Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name SPCS2P2
Plot displaying the genomic locations of a retrocopy (in chr10) and its respective parental gene (in chr11). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr10:100143611-100143997  UCSC
Coordinates (T2T) chr10:101027849-101028235  UCSC
Coordinates (hg19) chr10:101903368-101903754  UCSC
Strand -
Parental Sequence NM_014752.3
Parental seq. overlap 325 bp
Parental seq. overlap (%) 12.1%
Genomic Region Intergenic
Retrocopy Summary SPCS2P2, located on chr10:100143611-100143997, is a retrocopy of the parental gene SPCS2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name SPCS2
Full Name signal peptidase complex subunit 2
Also known as -
Coordinate chr11:74949266-74979033
Strand +
Gene summary Predicted to enable peptidase activity. Predicted to be involved in protein targeting to ER and signal peptide processing. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of signal peptidase complex. [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes SPCS2P2
Bonobo Pan paniscus SPCS2P2
Gorilla Gorilla gorilla SPCS2P1
Orangutan Pongo abelii SPCS2P3
Gibbon Nomascus leucogenys SPCS2P1
Crab-eating macaque Macaca fascicularis SPCS2P5
Rhesus Macaca mulatta SPCS2P5
Baboon Papio anubis LOC101026629P5
Golden snub-nosed monkey Rhinopithecus roxellana SPCS2P4
Marmoset Callithrix jacchus SPCS2P2
Green monkey Chlorocebus sabaeus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>SPCS2P2
GGCGGCAGCTGCCCAGGGCAGGAGAAGTGGTGGTGGCGGAGGCAGTAGTGGGGCCAGCGGTGGTCTCAGCTGCGCGACAGGCAGTAGCCTCAGTGGCTTGTTGGCTAAGTGGAAGACGGATGAGAAGCATGGAAAAACTGACAAGTGGGATGGATCCGCTATGAAAAACTCTGGATGATTCTGCCAGAAAGGTACTTCTGGAAAAATACCCGTAGGGGGAGAATTTTGGTCTCATTGACATTTGCCTCACTATCTGATTGCACTCCTGTTTCCTTACCATAGTAGCTTTGATTTGGGATTCTGTGCACCCCTTTGCCGAGTCCAAGCCCGTTTTGGCCATGTACATCCTATCCTATTTTGTGATGATGGGGATTCTGACCAt
>NM_014752.3
GAGACGCAGAGGCGGACAAGATGGCGGCGGCAGCTGTACAGGGCGGGAGAAGCGGTGGTAGCGGAGGCTGTAGTGGGGCTGGTGGTGCTTCCAACTGCGGGACAGGAAGTGGCCGTAGCGGCTTGTTGGATAAGTGGAAGATAGATGATAAGCCTGTAAAAATTGACAAGTGGGATGGATCAGCTGTGAAAAACTCTTTGGATGATTCTGCCAAAAAGGTACTTCTGGAAAAATACAAATATGTGGAGAATTTTGGTCTAATTGATGGTCGCCTCACCATCTGTACAATCTCCTGTTTCTTTGCCATAGTGGCTTTGATTTGGGATTATATGCACCCCTTTCCAGAGTCCAAACCCGTTTTGGCTTTGTGTGTCATATCCTATTTTGTGATGATGGGGATTCTGACCATTTATACCTCATATAAGGAGAAGAGCATCTTTCTCGTGGCCCACAGGAAAGATCCTACAGGAATGGATCCTGATGATATTTGGCAGCTGTCCTCCAGTCTTAAAAGGTTTGATGACAAATACACCTTGAAGCTGACCTTCATCAGTGGGAGAACAAAGCAGCAGCGGGAAGCCGAGTTCACAAAGTCCATTGCTAAGTTTTTTGACCACAGTGGGACACTGGTCATGGATGCATATGAGCCTGAAATATCCAGGCTCCATGACAGTCTTGCCATAGAAAGAAAAATAAAGTAGCCAATTCTAAAAGTAGCCCTCTTTCTCCTGGATCTTGCTGAATTAGTGGCTTGGGGGGTGGGGGAGATAAAAAGAACTTAAAATGGGTAAAGTAAGAAATGTTAAAAAGTCCCTGTTTTGTCCTGAAATTTTAGTCTATTCTGGGTAAATAGGATTTTCTGACACAGATATGAGAAGTTGTAGCTCTGATGTCTAGCTGTAGTCTCCTTGATCTGCTGATTGCATTATTTTAATTTGCTTTTCTGGGAAAGCAGTTTTGCTAAAAGCTGTACAGACTTTTTCTTTTGTACCTAGCAGTACTTTATATAGTATAGCTTTGGGCCATGTAGCATTTTAAGACTCAATTTTAAAAAATTATTAATCTGTTGCTGACTCTTAATTCCTATTTCAATATGTGTTTCCTTGAAGAATTCAGGATACAACTTCTTGTGTATGACAGCTTTCCTTCACACACTATTTTTGTGGGTGTGTATATATCTGATTTGGGAAGAATTTAAAAAACACATAGCTTTTTAATTTGTTTGAAACAGACTTTCTGCCTGTTACATTTTTGCTTTTAACCAATTAAAGAAGCCAATGGCATTTTAGTTTTATATTGTGTTTTCCACTAGTATATCCCTGTTGATTTGTTTGTGCCTTTTATTAACTGCCATTTTCTAAAATTTTTTTCAATAAAAGGAAGGAAGATGTGAAAAAAATGGAGTCATAGTTTTGATGGAGAGAACAGAGAAACAAGTGTTAACATCTTTCTACTATAGGTTTTTTTCATTTTTAGGCTATTTTACTTGTCAAAGGCCCCTGAGAACCTGTAGCTAAGGAACTCTTAGCTTTCCAGTGATAATAACaataataacaacattctgtacttactttgtgccagaaatgctccaagtactttacatgtgttaataatgctcacagcaatcctaagaggcaggtgctgttattatccccattttacacatgaggaaactgagatacaaaagttaaataattgtcacacagctagtgatagaactgggattcaaacctggggagtccggcttcagagtttgtggtcctgcagagacaaaacagccgcttttccagTATTTTCCCAGTATGGTCAGAGAAGACCTGGGTGCTTGCCAAGATCCTTTGACCTTTAGGAATATTTCCCTACAGCCTTACAAAACATCAATTTTGGCTGAGCCTAGTACCCAACACTATATTCAGTTTGTAAGAAATTACCATTATCACATTTCCTGTTTGTCTTGGAGAGGTTGTCCTATCTCGCACCACATGgtagggaattgtgaacaacactggacagaaagttaaagccttggattctgtactcttcattcctgtaaaccttgggtaagtttcggaattctctgtgagcttcTTAAAGTTTTTGAAAGCATGTAACCGGATAAGTGTATTTTTACAATGGAGGAGTTAcagtcatcttggtatttgtgggagattggttccaggatccccaagcataccaaaatccaaggatgctcaagtcccttatataaaatggtatagcatttgcatataacctacacacatcctcccatatacttttaatcacctctggattacctataatacctaatataatgtaaatgctatgtaaatagttatactgcattggttTTTTAATTTATATTTTTTGTTATTTTTTAAAATATATTTTTAATCCATGGTTGGTTAAATCTGTAGATATAGAGGGCCAACTGTACTGTTAGACACAAGGGTCTCGAGGCTTGCAGATAGAGACTGAATAACCCTCTCCATGATGATCCCTTAGAGTTCCCCCACTGTGcctttttctttacatgtgcatgcaaacatgtgtctccacatacattttttttaacaaaaattgaattatgttgatatatgtcctgtaatttgtgttttaaacttaatatatcttaggcattttcccTGTGTGTGTGTATAATGCAGCTATTAAAAATGAGTCTGAggccaggca

Publications

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