Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name MKNK2P1
Plot displaying the genomic locations of a retrocopy (in chr10) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr10:36942609-36944662  UCSC
Coordinates (T2T) chr10:36974763-36976816  UCSC
Coordinates (hg19) chr10:37231537-37233590  UCSC
Strand -
Parental Sequence NM_001377373.1
Parental seq. overlap 1497 bp
Parental seq. overlap (%) 55.3%
Genomic Region Intergenic
Retrocopy Summary MKNK2P1, located on chr10:36942609-36944662, is a retrocopy of the parental gene MKNK1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name MKNK1
Full Name MAPK interacting serine/threonine kinase 1
Also known as MNK1
Coordinate chr1:46557407-46604311
Strand -
Gene summary This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2012]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes MKNK1P1
Bonobo Pan paniscus MKNK1P1
Gibbon Nomascus leucogenys MKNK1P1
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>MKNK2P1
AAGTTTGGTTTTTTAACCATGCTGTTCCAGCAAAGATGGGACCTCAAACTACCACTGCAAGCCCATGGACTTCCCAGAGAGGGTAACGGCTTGCTCTTCTTTCTGGAATGTCCATGCATTTGGGTTTTGATCAGCAGTTCCCTATTGCTCTAACTGATTTTAAGCTGTTCCTATGACAAACTTAGAGACAGCGTCGGTGTCTGCTGCTGTGTCCCCAGGTATTGTGTGGGTGGCACAGATCTGGGCAGTTAGATGGAGCTCTATGCATGAGATGAAGCCACACTGGCGTGAAGCCTCGCTGCCCTGTTTGAGTGAGGCAGTCCCTGCTGCCCGAATGCGTGAAGGTACAGCCATTCAGGTAAGCTGAGCTATTGAGTTACATAGAGGAAATAGATTTGCATTTGTCAGGCAGACATTTATACAACACCACGATGTTTTATACATTATGCTTGTTTTAATAAAACTGAAATTCTAATACATGGCCCCTGAGGTGGTGGTAGTCTTCGTGGACCAGGCCACGTTCTACGATAAGCATTGTGACCTGGAGAGCCTGGGCATGGTCCTCTACATCATGCTGAGTGGCTACCTGCCCTTCGTGGGTCACTGCGGGGCCAACTGTGGCTGGGACCGGGGTGAGGTCTGCAGGGTGTGCCAGAAAAAGCTGTTTGAAAGCATCCAGGAAGGCAAGTATGAATTTCCTGACAAAGACTGGGCACACATCTCCAGTGAGGCCAAATGCCTCATCTCCAAGCTCCAAGCTCCTGGGGCGAGATGCGAAGCAGAAACTTAGCGCCGCCCAAGTTCTGCAGCACCCACGGGTGCAGGGGCAAGCTCCAGAAAAGGGACTCCCCACTCCGCAAGTCCTCTAGAGGAAGAGCAGCACAATGGACCTGACACTCTTCGCAGCTGAGGCCATCGCCCTTAACTGCCAGCTATCTCAGCACGAAGAGAACGAACTAGCAGAGGAGCCAGAGGCACTGGCTGATGGCCTCTGCTCCATGAAGCTTTCCCTTCCCTGCAAGTCACCCTGGCCCGGAGGACAGGAGCCCAACCACAGCACTCTGAAATGCTCCAGTCACACCTTATAGGCCCTAGGCCTGGCCAGGCATTGTCCCCCTGGAAACCTGTGTGGCTAAGGTCTGCAGAGCAGGCAGCAGCGTCTGCTCTATGGCTCCATTCAGGCTTTTTCATCTACGAAGGCCCTGAAGTTCCCACCAACCCCCCATTTCCCTAGGGTCCTCGAGGAAAAAGCTTTTTCCAAAGGGGTTGTCTTTGAAAAGGAAAGCAATCACTTGTCATTTTGCATAATTGCCTGCAGCAGGAACATCTCTTCGCTGGGCTCCACCTGCTCAGCCGCCTGCAGATCTGGGATCCGGTGTGCCCTCACCGCTCTAGCGGTGGCTGGGGCTGCAGCCTGCAGGGAGAAGCAAGAAGCATCAGTTGACAGAGGCTGCCGACCCGTACCTGTTCCCTCTCTGCTCTGTCACCCTCCTCTGGCGGTCCTTCCACCTTCCTCTGTCCTCTGAATGTCCTCTTTGCCCGTCTTATCCCTTGGCTGAGCAAAGCCATCCCCTCGATTCAGGAAAGGGCAAGGAGCCTTCCTCATTCAGGAAATCAGATCAGTCTTCCGGTCTGCAGCACGCAGAAGCACATAATCTGTCTCCCTCATTTATCATTCCCTTTGTTTGTGATTGCTGCTAAAGTCAGTATTATTTCTTTTTTTTAAGTTTGTTGTTGTTGTGTGt
