Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name TRIAP1P1
Plot displaying the genomic locations of a retrocopy (in chr10) and its respective parental gene (in chr12). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr10:27377050-27378280  UCSC
Coordinates (T2T) chr10:27407186-27408416  UCSC
Coordinates (hg19) chr10:27665979-27667209  UCSC
Strand -
Parental Sequence NM_016399.3
Parental seq. overlap 614 bp
Parental seq. overlap (%) 44.4%
Genomic Region Intergenic
Retrocopy Summary TRIAP1P1, located on chr10:27377050-27378280, is a retrocopy of the parental gene TRIAP1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name TRIAP1
Full Name TP53 regulated inhibitor of apoptosis 1
Also known as HSPC132|MDM35|P53CSV|WF-1
Coordinate chr12:120443964-120446384
Strand -
Gene summary Enables p53 binding activity. Contributes to phosphatidic acid transfer activity. Involved in several processes, including DNA damage response, signal transduction by p53 class mediator; negative regulation of apoptotic process; and positive regulation of phospholipid transport. Located in mitochondrial intermembrane space and nucleoplasm. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes TRIAP1P1
Bonobo Pan paniscus TRIAP1P1
Gorilla Gorilla gorilla TRIAP1P1
Gibbon Nomascus leucogenys TRIAP1P2
Orangutan Pongo abelii Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>TRIAP1P1
GATGATGATTTCTCACTTGCTCTGGTATCTTCTAGGAACCCAGGGTGCTAAAACTGAACAATTTCTTGGGATTATGATTGCAATACTTAGTCTGGGATCAGCTGTAAATATACCTTGTATGAAAATAATGATAAACTAGTCAGGATGATCAAGGTTGCCTGACCTCTTGATTTTTGCTACAAGTGACATTATGTACACTTGTACTGGGGTCATTGTTCATGAAAGCAATTGGTTAGGACCTCCTTTTTCTCTCAGGGAACTAATGCTCTGAAAGGGATCTGGGCACAACAGTTTCAGTCAGTGCTTCAGAGCAGAATTTTATTTTTACATGGTAACTTGCAGTTAAGATTGCTGGCAGCCTGGATAAGCAAAGAAGAAGCTTTTAAAACAATCCCCTGCCTTAACAAGAGGTTAAGATGTGAAAGCTTCAAGAATGTTGCAGTGAACACCATTTCAGAGCTCACAGTGTAGTTCAGGAATAAAGATATTCAGAGTGGCTATGGAGGAAAAGTCTAAATTGCACAGTTTGCTGCTGGCAGCTTTCAACTCAAGTCAAGAATTAAGTCAACCTGCAGATCATAAAAAATGTCAAACTGCTGCATATGGTTAAATGGTTCTCAAGGGCGACAGCTCTGGGGAGCCGTGCTCCAACCTCTTCAAGCATTACCTGCAGTGTGTTCAGAAAGCAACAACAGAGAGAATCTCTGTTGAAGGACTGAGTTCACGGGCCATGGTGAAGAAAAGTATGAAGAGTCTTCTTGACCTTGATGGTCACCTTGAAAATGGATTCTTCAAATCAAGAAATTGAGAACTCTGGATTTTGTCAACTAAGTCTGTGAAGACAGCCATCAGATTTGATGAGGAATTTAGGCAAGGCGAGTTTCGTTTCCTTCTTCTTGATGTTTTCCTCTCACTTGTAGAAGATGATGATTTCGGCc
>NM_016399.3
ACCACTGTCGCCATGAACAGTGTGGGGGAGGCATGCACGGACATGAAGCGCGAGTACGACCAGTGCTTCAATCGCTGGTTCGCCGAGAAATTTCTCAAGGGGGACAGCTCCGGGGACCCGTGCACCGACCTCTTCAAGCGCTACCAGCAGTGTGTTCAGAAAGCAATAAAGGAGAAAGAGATTCCTATTGAAGGACTGGAGTTCATGGGCCATGGCAAAGAAAAGCCTGAAAATTCTTCTTGACCTTGACAGTCACCTTGAAGGATTTCGCAAGTCCAGAAATTGAGGACTCTGGATTTTTGTCAACTAACTCTGTGAACATAGCCATCAGATTTGATGAGGAACTTAGGAGAGAGGAGTTTTATTTCCTCCTTCGATGTTTTCCTCTCAGTTGTAAAAGATGAACTCTTTGAGATGATTTCTCACCTGCTGTGGTATCTTGCAGGAACTGTGTGCTAAAATTGAACAATTTTTTTGAGATTATGGTTGCAATACTTGGCGTGGAATCAGCTTTACATAAATATACCTTGTATGCAAACGATGATAAACTAGTCAGGATGAGCAGAGCTGCCTGACCTCTTGATTTCTGCTGCAAAAGACATATACACTGTACTGGGGTCACTATTTATGAAAGCAATTGGTTAGGACCTCTTTTTTTCCTCTCAGGGAACTAATGCTCTGAAAAGGGATCTGGGCACAACAGTTTCAGTGAGTGCTTTTGAGCACACTTTTATTTTTATATAGTAACTAATGGTTAAGATTGATGGTGGCCTGGATTAGCAAAGAGGAAGACAGCTTTTAACACAGTTCCCTGCCTTCACAAGAGGTGTCAGATTAAGATGTGAAAGCTGCaagaatgttgcagtgaacaccatttcagagctctcagtgtgcagttcaggaattaagatacttggaatagctgtGGAGGAAGAACCTAAATTGCAAAGATCTGCTATTGCCAGCTCTCAACCCAAGTCAGTGAATTGTCAACCTGCATATCCTAAAAATGTCAAAATGCTGCATCTGGTTAAATGTCGGGGTAGGGGGGAAGCTGAAGGTGCTCGCTTCATTTGCCTTGTTTACTCATCCTGCCCTGTAATGTCTGTAATCCTGAAGATGGAATAAATTGTAACATTTAGTTTCTATCA

Publications

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