Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name ELOCP3
Plot displaying the genomic locations of a retrocopy (in chr10) and its respective parental gene (in chr8). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr10:10174153-10174785  UCSC
Coordinates (T2T) chr10:10185209-10185841  UCSC
Coordinates (hg19) chr10:10216116-10216748  UCSC
Strand +
Parental Sequence NM_005648.4
Parental seq. overlap 587 bp
Parental seq. overlap (%) 29.1%
Genomic Region Intergenic
Retrocopy Summary ELOCP3, located on chr10:10174153-10174785, is a retrocopy of the parental gene ELOC. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name ELOC
Full Name elongin C
Also known as SIII|TCEB1
Coordinate chr8:73945119-73972287
Strand -
Gene summary This gene encodes the protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been identified. [provided by RefSeq, Mar 2011]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes ELOCP8
Bonobo Pan paniscus ELOCP8
Gorilla Gorilla gorilla ELOCP7
Orangutan Pongo abelii ELOCP7
Gibbon Nomascus leucogenys ELOCP3
Marmoset Callithrix jacchus ELOCP9
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>ELOCP3
GGGCTGCGGTGGTTGTGGGGCTGATGAGAAACCACTGAAGTTCCTGGGGAAGCAAAGTAGAGTTTCATAAGAACAAAATGGATGGAGAGGAGAAAACCTGTGGTGGCTGTGAAGGCCCTGATGCGATGTATGTGAAATTGATATCATCTGATGGCCATGAATTTATTGTAAAAAGAGAACATGCATTAACATCAGGCACAATAAAAACCACATTGGGTGGCCCAGGTCAGTCTGCTGTGAATGAAACCAATGAGGTCAATTTTAGAGAGATACCTTCGCGTGTGCTATCAAAAGTATGCACGTATTTTATGTATAAGGTTCGCTACCCTAACAGCTCCACCGAGGTTCCAGAGCTCCCAATTGCACCTGAAATTGCACTAGAACTGTTAATGGATGTGAGCTTCCTAGATTGTGAAATAAAATAAATTATAATAAACTGTTAACTCTTTTCAGTATTTAATACCTGTAGTTCAGTTAGTAATTTTTTCATATATAGCATGTTGCCTGTATGCAGTTGAACTATATAAAGTTCATTGCAAAGGAGATTATCTTCTGTTTTTTGCATAGCAATCAAAGTTGAAGTTTGTTGCTACATCAACAAATTAAGGATATTTCCACAAACTGAGAAATAAA
>NM_005648.4
CTTTCGACTGCCCCGGAACCCACCGGAGCAGGCAGCTGGGGGTGGGGGGGCGGCCCTGGGATAGGGGCTGTGGCAGTACGCGGGGACCCGGCTGCGGTGGCTGCGGGACTGACGAGAAACTACTAAAGTTCCTGGGGAAGCAAAGTAGAATTTCATAAGAACAAAATGGATGGAGAGGAGAAAACCTATGGTGGCTGTGAAGGACCTGATGCCATGTATGTCAAATTGATATCATCTGATGGCCATGAATTTATTGTAAAAAGAGAACATGCATTAACATCAGGCACGATAAAAGCCATGTTGAGTGGCCCAGGTCAGTTTGCTGAGAACGAAACCAATGAGGTCAATTTTAGAGAGATACCTTCACATGTGCTATCGAAAGTATGCATGTATTTTACGTACAAGGTTCGCTACACTAACAGCTCCACCGAGATTCCTGAATTCCCAATTGCACCTGAAATTGCACTGGAACTGCTGATGGCTGCGAACTTCTTAGATTGTTAAATAAAATAAATTATAATAAACTGTTAACTCTTTTCAGTATTTAATACCTGTAGTTCAGTTAGTAACTTTTTCATATATAGCATGTTGCCTGTATGCAGTTGAACTATATAAAGTTCATTGCAAAGCAGATTATCTTGTTTTTTTGCATAGCAATCAAAGTTGAAATTTGTTTGCTACATCAACAAATTAAGGACATTTTCACAAACTGAGAAATAAACAAATATGCCAATTCGTAGGTGGTTTTGCCTTATCCTTTGAATGTGACTTAAAATCAGCAATGATGATATAGTAAATACTGAAATTTAGGTGTAAATCAATACGTTCTACAGGGAAATAATGAGGCTAAGTATTTTTATGTTTTTAGTGGTTTTTTAGAAACCTAATCTTATAGCCGCCATTAGCATTACTAGAGTTATGCAAATAATTGCATTATAAACATGTTTATAACTTAGCCAAAACATTGATTTTTATAACTCTCCAAGTATGAGTTGAAATTTCTTATGTCTTTTGATAAACTGCAGTATTCTTTAAGTGTACTTTGTCCTTTTGTTTATTGCTACAATTTAAGAACTTTATTTAAAAACAATTTTGGAAGGTTACTAGGTACAGCTTTTGCAGAAGAAACTGAACTGTAGCCAGATGGTCAGCAAGTAAACTACATGACTTAGAGTTCTTGTGCATTATACATTTTGGGTAATTCAAAGTACTGTATTTGCATTGACTATAAAGCGTCGTTTGCAATATTTATTCTTCCTTCATAGTCCCTTGTTGTGATTATACTTCCAGTTGTTTAAATGTATTTTAAAAGACTCACTATTAACTTTATTCAGATCTTAAAAGCTACACCTTTTTGAACTATTCCAGTCTTTCTCCATCCAATTAGAATGTTATGGAATAACATGTGAAGAGATACAGTGAAAATCATATTATAATGCATTGAAGATATCCTACATGAATTATCTTCTATTAAAATATGTCCCAATAAATATACCCATAATCAGTGGGTCTTCTACTGAAATCAAGCTCATTCAGCTTTTCTATTAAGCAGCCAAAAAATTTTTTGAAAAAATATGACAGCATCATTCCTTATGCATGGGGAAAGAAGCACTGGAGATGGGTTTAGTATTGTCTTTATCTCAGAGGTGGAACAAAGTTGTCATTATAGGGTCTATAAACTTAAGTCTCCAGCTTATTTGAGACTGGCTTAATATggctgagcccggtggctcatgcctgtaatcccagcactttcagaggacgaggcgggtagatcacttgaggccaggagtttgagaccagcctggccaccatggcaaaaccccatctctaccaaaaatgcaaaaattagctaggccatggtggcacacgcctgtaatcccagctacttgtgaggctgaggcatgagaatcgcttgaacctgggaggtggaggtggcagtgagccgagatcgcaccactgcactccagcctgggtgacagagcgagactgtctcaaaaaaaaaaaaaaaaaaa

Publications

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