Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name Hsc70-2P2
Plot displaying the genomic locations of a retrocopy (in chr3R) and its respective parental gene (in chr3R). Each line represents a retrocopy.
Species Drosophila melanogaster
Coordinates chr3R:24056453-24057098  UCSC
Strand -
Parental Sequence NM_079615.4
Parental seq. overlap 513 bp
Parental seq. overlap (%) 23.5%
Genomic Region Intergenic
Retrocopy Summary Hsc70-2P2, located on chr3R:24056453-24057098, is a retrocopy of the parental gene Hsc70-2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name Hsc70-2
Full Name Heat shock protein 70 cognate 2
Also known as CG7756|DmelCG7756|HSC-70|HSC2|HSC70|HSC70-2|HSP70cA8|HSP7B_DROME|Hsc-2|Hsc2|Hsc70|Hsc70.2|dhsc70|hsc2|hsc70
Coordinate chr3R:13044759-13047388
Strand +
Gene summary Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and misfolded protein binding activity. Predicted to be involved in several processes, including cellular response to unfolded protein; chaperone cofactor-dependent protein refolding; and protein refolding. Predicted to be active in cytosol; nucleus; and plasma membrane. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; systemic lupus erythematosus; toxic shock syndrome; type 2 diabetes mellitus; and urinary tract infection. Orthologous to human HSPA1L (heat shock protein family A (Hsp70) member 1 like); HSPA1B (heat shock protein family A (Hsp70) member 1B); and HSPA6 (heat shock protein family A (Hsp70) member 6). [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Human Homo sapiens Without Homology
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology

