Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name AZIN1P2
Plot displaying the genomic locations of a retrocopy (in chr6) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Sarcophilus harrisii
Coordinates chr6:99493675-99496380  UCSC
Strand +
Parental Sequence NM_001291487.1
Parental seq. overlap 1515 bp
Parental seq. overlap (%) 46.1%
Genomic Region Intergenic
Retrocopy Summary AZIN1P2, located on chr6:99493675-99496380, is a retrocopy of the parental gene AZIN1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name AZIN1
Full Name N/A
Also known as -
Coordinate chr1:584938744-584972444
Strand -
Gene summary The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 1, the first member of this gene family that is ubiquitously expressed, and is localized in the nucleus and cytoplasm. Overexpression of antizyme inhibitor 1 gene has been associated with increased proliferation, cellular transformation and tumorigenesis. Gene knockout studies showed that homozygous mutant mice lacking functional antizyme inhibitor 1 gene died at birth with abnormal liver morphology. [provided by RefSeq, Sep 2014]

Homology

Species Scientific Name Retrocopy
Human Homo sapiens Without Homology
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>AZIN1P2
TGTTATCTCTTGGAGAACTTTCTGACCAGGCATATGACTGTCCAGAGGATCTAGGAGCAGGACTTTATAGAGTGCAGTTCAACTTCAACAGTGAGTCACCTTGGGAATCTGGCTGATGAGAGGACAGTTCCATCTCCCAAGCTTGTTCATTTTGTTACTTATTTTAAGAATTCAAATGTAAGAGTTGGTGgtcctaGTTGATGGTCCACCTCCTAACTTTTCCTAGTTTATGTCTTTTGGCTTTGTGGAATATGACTGAGATGAAAGGATTTGTTGAAGATGCAAACTACTTCATTGGCTTGTAAGATGAAGGAGTATATGTTGGAAATGTTATTGATGACTATTTCCATGAACGTacactaaaagggaaaaatacatttttcttttcttggagaGCTTGGAAAAACTGTGAAGAAGCACAGTCAGTGGCAGAATGTTGTggctcaaataaaataatctaaacaGAAAAATGCAATCCATTTCCAGTTATTCTAGAAATTTTTGCAGCTTTTGGAACATGCTTTGCATATTACAGCAAAAATGAAATGGCATTGGTGCAAGAACTGGGTATTTCTCCTAAAATCATCATTGATATATGGTCATGTAAACAATCTTCTCAAGTAAAATATGCTGCAAAAACATCTCATCATGTGACAGTGAAGAAAAGTGTACTTAATCATCCAAATGCCAAGCTCTTGCTATACATTGCAAAGATATTGGTGGAAATGAAGAGAGTAATATGAAGTTTAGTGCCACACTGAAGAATTTTAGTCAACTTTTGGAATATGTTAAGGATGTCCAAATAATTTATGTTAAGTTTCATGTTTCAAGCACTTGAAAAGAACTTCAAGTATAAATTCAATGTGTGTTTGACATGGCTGGAATATTTGGCTTTAAGATGATGATATTGGACATTGGTGGAAGTTTCATGGGAAGTGAATTTCAGGTACAAGAGGTTGATCATGTTATTAGTTCTTTGTTAGATATCGGCTTTCCTAAAGGATATGGATCATTTCAGAATCTGGAAGCAACTAGGTAACTTCTGCATTCATTTTAGTAGTTAATCTCATTGCAAAGAAACTTGTTGAAAATGATGTTTCCTTTGGAGTAGGAAAAACTGGGAGCAATGAACCTGCCTTTATGTATTACATGAACGACGGCGTTTATGATTATTTTGCAAGTACATTGTCTGAGATCTTGAATAACATCCTAGAGGTTCataaaaaatacaagataaatgaACTTTTGTTTACAAGCACCCTTTGGAGTTCATCCTGTGATGAGTTTGATCAAATTGTGGAAAACTGTCTTCTTGAACTGAATGTAGGAGATTGTATGATCTTTGATAATATGAGAGCAGACACTATCCTTGCGTCATCTGCTTTTAATGGTTTTCAGAAGCCAACTATTTATTACATGATGTCAGTCAGTGATTGGTATGAGAAGCAAGATGTTAGAATTACTTTAGACATAATGATGAACTTCTTCTTGGTGCCCTCTTATATTCAGGTGACCCAATATGACAGTAGCTTTTCTACTGAAGCTTAAAATAGGTATTAATGCTTTTGTTTAGGCCCGAAGTTGAAAAACCTGAAGTTGCAAGCTTATCTGATCAATATTCcagtatgaaagaaaaattaaatgatattaaCCATTCATTCTCCAAAACGTGAAAGAAATTAGTAAAGAAAATAGCTAAATGGGAGTAGGCAAAACTAGATTGTAACTATAATTCTTTGGGCGTGAAATAGGAATTAGATGGGTCCAAATTTAAATTTATCTGTTCTCCATCCCTGAgcatttagaataaaatatg
>NM_001291487.1
GCCCTTTCTATCTGTTCCTCCTCCTCggccccctcccctctttcctcctccaccaccgcctgcctccctccctcccatgtCCTCACTGCAGTCCCTTCGCCAGCGGGGGAGCTGATCCCTGGCTTCCtggtggtggggagggggagggaggctgGCAGGCGGCTAGCCCGCCGGAGGCTGCGAGACCATAGACACCTGCACCGCCTGGTCACGTcgcccccctcccctttcccagcCCTTTCCCTCACCCCACGCCTTCTCCCCTCGCTCCTACTCCGGtacccctcccctttccttttccccagtgACTTCTCCCCGCCCCACTCGAACAGTGGCCCGGCCGGCTGTGACGTTGCTAAGCCCCGCCTCCTCCCGCCCCCCCGTATAAATACGGGCTCTTCGGGCGCTGCCTTCCCACACTCGCTTGCTCTTCGTCCCGGCTAGCATCCCCCATCTTTTTGCGTCGTcgcctttttcttcttccttttcttattctctccttttctcgCTCTGTTGCTCTTCTCTTTAAGGAACCTGCCTATCATCCTAAATCCCTACCCGCCCCCACCTCGTTTTGGGAGTTTTTTAAATTAgcgtttatttattttttttctcctcggCCGCCGTCGCCACTGCTGCATAGCTGGTGTCGGTGCCGCGCTTTTCCCCCCCACGTCCTCCCCGCAGCCTATGGCCCAGGCCGCCTCGGGTATTTCTGCTTTAGGTAACCACATCCCTCTTTAAAAATTCCGCCTAAAAAGAGAAGACGCTTTACCCGACTCTTTGGGCCGTTATCTCACggCGAACTTTCTGACCAGGTATACAACTATCCAGAGGGCCTAGGAGAAGTGCTTTATAGAGAGCAGTTCGACTTCAACGCTGAGCCACCTTGGGAACCTAGCTGATGATAGGAGGGTTCCATCTCCTAACTTGTCCATTTTGTTGCATATTCTAAGGACCCAAACGTAAGGCTTGGTGGCCCATCTCCTTGTTTTTCCTGGTTTATGACTTTCGGCTTTGTGGAATACGGCTGAGATGAAAGGATTTATTGAAGATGCAAACTACTCTGTTGGCTTGTTGGATGAAGGAACACATCTTGAAAATGTTATTGATAACTATGTCTATGAACATACCCTAacaggaaaaaatgcattttttgttGGAGATCTTGGAACAATTGTGAAGAAACACAGTCAGTGGCAGAATGTTGTGGCTCAAATAAAGCCATTCTACACAGTAAAATGCAATTCGGCTCCAGCTGTTTTAGAGATTTTAGCAGCTCTTGGAACTGGATTTGCATGTTCCAGCAAAaatgAAATGGCATTGGTGCAAGAATTGGGTGTTTCTCCTGAAAACATCATTGATATAAGTCCGTGTAAGCAATCTTCTCAGATAAAGTATGCAGCAAAAACTGGGGTTAACATCATGTCATGTGACaatgaaattgaattgaagaaaattGCACGCAATCATCCAAATGCGAAGCTCTTACTACACATCGCAACAGAAGATATTAGTGGAGATGAAGAGAGTAACATGAAGTTTGGCACCACACTGAAGAATTGTAGGCACCTCTTGGAATGTGCTAAGGAACTTGACGTCCAAATTGTTGGTGTTAAGTTTCATGTTTCAAGCTCTTGCAAAGAACCTCAAGTGTATATCCATGCTTTATCTGATGCTCGATGTGTGTTTGACATGGCTGGAGAATTTGGCTTTAAGATGACCATATTGGACATTGGCGGAGGCTTCACGGGTAGTGAATTTCAGTTACAAGAGGTTAATCATGTCATCAGCCCATTGTTGGATGTCTACTTTCCTGAAGGATCTGGCATTAAGGTCATTTCAGAACCTGGAAGCTACTATGTATCTTCTGCATTCACTTTAGCAGTTAATATCATTGCAAAGAAAGCTGTTGAAAATGTTTCCTCTGGAGTAGGAAAAACCGGGAGTAATGAACCAGCCTTTATGTATTACATGAATGATGGTGTTTATGGTTCTTTTGCAAGTAAATTGTCTGAGAACTTGAATACCATCCCAGAGGTTCACAAGaaATACAAGAAAGATGCGCCTCTGTTTACAAGCAGCCTTTGGGGTCCATCCTGTGATGAGCTTGATCAAATTGTGGAAAACTGTCTTCTTCCTGAGCTGAATGTGGGAGATTGGCTGATCTTTGATAATATGGGAGCAGATACTCTCCATGAGCCGTCTGCTTTTAATGATTTTCAGAGGCCAACTATTTATTACATGATGTCATTCAGTGATTGGTATGAAATGCAAGATGCTGGAATTACTTCAGACACAATGATGAAGAACTTCTTCTTTGTGCCTTCTTGCATTCAGCTGAGCCAAGACGACAGCACCTTTTCCACTGAAGCTTAAAACAGGCATTAACGCTTCCTTTTAGACCTGAAGTTGCAAGTTAAGCTTGTCTGGTCAACATTCCAGTGTGGAAGAAAAATTGAACAATCTTAACTATTCACTCTCCAAAACTTGAAAGaaattagtaataatagctaattgGGACCAGGCAAAACCAGCTTACAACTACAATTCTTTGGGGTGAGGTGGGAATTAGATAATGTGTCCAGATTTAAACTTACCAGTTGTCCAACCCCTAAgcgtttaaaataaaatatgcaacaAAATGGATGACTTAGTGGAGATGGAAGCCCATCACTTGGGTTCCCCATTATAAACCGTTTACATACAAGTACACAGTTTTTATACTAAGGATTCCTGTTAGAAAGTCTTGTAAAGTTATTGTCTTTCGCCCAGATATATCAAATGTCAGTGGAAGACCAGTGTGACTTCATTTAGATATGTTTAGTGTATTTAGAATGTGTAAATTTGTGCTTTGAACTGTagtttaataaatgtaaaattgcaTCATAGTATTTGTTGTATTTGACCTGACGTAACCCTTGTATGATTGCAATAAAATTTTGTGTAGATTTTACTGTTTTTTCAGGCTAAAACTTTGGGAAAGGGGCTAGTTAGCAAAGGTAGTTTTGAAATAGATGTGTATATGACtgttttgaaagttatttttctttagcccattatttcaagtttagtttggcagtactttaattttttttcaattatttaagttttcaataatttaagtaaaataagTTTGATAAATCATTGTGAATTTCAGATTCTTTACTGGAAAGTTGACATGTAGTTTGCAATGTTTATTAAACATAGTATGTTTTCTTTAACAATTCTAAcaccaaaaatgtt

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