Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name CCND3P1
Plot displaying the genomic locations of a retrocopy (in chr10) and its respective parental gene (in chr6). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr10:30403280-30403732  UCSC
Coordinates (T2T) chr10:30434283-30434735  UCSC
Coordinates (hg19) chr10:30692209-30692661  UCSC
Strand -
Parental Sequence NM_001760.5
Parental seq. overlap 386 bp
Parental seq. overlap (%) 18.8%
Genomic Region Intergenic
Retrocopy Summary CCND3P1, located on chr10:30403280-30403732, is a retrocopy of the parental gene CCND3. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name CCND3
Full Name cyclin D3
Also known as -
Coordinate chr6:41934933-42048894
Strand -
Gene summary The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes CCND3P1
Bonobo Pan paniscus CCND3P1
Gorilla Gorilla gorilla CCND3P1
Orangutan Pongo abelii CCND3P1
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>CCND3P1
GGGGATCAGCGCGTCCTGCAGAGCTTGCTCCCCTTGGAGTAGCGCTGCGTGCACTGCGCCTACTTCCAGTGCGTGCAAAGGGAGAGCAAGCCGCACATGCGGAAGATGCTGGTTTACTGGATGCTGGAGGTGTGTGAGGAGCAGTGCTGTGAGGAGGAGCAGTGCTGTAAGGAGGAAGTCTTTCCCCTGGCCATGAACCACCTGCATGCTACCTGTCCTACGTCCCCACCCACCCGAAAGGCACAGTTGCAGCTCTTGGTTGCGGTCTCCATGCGGCTGGCCTCCAAGCTGCGTAAGACTGGGCCCATGACCATTGAGAAAATGTGCATCTACACCGACCACGCTGTCTCTCCCTGCCAGTTGCGGGACTGGGAGGTGATGGTCCTGGGGAAGCTCAAATGGGACCTGGCCGCTGTGATTGCTCATGACTTCTTGGCCCTCATTCTGCACCGA
>NM_001760.5
GTCAGGGAAgcggcgcgcgcgcgcgggcggcgggcgggctggGGATCcgccgcgcagtgccagcgccagcgccagacccgcgccCCGCGCTCTCCGGCCCGTCGCCTGCCTTGGGACTCGCGAGCCCGCACTCCCGCCCTGCCTGTTCGCTGCCCGAGTATGGAGCTGCTGTGTTGCGAAGGCACCCGGCACGCGCCCCGGGCCGGGCCGGACCCGCGGCTGCTGGGGGACCAGCGTGTCCTGCAGAGCCTGCTCCGCCTGGAGGAGCGCTACGTACCCCGCGCCTCCTACTTCCAGTGCGTGCAGCGGGAGATCAAGCCGCACATGCGGAAGATGCTGGCTTACTGGATGCTGGAGGTATGTGAGGAGCAGCGCTGTGAGGAGGAAGTCTTCCCCCTGGCCATGAACTACCTGGATCGCTACCTGTCTTGCGTCCCCACCCGAAAGGCGCAGTTGCAGCTCCTGGGTGCGGTCTGCATGCTGCTGGCCTCCAAGCTGCGCGAGACCACGCCCCTGACCATCGAAAAACTGTGCATCTACACCGACCACGCTGTCTCTCCCCGCCAGTTGCGGGACTGGGAGGTGCTGGTCCTAGGGAAGCTCAAGTGGGACCTGGCTGCTGTGATTGCACATGATTTCCTGGCCTTCATTCTGCACCGGCTCTCTCTGCCCCGTGACCGACAGGCCTTGGTCAAAAAGCATGCCCAGACCTTTTTGGCCCTCTGTGCTACAGATTATACCTTTGCCATGTACCCGCCATCCATGATCGCCACGGGCAGCATTGGGGCTGCAGTGCAAGGCCTGGGTGCCTGCTCCATGTCCGGGGATGAGCTCACAGAGCTGCTGGCAGGGATCACTGGCACTGAAGTGGACTGCCTGCGGGCCTGTCAGGAGCAGATCGAAGCTGCACTCAGGGAGAGCCTCAGGGAAGCCTCTCAGACCAGCTCCAGCCCAGCGCCCAAAGCCCCCCGGGGCTCCAGCAGCCAAGGGCCCAGCCAGACCAGCACTCCTACAGATGTCACAGCCATACACCTGTAGCCCTGGAGAGGCCCTCTGGAGTGGCCACTAAGCAGAGGAGGGGCCGCTGCCACCCACCTCCCTGCCTCCAGGAACCACACCACATCTAAGCCTGAAGGGGCGTCTGTTCCCCCTTCACAAAGCCCAAGGGATCTGGTCCTACCCATCCCCGCAGTGTGCACTAAGGGGCCCGGCCAGCCATGTCTGCATTTCGGTGGCTAGTCAAGCTCCTCCTCCCTGCATCTGACCAGCAGCGCCTTTCCCAACTCTAGCTGGGGGTGGGCCAGGCTGATGGGACAGAATTGGATACATACACCAGCATTCCTTTTGAACGCCCCCCcccacccctgggggctctcatgttttcaactgccaaaatgctctagtgccttctaaaggtgttgtcccttctagggttattgcatttggattggggTCCCTCTAAAATTTAATGCATGATAGACACATATGAGGGGGAATAGTCTAGATGGCTCCTCTCAGTACTTTGGAGGCCCCTATGTAGTCCGTGCTGACAGCTGCTCCTAGAGGGAGGGGCCTAGGCCTCAGCCAGAGAAGCTATAAATTCCTCTTTGCTTTGCTTTCTGCTCAGCTTCTCCTGTGTGATTGACAGCTTTGCTGCTGAAGGCTCATTTTAATTTATTAATTGCTTTGAGCACAACTTTAAGAGGACATAATGGGGTCCTGGCCATCCCACAAGTGGTGGTAACCCTGGTGGTTGCTGTTTTCCTCCCTTCTGCTACTGGCAAAAGGATCTTTGTGGCCAAGGAGCTGCTATAGCCTGGGGTGGGGTCATGCCCTCCTCTCCCATTGTCCCTCTGCCCCATCCTCCAGCAGGGAAAATGCAGCAGGGATGCCCTGGAGGTGGCTGAGCCCCTGTCTAGAGAGGGAGGCAAGCCCTGTTGACACAGGTCTTTCCTAAGGCTGCAAGGTTTAGGCTGGTGGCCCAGGACCATCATCCTACTGTAATAAAGATGATTGTGAAATAAAA

Publications

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