Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name nonAP1
Plot displaying the genomic locations of a retrocopy (in chr3R) and its respective parental gene (in chrX). Each line represents a retrocopy.
Species Drosophila melanogaster
Coordinates chr3R:16641339-16641937  UCSC
Strand +
Parental Sequence NM_167505.2
Parental seq. overlap 483 bp
Parental seq. overlap (%) 20.5%
Genomic Region Intergenic
Retrocopy Summary nonAP1, located on chr3R:16641339-16641937, is a retrocopy of the parental gene nonA. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name nonA
Full Name no on or off transient A
Also known as Bj6|Bj6-1|CG4211|DmelCG4211|NONA|NonA|dNONO|diss|non-A|nonA/diss|nona|opm2|p54[nrb]|x14
Coordinate chrX:16361569-16371547
Strand +
Gene summary Predicted to enable mRNA binding activity. Involved in male courtship behavior, veined wing generated song production and visual perception. Located in nucleus. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in several structures, including germline cyst; gut; head; somatic muscle cell of thorax; and ventral nerve cord. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability 34. Orthologous to human NONO (non-POU domain containing octamer binding); PSPC1 (paraspeckle component 1); and SFPQ (splicing factor proline and glutamine rich). [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Human Homo sapiens Without Homology
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology

Expression

Related Sequence

>nonAP1
GCCATTGTGCGTGTGACTAATCTCAACCAGTTCGTGTCCAACGAGCTGCTGCACCAGTCCTTTGAGATCTTTGGACCCATCGAGCGCGCCGTTATCTGCGTAGACGATCGCGGTAAGCATACCGGCGAAGGCATTGTTGAGTTCGCCAAGAAGTCCTCGGCCAGCGCCTGTCTGCGCCTGTGCAACGAAAAATGCTTCTTCTTGACTGCTTCATTGCGTCCGTGTCTGGTGGAACCGATGGAGGTGAACAACGACAATGACGGCTTGCCGGATAAGACGTTAAACAAAAAGTCGCTGGAATTCAGACATGAGCGTAGTGTCGGACCGCGTTTCGCTTGTTTAAATTCGTTTGAGCACGAGTATGGATCACGCTGGAAGCAATTGCACGATCTCTTCAAGAGCAAACAGGACTCACTCAAGCGTGAGTTGAAAATGGAGGAGGACAAGCTGGAGGCCCAGATGGAGTACGCTCGCTACGAACAGGAGACCGAACTGCTGCGCCAGGAGCTGAAGAAGCGCGAGCTGGACAACGAGCGCATGAAACTGGAGTGGGAGATGCGTGAGAAACAAGCCGAGGAGATTCGAAAGCGGGAAGAGGA
>NM_167505.2
