Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name OAZ1P3
Plot displaying the genomic locations of a retrocopy (in chr4) and its respective parental gene (in chr3). Each line represents a retrocopy.
Species Monodelphis domestica
Coordinates chr4:9729130-9729445  UCSC
Strand -
Parental Sequence NM_001291427.1
Parental seq. overlap 271 bp
Parental seq. overlap (%) 22%
Genomic Region Intergenic
Retrocopy Summary OAZ1P3, located on chr4:9729130-9729445, is a retrocopy of the parental gene OAZ1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name OAZ1
Full Name N/A
Also known as -
Coordinate chr3:455037612-455044205
Strand +
Gene summary The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamine in cells. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis pathway; thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as by inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs, and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization (PMID:16120325). A pseudogene of antizyme 1 has been noted on chromosome 4. [provided by RefSeq, Jul 2014]

Homology

Species Scientific Name Retrocopy
Human Homo sapiens Without Homology
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>OAZ1P3
CCAGTCCAGGGTTACAGATGCCAAACATGCTAATTAGACAGCAATTCTGACAACAGCCTCCACACTGAAATTGCAGGCCGGGTTCTACCTGAAAGGAGGAAAGATAGTTTTGTGTTTCTTCTTGAGTTTGCAGAAGTTTCACGTGGATGCTGTCTTTATCTGCTTCCATAAGAATAAAGATGATAGAGTTTCATTCTCCATACTTTCAGCTTTTTTAGCTTTTCGATTATGACACCAGGGCATCTCCTTGGTCCCAAGAGATCAGATGCTTGCTTCATGGCCATCACATTTGAGAGACTCTTCAGAAGAAGACTAA
>NM_001291427.1
aTTTTGCGAACGGCGAGCAGCAGCGGCGGCCCGGAGAGGTGCAGCGGAGGTTTCCTGGTTTCGGACCCCCAGCGGCCGGATGGTGAAATCCTCCCTGCAGCGGATCCTCAACAGCCACTGCTTCGCCCGAGAGAAAGAGGGGGATAAACCCAGCACCACCGTCCACGTCAGCCGCGCCATGCCAGTCCTCAGCCTCCACAGCAGCGGCAGCCGCAGCAGCGAGAGttCCAGGGTCTCTTTTAATTGCTGTAGTAACCTGGGTCCAGGGCCTCAGTGGTGCTCCTGATGTCCCTCACCCACCCCTGAAGATCCCAGGTGGGCGAGGGAATAGTCAGAGGGATCACAATCTTTCagctaatttattttattctGATAATCGGCTGACTGTAACAGAGGAACTAACGTCTAATAACAGGACAAGAATTCTAAATGTCCAGTCCAGGCTTACAGATGCCAAACACGTTAATTGGAGAGCAGtgctgaacaacaacagcctctACATTGAAATTCCAGGTGGTGCTCTACCTGAAGGGAGCAAAGATAGttttgcaGTTCTTCTGGAGTTTGCAGAAGAACAGCTTCATGTTGATCACGTCTTTATCTGCTTCCACAAGAATAGAGATGATAGAGCTGCATTGCTCCGTACTTTCAGCTTTTTGGGCTTTGAGATTGTGAGACCAGGGCATCCCCTTGTCCCCAAGAGACCAGATGCTTGCTTCATGGCCTACACATTTGAGAGAGACTCTTCGGAAGAAGACTAGATTGCAATGTTTTGCATCTTTAGAGCTTTCTTGTTGTCTGTAAAGATGAGTCTGTGGAAATTTTGTCAACATCGATTACAGTGCATTTAATGTTGTGCTTTGTACGAAATATTGTGACCAACTGCTCTAGTGGTGGGATGTTGAAAATTTCAGACTTTATCATCTTTTCTGGATTTGTCCGCATGTTGTGATTGTGCAAATAAATGCTCACTCCAAATTAGCAGTATATTTCTTGAAGTTTAATATTGTGTTTGTGATACTGAAGTATTTGCtttaattctaaataaaaatttatattttacttttttattgctGGTTTAAGATGATTAAGACTATCCTTACACATTCAAAAGAAGTTTATTTGAAGTAAAGTAGTATCCTAGGCACCAAAATGGTAGGTCTCTTAACTTTGAAAGAGAGGTATTAATCTGCCCTTCTATTGCTCTCAAATcagaataaaaagattaaaacta

Publications

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