Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name GSK3BP1
Plot displaying the genomic locations of a retrocopy (in chr10) and its respective parental gene (in chr3). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr10:18940499-18941058  UCSC
Coordinates (T2T) chr10:18959537-18960096  UCSC
Coordinates (hg19) chr10:19229428-19229987  UCSC
Strand +
Parental Sequence NM_001146156.2
Parental seq. overlap 516 bp
Parental seq. overlap (%) 6.7%
Genomic Region Intergenic
Retrocopy Summary GSK3BP1, located on chr10:18940499-18941058, is a retrocopy of the parental gene GSK3B. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name GSK3B
Full Name glycogen synthase kinase 3 beta
Also known as -
Coordinate chr3:119821321-120094447
Strand -
Gene summary The protein encoded by this gene is a serine-threonine kinase belonging to the glycogen synthase kinase subfamily. It is a negative regulator of glucose homeostasis and is involved in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptotic pathways. Defects in this gene have been associated with Parkinson disease and Alzheimer disease. [provided by RefSeq, Aug 2017]

Homology

Species Scientific Name Retrocopy
Gorilla Gorilla gorilla GSK3BP1
Orangutan Pongo abelii GSK3BP1
Gibbon Nomascus leucogenys GSK3BP1
Green monkey Chlorocebus sabaeus GSK3BP1
Crab-eating macaque Macaca fascicularis GSK3BP1
Rhesus Macaca mulatta GSK3BP1
Baboon Papio anubis GSK3BP1
Golden snub-nosed monkey Rhinopithecus roxellana GSK3BP1
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>GSK3BP1
TAATAATCAAGGACCTGGGAACTCCAACAAGGGAGCAAATTAGAGAAGTGAACCCAAACTACACAGAATTTAAATTCCCTCAAATTAAGACACATCCTTGGACTATAGTCTTCTGACCCTGAACTCCACTGGAAGCAATTGCACTGTGTAGCCGTCTGCTGGAGTATACATCAACTCTCGACTGGCACCACTGGAAGTTTGTGCACATTCGTTTTTTCATGAATTACAGGATCCAAATGTCAAACTACCAAATGGGTGAGACACACCTCCACTGTTCAACTTCACCACTCAAGAACTGCCAACTAATCTACCTCTGGCTACCATCCTTATGCCTCCTCATGCTTGGATTCAAGCAGCTGTTTCAATCCCCACAAATGCCACAGCAGCCACCGATGCTAGTGCTGGAGACCGTGAACAGACCAATAATGCTGTTTCTGCATCATCTTCCAACTTTACCTGAACAGTCCCCAGAAGCCAGCTGCACAGGAAAAGCCACCAGTTACTTGAGTCACTCAGCAACACTGGTCACTTTTGGAAAGAATATTAAAAAGAGAAAAAAA
