Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name Tktl1P1
Plot displaying the genomic locations of a retrocopy (in chr8) and its respective parental gene (in chrX). Each line represents a retrocopy.
Species Mus musculus
Coordinates chr8:66965620-66966182  UCSC
Strand +
Parental Sequence NM_031379.2
Parental seq. overlap 464 bp
Parental seq. overlap (%) 18.7%
Genomic Region Intergenic
Retrocopy Summary Tktl1P1, located on chr8:66965620-66966182, is a retrocopy of the parental gene Tktl1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name Tktl1
Full Name transketolase-like 1
Also known as -
Coordinate chrX:73220865-73252104
Strand +
Gene summary Predicted to enable thiamine pyrophosphate binding activity and transketolase activity. Predicted to be located in cytosol. Is expressed in early conceptus and secondary oocyte. Orthologous to human TKTL1 (transketolase like 1). [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Human Homo sapiens TKTL2
Chimpanzee Pan troglodytes TKTL1P1
Bonobo Pan paniscus TKTL1P1
Orangutan Pongo abelii TKTL1P1
Gibbon Nomascus leucogenys TKTL1P2
Green monkey Chlorocebus sabaeus TKTL1P1
Crab-eating macaque Macaca fascicularis TKTL1P1
Rhesus Macaca mulatta TKTL1P1
Baboon Papio anubis TKTL1P1
Golden snub-nosed monkey Rhinopithecus roxellana TKTL1P1
Marmoset Callithrix jacchus TKTL1P1
Mouse lemur Microcebus murinus TKTL1P1
Rat Rattus norvegicus Tktl1P1
Cow Bos taurus TKTL1P1
Horse Equus caballus TKTL1P1
Panda Ailuropoda melanoleuca TKTL1P1
Cat Felis catus TKTL1P1
Greater horseshoe bat Rhinolophus ferrumequinum TKTL1P3
Egyptian rousette Rousettus aegyptiacus TKTL1P3
Gorilla Gorilla gorilla Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Dog Canis familiaris Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>Tktl1P1
ACCTTTGCTGCCTTCCTGACCCGAGCCTTTGATCAGATCCGAATGGGAGCCATCTCTCAAACCAACATCAACTTCGTTGGTTCCCACTGCGGGGTGTCTGTTGGAGAAGACGGACCTTCCCAGATGGCCCTGGAGGACCTAGCCATGTTCAGAAGCATCCCCAACTGCACTGTTTTCTATCCAAGTGATGCTGTCTCGACAGAACACGCTGTTTATCTGGCAGCCAACACGAAGGGAATGTGCTTCATTCGTACCACTCGGCCAAAAACAGCAGTTATTTATACAGCTGAAGAAAACTTTGTGATTGGACAGGCCAAGGTGATCCGCCAGAGTGCAGTCGACAAGGTGACAGTTATTGGAGCAGGGGTTACTCTGCATGAAGCCTTAGTAGCTGCTGAGGAGCTTTCTCAACAAGGGATTTTTATTCGTGTCATTGACCTGTTCACTATCAAACCTCTGGATGCTGTCACCATTATCCAAAGTGCCAAAGCCACAGGTGGCCAGATCATCACTGTGGAAGATCACTACCGAGAAGGTGGCATTGGTGAAGCTGTGTGTGCAGC
>NM_031379.2
