Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name AMD1P1
Plot displaying the genomic locations of a retrocopy (in chr10) and its respective parental gene (in chr6). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr10:20349886-20351696  UCSC
Coordinates (T2T) chr10:20368274-20370084  UCSC
Coordinates (hg19) chr10:20638815-20640625  UCSC
Strand +
Parental Sequence NM_001634.6
Parental seq. overlap 1500 bp
Parental seq. overlap (%) 43.2%
Genomic Region Intergenic
Retrocopy Summary AMD1P1, located on chr10:20349886-20351696, is a retrocopy of the parental gene AMD1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name AMD1
Full Name adenosylmethionine decarboxylase 1
Also known as ADOMETDC|AMD|SAMDC
Coordinate chr6:110814617-110895713
Strand +
Gene summary This gene encodes an important intermediate enzyme in polyamine biosynthesis. The polyamines spermine, spermidine, and putrescine are low-molecular-weight aliphatic amines essential for cellular proliferation and tumor promotion. Multiple alternatively spliced transcript variants have been identified. Pseudogenes of this gene are found on chromosomes 5, 6, 10, X and Y. [provided by RefSeq, Dec 2013]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes AMD1P5
Bonobo Pan paniscus AMD1P5
Gorilla Gorilla gorilla AMD1P3
Orangutan Pongo abelii AMD1P5
Gibbon Nomascus leucogenys AMD1P4
Green monkey Chlorocebus sabaeus AMD1P2
Crab-eating macaque Macaca fascicularis AMD1P6
Rhesus Macaca mulatta AMD1P6
Baboon Papio anubis AMD1P6
Golden snub-nosed monkey Rhinopithecus roxellana AMD1P6
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>AMD1P1
TTTTTTTTTAAAGCAGTTAATATAAAATTATAGCATTAAAAGAAAAGCAACCTGTATTTAGTAACACAGCGGGAACAATCTGCAGGAGTGGTGGCAGTGGCGAGAGAAAAGGTCTAATTTAAACAATTTTCTGTAGTTGTTGGTTGTTCACTTTTCTCATGGTGATGACAGTAGACATTTTTTCAAAGGGGACGAGAAGCTGCTGGAGGTTTGCTGCTCCCAAGGATCTGGGAATCTTTGCACTACTTCAGGATCTGAGTAAGTCGTATTAAAAGTAATGTAAGTTGTATTAAAAGTACGcTGAACACATTTGATAAATGTGCAATGTTCAATCCTAAGCCTGACAAAAACTGACAAATAGGAAGCTTATGTACGCAGTGAGAGTAGCATGTTTGTCTTCAAGAGATGTCTCGTTTTGCAGACATGTGGAACTACCCTCTTTCTGCAAGCACTGGTTCCCATATTGAAGCTTGCTAGACATGACAATGGGTTTGACTCAATTAAAGCTTCTTTTATTCGCATAAGAATTTCATGAAGCTTCTTCACCAAGGATACTCACGCCAGAATTTCCAGGAAGAAATAGAGATTCTTAATGCAATTTTCCCAAATGGAGCAGCATATTGTATGAGATGTATGAGTTGTGATGTTGGTACTTATATGTACTGGGTTTCCCAGGGAGTGGGGTAATCAGTCAGACAGATTAAACCCTGGAAATTCTGATGAGTGTGCTTGACCCAGCAGTTATGGACCAGTTCTGCATGAAAGATGGTGTTACTGTAGATGACGTCACTCTCTAGAATGAAATTCATGACTTGATACCAGATCCTGTCATTGAGGCCACACTGTTCAATCCTTGGGGGATCTGATGAATGGAATGAAATAAGATAGAACTTATTGGACTATTCATATCACTCCAGAACCAGAATTTTCTTACTTTAGTTTTAAAAGAAACTTAGGTCATACCTCCTATGATGACCTAATCGGGACAGTTGTGAAAGTCTTCAAGACAGGAAAATTTGTGACCACCTTGTTAGCTAATCAGAGCTCTAAATGTCACACCATGTTTTCTTCACCCCAGCAGACTGAAGGTTTTAAATGTCTTGATTGCCAGAATGCTGTGTTCAATGATTACAATTTTGTTTTTACCGGTTTTGCAAAGCAGCAATGACAACAGAGACTTGATTAAGAAAAATGAAGGAAGAAATGCAAAAAGAGAACACATGTAGAAGGGAGTGGCTGCTTTCTAGATGTTCATGCCAGGGACCATGCTTTCTATAACCATCACCTTGTTGTTGCAGAAAGCCTTAGATATAATCATAGTGCAATCATTTTGAACTGTATGCATTATTATATGAAGGAGTTAGATATCTTGCATGAATGCTCTCTTCTGTGTTTAGACGTTCTCTATCACTCTTGCTGTGAAATTGAAGTATGTGTAGAAAAAAACACGTTTTATGATATAAAACTTTGCAACACTTGTGAAAACAATTCAATTTAGTTTATGTGCAGTATGATATTTCTCCAAGTATCATCCAAAATTTCCCGCACACAATTTTGTCCCAATTAGGTGTTGGTCTCCGCCTAACCATCTGAGACTGTTCTGTAAAATTGCTGCCAGAATTTTACATCCAATTGCCTCTACTTTCTAGCACACATTCTTTACTGTTACTGAAACCAATTTCTACTTTATACAGAATTTTTTGCCACTGTAATTAAAATTTTTCTTCCATGAGTCAAGTCCTCTTATGAAAATGATTTCAGCTACTCATTTTG
>NM_001634.6
GCTTACACAGTATGGCCGGCGACATTAGCTAGCGCTCGCTCTACTCTCTCTAACGGGAAAGCAGCGGAATACAAGAGACTGAACTGTATCTGCCTCTATTTCCAAAAGACTCACGTTCAACTTTCGCTCACACAAAGCCGGGAAAATTTTATTAGTCCTTTTTTTAAAAAAAGTTAATATAAAATTATAGCAAAAAAAAAAAGGAACCTGAACTTTAGTAACACAGCTGGAACAATCCgcagcggcggcggcagcggcggGAGAAGAGGTTTAATTTAGTTGATTTTCTGTGGTTGTTGGTTGTTCGCTAGTCTCACGGTGATGGAAGCTGCACATTTTTTCGAAGGGACCGAGAAGCTGCTGGAGGTTTGGTTCTCCCGGCAGCAGCCCGACGCAAACCAAGGATCTGGGGATCTTCGCACTATCCCAAGATCTGAGTGGGACATACTTTTGAAGGATGTGCAATGTTCAATCATAAGTGTGACAAAAACTGACAAGCAGGAAGCTTATGTACTCAGTGAGAGTAGCATGTTTGTCTCCAAGAGACGTTTCATTTTGAAGACATGTGGTACCACCCTCTTGCTGAAAGCACTGGTTCCCCTGTTGAAGCTTGCTAGGGATTACAGTGGGTTTGACTCAATTCAAAGCTTCTTTTATTCTCGTAAGAATTTCATGAAGCCTTCTCACCAAGGGTACCCACACCGGAATTTCCAGGAAGAAATAGAGTTTCTTAATGCAATTTTCCCAAATGGAGCAGCATATTGTATGGGACGTATGAATTCTGACTGTTGGTACTTATATACTCTGGATTTCCCAGAGAGTCGGGTAATCAGTCAGCCAGATCAAACCTTGGAAATTCTGATGAGTGAGCTTGACCCAGCAGTTATGGACCAGTTCTACATGAAAGATGGTGTTACTGCAAAGGATGTCACTCGTGAGAGTGGAATTCGTGACCTGATACCAGGTTCTGTCATTGATGCCACAATGTTCAATCCTTGTGGGTATTCGATGAATGGAATGAAATCGGATGGAACTTATTGGACTATTCACATCACTCCAGAACCAGAATTTTCTTATGTTAGCTTTGAAACAAACTTAAGTCAGACCTCCTATGATGACCTGATCAGGAAAGTTGTAGAAGTCTTCAAGCCAGGAAAATTTGTGACCACCTTGTTTGTTAATCAGAGTTCTAAATGTCGCACAGTGCTTGCTTCGCCCCAGAAGATTGAAGGTTTTAAGCGTCTTGATTGCCAGAGTGCTATGTTCAATGATTACAATTTTGTTTTTACCAGTTTTGCTAAGAAGCAGCAACAACAGCAGAGTTGATTAAGAAAAATGAAGAAAAAACGCAAAAAGAGAACACATGTAGAAGGTGGTGGATGCTTTCTAGATGTCGATGCTGGGGGCAGTGCTTTCCATAACCACCACTGTGTAGTTGCAGAAAGCCCTAGATGTAATGATAGTGTAATCATTTTGAATTGTATGCATTATTATATCAAGGAGTTAGATATCTTGCATGAATGCTCTCTTCTGTGTTTAGGTATTCTCTGCCACTCTTGCTGTGAAATTGAAGTGCATGTAGAAAAAACCTTTTACTATATGAAACTTTACAACACTTGTGAAAGCAACTCAATTTGGTTTATGCACAGTGTAATATTTCTCCAAGTATCATCCAAAATTCCCCACAGACAAGGCTTTCGTCCTCATTAGGTGTTGGCCTCAGCCTAACCCTCTAGGACTGTTCTATTAAATTGCTGCCAGAATTTTACATCCAGTTACCTCCACTTTCTAGAACATATTCTTTACTAATGTTATTGAAACCAATTTCTACTTCATACTGATGTTTTTGGAAACAGCAATTAAAGTTTTTCTTCCATGAGTTGAGTCCTTAAGAAAATGATTCCAGTTACTCATTTTGCATATTTGCTATTTTAACATTATTGGACCCTGCATTTATAGTCCTTTGATTTCTTCCCTCTCCCTGGTGTCTCCCCCAAGACCCCAAATAAAGCAATACACTGTTAACACTGTGGGTTTATATACTAATTCTATACCCCAGATGGGGAATGGGGGAGATGGTCCCTGGGCTTAATATTCTTTAAAGGGCATGGGAATTTAGCCTCTCTTTTATTGTAATGTGCTCTTTTGGAAAATAGTTGGTTAGCAGGGAAGACCCAGAGTTGTAGATTGAGATTAGGGTGTACTGGCTGAACTGTGGAAAACATACAATTCTGTGTTCCTCAGTAAATGAGATTAGCGTCTAATGAGTAGCACCCCTTTACTAACTTAGTAGTAGTATAAAATCATTTTTATTTAGTTAATTACCAGAGAGATTTAGCATAATTTTGTTCTGGATTCAGTAAATCAAGTCAGCTTGGATCATTCACCTTAACTTTTCCTTTAGCAGCCATTTCCACTAGTTTCCATTAAGTAGTGTTCTATAAACTTTGATCCAAAGCAGAATCAATGTCTTTTCCATCTCGTGACTTAAAGTTCTGTGACTGTGATGCATGTGAGTGTTCCGACTTCATCTGTTCCTCTTAACTACGGTGTTTCCCTTACCATGGCATTCATAGGATGAAATGAATGACTGCCCAGAATGAGAATTTGTCCAGATTATTCAGATAAACATCATAAAGCAGaatacattataaataagtagaatatgaataaatagaataataaaATTCCAAAATACTCAATGGGAAATGACTAGTAATATAGGCTTTCAAGAGTTGGTACCTTTTAGCTATATTTGCAGATTCTCTGGGATTTTAAGGAACTGAGAAAACAGCAAAGTTGACTAAATTTTATATTTCTTGTCCTCTAAATATTTTGATAATTTCTGGATTGATGCAGTGATGTTTTTGTTCCTTCCGTATTTATAAATGAAACACCTTTTTTTAGTGTTTCTAAACCTAAAATCTACTTGGTTTGAAATCAAGTGGTTGGAACACTGTTTGACTTTTATTTGAAGCATGTTGTTGATTGAAAATTTCATTGAGGAAGTTTTCAATCAGTGTGATCAGTTTGATTCTGTAATGAGCACAGCACCTAATATTTTGAGGAGCTCTGTTTTGAGGACCAATGCTTAAGGTGGACTTTGTTCGTAAACAATATCCCAATAGATTTGTTGACTTGAGGTCTGgtttggttttgtttttgttttgttttgttttgttttgtttCCAATAGAATTAAGAATTCTAATGTTGAAAAACTGCACAAATTTTTATGGGACAAAGCCTAGAAAAGAGAAATGTAGTTTGAATCATAATCTAAATCATCGTATGATAGAAGAGGGAAAGTTTTGGTGCCATAATTTCTCCTTTCACTGGTGTTGGACTTAAATCAGTTGAAATGTATTTCTGTACCACAATTTACGCTTCAATAAAAGTTTAATTGTCTAGTGACATTCAGAAA

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