Expression

Related Sequence

>Hsc70-2P2
GCCATTGGAATCGATTTGGGCACCACATACTCCTGCGTGGGAGTCTTCCAGTACGGAAAAGTGGAGATCATTGCCAACGACCAGGGTAACCGTACCACACCATCGTACGTGGCCTTCACCGACTCGGAACGCCTTATTGGAGATGCCGCCAAGAACCAGGTGGCCATGAACCCCAAGAACTCTGTGTTCGATGCCAAACGCCTGATTGGGCGTCGTTTCGACGATTCCAAGATCCAGGAGGACATTAAGCACTGGCCGTTCAAAGTGATCAACGACAACGGCAAACCAAAGATAAGCGTGGAGTTCAAGGGCGCGAATAAGTGCTTCTCTCCCGAGGAGATTAGCTCGATGGTACTCACCAAAATGAAGGAGACTGCAGAAGCCTACCTGGGCACTACAGTGAAGGACGCTGTCATCACAGTGCCGGCCTACTTCAACGACTCCCAGCGCCAGGCAACAAAGGATGCTGGTGCCATCGCTGGCATCAATGTGCTCCGCATCATCAACGAGCCAACAGCGGCGGCTCTGGCCTACGGCCTGGACAAGAATCTGAAGGGAGAGCGCAATGTGCTGATTTTCGATTTGGGCGGTGGTACTTTTGACGTCTCCATCTTGACCATTGACGAGGGATCCCTGTTTGAGGTGC
>NM_079615.4
GCTTCTAGAACAAACACACACACACACTTTTCGATTTTTCGGCGTGCGAAAAATATAGGAAACCAAAATTTTATTCGTTGCTGCACCATATAAATAAGTGCAACAATCGCGCTTTTTTCAGTTCAAAATCAACACTAGTAGCTGCAGCATCACACATTTTGGATATTCAGCATAAGGCGATTAGTAACCAGAAAAAATGGGTAAAATTCCGGCCATCGGCATCGACTTGGGCACCACCTACTCCTGTGTGGGAGTTTGGCAGAACAGCAAGGTGGAGATCATCGCCAACGATCAGGGAAACCGCACCACGCCCTCGTATGTGGCATTCAACGAGACGGAGCGCTTGATTGGCGATCCGGCCAAGAACCAGGTGGCCATGAATGCCAAGAACACGGTTTTCGATGCCAAGCGATTGATTGGACGGAAGTTCGACGACAAGAAGATACAGGAGGACCTGAAGCTCTGGCCCTTCAAGGTCATCAATGAGAAGGGAAAGCCGAAGATCGAGGTGGAGTTCAAGGGCGAACGGAAGCGATTTGCCCCCGAGGAGATCAGTTCGATGGTGCTGACCAAGATGCGCGAAATCGCCGAGGTCTATCTGGGTGGCAAGGTGAAGGACGCGGTGGTCACAGTGCCGGCCTACTTCAATGATAGCCAGCGTCAGGCGACCAAGGATGCGGGCTCCATTGCTGGACTGAATGTGCTGAGGATCATCAATGAGCCCACTGCGGCAGCTCTGGCCTATGGGCTGGATAAGAATCTTAAGGGAGAGCGAAATGTGCTCATCTTCGACTTGGGCGGCGGCACCTTCGACGTCTCCGTACTGAGCATCGATGAGGGTTCCCTGTTCGAGGTGAAGGCCACGGCCGGCGATACCCATTTGGGTGGTGAGGATTTCGACAACCGGTTGGTCAATCATTTTGCCGAGGAATTCAAGCGGAAGCACAAGTCGGACATCAAGGGAAATGCCAGAGCGTTGAGACGCCTGAGAACGGCTTGTGAACGGGCGAAGAGGACGTTGTCCTCCAGCACGGAGGCATCCTTGGAGATTGATGCCCTGCACGAGGGCATTGACTTTTACTCGAAAATTTCGAGAGCGCGTTTCGAGGAGCTGAACATGGACCTCTTCCGGTCCACCATGCAGCCGGTGGAGCGGGCACTGAGCGATGCCAAGATGGACAAGAAGGCCATTCATGATGTGGTCCTGGTGGGCGGCTCCACGCGTATTCCCAAGATTCAGAAACTACTGCAAGATCTGTTTGGTGGCAAGCAGCTAAATCTTTCAATCAATCCCGATGAGGCGGTGGCTTATGGAGCCGCCGTACAGGCTGCCATTCTCACCGGCGTGGGCAGCTCACAGATCCAGGACCTGCTCCTCGTGGACGTGGCTCCCCTTTCGCTGGGCATCGAGACCGCTGGCGGCGTGATGACCAACTTGGTGGAGCGCAATGCCCGCATTCCCTGCAAGCAGCAGCAGATCTTCACCACCTACAGTGACAACCAGAATGCGGTGACCATTCAGGTGTACGAGGGCGAGCGGGCCATGACCAAGGATAACAATCTACTGGGCACCTTTAACCTCACCGGCATTCCGCCAGCTCCTCGGGGAGTGCCCCAGATCGAGGTGGCCTTCGACTTGAATGCGGATGGCATCCTGAATGTGAATGCCAAGGACAACAGCACCGGGAAGAGCGAAAAGATCACCATTTCCAACGACAAGGGCAGACTTTCCAAAGCGGAAATCGATCGCATGCTCTCGGAGGCGGAGAAGTACAAGGTCGAGGACGATCGTCAGAGGGAGCGGGTTCAGTCCAAGAACAATCTCGAGGCATACATCTACGCATGTCGCCAGGCCGTCGACGACGCTCCATCCGGCGTTCTTTCCGAAACCGAACGCTCCAAGGTGCGCGACAAGTGCTCCTCCGAGGCATCCTGGCTGGACAAGAACTCGCTGGCCGAGAAGGAGGAGTTCGAGAGTCACCTGAAAGAGTGCCAGCGCATCTGTACTCCAATAATGTCGAAAATCCATGGCGGCAAAAAGGGCAAATCATCGATGGGCAAGGGTTCCCATCCCACTGTGGAGGAGGTGGATGGATAGTACGATCCACCGACCTAAATTATTCAGTCATTTTTTGATTAATATTATTTTGAAAATAAAGTAGACCTTCACTTTC

Publications

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