Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name TPRKBP1
Plot displaying the genomic locations of a retrocopy (in chr10) and its respective parental gene (in chr2). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr10:28658998-28659472  UCSC
Coordinates (T2T) chr10:28690389-28690863  UCSC
Coordinates (hg19) chr10:28947927-28948401  UCSC
Strand +
Parental Sequence NM_001330388.2
Parental seq. overlap 425 bp
Parental seq. overlap (%) 52.6%
Genomic Region Intergenic
Retrocopy Summary TPRKBP1, located on chr10:28658998-28659472, is a retrocopy of the parental gene TPRKB. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name TPRKB
Full Name TP53RK binding protein
Also known as CGI-121|CGI121|GAMOS5
Coordinate chr2:73729873-73737345
Strand -
Gene summary Enables protein kinase binding activity. Involved in tRNA threonylcarbamoyladenosine modification. Located in cytosol and nucleus. Part of EKC/KEOPS complex. Implicated in Galloway-Mowat syndrome 5. [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes TPRKBP1
Bonobo Pan paniscus TPRKBP1
Gorilla Gorilla gorilla TPRKBP1
Orangutan Pongo abelii TPRKBP1
Gibbon Nomascus leucogenys TPRKBP2
Green monkey Chlorocebus sabaeus TPRKBP2
Crab-eating macaque Macaca fascicularis TPRKBP1
Rhesus Macaca mulatta TPRKBP1
Baboon Papio anubis TPRKBP1
Golden snub-nosed monkey Rhinopithecus roxellana TPRKBP1
Marmoset Callithrix jacchus LOC100390200P1
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>TPRKBP1
ATTATTTAAAGACGTAAAAAATGTGGGGAACTTGAGAAAGAAAGCCATGGAAGGTGTCATTGATGGCTCACTGATACATCCTGCAGTGATTGTCAATCCATTTGAGATATTTGCAGCCACAAAGAAAGCAGTTTGCCTCTACAAACTGGGAGAAATGAAGACAAGAGCTCTATCTACTGAAATTATTTTCAACCTTTCCCCAAATAACAATATTTCAGAGGCATTGAAAAAATGTGGTATCTCAGCAAATGACACTTAAATTCCAATTGTTTATACTAACGAGGGAGAAAAACAAATAAATCAAGGATATCTAATATCTCAAATAGAAGGTCAGCAGGTTTCTCTGAAAAATCTTCCTGAAATAATAAATATTACAAAAGTCAAAAAGAAATATACACTCCCTCCACAAGAAGAAAGCATTGGGAACATTATTGGATGGTATTTGTAGAATGTCAACAAAGAATGTTTTGTGAAA
>NM_001330388.2
GGAGGGTCCGGGCAGTTTTAGTAGTGTCTTTGGGACAACGGCTGCGgatcactgtaactgctggtgacgactggattataggagggcaggaattgtgagaaaccactcagaaggctactgctgtagatgagcgatgtgacctagcgtatgggagagaagtggacgaatcaaaagtatatttagcagTAGAATCCTGCTTATCTGTGAAATGCAGTTAACACATCAGCTGGACCTATTTCCCGAATGCAGGGTAACCCTTCTGTTATTTAAAGATGTAAAAAATGCGGGAGACTTGAGAAGAAAGGCCATGGAAGGCACCATCGATGGATCACTGATAAATCCTACAGTGATTGTTGATCCATTTCAGATACTTGTGGCAGCAAACAAAGCAGTTCACCTCTACAAACTGGGAAAAATGAAGACAAGAACTCTATCTACTGAAATTATTTTCAACCTTTCCCCAAATAACAATATTTCAGAGGCTTTGAAAAAATTTGGTATCTCAGCAAATGACACTTCAATTCTAATTGTTTACATTGAAGAGGGAGAAAAACAAATAAATCAAGAATACCTAATATCTCAAGTAGAAGGTCATCAGGTTTCTCTGAAAAATCTTCCTGAAATAATGAATATTACAGAAGTCAAAAAGATATATAAACTCTCTTCACAAGAAGAAAGTATTGGGACATTATTGGATGCTATCATTTGTAGAATGTCAACAAAAGATGTTTTATGAAATGTCAGAAATATTAACAAAAATTCTCAGCATTAAAGAAAACATTGATTTTCCTTTCCTGACTATAAAA

Publications

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