>NM_001146156.2
ACACAGAGCAGCTCCTGACCCGGGCGAATGCGGGCTTGTgccgccgccgccgccgccgccgccCGGGCCAAGTGACAaaggaaggaaggaagcgaggaggaGCCGGCCCCGCAGCCGCTGACAGGGCTCTGGGCTGGGGCAAAGCGCGGACACTTCCTGAGCGGGCACCGAGCAGAGCCGAGGGGCGGGAGGGCGGCCGAGCTGTTGCCGCGGACGGGGGAGGGGGCCCCGAGGGACGGAAGCGGTTGCCGGGTTCCCATGTCCCCGGCGAATGGGGAACAGTCGAGGAGCCGCTGCCTGGGGTCTGAAGGGAGCTGCCTCCGCCACCGCCATGGCCGCTGGATCCAGCCGCCGCCTGCAGCTGCTCCTGGCGCAATGAGGAGAGGAGCCGCCGCCACCGCCACCGCCCGCCTCTGACTGACTCGCGACTCCGCCGCCCTCTAGTTCGCCGGGCCCCTGCCGTCAGCCCGCCGGATCCCGCGGCTTGCCGGAGCTGCAGCGTTTCCCGTCGCATCTCCGAGCCACCccctccctccctctccctccctcctacccatcccCCTTTCTCTTCAAGCGTGAGACTCGTGATCCTTCCGCCGCTTCCCTTCTTCATTGACTCGGAAAAAAAATCCCCGAGGAAAATATAATATTCGAAGTACTCATTTTCAATCAAGTATTTGCCCCCGTTTCACGTGATACATATTTTTTTAGGATTTGCCCTCTCTTTTCTCTCCTCCCAGGAAAGGGAGGGGAAAGAATTGTATTTTTTCCCAAGTCCTAAATCATCTATATGTTAAATATCCGTGCCGATCTGTCTTGAAGGAGAAATATATCGCTTGTTTTGTTTTTTATAGTATACAAAAGGAGTGAAAAGCCAAGAGGACGAAGTCTTTTTCTTTTTCTTCTGTGGGAGAACTTAATGCTGCATTTATCGTTAACCTAACACCCCAACATAAAGACAAaaggaagaaaaggaggaaggaaggaaAAGGTGATTCGCGAAGAGAGTGATCATGTCAGGGCGGCCCAGAACCACCTCCTTTGCGGAGAGCTGCAAGCCGGTGCAGCAGCCTTCAGCTTTTGGCAGCATGAAAGTTAGCAGAGACAAGGACGGCAGCAAGGTGACAACAGTGGTGGCAACTCCTGGGCAGGGTCCAGACAGGCCACAAGAAGTCAGCTATACAGACACTAAAGTGATTGGAAATGGATCATTTGGTGTGGTATATCAAGCCAAACTTTGTGATTCAGGAGAACTGGTCGCCATCAAGAAAGTATTGCAGGACAAGAGATTTAAGAATCGAGAGCTCCAGATCATGAGAAAGCTAGATCACTGTAACATAGTCCGATTGCGTTATTTCTTCTACTCCAGTGGTGAGAAGAAAGATGAGGTCTATCTTAATCTGGTGCTGGACTATGTTCCGGAAACAGTATACAGAGTTGCCAGACACTATAGTCGAGCCAAACAGACGCTCCCTGTGATTTATGTCAAGTTGTATATGTATCAGCTGTTCCGAAGTTTAGCCTATATCCATTCCTTTGGAATCTGCCATCGGGATATTAAACCGCAGAACCTCTTGTTGGATCCTGATACTGCTGTATTAAAACTCTGTGACTTTGGAAGTGCAAAGCAGCTGGTCCGAGGAGAACCCAATGTTTCGTATATCTGTTCTCGGTACTATAGGGCACCAGAGTTGATCTTTGGAGCCACTGATTATACCTCTAGTATAGATGTATGGTCTGCTGGCTGTGTGTTGGCTGAGCTGTTACTAGGACAACCAATATTTCCAGGGGATAGTGGTGTGGATCAGTTGGTAGAAATAATCAAGGTCCTGGGAACTCCAACAAGGGAGCAAATCAGAGAAATGAACCCAAACTACACAGAATTTAAATTCCCTCAAATTAAGGCACATCCTTGGACTAAGGTCTTCCGACCCCGAACTCCACCGGAGGCAATTGCACTGTGTAGCCGTCTGCTGGAGTATACACCAACTGCCCGACTAACACCACTGGAAGCTTGTGCACATTCATTTTTTGATGAATTACGGGACCCAAATGTCAAACTACCAAATGGGCGAGACACACCTGCACTCTTCAACTTCACCACTCAAGAACTGTCAAGTAATCCACCTCTGGCTACCATCCTTATTCCTCCTCATGCTCGGATTCAAGCAGCTGCTTCAACCCCCACAAATGCCACAGCAGCGTCAGATGCTAATACTGGAGACCGTGGACAGACCAATAATGCTGCTTCTGCATCAGCTTCCAACTCCACCTGAACAGTCCCGAGCAGCCAGCTGCACAGGAAAAACCACCAGTTACTTGAGTGTCACTCAGCAACACTGGTCACGTTTGGAAAGAATATTAAAAAGAGAAAAAAATCCTGTTCATTTTAGTGTTCAatttttttattattattgttgttcttattTAACCTTGTAAAATATCTATAAATACAAACCAATTTCATTGTATTCTCACTTTGAGGGAGATCCAGGGGGTGGGAGGGGTTGTGGGGAGGGGGAAAGCGGAGCACTAGAACATACAATCTCTCTCCCACGACAATCTTTTTTTATTAAAAGTCTGCTGTTGTATACTTTAAAAACAGGACTCCTGCCTCATGCCCCTTCCACAAAAGAAGAAAACCTTTTTCTGTGCTGATGGGTTTTTTTGAACTTTGTTTTCTTTTAAAGTCTAGTGTGAGACTTTGGTATAGTGCACAGCTTGAAATTGGTTGGGAGCTTAGCAGGTATAACTCAACGGGGACTTAAATGTCACTTGTAAAATTAATCCATATCTTCGGGTATTTATAGACTTGCCTTTGGCATGTTGGTGGCAGGTGTGGCAGACAAAGAAATGTGTATCATTCGTAACCCAGGGAGGTCAATAAAGTTTGGAACTCTACAGGGAAGATTCTTAGTAGATTTGTTAAGGTTTTGTTTTGCTCTCAGTTAGTGCTAGTGATGTAGAGGCTTGTACAGGAGGCTGCCAGAGGGGAAGCAGCAAGCAAGACTCAGGCACACATGCTCTACAGGTGGCTCTTTGTTTGCCTGACCAAAGTTCTTTGCAAATCTTAGCACAGTTTCAAACTAGTGACCTGGGAGGAGATGGAAGGGGTGTTGAGCAGGCTGAGCTAGCTGCTGAGGTCAAAGGCTGATGAGCCCAGAGGAAGGGGACAGGTCAGGGATACATCTCACCACTGTGAATAAGTTTGTCCAGATTTTTTTCTAAAGTTACTTCCCTTGGAAAGATACACTTGAGAGGACATTGTAGTTAAATAATGTGAACTGTAACAGTCATCTACTGGTTTATTTTTCATATTTTTTAATTGAAAATTGAGCTTGCAGAAATAGCCACATTCTACACATAGTtctaattttaaatccaaatctagaatctgtatttaaTTTGTTTTTTAACCTCATGCTTTTTACATTTATTTATTGATGCATGTCAGATGGTAGAAATATTAAAAACTACACATCAGAATGATACAGTCACTTATACCTGCTGACTTTATAGGAAAGCTGATGatataaatgtgtgtatatatgttatatatacatatatTCAATACTGCCTTTTTTTTTGTCTACAGTATCAAAATTGACTGGTTGAAGCATGAGAAGAATGTTTCCCCCACACCCAGTTAAGAGTTTTTGTGTCTGTTTTCTTTGTGTATCAGTGAACGATGTTAAGAATCAGTCTCTCTTTTTGAAGAAAAAGCAATATTCCTTGGAAAGCAAGGAGAATTGAAGGACTATGTTTGCCGTGAGGAAATAGATTTTCATGACTAGTTTGTTTTATACTTTTAAGGTTGGCATCTATGTGGGCCTTATATACTCTAAAATGAACTTTAGTCACCTTGGTGCTTATGGGCCATTACTTGACCTATGAATCTTTAAGGCACAATCAGTTGTACTTTACATTTAAAGATCACTTGAGTGATGGCCGCCTTTCCCTCCTACCCGCTCCTTCCCCACATGCCTTCCAAGGTTAGCTGGTAACTGTAGGGCTGCAGAGCTGAGCCCATGGTTGTGTGTAACTTGCCCTCACCCTCCTCATTGCCACCTTAGGTCACTTTATGGGTCTCGTCCTCCAGAGGGTTCGGAAGTGGAGTCTGTTGGCAGCCCTCCTGCAGGCCCTAGCACCCTGTCCTGCTCCTTAACTGTGTGTGTGACTCTCCAAGAGAGTTGTCCTGCCTGCTGAAGTGAACCAGTACCCAGAAAGACAACTGTGAGCCATCTTGGTTTTCACTCGCTGTTTAGCTGAGGTCTTGGGCCACAAAAGGGGTTTCACAAACCTCTGGATATATCAGAGTTTATGAGAAAGGAAACATGCTCAGTCAAACCAAATCAAACAAATTGAATTTTATGTTTTATAAAGTGCTTCTGAAAGCTAAGATTTGAAAGAAGTCTGAAATCAAAGTATTTGGCAGCATAACTCCTTAAAGGTAGTGGCGTTGATAGACCATTTTCAGACAGAATTTATAAAGAATCTGAAAAGGCAGGTCTGTGATAGAGAAATGGACCTGCATTCAGATCCAACTGCCCAGCAAGCGTTTGGATGCAGACACTGCTCTGGACGTGGTATACTCCCCAGAGTCCATAAAAATCAGTGCTTATTTTAGGAAACAGGTTGCCCCCCACAACTGGGGTAAAAGAAGAGAGAAAAGTCACGCTTTTCTCTCATTTCATtgtgtgtgcatgtgtgcgtgtgtgtgtgtgtgtgtgtgtgCTGAGATGTGTGATTTTTCTTTCTCAAGGATCATGGTGGGATCACAGAACTCTTTTATACAAGTGAGATCCAGGTCTCTGAATATCTTTTTGTATATAATAATAATAAAAAGCTCCTCACCAAATTCAAGCTTGTACATTATATTTTCTTTCTGTGTTTTTAAATTTAAGTTTTATTGTTTTGTATGTAAATATGTGGACCCAGGAACTGTTATTAATGAGCAAAAAGTTACTGTTCAGGGCAGTGATTCTGTTTAATAATCAGACAAAATGTAGACGAGCTTTTTAAAGCCATATAGTTTTAACTCTGTACAGTAGGTACCGGCCTGTATTATTGTAACAATAACTCTAGCAATGTATAGTGTATCTATATAGTTTGGAGTGCCTTCGCTTCCATGTGtttttttttttaatttgttcttttttaaattttaattGGTTTCCTTTATCCATGTCTCCCTGTCCACCCCCTTTCCCTTTGAAATAATAACTCACTCATAACAGTATCTTTGCCCCTTCCACAGTTAAGTTTCAGTGATACCATACTCAGGAGTGGGAAGAGGAAATCATATTCGTAATTTCATTTCGTTGAAGCCCTGCCTTTGTTTTGGTTCTGAATGTCTTTCCTCCTCGGTAGCAGTGAGACCGGTTTCATTTCATACTTAGTCCATTCAGGGACTTAGTGTAGCACCAGGGAGCCCTAGAGCTGGAGGATATCGAATAGATTAAATTTTGCTCGTCTCTTCCACAAGCCCTAACCATGGGTCTTAAAAACAGCAGATTCTGGGAGCCTTCCATGCTCTCTCTCTCTCCTCTTTTATCTACTTCCCTCCCAAATGAGAGAGTGACAGAGAATTGTTTTTTTATAAATCGAAGTTTCTTAATAGTATCAGGTTTTGATACGTCAGTGGTCTAAAATGCTATAGTGCAATTACTAGCAGTTACTGCACGGAGTGCCACCGTGCCAATAGAGGACTGTTGTTTTAACAAGGGAACTCTTAGCCCATTTCCTCCCTCCCGCCATCTCTACCCTTGCTCAATGAAATATCATTTTAATTTCTTTTAAAAAAAATCAGTTTAATTCTTACTGTGTGCCCAACACGAAGGCCTTTTTTGAAAGAAAAATAGAATGTTTTGCCTCAAAGTAGTCCATATAAAATGTCTTGAATAGAAGAAAAAACTACCAAACCAAAGGTTACTATTTTTGAAACATCGTGTGTTCATTCCAGCAAGGCAGAAGACTGCACCTTCTTTCCAGTGACATGCTGTGTCATTTTTTTTAAGTCCTCTTAATTTTTAGACACATTTTTGGTTTATGTTTTAACAATGTATGCCTAACCAGTCATCTTGTCTGCACCAATGCAAAGGTTTCTGAGAGGAGTATTCTCTATCCCTGTGGATATGAAGACACTGGCATTTCATCTATTTTTCCCTTTCCTTTTTAAAGGATTTAACTTTGGAATCTTCCAAAGGAAGTTTGGCCAATGCCAGATCCCCAGGAATTTGGGGGGTTTTCTTTCTTTTCAACTGAAATTGTATCTGATTCCTACTGTTCATGTTAGTGATCATCTAATCACAGAGCCAAACACTTTTCTCCCCTGTGTGGAAAAGTAGGTATGCTTTACAATAAAATCTGTCTTTTCTGGTAGAAACCTGAGCCACTGAAAATAAAAGAGACAACTAGAAGCACAGTAGAGTCCCAGACTGAGATCTACCTTTGAGAGGCTTTGAAAGTAATCCCTGGGGTTTGGATTATTTTCACAAGGGTTATGCCGTTTTATTCAAGTTTGTTGCTCCGTTTTGCACCTCTGCAATAAAAGCAAAATGACAACCAGTACATAAGGGGTTAGCTTGACAAAGTAGACTTCCTTGTGTTAATTTTTAAGTTTTTTTTTCCTTAACTATATCTGTCTACAGGCAGATACAGATAGTTGTATGAAAATCTGCTTGCCTGTAAAATTTGCATTTATAAATGTGTTGCCGATGGATCACTTGGGCCTGTACACATACCAATTAGCGTGACCACTTCCATCTTAAAAACAAACCTAAAAAACAAAatttattatatatatatatatatatatataAAGGACTGTGGGTTGTATACAAACTATTGCAAACACTTGTGCAAATCTGTCTTGATATAAAGGAAAAGCAAAATCTGTATAACATTATTACTACTTGAATGCCTCTGTGACTGATTTTTTTTTCATTTTAAATATAAACTTTTTTGTGAAAAGTATGCTCAATGTTTTTTTTCCCTTTCCCCATTCCCTTGTAAATACATTTTGTTCTATGTGACTTGGTTTGGAAATAGTTAACTGGTACTGTAATTTGCATTAAATAAAAAGTAGGTTAGCCTGGAAATGAAATTAAAATTCACAAGTGTGTGGTCTTTATTTCAGTACCCAACCCTCTTCCTTCACCCTACTATTTTGCCGCTGCAATATGTAGTCACATCACCATTTCCATTCCTCTAATTAGGGAAACATTAATCTTTGTTATACAGAACAAGATATCAATACCACTTCTTGTTCTTTCCAATGATTTTATTCCATTGTGTAGCCCCAAGAGGTGCAGCTTCCACCTTGGAAACCTTTGGATTTGATGTAGAGGAAGCTTTGCAGACACTGCTTAGAAAAGAAAGAAAACAACTCTGAAAGGGACAGTTTTTAAATGTGTATAAGCTGCTGTCTTTGATTACTGTGTTCATGATTTGGTGTGGCTGTATTTTCTTTTAACTTTCATCCTATTAGTAATGGTCTTTGGGGGTCTCTGTAAAATATATGGACACCACGAACAGTGGGGCTGTACCTCCCAGGTAACCAACACATGTTGTGTTTGAGTCTGCTCATTTCCAATACTGGATGATGTATGTAAACATGTTATGTCTCTTAGTGCAAAAAGAAACATCATTTTTTTAGGGCTGGCTCACTCTGTCAGGCCTAATCTAAAGGCTAGATATAAGGTCATGTGACTGCTGCTTCAATAAAAACAAATTTATATTCGA

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