTP binding activity; GTP-dependent protein binding activity; and GTPase activity. Involved in several processes, including engulfment of apoptotic cell; nervous system development; and regulation of cell migration. Acts upstream of or within several processes, including cell morphogenesis involved in differentiation; cochlea morphogenesis; and neuron differentiation. Located in several cellular components, including kinocilium; pericentriolar material; and ruffle membrane. Is extrinsic component of plasma membrane. Is expressed in several structures, including central nervous system; early conceptus; embryo mesoderm; eye; and genitourinary system. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 48; colon adenocarcinoma; and pancreatic adenocarcinoma. Orthologous to human RAC1 (Rac family small GTPase 1). [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Human Homo sapiens Without Homology
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>Rac1P3
AGAGCTGCTGGTAAAACCTGCCTGCTCATCAGTTACCCGACCAATGCATTTCCTGGACAGTACATCCCCACCGTCTTTGACAACTAGTCTGCCAATGTTATGGTAGATGGAAAACCAGTGAATCTGGGCCTATGGGACACAGCTGGACAAGAAGATCATGACAGATTGCATCCCCTCTCCTACCTGCAAACAGACGTGTTCTTAATTTGCTTTTCCCTTGTGAGTCCTGCATCATTTGAAAATGTCTGTGTAAAGTGGTCTCCTGAAGTGCGACACCACTGTCCCAATACTCCTATCATCCTAGTGGGGACGAAGCTTGATCTTAGGGATGATAAGGACACCATtgagaagctgaaggagaagaAGCTGACTCCCATCACCTACCCGCAGGGGTAGCCATGGCCAAAGAGATCGGTGCTGTTAAATACCTGGAGTGCTCAGCTCTCACACAGCAAGTACTCAAGACAGTGTTTGACGAAGCTATCCGAGCAGTTCTCTGTCCCCCTCCTGTCAAGAAGAGGAGAGAATGCCTGCTGTTGTAAATGTCGGAGCCTGTCGTTCTCGGTCCTGTCTGGAACCTTTGTACGCTTTGCTCAAAAATCAGCGGAGCCTTCGCTTGCAGTTGATGCTGAGTTTTTGTTACAGATTAATTTTTCCATAAAACCATTTTGAACCAATGAACCAGCCAATAAGTTTAAGGTTCTGTTTTAAATGTAAGAATTCCAACTTACAGTCTATTAAAATTCAGCCCTAAAATGACAAAGCCTTCTTCaagccttatttttaaaatccccCATTCTTGCTCAGATTAAGAATTGCCAAAATagttgccaaAATAACCTTCTGAACTAAGTTGCGTTGTGCTGAGAACACCTAAGCACTAAACTCTCTTGAGAGACTTCTGCTGCTAAGAAGGACTGCAGCTTCTGGAGCCAGGTCAGGGGTGCAGGCCCTTCCAGAGTCCCCAGACCGTGTGACACAGCACAGCCTCCTTAATGACACGTTGCCACGTAACGCACCTGTAACTTATCAGCCCATGTTCATTACGTAACTTTGTACTGTACGTCACAGTGATGAGTGTGACAGCTCAGCTCTTCGATTTCATAGTGAGTTTTCTAAAAGACCAGCCGACTAGCTTTTGCAGACTTTGAACAGATCTCTGGTTCCTGTGTTGCCTCTAATGAAGTATTCTGTTCCTAGTTGTGGGTGTGCTGGGTGGAGTGTGAAACACGACATGATCAAAGGAGACAGACACAGTATTTTGACTAATATGAAGTAGAGATTACACTACATTGTACATGGAGTAATTCAACTGAATAAAAGTGTCACGggt
>NM_009007.2
