Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name Tmed2P3
Plot displaying the genomic locations of a retrocopy (in chr10) and its respective parental gene (in chr5). Each line represents a retrocopy.
Species Mus musculus
Coordinates chr10:121914095-121915890  UCSC
Strand -
Parental Sequence NM_019770.2
Parental seq. overlap 1539 bp
Parental seq. overlap (%) 74%
Genomic Region Intragenic (Susd1)
Retrocopy Summary Tmed2P3, located on chr10:121914095-121915890, is a retrocopy of the parental gene Tmed2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name Tmed2
Full Name transmembrane p24 trafficking protein 2
Also known as 1110032D12Rik|1810020N21Rik|Rnp24|Sid394|p24beta1
Coordinate chr5:124677969-124688569
Strand +
Gene summary Involved in embryonic morphogenesis; labyrinthine layer blood vessel development; and maternal placenta development. Acts upstream of or within several processes, including PERK-mediated unfolded protein response; chordate embryonic development; and regulation of gene expression. Located in endoplasmic reticulum membrane and endoplasmic reticulum-Golgi intermediate compartment. Is expressed in several structures, including cardiovascular system; early conceptus; embryo ectoderm; placenta; and trunk mesenchyme. Orthologous to human TMED2 (transmembrane p24 trafficking protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Rat Rattus norvegicus Tmed2P2
Human Homo sapiens Without Homology
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>Tmed2P3
TGCTGGCCAGGGCCCTGGGCTACTTTGTCAGCATCGACACACATGCTGAGAAGTGCTTCTTTGAGCGGGTTACCTAAGGGAATCAAGATGGGCCTCATCttcaagggggtgggggtggagggcaggGCTTCCTGGACATCAACATGGAGATCGCAGGACCAGATAATAAAGGACTCTGTAAAGGAGATCGAGAGTCTAGAGGGAAGTACATGTTGTCAGCCCACATGGATGGGACTGACAAGTTCTGCTTTTACTAATAGTCTGTCCACTATGACTCCAAAAATCATAATGTTCACCATTGACATTAGGGAGGCTCCCAAAGGCCAAGACATGGAGACAGAAGCTCATCATAACAAGCTAGAAGTGAGTAATGAACTGGCAGTGATAATGACCACTGTGAAGCACGAACAGGAGGAGTACATGGAAGTCTGGGAGAGAATACACAGAGCCATCAATGACAACACAAACAGCAGAGTGGTCCTTTGGTCCTTCTTCCAATGACAACACAAACAGCAGAGTGGTCCTTTGGTCCTTCTTTGAAGCTCTTGTTGTAGTTGCCATGACACTGGGACAGATCTACTACATGAAGAGATTTTTGTGAAGCCCTAAGGGTTGTTTAAAAGGCCTTTTCCTGTTACCCCAAATTCATGATTTACTCATTTACCAAACACCTTGGTCATCATAATGTCATCAGTTTATACATTGTTCTTATCTGAACATTCATGACTTATGTTTCTTTGTGATTAGTAGCTGTTGGGGAAAACCTATTTGAGAAAGTCAGAGTGAAAATTTGACATTTGATTGACCTGTAATTCTTACTTGAAAGCAGACCCATTATACAGGTCCTTCCAAGAATCCAGAGGCTGTTAATGGTGTATGGGACTATGGTCTTTATTATGTTTTTACCTTTggtttttataataaaatgcaGGTTATCCAGGAAGTAGCCCACAGCCTGACAATACTTGTTAACTGACTTCATTCATCAGAGGCTCATTTTGTTATTACAGCAACAGCGATCTGAATCCTGACCCTTGTGGCCCTGCCTCAGGGCAGAGACCTGATGGGGCATGTTACCCGTGTGGTCACTCACACTTTGTCTTGAGTTTGATGTTAAGACTTTTCTCATCACTTCACCCTAAAGTTTTATATTGAACCTTAGAACTGATTCACCTATAACTGAATTGACATAAACAGCCAATAACTTAGCTGTCTGTTGAATCCAGTTTCCCAAGTGTCAGAACAGACTGCTGTTTCCCTTGAGCTGCATAGTCTGTCTATTGTTGGCACTTAGGAAGAGCGAATTCCTCACCTGGAAACCTGCATTTCTCAAAACAAAGGGTTAAGCCTCTGGGATTGCTGGCAGTGATAGGCAGCCACTGTTATGTTTTTAGTCAGTGGCCTTTAGGCCCTGGTCTTCAGTGTCAGCACTAGGGTTTGTTTGTCCTCTGGGGTCTTTCTCTTCTGGCACATGCCAGTTTTGTTTATATAAAGTGAAGATAGAATCTTCTCTTCATGATAGAAGAACATTCTATGTTAGGTTTAACGAAAGGTGCTCTGCTTTGGGTGTGGGTGGTCCACACCCAATCTGATAACTGTTAGTTACCTGgatatcttatttttctttttggatctTACAAGGGAAAAACTACAAATAACaagttttataaatttaatttaaatttgttaCAGGTTTTTATGTTTAGGACAAATAATTTTTCAACCATTAGTGATAACTTTGCAACAGTTTGTTGGTAAGGTGACTCACCATAGGGCAGCTGTTGTATGctaatttg
>NM_019770.2
GCTGAGGCGGCAGCGGTGGCGGCGGCTCCGGAGGCCGCAGTCCGCGTCCCGGCGTCGGCCCGTCCCGCACCATGGTGACGCTCGCCGAGCTGCTGGCGCTGCTGGCCGCGCTGCTGGCCACGGCCTCGGGCTACTTTGTCAGCATCGACGCGCACGCCGAGGAGTGCTTCTTCGAGCGGGTCACCTCCGGCACCAAGATGGGCCTCATCTTCGAGGTGGCGGAGGGCGGCTTCCTGGACATCGACGTGGAGatcACAGGACCAGATAATAAAGGAATCTATAAAGGAGACCGGGAGTCCAGCGGGAAGTACACATTTGCAGCCCACATGGATGGGACATACAAGTTCTGCTTTAGCAATAGGATGTCCACTATGACTCCAAAGATAGTAATGTTCACCATTGACATTGGGGAGGCTCCCAAAGGACAAGACATGGAGACAGAAGCTCATCAGAACAAGCTAGAAGAAATGATTAATGAGCTGGCAGTGGCAATGACAGCCGTAAAGCACGAACAGGAGTACATGGAAGTCCGGGAGAGAATACACAGAGCCATCAATGACAACACAAACAGCAGAGTGGTCCTTTGGTCCTTCTTCGAAGCTCTTGTTCTAGTTGCCATGACATTGGGACAGATCTACTACCTGAAGAGATTTTTTGAAGTCCGGAGGGTTGTTTAAAAGGCCTTTTCCTGTTGATCCCAAATTCATGATTTACTTGTTTACCAAACACCTTGGTCATAATAATGTCATtagtttatacatttttattttctgaacgtTCATGACTTATGTTTCTTTGTGATTAGTAGGTGTTGGGGAAAACCTGTTTAAGAGAGTTAGAGTGAAAATTTGACATTTGATTGGCCTATAATTCTTACTTGAAAGGAGCCCCATTATATAGGCCCTTCCAAGAATCCAGAGGCTGTTAATGCTGTATGGGACTATGGTCTTTATTATGTTTTTACCTTTGGTTTTCATAATAAAATGCAGTTCATCCAGGAAGTAGCCCACAGCCTGACAATACTTGTTAACTAACTGCATTCTAGTAGTCCCTTGGTTCATCATCAGAGGCTCATTTTGTTATTACAGCAACAGCAATCTGAATCTTGACCCTGTGGCCCCGCCTCAGGGTGGAGAGTCCTGATGGGGCCTGTTACCAGGGTGGGCACTCATGCTTTCTCTTGAGCTCGATTTAAAGACTCATCAAAACTCTTCCCCCTAAAGTTTTATATTGAACCTTAGAACTGAATCACCTCTAATTGAATTGAACAAGCAGCCAATAACTTAGCCGTTCTTTGAATCCAGTTTCCCAGGTGTTGGAACAGACTGCTGTCCTGTGTGCTGCAGAGTCTGTCCCTTGTTGGCACTTAGGAAGATCCAGTTTCTCCCTCACTGGAAGTCTGCACTTCTCAAGCAGAAGGATTAAGCCTCTGGGGTTGCTTGCAGTGATAGGCAGCCACTGATGTCTTTTTAGTCAGTGGCCTTTGGGCCCTGGTCTTCAGTGTCAGCACTAGGGTTTGTTTGTCCTCTGGGGTCTTTTTTGGCACATGTCAgttttgtttatataaaatgaaGAGACTGTCTCTCTGATGATGGGTTTAATGAAAGGCACTCTGCTTTGGGTGTGGGCGGTCCAGGATTATGTGGTAACTATTGTCTGTTAGTTacctggatattttatttttctttttggatctTGCAAGGGGAAAACTACAAGTAACaagttttataaatttaatttaaattgttACAGGTTTTCATGTTCAGGACAAATAATTTTTCAACCTTCGATGATATCCTTGCAGCAGTTTGTTGGTAAGGTGACTTTCACCTAGGGCAGCTGTTgcatgccaattttttttttttgtgtgtgtgtgtgaaaacactTCAGAATTGAATTAAAAGATGTAAATTTAAAATTGGTTGTGTATCTAATATGCCCAGGTTCAGtaaataaacaattctttttaaaaaca

Publications

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