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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name MARCKSL1P1
Plot displaying the genomic locations of a retrocopy (in chr10) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr10:103175533-103175786  UCSC
Coordinates (T2T) chr10:104061777-104062030  UCSC
Coordinates (hg19) chr10:104935290-104935543  UCSC
Strand +
Parental Sequence NM_023009.7
Parental seq. overlap 226 bp
Parental seq. overlap (%) 14.6%
Genomic Region Intragenic (NT5C2)
Retrocopy Summary MARCKSL1P1, located on chr10:103175533-103175786, is a retrocopy of the parental gene MARCKSL1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name MARCKSL1
Full Name MARCKS like 1
Also known as F52|MACMARCKS|MLP|MLP1|MRP
Coordinate chr1:32333839-32336233
Strand -
Gene summary This gene encodes a member of the myristoylated alanine-rich C-kinase substrate (MARCKS) family. Members of this family play a role in cytoskeletal regulation, protein kinase C signaling and calmodulin signaling. The encoded protein affects the formation of adherens junction. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are located on the long arm of chromosomes 6 and 10. [provided by RefSeq, Jun 2012]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes MARCKSL1P2
Bonobo Pan paniscus MARCKSL1P2
Gorilla Gorilla gorilla MARCKSL1P2
Orangutan Pongo abelii MARCKSL1P2
Gibbon Nomascus leucogenys MARCKSL1P2
Crab-eating macaque Macaca fascicularis MARCKSL1P2
Rhesus Macaca mulatta MARCKSL1P3
Golden snub-nosed monkey Rhinopithecus roxellana MARCKSL1P2
Marmoset Callithrix jacchus MARCKSL1P5
Green monkey Chlorocebus sabaeus Without Homology
Baboon Papio anubis Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>MARCKSL1P1
ACCCCCCAGCAGACCCCCATCATAGGCAGCCAGAGCTCCAAGGCTCCTCGGAAGACGTGACCACCAAGGTTGCGGCAGGTGCTTCCCCTGCAAAGGCCAACGGACAAGACGATGGCCACGTGAAAAGCAATGAAGACTTATCTCCCAAGGGTGAAGGAGTGTTGCCTCTGTGAACAGAACACATGAGGCAGCCGGGGCCACTGGCGATGCCATTGAGCCAGCATCCCCTATCCAGGGTGCTGAGGCCAAGGGGG
>NM_023009.7
ggcattctggcgcggagcggagcggcggcgggcgcagctagcgggtcggccgcggagcggagGTGCAGCTCGGCTTCCCCCGGCACCCCTCCCCCTCGGGCGCCAGCCCCACCCCTCCGCCGGCCGGGCCGACCCCGCCGTACTATCCCCTGCGGCGCGAGCCCGGGGCGGCTCCAAGCGCCCCCCAGCAGACCCCCATCATGGGCAGCCAGAGCTCCAAGGCTCCCCGGGGCGACGTGACCGCCGAGGAGGCAGCAGGCGCTTCCCCCGCGAAGGCCAACGGCCAGGAGAATGGCCACGTGAAAAGCAATGGAGACTTATCCCCCAAGGGTGAAGGGGAGTCGCCCCCTGTGAACGGAACAGATGAGGCAGCCGGGGCCACTGGCGATGCCATCGAGCCAGCACCCCCTAGCCAGGGTGCTGAGGCCAAGGGGGAGGTCCCCCCCAAGGAGACCCCCAAGAAGAAGAAGAAATTCTCTTTCAAGAAGCCTTTCAAATTGAGCGGCCTGTCCTTCAAGAGAAATCGGAAGGAGGGTGGGGGTGATTCTTCTGCCTCCTCACCCACAGAGGAAGAGCAGGAGCAGGGGGAGATCGGTGCCTGCAGCGACGAGGGCACTGCTCAGGAAGGGAAGGCCGCAGCCACCCCTGAGAGCCAGGAACCCCAGGCCAAGGGGGCAGAGGCTAGTGCAGCCTCAGAAGAAGAGGCAGGGCCCCAGGCTACAGAGCCATCCACTCCCTCGGGGCCGGAGAGTGGCCCTACACCAGCCAGCGCTGAGCAGAATGAGTAGCTAGGTAGGGGCAGGTGGGTGATCTCTAAGCTGCAAAAACTGTGCTGTCCTTGTGAGGTCACTGCCTGGACCTGGTGCCCTGGCTGCCTTCCTGTGCCCAGAAAGGAAGGGGCTATTGCCTCCTCCCAGCCACGTTCCCTTTCCTCCTCTCCCTCCTGTGGATTCTCCCATCAGCCATCTGGTTCTCCTCTTAAGGCCAGTTGAAGATGGTCCCTTACAGCTTCCCAAGTTAGGTTAGTGATGTGAAATGCTcctgtccctggccctacctccttccctgtccccacccctgCATAAGGCAGTTGTTGGTTTTCTTCCCCAATTCTTTTCCAAGTAGGTTTTGTTTACCCTACTCCCCAAATCCCTGAGCCAGAAGTGGGGTGCTTATACTCCCAAACCTTGAGTGTCCAGCCTTCCCCTGTTGTTTTTAGTCTCTTGTGCTGTGCCTAGTGGCACCTGGGCTGGGGAGGACACTGCCCCGTCTAGGTTTTTATAAATGTCTTACTCAAGTTCAAACCTCCAGCCTGTGAATCAACTGTGTCTCTTTTTTGACTTGGTAAGCAAGTATTAGGCTTTGGGGTGGGGGGAGGTCTGTAATGTGAAACAACTTCTTGTCTTTTTTTCTCCCACTGTTGTAAATAACTTTTAATGGCCAAACCCCAGATTTGTACTTTTTTTTTTTTTCTAACTGCTAAAACCATTCTCTTCCACCTGGTTTTACTGTAACATTTGGAAAAGGAATAAATGTCGTCCCTTTA

Publications

PMID - Link Title