Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

Advanced Search

Summary

Retrocopy Name MRM3P1
Plot displaying the genomic locations of a retrocopy (in chr10) and its respective parental gene (in chr17). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr10:21394016-21394591  UCSC
Coordinates (T2T) chr10:21412973-21413548  UCSC
Coordinates (hg19) chr10:21682945-21683520  UCSC
Strand +
Parental Sequence NM_018146.4
Parental seq. overlap 523 bp
Parental seq. overlap (%) 30.2%
Genomic Region Intergenic
Retrocopy Summary MRM3P1, located on chr10:21394016-21394591, is a retrocopy of the parental gene MRM3. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name MRM3
Full Name mitochondrial rRNA methyltransferase 3
Also known as RMTL1|RNMTL1
Coordinate chr17:782353-792509
Strand +
Gene summary Efficient translation of mitochondrial-derived transcripts requires proper assembly of the large subunit of the mitochondrial ribosome. Central to the biogenesis of this large subunit is the A-loop of mitochondrial 16S rRNA, which is modified by three rRNA methyltransferases located near mtDNA nucleoids. The protein encoded by this gene methylates G(1370) of 16S rRNA, and this modification is necessary for proper ribosomal large subnit assembly. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes MRM3P1
Bonobo Pan paniscus MRM3P1
Gorilla Gorilla gorilla MRM3P1
Orangutan Pongo abelii MRM3P1
Crab-eating macaque Macaca fascicularis RNMTL1P1
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>MRM3P1
gGTCTCAGGGAAGATGGTGACGCTGGTGAAACCCGCGCAGTTTGTTGTGCCACCGTTGCTGCAGGTGGTCCAGACTTGGAACCTTGACACAAGGCCCAGGGTCTGGGCGCTGCGGCGGAGCCCAGTGAAAGTGGCGTTTCCTTCCGGAGAGGTGGGGGAACGGAAGCGCGCTCCCGGGAAGCAGCCCGGCAAGGCAGCATCTGAGGCCAGTGCCCATGAGCTACGAGAGACACAGCCGCTTGAGGTGTCCCCATCCCACACTCCCAGCACCTGGGAAGAGTCTGGACTTCGCTACAATAACGTTTTTCCCGGGGACAGGAGGCTGAGCGGTGTAATGACAATAGTAAAGTCCAGGCCATTTCAGGAAAAACAAGGGTAGATACTGCTGGAAGGTCGCAGGCTCATTGCAGAAGCTCTCAAGGCTGGAGCTGTGCCAAACATTTCTTCTTTAGCCGTCTAGAATACCTAAAGGGGCTGCCAGTCGATAAGCTGAAAAGTGTCAGCCTCATTAAGGTGAAATTTGGGGAGATCAAGGATTGGTCCGACCTAGTAACACCACAAGGAATAATGGG
>NM_018146.4
GTGACGCAGCCCGGGTCTCAGGGAACATGGCGGCGCTGGTGAGACCCGCGAGGTTTGTCGTGCGACCGTTGCTGCAGGTGGTCCAGGCTTGGGACCTTGACGCGAGGCGCTGGGTCCGGGCGCTGCGGCGGAGCCCAGTGAAAGTGGTGTTTCCTTCCGGAGAGGTGGTGGAACAGAAGCGCGCTCCTGGGAAGCAGCCCCGCAAGGCACCATCTGAGGCCAGTGCCCAGGAGCAACGAGAGAAACAACCGCTCGAGGAGTCCGCATCCCGCGCTCCCAGCACCTGGGAAGAGTCTGGGCTTCGCTACGATAAAGCTTATCCCGGGGACAGGAGGCTGAGCAGTGTAATGACAATAGTAAAGTCCAGGCCATTTCGGGAAAAACAAGGGAAGATCCTGCTGGAAGGTCGCAGGCTCATTTCAGACGCTCTCAAGGCTGGAGCTGTGCCAAAAATGTTCTTCTTTAGCCGTCTAGAATACCTAAAGGAGTTGCCAGTCGATAAGCTGAAAGGTGTCAGCCTCATTAAGGTGAAATTTGAGGATATCAAGGATTGGTCCGACCTCGTAACGCCACAAGGAATAATGGGGATTTTTGCCAAGCCTGACCATGTTAAGATGACATATCCAAAGACTCAGCTTCAGCATTCACTGCCTTTATTATTGATTTGTGACAATCTCCGTGACCCTGGGAACCTGGGGACAATTCTGAGATCTGCAGCTGGGGCAGGCTGCAGCAAAGTGTTACTCACCAAAGGCTGTGTGGATGCCTGGGAGCCCAAAGTGCTCCGGGCGGGTATGGGCGCACATTTCCGGATGCCCATTATCAATAATCTGGAATGGGAAACCGTGCCCAATTACCTGCCCCCTGACACTCGGGTCTATGTGGCTGACAACTGTGGCCTTTATGCCCAGGCTGAGATGTCTAATAAAGCTAGTGACCATGGCTGGGTGTGTGATCAACGAGTGATGAAGTTTCACAAGTATGAGGAAGAGGAAGATGTAGAAACCGGAGCCAGTCAAGATTGGCTGCCTCATGTTGAGGTTCAGAGTTACGACTCGGACTGGACAGAGGCGCCGGCAGCTGTGGTGATTGGCGGGGAGACCTACGGCGTGAGCCTGGAGTCCCTGCAGCTGGCCGAGAGCACTGGTGGCAAGAGGCTGCTGATCCCCGTTGTGCCTGGTGTGGACAGCCTCAACTCGGCCATGGCGGCAAGCATCCTGCTTTTCGAAGGGAAAAGACAGCTGCGGGGGAGGGCGGAGGACTTGAGCAGGGACAGGAGTTACCACTGAGGACGCAGAAGTGACTTCTGCTTGAGGACGTCTGCAGCTCCTCCTACACCAGCACACTGGTGGGAGGCTGGCGGAGTCAGTGACTATGGCCCCCACGTTCAGGAGGAAGGTGTGATGCCGTCATACAGTTACAGGAAAAATAAGAACTTCCTCAGAAAGAACAGGTCCGAATTCTTCCTGTCGCGTCACTGATTTTGAGGTTCTTTTTTCTCTTGGTGACAATAGGTGACCCACGTGGCTCTGTGTGTTTTTAAAAATTGTCCACCAAGAAGCACTTTGTGCCCAGAAAGTTCCTGAAGCATCATCCTGGCAGGGAGGCGCCTGCTCCACCAGCTGGTGGGTGTTTGTAATCGCCAAGCACCAGCTATAGGTCACAGCCACATCACTCACAGCTGATCACTGGTTGGTGGAAAATAAACTATGAGCAGCAGATTACGTTA

Publications

PMID - Link Title