>NM_001377373.1
CTAGCACCGCCTCTTCCGCGTTCTCGGAGGAGCGATCTGCAGGTTTCCATGTCAGAGGCCGATGGAGAACTGAAGATTGCCACCTACGCACAAAGGCCATTGAGACACTTCGTGTAGCTGGAAGACACCAACTTCCTGACAGGAGCTTTATTTCATTTGGGATTTCAAGTTTACAGATGGTATCTTCTCAAAAGTTGGAAAAACCTATAGAGATGGGCAGTAGCGAACCCCTTCCCATCGCAGATGGTGACAGGAGGAGGAAGAAGAAGCGGAGGGGCCGGGCCACTGACTCCTTGCCAGGAAAGTTTGAAGATATGTACAAGCTGACCTCTGAATTGCTTGGAGAGGGAGCCTATGCCAAAGTTCAAGGTGCCGTGAGCCTACAGAATGGCAAAGAGTATGCCGTCAAAATCATCGAGAAACAAGCAGGGCACAGTCGGAGTAGGGTGTTTCGAGAGGTGGAGACGCTGTATCAGTGTCAGGGAAACAAGAACATTTTGGAGCTGATTGAGTTCTTTGAAGATGACACAAGGTTTTACTTGGTCTTTGAGAAATTGCAAGGAGGTTCCATCTTAGCCCACATCCAGAAGCAAAAGCACTTCAATGAGCGAGAAGCCAGCCGAGTGGTGCGGGACGTTGCTGCTGCCCTTGACTTCCTGCATACCAAAGGCATTGCTCATCGTGATCTGAAACCAGAAAATATATTGTGTGAATCTCCAGAAAAGGTGTCTCCAGTGAAAATCTGTGACTTTGACTTGGGCAGTGGGATGAAACTGAACAACTCCTGTACCCCCATAACCACACCAGAGCTGACCACCCCATGTGGCTCTGCAGAATACATGGCCCCTGAGGTAGTGGAGGTCTTCACGGACCAGGCCACATTCTACGACAAGCGCTGTGACCTGTGGAGCCTGGGCGTGGTCCTCTACATCATGCTGAGTGGCTACCCACCCTTCGTGGGTCACTGCGGGGCCGACTGTGGCTGGGACCGGGGCGAGGTCTGCAGGGTGTGCCAGAACAAGCTGTTTGAAAGCATCCAGGAAGGCAAGTATGAGTTTCCTGACAAGGACTGGGCACACATCTCCAGTGAAGCCAAAGACCTCATCTCCAAGCTCCTGGTGCGAGATGCAAAGCAGAGACTTAGCGCCGCCCAAGTTCTGCAGCACCCATGGGTGCAGGGGCAAGCTCCAGAAAAGGGACTCCCCACGCCGCAAGTCCTCCAGAGGAACAGCAGCACAATGGACCTGACGCTCTTCGCAGCTGAGGCCATCGCCCTTAACCGCCAGCTATCTCAGCACGAAGAGAACGAACTAGCAGAGGAGCCAGAGGCACTAGCTGATGGCCTCTGCTCCATGAAGCTTTCCCCTCCCTGCAAGTCACGCCTGGCCCGGAGACGGGCCCTGGCCCAGGCAGGCCGTGGTGAAGACAGGAGCCCGCCCACAGCACTCTGAAATGCTCCAGTCACACCTTATAGGCCCTAGGCCTGGCCAGGCATTGTCCCCTGGAAACCTGTGTGGCTAAAGTCTGCTGAGCAGGCAGCAGCCTCTGCTCTGTGGCTCCATTCAGGCTTTTTCATCTACGAAGGCCCTGAGGTTCCCATCAACCCCCATTTCCCTAGGGTCCTGGAGGAAAAAGCTTTTTCCAAAGGGGTTGTCTTTGAAAAGGAAAGCAATCACTTCTCACTTTGCATAATTGCCTGCAGCAGGAACATCTCTTCACTGGGCTCCACCTGCTCACCCGCCTGCAGATCTGGGATCCAGCCTGCTCTCACCGCTGTAGCTGTGGCGGCTGGGGCTGCAGCCTGCAGGGAGAAGCAAGAAGCATCAGTTGACAGAGGCTGCCGACACGTGCCTCTTCCCTCTCTTCTCTGTCACCCTCCTCTGGCGGTCCTTCCACCTTCCTCTGTCCTCCGGATGTCCTCTTTGCCCGTCTTCTCCCTTGGCTGAGCAAAGCCATCCCCTCAATTCAGGGAAGGGCAAGGAGCCTTCCTCATTCAGGAAATCAAATCAGTCTTCCGGTCTGCAGCACGGAAAAGCACATAATCTTTCTTTGCTGTGACTGAAATGTATCCCTCGTTTATCATCCCCTTTGTTTGTGATTGCTGCTAAAGTCAGTAGTATCGTTTTTTTAAAAAAAAAGTTTGGTGTTTTTAACCATGCTGTTCCAGCAAAGATGATACCTTAAACTCCCACTGCAAGCCCATGAACTTCCCAGAGAGTGGAACGGCTTGCTCTTCTTTCTAGAATGTCCATGCACTTGGGTTTTAATCAGCAGTTCCCTATTATTCTGATTTTAAGCTGTTCCTGTGATGAACTTAGAGACAGCATCGGTGTCTGCTGCTGTGTCCCCAGGTCTTGTGTGGGTGGCACAGATCTGGGCAGTTAGATAGTGCTCTGTGCCTAAGGTGAAGCCACACTAGGGTGAAGCCTCACTTCCCTGTTTGAGCAATGCAGTGCCTGCTGCCCGTGTGCATGAAGGTACAGCCATTCAGATAAGTGGAACTATTGAGTTACATAAAGAAAATAGATTTGCATTTGTCAGGCAGACGTTTATACAACACCACGGTGCTTTTATACATTGTGCTTATTTTAATAAAACTGAAATTCTATGTGTGGCCTA

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