GTTTAGTTCTGCGGCACAACGTAGAGGAAGGATGTCGGAAGCTGAGGCAAGCAGTGGGATGGCCCACAACGCTGGACCTGATGAGAAGACATTGCAGGTGTTGCGGGACATGGCCAACCGCCTGCGAATCCGTTCCATCAAGGCCACAAATTCCTCGACCACTAGCTATCTCATACCATGCAGCAATGCTGAGATCATGTCTGTGCTGTTCTTTTATACAatgagatataaacaagaagaccCTGAAAACCCAGACAATGACCGGTGCATCCTTTCAAAGGGACTACCATTTGTTAATGTGGCAACAGGATGGCCTGGACAAGGACTAGGGGCTGCCTGTGGGATGGCATATACTGGCAAGTACTTTGACCAAGCCAGCTACCGGGTGTTCTGTCTTCTGGGGGATGAGGAATCCACAGAAGGCTCTGTTTGGGAGGCATTTGCCTTTGCATCCTACTACAATTTGGACAATCTTATGGCAATCTTTGATGTGAACCGCATTGGACACAGTAGCTCCATGTCTGTTGAGCACTGCATTGCCATCTACCAGAAGCGTTGTGAAGCCTTTGGGTGGAATACTTACGTGGTGGATGGCCGTGATGTCAAGACCCTGTGCCATGTATTCTCACAGGCAGCTCAAGTGAGAGGCAAGCCCACTGCTGTGGTTGCCAAAACCTTCAAGGCCCGAGGCATGCCAAATGTTGAGGATGCGGAAAGTTGGTATGGAAGGCCAATGCCAAAAGAAAGAGCAGATGCAATTGTCAAGTTAATTGAGAGCCAGATACAGACCAACAAAATTCTTGTACCATCACCCCCTATTGAGGACTCGCCTCAAATTAAcatcatgaatatatgtatgactTCGCCCCCTGTTTACGTAGCTGATGACAAGGTGTCTACTCAAAGAGCATGTGGTTTGGCTCTAGCTAAACTGGGCCATGAAAATGACAGAGTTATTGTGCTGGGTAGTGACACCAAGAACTGCAATTTTTCTGACATATTCAAGAAAGAACACCCAGAGAGATTCATCCAGTGTTGTATTGCTGAACAAAACATGGTAAATGTGGCTCTAGGATGCTCCACCCGTGACCGGACCATTGTTTTTGCTTACTCCTTCGCTGCCTTTTTCACCCGAGCATTTGATCAGATCCGATTGGGAGCCATCTCTCAAATCAACATCAACCTTATTGGTTGTCACTGCGGGGTATCTACTGGTGATGACAACCCTTACCATATGGCCCTGGAAGACCTGGCCATGTTCCGAGCAATTCCCAATTGTGTTGTTTTCTATCCAAGTGATGCCGTCTCCACAGAACATGCTGTTTACTTAGCAGCCAATACTAAGGAAATGTGCTTTATTCGTACCAGCCAAGCAGAAACTGCAATTATTTACACCACTCAAGAAACCTTTCAGATTGGACAGGCCAAGGTTGTCCGCCATAGTGACAATGACAAGGTCATAGTTATTGGAGCAGGAGTCACCCTGCATGAAGCCCTAGTAGCTGCTGCTGAGCTCTCTAAAGAAGATATATCTATCCGTGTCATTGACTTGTTTACCATTAAACCTCTGGACATTGCCACCATCATTTCCAATGCAAAAGCCACAGGTGGCCGAATTATCACCGTGGAGGATCACTATCCTGAAGGTGGCATTGGAGGAGCTGTCTGTGCAGCAGTCTCCATGGAGCCTAACATTGTGGTTCATAACCTGGCAGTAATGGATGTGCCTCGTAGTGGAAGATGCAATGAAGCACTAGATTTTTCTGGAATCAGTTCCAGACACATCATTGTGGCTGTGAAATGCATCTTAATGACCTAAATTAGCTGTTGTCTTTGGTCTGAGAAGACTAGCCTCTTCTCTGTATGTTTATGCTTGTGCCAAAACCATCAATTAGATAGAAATGATGATTGCGCTTTGTTCTCCTTAAAGGCAAAACCAGTTAACACCTTTGTTCCACATTCAGAAATTCTAATTCCCCTCTAATCTGTGACTACACATACAAATATCACTGTTTTAACCATCAAAGGGGTTATAAGATTTATAATGGCAGAATAGATAACAAGACAACTACCTGACACTGAACTTTCTCATAAGACTgaatataagtggattaaggaacaaTGTAGAAGTGACAGTTTGGAAGTATTTTCTTCATAAGTAAAGCAAATGTGTGTTGAATTGTAGTCCGCAGCCCACCTTTCACAGAACTAGACCCCCGAGATACATAGTGCTGTTCAACTTGAGTTACCATGTACACTGCCTGCAGGTTCCTGAGTTATGTGTAATTTCAGATGCTCTTGATTTTTCTCTGCTGTTTCCCTTTATATCCCCTCCACAGTTCACAGGTTGATGAACAGAACAAAAGCAGTTATGATCACTTGTGCTGTTGTGATGACTGTTCTGTGAAGACGTAAGGACACTTGATCTCCACACTATGCTGTTTGATGttaataaagcatttaaaaaaccA

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