Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name rac1aP1
Plot displaying the genomic locations of a retrocopy (in chr1) and its respective parental gene (in chr12). Each line represents a retrocopy.
Species Danio rerio
Coordinates chr1:56939648-56939800  UCSC
Strand -
Parental Sequence NM_199771.1
Parental seq. overlap 122 bp
Parental seq. overlap (%) 6.8%
Genomic Region Intergenic
Retrocopy Summary rac1aP1, located on chr1:56939648-56939800, is a retrocopy of the parental gene rac1a. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name rac1a
Full Name Rac family small GTPase 1a
Also known as rac1|wu:fd16e02|zgc:55823|zgc:55917|zgc:86934
Coordinate chr12:10464897-10476337
Strand -
Gene summary Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Acts upstream of or within cell migration involved in gastrulation; myoblast fusion; and neutrophil chemotaxis. Predicted to be active in several cellular components, including cell cortex; cytoplasmic vesicle; and dendritic spine. Is expressed in liver; retina; and retinal ganglion cell layer. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 48; colon adenocarcinoma; and pancreatic adenocarcinoma. Orthologous to human RAC1 (Rac family small GTPase 1). [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Human Homo sapiens Without Homology
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>rac1aP1
TTCCTACTGTCTTTGATCATTTTTCTGCCAATGAGATTGTTGATGGGAATCCAGTGAGACTACAACTGTGGGATACAGGAGGAAATGAGGAATATGACAGGCTTCGAGAAATGTCCTACCCAGAGACAGATGTGTTCTTGATCTGTTTCTCTA
>NM_199771.1
GTGGCTGTTTGTTTAACTGGAAGCAGCGGCAGTAAATGCGCCGGAATGCAGGATTCCAGCTAACTTTTCTCCGTCGAGTTTGAGCGAAATTCCTCATTTTCTGTCGACTTCTATCGACTCCGCTCTTGTTTTGCGTGTTGAATTGTGAGGGCGGGTGTCTCTGGCACAGCAGCTTTTATTGATTCATTCACAGATACAGCTAGCGGGATAGCGTGCTAAACGAACACAGATGCAGGCCATAAAGTGTGTGGTCGTCGGGGACGGGGCTGTGGGAAAAACATGCCTTCTGATCAGCTACACCACCAATGCTTTTCCTGGGGAATACATTCCCACTGTGTTTGATAATTATTCTGCAAATGTGATGGTCGATGGGAAACCAGTAAACCTGGGATTGTGGGATACAGCAGGACAAGAGGATTATGACAGGCTTCGACCGCTTTCCTACCCTCAGACGGATGTGTTCCTGATCTGCTTCTCTCTTGTGAGTCCGGCCTCATTTGAAAACGTCCGTGCAAAGTGGTATCCGGAGGTCAGACATCATTGCCCTAACACTCCAATAATTCTTGTTGGGACTAAGCTTGATTTGCGAGATGACAAGGACACCATCGAAAAGTTAAAGGAGAAGAAACTCACTCCCATCACCTACCCTCAAGGCCTTGCTATGGCCAAAGAAATAGGAGCTGTGAAGTACCTGGAGTGCTCTGCCTTAACCCAACGCGGCCTTAAAACTGTGTTCGATGAAGCCATCCGTGCAGTGCTGTGTCCACCTCCGGTGAAGAGGAGGAGGAGAAGATGTCTCCTTCTGTGAACTGACTGCGCCCACAGCACCAGCTGCAATCTGAGCTCACCTGAGAGAAGAACAATGGAAGCGGGGATGACGGGAAATGATATGGTGTATTCATACAGATATTTCTCTTTCTCTCTCTCTTGAATTGTAATTATAATTACGCCACTAACTAGCTGTTAAGATGCCAGAGTATTTACTTTGAGAGATGAAGAGCGGCATCCATAGTCATTTCCCAATGTACACTAAGAAATTCCTGCTGCCTTCTAATGACCTTCTTTCTTTTCCCTTCATTTTGATGTTAGGAAACTACATACTCCTTTTCTCTTTCTCCATCTTTGTGAGTCCACGTGTTTTGTTTACAATCTGCGTTTTTGTAGAGAATGAAATATTGCCAAAAGTTAAACCTGCATCTCAGTTTGCTCACACTAACGCTCTCGTTTTCCTTGAGCACTTGGGAAGGGGGGCGGTTGTCAGAGGCAGATTGCAGTAATACTGAAGGAACTATTTTACAAGAGGAAAGTTGAAGAAACACTTTTTTTTCCCCCGATGCTAGAGACTTTATTTTTCTTTAAGTGTATAAGAAACAAACCTAGTTAAATGCATATAACAGCTTTGTTTTGTCAAGAGTATAGCATATTTTCACTACTGTATCTGAATTTAAGAAGACATGTCATGTTTAAACTCTCTGTGTTTTAGTCTGTCTATTGGATGAGTCTGGCAGTGTTTTATCCACTTTTACAGTCCCAGTGTTGTATTTAGACTACAGAAACATCTCTACTGTATACTTGATAACAGTAATTGTTAGGGTCATCAAGTATTAAATCTCTAATTGATCTTCACACATGATCCGGTGGTTGTGATTAGCCACATGGAGTGTTCAATTTTGACAGTTCAGTAATGACGATTGAAATGCTTCATTTATTCATGCTTTTACTGTCTCCACTAAATCTACAGTGTATTAACCTTTGTGTCTAAAATACAAAAATGTAAAAACA

Publications

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