Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name TLK2P2
Plot displaying the genomic locations of a retrocopy (in chr10) and its respective parental gene (in chr17). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr10:37817358-37821028  UCSC
Coordinates (T2T) chr10:37861322-37864992  UCSC
Coordinates (hg19) chr10:38106286-38109956  UCSC
Strand -
Parental Sequence NM_001375271.1
Parental seq. overlap 2633 bp
Parental seq. overlap (%) 44.2%
Genomic Region Intragenic (ZNF248)
Retrocopy Summary TLK2P2, located on chr10:37817358-37821028, is a retrocopy of the parental gene TLK2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name TLK2
Full Name tousled like kinase 2
Also known as HsHPK|MRD57|PKU-ALPHA
Coordinate chr17:62470908-62615481
Strand +
Gene summary This gene encodes a nuclear serine/threonine kinase that was first identified in Arabidopsis. The encoded protein is thought to function in the regulation of chromatin assembly in the S phase of the cell cycle by regulating the levels of a histone H3/H4 chaperone. This protein is associated with double-strand break repair of DNA damage caused by radiation. Pseudogenes of this gene are present on chromosomes 10 and 17. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes TLK2P1
Bonobo Pan paniscus TLK2P1
Gorilla Gorilla gorilla TLK2P2
Orangutan Pongo abelii TLK2P1
Gibbon Nomascus leucogenys TLK2P1
Green monkey Chlorocebus sabaeus TLK2P1
Crab-eating macaque Macaca fascicularis TLK2P1
Rhesus Macaca mulatta TLK2P1
Baboon Papio anubis TLK2P1
Golden snub-nosed monkey Rhinopithecus roxellana TLK2P1
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>TLK2P2
GAAAATACAGACTAGGCTAGTCCAGTGTCTATATTTAGACTTGTTCTTTTAATAAAGTTTAGGTAACATCTTCTAAAAAGTTTGTAGCACAAAGGCTCAGCTGGGGATGGTGTTTGACTTCGGGGGGAAAAAATGCTGTTGCCTATTAAAGACACTAGAGTTAGTGTTTTATCCCTAAATAATTTCAATTTTTAAAAACATGCAGCTTCCCTCTCCCCTTTTTTATATTTGAAAGAATTCATTTGGTTGTAAAGTGAAACCCATATTAGCAAGTACGTGGCAATGTTCATTCCAATCAGATGCAGCTTTCTCCTCTCTCTGGTCTCCTGTTTGCAATTGCTTCCCTCCTCAGTAGGGAAAAAATTGAGTGGGAGTACTGAGATGTGTGGGTTTTTGTCATTGGACAAAGAATGAGGTTAGAAGACTGTGGCTTGGAGTCTCTCTAGGTTTTCAACTATTTCTTCACAATTTGAATACCTGATGGTTGTCCCTTTTAATTTATTTGAAGTGCTATTTTTTTTTTAAAAATAAAGGTTCATCCGATCCCAGAGCACCTTTAGTCTCGGGAGACGCTCTGCCAGCCAGAAATGATGGAAGAATTGCATAGCCTGGACCCACGACGGCAGGAATTATTGGAGGCCAGGTTTACTAGAGTAGGTATTAGTAAGGAAAACTAGAAGAGGAAAAAACAATAAATATGCAAGAAGAAATAAATACATGCAAAACAGAATGGGAAATATTCAAGAGTTGGAAAATCAGGAAACAAAAGGCAAAATGAAGGAGAGTACATCAGATTTAACAAAAGGGACCACTTAATAGTGAGTCTTCCAACCAGAGCTTGTGCAGCATGGGATCCTTGAGTGATAAAGAAGTAGAGACTCCCGAGAAAAAGCAGAATGACCAGCGAAAGTGGAAAAGAAAAGCCGAACCACATGAAACTAGCCAAGGGAAAGGCACTGCTGGGGGACGTAAAATTAGTGATTACTTTGAGTTTGCTGGGGGAAGCGGGCCAGGGACCAGCCCTGGCAGAAGTGTTGCACCAGTTGCACGATCCTCACCGCAACATTCCTTATCCAATCCCTTACTGTGACAAGTAGAACAGCCCCTCTGTGGTTTAGATGGCAGCACTGCAAAGGAGGCAACGGAGGAGCAGTCTGCTCTGCCAACAGCCTCATGTCAGCAATGCTAACAAAACCTCGGCTTGACCCAGAGCAGCTGGCACAAAGGGGAGCTGGCCTGTGCTTCACTTCTGTTTCAGCTCAGCAAAACAGTCCCTCATCTATGAGATCTGGCAACACAGAGCATTTCTGCAGCTCCCAAAAACAGATCTCCATCTGGCACAGACAGACCCAGTCCGACCTCACAATATAAAAAATATCTGCACTAGAAAACAGTAAGAATTCTGACTTAAGAAGGAGGGAAGAATAGATGATTTATTAAGAGCCAACTGTGATTTGACACAGCAGATTGATGAACAGCAAAAGATGCTACAGAGATACAAGGATGATTAAATAGATGTGTGACAATGAGCAAGAAAGTCCTCATAGAAAAGTCAAAAAGAGAAGATGGCATGTAGAGATAAGAGCATGCAAGACCGCTTGAGATGGGGCCGCTTTACTACTGTCCGACATGGGGCCTCGTTTACTGAACAATGGGCAGATGGTTATGCTTTTCAGAATCTTATCAAGCATCAGAAAAGGATAAATTCACAGAGGGAAGAGATAGACAACGGAAAATGTTAGCAAAGCGGAAACCTCCTGCCATGGGTCAGGACCCTCCTGCAACCAGTGAGCAGAAACAGTGGAAAAGCAGGACCAATGGAGCTGAAAATAAAACGTTAACATTAGCAGAATACCATGAACAAGAAGAAATCTTCAAACTCCGGTTAGGTCATCTTAAAAAGGAGGAAGCAGAGATCCAGGCAGAGCTGGAAAGGCTAGAAAGGGTTAGAAATCTACGTATCGGGGAACTAAAAAGGATACATAATGAAGATAACTCACAATTTAAAGATCATCCAATGCTAAATGACAGATATTTGTTGTTACATCTTTTGGATAGAGGAGGTTTCAGTAAAGTTTACAAGGCATTTGAACTAATAGAGCAAAGATACGTAGCTGTGAAAATTCACCAGTTAAATAAAAACTGGAGAGATGAGAAAAAGGAGAATTACCACAAGCATGCATGTAGGGAATACTGGATTCATAAAGAACTGGATCATCCCAGAATAATTAAGCTGTATGATTACTTTTCACTGGATACTGACTCATTTTGTACAGTGTTAGAATACTGTGAGGGAAATGATCTAAACTTCTATCTGAAACGGCACAAATTAATGTCAGAGAAAGAGGCCTGGTCCATTATCATGCAGACTGTAAATGCTTTAAAGTACTTAAATAAAATAAAACCTCCCATCATACACTATGACCTCAAACCAGGGAATATTCTTTTAGTAAATGGTACAGTGTGTGGAGAGAGAAAAATTACAGAGCTTGGTCTTTCGAAGATCATGGATGATGATAGCTACAATTCAGTGGGTGGCATGGAGCTGACATCACAAGGTGCTGGCACTTATTGCAATTTAACACCAGAGTTTTGTGGTTGAGAAAGAACCACCAAAGATCTCAAATAAAATTGTTGTGTGGTCGGTGGGTGTGATCTTCTATCAGTGTCTTTCTGGAGGGAAGCCTTTTGGCTATAACCAGTCTCAGCAAGACATCCTACAAGAGAATACTATTCTTAAAGCTGCTGAAGTGCAGTTCCCACCAAAATGAGTAGTAACACCTGAAGCAAAGGCGTTTATTTGACGATGTTTGGCCTACCAAAAGGAGGACTGCATTGATGCCCAGCAACTGGCCTGTGACCCCCTACTTGCTGCATTATATCCAAAAATTGGTCTTTGTGAGTAGCCCTGCTGGGGCTGCTATTGCATCAACCTTTGGGGTGTCCAACAGCTGTTCTTCGAATTGAGACTGACTCCAAGGCCACAAACTGTTCAACACACACAAAGTGGACAAATAGCATTTAGCAGCAGGTTTGGAACGTAGAGAATCTGAATGGATCTGATGAAACCTGAACCAGGTGCTTATTTTGTTGCTTTTTTCCCATCCACTGAGCATGACAGCATGGATTCTCTTTAAGGAGAAACCATGGGCAGCTCCAGCCAGGCCTCATAGGAAAAGGCCCGGCATGAGGTTCTGGCGTCAATGGCCACTGTGTATGGCTGCTCTGAGTGAGGAAAAAACTAAAAAGAAAAACTGGTTCCATGTACTGTGAACTTGAAAACATGCAGACTCACGGGGGTTCCTGATGCAATGCTTCAGATGAAGATTGTGGACTTGAAAATACAGACTAGAAg
>NM_001375271.1
CTTGCCCGCTAGATAGTTCTCATTCCTCAGGAGATACTCTGTGAGGGGCCGGCGTGTTTTCTCCATCTTGGCACTTACCCTCAGACCCTCCTAAGTACCCGGGAGGGCCGTGTTTTTCATCGGAGGTTGAAATGGAACCTCCCCCTGGGTGCCCGGGGAGAGTACCTTGGGGGCAGCGCCCCTCCTTCCGGAGGGCAGCATCCCCGCGGGGGCGGGGGCTCGGCTTTGATCCCAGGGCACCTTTTGTCCCTGGAGACGCTCTGCCAGCCAGAAATGATGGAAGAATTGCATAGCCTGGACCCACGACGGCAGGAATTATTGGAGGCCAGGTTTACTGGAGTAGGTGTTAGTAAGGGACCACTTAATAGTGAGTCTTCCAACCAGAGCTTGTGCAGCGTCGGATCCTTGAGTGATAAAGAAGTAGAGACTCCCGAGAAAAAGCAGAATGACCAGCGAAATCGGAAAAGAAAAGCTGAACCATATGAAACTAGCCAAGGGAAAGGCACTCCTAGGGGACATAAAATTAGTGATTACTTTGAGTTTGCTGGGGGAAGCGCGCCAGGAACCAGCCCTGGCAGAAGTGTTCCACCAGTTGCACGATCCTCACCGCAACATTCCTTATCCAATCCCTTACCGCGACGAGTAGAACAGCCCCTCTATGGTTTAGATGGCAGTGCTGCAAAGGAGGCAACGGAGGAGCAGTCTGCTCTGCCAACCCTCATGTCAGTGATGCTAGCAAAACCTCGGCTTGACACAGAGCAGCTGGCGCAAAGGGGAGCTGGCCTCTGCTTCACTTTTGTTTCAGCTCAGCAAAACAGTCCCTCATCTACGGGATCTGGCAACACAGAGCATTCCTGCAGCTCCCAAAAACAGATCTCCATCCAGCACAGACAGACCCAGTCCGACCTCACAATAGAAAAAATATCTGCACTAGAAAACAGTAAGAATTCTGACTTAGAGAAGAAGGAGGGAAGAATAGATGATTTATTAAGAGCCAACTGTGATTTGAGACGGCAGATTGATGAACAGCAAAAGATGCTAGAGAAATACAAGGAACGATTAAATAGATGTGTGACAATGAGCAAGAAACTCCTTATAGAAAAGTCAAAACAAGAGAAGATGGCGTGTAGAGATAAGAGCATGCAAGACCGCTTGAGACTGGGCCACTTTACTACTGTCCGACACGGAGCCTCATTTACTGAACAGTGGACAGATGGTTATGCTTTTCAGAATCTTATCAAGCAACAGGAAAGGATAAATTCACAGAGGGAAGAGATAGAAAGACAACGGAAAATGTTAGCAAAGCGGAAACCTCCTGCCATGGGTCAGGCCCCTCCTGCAACCAATGAGCAGAAACAGCGGAAAAGCAAGACCAATGGAGCTGAAAATGAAACGTTAACGTTAGCAGAATACCATGAACAAGAAGAAATCTTCAAACTCAGATTAGGTCATCTTAAAAAGGAGGAAGCAGAGATCCAGGCAGAGCTGGAGAGACTAGAAAGGGTTAGAAATCTACATATCAGGGAACTAAAAAGGATACATAATGAAGATAATTCACAATTTAAAGATCATCCAACGCTAAATGACAGATATTTGTTGTTACATCTTTTGGGTAGAGGAGGTTTCAGTGAAGTTTACAAGGCATTTGATCTAACAGAGCAAAGATACGTAGCTGTGAAAATTCACCAGTTAAATAAAAACTGGAGAGATGAGAAAAAGGAGAATTACCACAAGCATGCATGTAGGGAATACCGGATTCATAAAGAGCTGGATCATCCCAGAATAGTTAAGCTGTATGATTACTTTTCACTGGATACTGACTCGTTTTGTACAGTATTAGAATACTGTGAGGGAAATGATCTGGACTTCTACCTGAAACAGCACAAATTAATGTCGGAGAAAGAGGCCCGGTCCATTATCATGCAGATTGTGAATGCTTTAAAGTACTTAAATGAAATAAAACCTCCCATCATACACTATGACCTCAAACCAGGTAATATTCTTTTAGTAAATGGTACAGCGTGTGGAGAGATAAAAATTACAGATTTTGGTCTTTCGAAGATCATGGATGATGATAGCTACAATTCAGTGGATGGCATGGAGCTAACATCACAAGGTGCTGGTACTTATTGGTATTTACCACCAGAGTGTTTTGTGGTTGGGAAAGAACCACCAAAGATCTCAAATAAAGTTGATGTGTGGTCGGTGGGTGTGATCTTCTATCAGTGTCTTTATGGAAGGAAGCCTTTTGGCCATAACCAGTCTCAGCAAGACATCCTACAAGAGAATACGATTCTTAAAGCTACTGAAGTGCAGTTCCCGCCAAAGCCAGTAGTAACACCTGAAGCAAAGGCGTTTATTCGACGATGCTTGGCCTACCGAAAGGAGGACCGCATTGATGTCCAGCAGCTGGCCTGTGATCCCTACTTGTTGCCTCACATCCGAAAGTCAGTCTCTACAAGTAGCCCTGCTGGAGCTGCTATTGCATCAACCTCTGGGGCGTCCAATAACAGTTCTTCTAATTGAGACTGACTCCAAGGCCACAAACTGTTCAACACACACAAAGTGGACAAATGGCGTTCAGCAGCGGGTTTGGAACATAGCGAATCCGAATGGATCTGATGAAACCTGTACCAGGTGCTTTTATTTTCTTGCTTTTTTCCCATCCATAGAGCATGACAGCATCGATTCTCATTGAGGAGAAACCTTGGGCAGCTCCGGCCAGGCCTTGTAGGAAAAGGCCCCGCCCGAGGTTCCAGCGTCAACGGCCACTGTGTGTGGCTGCTCTGAGTGAGGAAAAAATTAAAAAGAAAAACTGGTTCCATGTACTGTGAACTTGAAAACTTGCAGACTCAGGGGGGTCCCTGATGCAGTGCTTCAGATGAAGAATGTGGACTTGAAAATACAGACTGGGCTAGTCCAGTGTCTATATTTAAACTTGTTCTTTTCTTTTAATAAAGTTTAGGTAACATCTCCTGAAAAGCTTGTAGCACAAAGGCTCAGCTGGGGATGGTGTTTGACTTCGGAGGAAAAAAGTTGCTATTGCCCGTTAAAGGCACTAGAGTTAGTGTTTTATCCCTAAATAATTTCAATTTTTAAAAACATGCAGCTTCCCTCTCCCCTTTTTTATTTTTGAAAGAATACATTTGGTCATAAAGTGAAACCCGTATTAGCAAGTACGTGGCAATGTTCATTCCAATCAGATGCAGCTTTCTCCTCCGTCTGGTCTCCTGTTTGCAATTGCTTCCCTCATCTCAGTAGGGAAAAAATTGAGTGGGAGTACTGAGATGTGTGGGTTTTTGCCATTGGACAAAGAATGAGGTTAGAAGACTGCAGCTTGGAGTCTCTCTAGGTTTTCAACTATTTCTTCACAATTTGAACACTTGACGGTTGTCCCTTTTAATTTATTTGAAGTGCTATTTTTTTAAATAAAGGTTCATCTGTCCATGCAGTCCTCTTGGATTCTCTGAATGTAGTAACTATGAAGCTATGCCAAAGGTAGGCAGAAAATGGGCTTGGGAGCCAGACACTCCAGGGATCAGTAGTTCCTACCCATAGTCTTTGTGTGCTTGCTAAATGGTGTACATTTCTTGTTAACCACGTTATTAAAACTTGATCAGCACATAAGCTTTCTTCTGTTAGATCTTTTGGCAGCAAACAACCTTCCCCCCAAGCCTCTGAATTTtgtgggtgtgtggtggtgtgtgtctgtgtgtgCATGTACACACACACTTTGTCTAGCTCACTTTAAAAGATTCATCAAATGGAATTTTAAAAATAATCTGAAAAGAAATAGATATTTCAggccgggcctggtggttcacgcctgtaatcccagcactttgggaggccgaggtgggtggatcacgaggtcgggagttcgagatcagtctggtcaacatggtgaaacgccatctctactaaaaatataaaaattagcctggcgtggtggcgtgtgcctctagtcccagctacccgggaggctgaggcaggagaatttctggaacccaggaggcggaggttgcagtgagccgagatggcaccactgcaatccagcctaggcaacagaatgagactctgtctcagaaaaaaaaaaaaaaaaaaaaggagaaaTAGATGTTTCAAATATGAACATTCTTTTGGCACCAATTTTCTTTTTTAATTTGGTTGTTTCTGAGATGTATGATCAACTGAAGATGGAGCTGAAATGGGAGACGGGTGGCCCCACCGTGCCCTTGAAACAGCAGAGCACTCCTCAGTAGAGAGGGAGGGAGCCAAGAGCCTGAACATGTGGTCGCCAGCTTGGAATGTTACTGACATATGTGGCGAGGGCTTAGCCAGAAATATTTAAAGATGTAGTATTCCGGCCTGTGAGTTGTCTGGGCAGGGAGGGGGAGTCAGAAAGGGTAGAGAGCTCTCAAATAACTCATGACTCTAGTGTTCCTTTCACATGTGAACAGTGTCACTGATGACACATTTTCTAGGACCTTCGTTTGTTTTGTGGACCTGCCTCAGTCTCCTCAGTATCAGGCGATCTTAAGGGAAGATGGAGTGTTTCAAATTGGAGAGAAGTTCATGGGTAGGTATCGTCCTGTGGAATTCTGAATGCAAGGAAGTCAACCCCAGAGGCCTTGGTACCCCCAGCTTTCTAAAACTACTTTATTACAATTTAtatgtatatacacatgcacatataaacgtgtgcatttatgtatgtgtgtatagtaCCTTTTTTAAAAAAACATTTCCTCCAAGCTGCTAAGCAAAGGGTCTCACAGGTCGAGCACAGTGCTGAGAGGATGGTGTCTGCATAATGAAGACATGGATGAAGCTGAGACCGTGTTCAAACTCACTGAAAACAATGAAGTTCTATTCCTTTTTTCTTCCTCTCCAATGATCTTGCAGTTGATTTGTTTGTTTTTTAATTTTTTAACATTTTTTTAACGTTGAAAAAATGCTGCGTCTTTCTTTAAGCCTTCCCAGTAACTTCCTGCCTTTTTTTTCCCCGTGGGCTTTTAAGTGAAGCTGCAGGATTTTATCTTTCAATCTGCCCTTTCTACCCTTGTCCTATTGAAAGGATGCCCTCTTCCCTTGCTTTTTTGGTCTAGGGCCTGTTTGGAGCTAACTAGGCTTGGCTGAGTCCGGGCAAGACCTTCTTCCGAGGCATGGACAAGCCCCAGAGAACATGCAGAACATTGACCTTTCCATTGACTGTCTTTCAAGCAGCCAGTGAAATCACTAAGTGGGGTTCTTCCATGACATATTTTGTTAATATGGGTTTCACTTTTTCCAAGAATAGTCCCTTGTTGCCACAATGTTGATTTACTTTACACAATGACAGTATGTATTAATTTGTAATTAAACCCATCCAGATTGTTTTAGCCTTTTCCCAATGGGGTGGGGGAGGGAAGAAGGATATTAAAATAAGTTTTAAGAAGCAAA

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