AGTTTTCCCCAGCTTTGGGTGGTGGCTGCTGCTGCGCTTCGCCTTCCCGTGCGCTGAGGGCCCGGCGGCGTGGACAGCAGTCCCGGCACTCGGCGCCCCGCCGCCCGCAGCCTCGCCCAGCGCTTCCCGAGCCCGCCGCTTCGCGCCTCAGCCaccggccgccgccgccgccgccgcggcccACCGAGCGGCCCAGATGCAGGCCATCAAGTGTGTGGTGGTGGGAGACGGagCTGTTGGTAAAACCTGCCTGCTCATCAGTTACACGACCAATGCATTTCCTGGAGAGTACATCCCCACCGTCTTTGACAACTATTCTGCCAATGTTATGGTAGATGGAAAACCAGTGAATCTGGGCCTATGGGACACAGCTGGACAAGAAGATTATGACAGATTGCGTCCCCTCTCCTACCCGCAGACAGACGTGTTCTTAATTTGCTTTTCCCTTGTGAGTCCTGCATCATTTGAAAATGTCCGTGCAAAGTGGTATCCTGAAGTGCGACACCACTGTCCCAATACTCCTATCATCCTCGTGGGGACGAAGCTTGATCTTAGGGATGATAAGGACACCATtgagaagctgaaggagaagaAGCTGACTCCCATCACCTACCCGCAGGGGCTGGCCATGGCGAAAGAGATCGGTGCTGTCAAATACCTGGAGTGCTCAGCTCTCACACAGCGAGGACTCAAGACAGTGTTTGACGAAGCTATCCGAGCGGTTCTCTGTCCCCCTCCTgtcaagaagaggaagagaaaatgccTGCTGTTGTAAATGTCGGAGCCCCTCGTTCTCGGTCCTGCCTGGAACCTTTGTACGCTTTGCTCAAAAATCAGCGAGCCTTCGCATTTGATGCCAAGTTTTTGTTACAGATTAATTTTTCCATAAAACCATTTTGAACCAATGAACCAGTCAATAATTTTAAGGTTCTGTTTTAAATGTAAGAATTCCAACTTACAGTCTATTAAAATTCAGCCCTAAAATGACAAAGCCTTCTTAaagccttatttttaaaatccccCATTCTTGCTCAGATTAAAAATTGCCAAAATACCTTCTGAACTAAGTTGCGTTGTGCTGAGAACACCTAAGCACTAAACTCTCTTGAGAGACTTCTGTTGCTAAGAAGACCGCAGCTTCTGGAGCCAGGGGTGCAGACCCTTCCAGAGTTCCCAGACCGTGTGACACAGCACAGCCTCCTTAATGACACGTTGCCATGTAACGCACCTGTAACTTATCAGCCCATGTTCATTACGTAACTTTGTACTGTACGTCACAGTGATGAGTGTGACAGCTCAGCTCTTTGATTTCATAGTGAGTTTTCTAAAAGACCAGCCGACTAGCTTTTGCAGACTTTGAACAGAACTCTGGTTCCTGTGTTGCCTCTAATGAAGTATTCTGTTCCTAGTTGTGGGTGTGCTGGGTGGAGTGTGAAACACGACATGATCAAAGGAGACAGACAGTATTTTGACTAATATGAAGTAGAGATTACTTTACACTACATTGTACATGGAGTAATTCAACTGAATAAAAGTGTCACGGGTAAAGCTTTTTAACGGTTAATTTCTGTCAAACAGTAGGTGACAAATGGCCGATCTTATCAGTGTCTCTTGAGCATCCCTTCGCGCCCCCCACCCTCCACTGCCGTCCCTCCCCAGATGGGGCGTTGAGTCCATATTTAAACTGGCCACCCTCACAGTTCTAACTTAGCAAGTGCTTTTCTTTAGAACCCCTTCTTAACGAGCAATATGTCTGACCTGTACTATAAGATCTTTCTGATAACGcagagattttttgtttttttttggtagcTCAGTAGAAGTGCGTCCTGTTTTCGCCTTACTTTACTCAGAGCTAGTTAGTGCTTCCTTAGTTTCCTAGCAACTAGGTGTGCAAATCATGTGTTGCAGCTTTACggtttttaaactattttagatATTCTTAAACTATGAACCTTCTAAACAGTACCAACACTGTCATGTGACTAATGCTGCCTCTAGACCTCGCCCACGTGGACAGACGCTTCCTGTCATGGCTCTGCCTAGAGATGTTCCTTGGGGTCTGTGAGGTTCTGTCAACTGCTAGTGCTAACGCTGTCCTGTACAACCTAACTCACTGGCAAGAATGCAGTGTTGGGCCTTTCAACCACTAGAACAAACTTTTTTCAATTGACAGTTGCAGAATTGTGGAGTGTTTTTACATTGATCTTTTGCTAATGCAGTTAGCAGTATGTTTTGCATGTATGAATTAATAAATCCTTGAATCATA

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