GCTGTGTACGTATAATACGTTTATCTGCTTTGTTCCATTACATTCAGTTTTTCGATTTTGACGACGGTTGTCAACGAGTTGTAGCAAGCACATTTTAATAAAGCGAAAGGAAATAATAATATTTAAAAAATGGAAAGTGCGGGGAAACAAGATAATAACGCCACGCAACAGTTGCCGCAGCGACAGCAGCGGGGAAACCAGCAGGCCAACAAAAATCTCGGCAAGCATAATGCACAAAAACAAAATGATTCCGCGGACGGAGGCCCGGCTGAAAAGAAGCAACGATTCGGTGGTCCAAATGCCCAGAATCAAAACCAGAACCAGAATCAAAATGGTGGTGTAACGGGCGGTGGTGGTGCAGTTGGTGGCCCCAATCAAAATAAGAATTTTGGAAACAACAAGGGTGGGTTCGTTGGAAACCGCAATCGCAACAATAATCGCGCTGGAAACCAAAACCGGACTTTTCCAGGCAACAACAATCCAAATCAAAAGCCCAATAACGAAACATCAAAGGCGGACGGCCCTAATGCACTTGCTAAGAACAATGAACCGGCAACTGCAGCTGCTGGCCAAAATCAAGCGAATCAGAACGCCAACAAGGGCcaaaatcaacggcaaggacaaaaccaaaatcaaaatcaaGTCCATGGTCAAGGAAATCAAGGAGGACCAGGAAATCAAGGGGGAGCAGGCAATCAAGGAGGCCAAGGAAATCAAGGAGGAGCCGGAAATCAGGGAAATGGTCAAGGATTCAGAGGTCGCAATGCTGGTAACAATCAAGGTGGCGGTTTCTCCGGAGGTCCGCAGAACCAGCAGCGTGACAACCGAAACCGGAGTGGTCCACGCCCTGGCGGAGGTGCTGGTGGCGCGATGAACAGCACCAATATGggtggtggtggtggtggcggtggaggcggtggtCCGCGCGGCGGTGAAGACTTCTTCATTACCCAGCGGTTACGCAGCATTTCTGGGCCCACCTTTGAACTGGAACCGGTGGAAGTGCCCACGGAGACGAAGTTCTCTGGACGAAATCGTCTCTATGTGGGCAACCTGACCAATGACATCACCGACGATGAGCTGCGCGAGATGTTCAAGCCATATGGCGAGATTAGCGAGATCTTCTCGAACCTGGATAAGAACTTTACATTCCTAAAGGTCGACTATCATCCCAATGCCGAGAAGGCTAAACGCGCCCTGGACGGATCGATGCGAAAGGGTCGCCAGTTGCGTGTACGATTCGCACCGAATGCCACCATTTTGCGGGTGAGCAATCTCACACCGTTCGTTTCCAACGAGCTGCTGTACAAGTCTTTCGAAATCTTTGGTCCCATCGAGAGGGCCAGCATCACCGTCGACGATCGTGGCAAGCATATGGGCGAGGGCATAGTTGAGTTTGCCAAAAAGTCATCGGCCAGCGCCTGTCTGCGGATGTGCAATGAGAAGTGCTTCTTCCTGACTGCTTCCCTTCGACCGTGTCTGGTTGATCCGATGGAGGTGAATGACGATACCGACGGACTGCCGGAGAAGGCGTTCAACAAAAAGATGCCCGACTTCAACCAGGAGCGTAGCATTGGTCCGCGCTTCGCCGATCCCAATTCGTTTGAGCACGAGTACGGTTCGCGCTGGAAGCAGCTGCACAATTTGTTCAAAACCAAGCAGGACGCGCTCAAACGCGAACTGAAAATGGAGGAGGACAAGTTGGAGGCTCAGATGGAGTATGCACGCTATGAGCAAGAAACTGAACTGTTGCGTCAAGAGCTGCGAAAACGCGAAGTTGACAACGAGCGCAAGAAATTGGAGTGGGAGATGCGCGAGAAGCAGGCCGAGGAGATGCGCAAGCGCGAGGAGGAGACCATGCGACGTCATCAGACCGAGATGCAGAGCCACATGAATCGCCAGGAGGAGGACATGCTCCGTCGGCAGCAGGAGACACTGTTCATGAAGGCACAGCAGCTCAATTCGTTGCTGGATCAGCAGGAGGGATTTGGTGGCGGCGGCGGCGGTAACAACTCCACTTTTGACAACTTCGCTGGCAATAGCAATTCGCCATTCGAGGTTTTTAGAGGCAATAACAATAACAATTCCACAATGATTGGAAACAATGCTGCCCCCAACACACAGGAGATCAAACGCCTTGACGGTCCTATAAACGAGATTACTTCAAACTTCAGCCCACCAGATTTGGATTCGGATATAATTTTAGTGGCATTCGTATTGGAAGAGTTCTCATCTCACGTGTTTTATACGAAAATTGTACAGAAATGTGAAAGCTTTAAGAAACGCACACAGCTTAATGCTCGATCAAATATTATTAAAAAATGCATAAGCAACTTAAATTGGTTAATTGTTTTATGA

Publications

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