Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name PPP2R2AP1
Plot displaying the genomic locations of a retrocopy (in chr10) and its respective parental gene (in chr8). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr10:131947531-131947779  UCSC
Coordinates (T2T) chr10:132887397-132887645  UCSC
Coordinates (hg19) chr10:133761035-133761283  UCSC
Strand +
Parental Sequence NM_002717.4
Parental seq. overlap 196 bp
Parental seq. overlap (%) 5%
Genomic Region Intragenic (PPP2R2D)
Retrocopy Summary PPP2R2AP1, located on chr10:131947531-131947779, is a retrocopy of the parental gene PPP2R2A. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name PPP2R2A
Full Name protein phosphatase 2 regulatory subunit Balpha
Also known as B55A|B55ALPHA|PR52A|PR55A|PR55alpha
Coordinate chr8:26291508-26372680
Strand +
Gene summary The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes PPP2R2AP1
Bonobo Pan paniscus PPP2R2AP1
Gorilla Gorilla gorilla PPP2R2AP1
Orangutan Pongo abelii PPP2R2BP1
Gibbon Nomascus leucogenys PPP2R2AP1
Green monkey Chlorocebus sabaeus PPP2R2AP1
Baboon Papio anubis LOC101017040P1
Golden snub-nosed monkey Rhinopithecus roxellana PPP2R2AP1
Chinese hamster Cricetulus griseus Ppp2r2c_1P1
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>PPP2R2AP1
TTTTGAAGAGCCTGAAGATCCCAGCAGTAGGTCCTTCTTCTCAGAAATAATTTCATCCATATCCGATGTAAAATTCAGTCATAGTGGGCGGTACATGATGACCAGAGACTACCTGTCGGTGAAGGTGTGGGACCTCAACATGGAGAGCAGGCCGGTGGAGACCCACCAGGTCCACGAGTACCTGCGCAGCAAGCTCTGCTCTCTCTATGAGAACGACTGCATCTTTGACAAGTTTGAGTGTTGCTGGAA
>NM_002717.4
AGGCCAGCCGGCGCCATTTTGAAAGTGGAGTcgcctgcccctgccgctgccgccgccgccgtcgctgtcgtagtcgccgccgccgctgccgGAGAAAGAGCACGAGCGGGGAAGCCCCAGAGTGAAATCTAGCATCCTGCCGGCTGGTCTGCCCGCCCCTCCTTCCTTTTCCCCCCGGCCCCCGTCCCCTCCCCCCGCAGGTGCCATCCGCCGCCATCCGCCCTCTCTACCCCCCCATCCCCAGGTGAGGGGGGTGAGTTCAGGAAGCGGAGACCCCGAGGAACCCAGCAGGGTCACCATTTGCAGCGCAACATGGCAGGAGCTGGAGGAGGGAATGATATTCAGTGGTGTTTTTCTCAGGTGAAAGGAGCAGTAGATGATGATGTAGCAGAAGCAGATATAATTTCTACAGTAGAATTTAATCATTCTGGAGAATTACTAGCAACAGGAGATAAAGGTGGTAGAGTTGTCATCTTTCAACAGGAGCAGGAGAACAAAATCCAGTCTCATAGCAGAGGAGAATATAATGTTTACAGCACCTTCCAGAGCCATGAACCAGAGTTTGACTACTTGAAAAGTTTAGAAATAGAAGAAAAGATCAACAAAATTAGGTGGTTACCCCAGAAAAATGCTGCTCAGTTTTTATTGTCTACCAATGATAAAACAATAAAATTATGGAAAATCAGTGAAAGGGACAAAAGACCAGAAGGGTATAACTTGAAAGAGGAGGATGGAAGGTATAGAGATCCTACTACAGTTACTACACTACGAGTGCCAGTCTTTAGGCCTATGGATCTAATGGTTGAGGCCAGTCCACGAAGAATATTTGCCAATGCTCATACATATCACATCAACTCAATTTCTATTAATAGTGATTATGAAACATATTTATCTGCAGATGATTTGCGGATTAATCTTTGGCATCTGGAAATTACAGACAGGAGTTTTAACATTGTGGATATCAAGCCTGCCAATATGGAAGAGCTAACAGAGGTGATTACAGCAGCAGAATTTCATCCAAACAGCTGTAACACATTTGTATACAGCAGCAGTAAAGGAACTATTCGGCTATGTGACATGAGGGCATCTGCCCTCTGTGATAGACATTCTAAATtgtttGAAGAACCTGAAGATCCCAGTAACAGGTCATTTTTTTCCGAAATCATCTCCTCTATTTCGGATGTAAAATTCAGCCATAGTGGTCGATATATGATGACTAGAGACTATTTGTCAGTCAAAATTTGGGACTTAAATATGGAAAACAGGCCTGTGGAAACATACCAGGTGCATGAATACCTCAGAAGTAAACTCTGTTCACTGTATGAAAATGACTGCATATTTGACAAATTTGAATGTTgttggaatggatctgacagTGTTGTCATGACTGGATCTTACAATAATTTCTTCAGAATGTTTGACAGAAACACAAAGCGAGACATAACCCTAGAAGCATCGCGGGAAAACAATAAGCCTCGCACAGTTCTGAAGCCTCGCAAAGTCTGTGCAAGTGGCAAGCGAAAGAAAGATGAAATAAGTGTTGACAGCCTAGACTTCAATAAGAAAATCCTTCACACAGCCTGGCACCCCAAGGAAAATATCATTGCCGTAGCTACTACAAACAATCTGTATATATTTCAAGACAAAGTGAATTAGGGTTGGCATTCCTAGCAGAAGAACCCACTTCCTGCTTAGTTGAGATAGTTGAATCTAGCATTCGTTCCTATAAAAGAGAGAGGTCCATTGTGGCGCCCCTTTCCAGTGTTTGACAGTGTGCCATTCGACAACACATTGTTATAGCTACATGGAGAAAGCTCTGTGGATTCATCACTGTGGTGTTCTCCATGTCTGCTAGCCATTTAGGTAAGGGTAGGGCACTTTTAATTTAAATGACTTCTTGCACCATCTTGCCTAATGGACTAGATTGGACTGTATCAACATTGATTTACTCCACTTTTTATGCCTTCCATTGTGATGACGTCAAACACAGTGAAAGCCTTCAGTCATGCTATGGGATTTAATTGTGTATCCTCATTACTGTATCATTTGTGGGGTACACCCCTTCCCCCTTTTTTTAAATTAAATACAGCTCATTCTTACTGTGGCTTGTAGCATTCCTCCTCTTCTGGCCTCCTGGACTGCTCCCCTTCATCTCTTACCCTTGCCCCCTCCACCCGGTCTTGGTGGTGGTATATTAAAAAAAGAAAGAATGAAAGCACACAAAATGAGTCAGTTTGGGGTCAGTGGTATAAAGGGGGTATATGTTGCAAACAAATGTTTTAGTAACAGTTGGCTGTAATCACTCCTCGCCGTGTCTGGCACTGAAAATAAGGAAAAAAAACCTACTACTGAATAAAAGTGACAAAGAATGGAGAATCTGGTTTTCTTTTTCTTTTTAACCTACCTCTTGTAGCCAATATTTTGTGTCATACCTTTGGGCACAGTGAAACAAAATGGGTTTTCATTGTTTATTGGTATTTTTGTTAATTATTTTTAACAAGTGTTCTTTTACATGCAGGAGGAGAGGTATTGGTTCTCTATGAACATATTTTGAATATAGGTTTTATTAAGGATTTCACAATCTATAAATGCTACTAGtttttttttttttttttACCATCATGAGGGTATTGGATACATTGTGTCTCTATTTAACTCATTATGTGTTAATGAAATTGTTGTAAATGGGAACCAAATTTGTAGAACTTAATTTCTACTTTTTAGAGTGCTTAATTTCATTTTTGCCTTACTAAATAGTCAAAGACTTATAAAACATTTTTAACAAGTTAGAACTTTTTTGTTATTCAGTCATATAAAATAGCAGAAAACTAACATCAAGTGACACTGCACTAAATACTTTTTTTGTATTTTACTGCTATCAAATCAGAATGAAATATACTTTACCATAGATATTTTTCTTCTATTTTTGGTTTTCCAAAGCTATATGAAAGACAAATTTTTAAAGGTACAGCGTTCAAAAAGTGCTTAATGAACTCCAACAGCTGCCTCAAATAAAAATCTGTATATGAATACATTTTCCCTAAGCGGTGATACATTATCCAAAGATGAAGAGTGCTCCTATTTTTAATAGGTAGAATGTACCTTTGTCAGTCTTGCAGAAACTTTAATGGAGAAGAAATGGACTTTATTTTTGAAAGGTGAAATGAACAGGCATTTATATTATTAGAGAATGGTAGTCTTATTTTGGTGGAACATAATGTAACAACCTTGAATTTCAGAGGACTCTGAGTGCTTCTATGTCCACTACCTATTGTTCTATTCTTCAATAATGAAAAAGAATTCAACGAGCCGACCGTGATTCCCTCTACTACAAATATTATGTCTTGTAAGTTAGCATTTTTAGCACACAGGAGAAATTTTATGTAATAAAATTACTGTATCTTTTGGATTTAACAAATTTGTATTTGAAACACATTCTATGTCTGATAATTCTTAATGGCACTTTTACTAATTTATTTGGGGATCTTGGGTACATTCTTAATTTGTGTTTATTCTTCACGCTTGACTTGCAAGTGGGATATTCCCCTGCCACAAGTGTCAAACAGTGATATTCTTCCTGTGTTGTGACTGGACAGTTTTCCAGATCTTTTTTGGGAGATTTTCCTACAGCTTGGTTGTATGTCTTGAGATAACACCACCAAACAGCTCTCAGAAATTCTTTTTTGATTGATCAGTAGCTATGATGATTCTCCTCCATGACACTAAGGATTAGTTTATATATTTAAGAGAAATAATTGCTAAAATTAAAATGCCTCTATCAAGGAATGCTATTATAAATTATTGTTAACATTCTCAAGTATTAATTTTTTAATTTCATTGGTGTAGCAAACTCTAAGCCCAGCCACTCATTTTACATGGCCATGGTTAATCTTTTTATTAATAAAAATTATACTTAGAATAAA

Publications

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