Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name EIF2AP4
Plot displaying the genomic locations of a retrocopy (in chr10) and its respective parental gene (in chr3). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr10:44806769-44808026  UCSC
Coordinates (T2T) chr10:45687344-45688601  UCSC
Coordinates (hg19) chr10:45302217-45303474  UCSC
Strand +
Parental Sequence NM_032025.5
Parental seq. overlap 1057 bp
Parental seq. overlap (%) 27.2%
Genomic Region Intergenic
Retrocopy Summary EIF2AP4, located on chr10:44806769-44808026, is a retrocopy of the parental gene EIF2A. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name EIF2A
Full Name eukaryotic translation initiation factor 2A
Also known as CDA02|EIF-2A|MST089|MSTP004|MSTP089
Coordinate chr3:150546726-150586016
Strand +
Gene summary This gene encodes a eukaryotic translation initiation factor that catalyzes the formation of puromycin-sensitive 80 S preinitiation complexes and the poly(U)-directed synthesis of polyphenylalanine at low concentrations of Mg2+. This gene should not be confused with eIF2-alpha (EIF2S1, Gene ID: 1965), the alpha subunit of the eIF2 translation initiation complex. Although both of these proteins function in binding initiator tRNA to the 40 S ribosomal subunit, the encoded protein does so in a codon-dependent manner, whereas eIF2 complex requires GTP. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes EIF2AP1
Bonobo Pan paniscus EIF2AP1
Gorilla Gorilla gorilla EIF2AP1
Orangutan Pongo abelii EIF2AP1
Gibbon Nomascus leucogenys EIF2AP1
Green monkey Chlorocebus sabaeus EIF2AP1
Crab-eating macaque Macaca fascicularis EIF2AP1
Rhesus Macaca mulatta EIF2AP1
Baboon Papio anubis EIF2AP1
Golden snub-nosed monkey Rhinopithecus roxellana EIF2AP1
Marmoset Callithrix jacchus EIF2AP1
Horse Equus caballus EIF2AP1
Egyptian rousette Rousettus aegyptiacus EIF2AP1
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>EIF2AP4
CTTGAAGTCTTTCATCAAGGAAAAAATGTAAATTGGTATCCATCTGGTCAGATGATGAAACTGTTTTGTGTCCAAAATGTTAACAATAAAGTTCACTTCTTTGTAAACGATGATTTTATAAAATTGCAAGTAAATTGTCTTTGCAGAAAATTAATTGTGGGTTATCACTTGGACTCCAGTCACACAAGGGGGCTGTCTATGTTTCAGGGAGTGAGGGTGTACTTTCATTTGTTGTATTATACTCATACCCCAACTTTTTTGGACCTCATGCAGCTTTAGCCAACAGCAGTTTCTCTAAGCCGATGAGGTTACAACGCTGTGGAATGAAAAAGCCACTGCTGGCTTGTAATAGCGAGAACAGATGTTGACAAGAGAAGAACTTCCTGCTATGGGGAACAAAGGCTGCATTGCACTGCAACAAATGGAGAAAGTGCTGTCATTTGTTCAATTACTAAAACATAGCCCCATTTATGATATAATTTGGAATTCTGGTTCTACTGAGTTTTATGCTATTTATGGTTTTATGCCTGCCAAAGCTATGATTTTCAACTTGAAATGTGATCTTGTGTTTGACCTTGGAACTGGTGCTCTAAGGCAGCCTATTCGGTCCTTGTGGCCATATATTAATACTAACTGGATTTGGAAATCTGAGGAACAAACGTGAGTGTGGGATATTAAAAGCTACAAACTTATTTCCAAACAAGTATCCTCTGATCATACATATTTTGCTAGGTACCTAGATGGGAGCACCTTTTACTATCACACATGCTCCCAGGTTGTGTGTTAATAATGGATACAAGCTTTGACATTATACCAGCCCTATCCTGCATGAGTAAGATGTGTCACCAAATGTAGAAATATGGCAGGCTTCTTGGCAGACATTTCTGGATGAACTATTTCCAGCAAAAGCAGTAACTTATCAAGCAGTTCCAAGTGAAGTACCCAACTAGGAACCTAAATTTGCAATGACTGATAGACTCCCAGCTTTAAGAAATAAAACAATCACCAATTCTAAGCTGTATGAAGAGAAATCACCCCAGAATAAGAAATCCCAACCAGGAAATGATAAACCATTAACAAAAGCAGCCCTGAAAAATCAAAGGAAATATAAAGCTAAGAAAGCTACAAAGCAGGAAGTAAGAAGTGACAAGAGTCCAGATTTGACACCTACCCCTGTCCCCCAGAGCACACCCTGAAATACAGTGTCTCAGTTAACATCTGGAAACCCTGAGATAGATGAAAAATTCAAGAACCTAAA
>NM_032025.5
CTCTTTCCGGGACAACATGGCGCCGTCCACGCCGCTCTTGACAGTCCGAGGATCAGAAGGACTGTACATGGTGAATGGACCACCACATTTTACAGAAAGCACAGTGTTTCCAAGGGAATCTGGGAAGAATTGCAAAGTCTGTATCTTTAGTAAGGATGGGACCTTGTTTGCCTGGGGCAATGGAGAAAAAGTAAATATTATCAGTGTCACTAACAAGGGACTACTGCACTCCTTCGACCTCCTGAAGGCAGTTTGCCTTGAATTCTCACCCAAAAATACTGTCCTGGCAACGTGGCAGCCTTACACTACTTCTAAAGATGGCACAGCTGGGATACCCAACCTACAACTTTATGATGTGAAAACTGGGACATGTTTGAAATCTTTCATCCAGAAAAAAATGCAAAATTGGTGTCCATCCTGGTCAGAAGATGAAACTCTTTGTGCCCGCAATGTTAACAATGAAGTTCACTTCTTTGAAAACAACAATTTTAACACAATTGCAAATAAATTGCATTTGCAAAAAATTAATGATTTTGTATTATCACCTGGACCCCAACCATACAAGGTGGCTGTCTATGTTCCAGGAAGTAAAGGTGCACCTTCATTTGTTAGATTATATCAGTACCCCAACTTTGCTGGACCTCATGCAGCTTTAGCTAATAAAAGTTTCTTTAAGGCAGATAAAGTTACAATGCTGTGGAATAAAAAAGCTACTGCTGTGTTGGTAATAGCTAGCACAGATGTTGACAAGACAGGAGCTTCCTACTATGGAGAACAAACTCTACACTACATTGCAACAAATGGAGAAAGTGCTGTAGTGCAATTACCAAAAAATGGCCCCATTTATGATGTAGTTTGGAATTCTAGTTCTACTGAGTTTTGTGCTGTATATGGTTTTATGCCTGCCAAAGCGACAATTTTCAACTTGAAATGTGATCCTGTATTTGACTTTGGAACTGGTCCTCGTAATGCAGCCTACTATAGCCCTCATGGACATATATTAGTATTAGCTGGATTTGGAAATCTGAGGGGACAAATGGAAGTGTGGGATGTGAAAAACTACAAACTTATTTCTAAACCGGTGGCTTCTGATTCTACATATTTTGCTTGGTGCCCGGATGGTGAGCATATTTTAACAGCTACATGTGCTCCCAGGTTACGGGTTAATAATGGATACAAAATTTGGCATTATACTGGCTCTATCTTGCACAAGTATGATGTGCCATCAAATGCAGAATTATGGCAGGTTTCTTGGCAGCCATTTTTGGATGGAATATTTCCAGCAAAAACAATAACTTACCAAGCAGTTCCAAGTGAAGTACCCAATGAGGAACCTAAAGTTGCAACAGCTTATAGACCCCCAGCTTTAAGAAATAAACCAATCACCAATTCCAAATTGCATGAAGAGGAACCACCTCAGAATATGAAACCACAATCAGGAAACGATAAGCCATTATCAAAAACAGCTCTTAAAAATCAAAGGAAGCATGAAGCTAAGAAAGCTGCAAAGCAGGAAGCAAGAAGTGACAAGAGTCCAGATTTGGCACCTACTCCTGCCCCACAGAGCACACCACGAAACACTGTCTCTCAGTCAATTTCTGGGGACCCTGAGATAGACAAAAAAATCAAGAACCTAAAGAAGAAACTGAAAGCAATCGAACAACTGAAAGAACAAGCAGCAACTGGAAAACAGCTAGAAAAAAATCAGTTGGAGAAAATTCAGAAAGAAACAGCCCTTCTCCAGGAGCTGGAAGATTTGGAATTGGGTATTTAAAGATTCACGGAAAGCAAGTTGATGACCAGAAATCAGTGCAAACACATCTTCTGTTAAACCCATTGGTATACACAGAATATTCCTGTGCCCACACTTAATGTCAATCTATAATTTTAACCATTTATCCAAGATTCTACTAAGTGTAAAATTATTTAATAATGTCTATTAAATTGATATTTATATCTTGCATCCTATATCATGTCAATATGTGATATAGAAAAGAGATACGTGAATTTTTTAGCTAAGCTTGACAGATTGAAAGACAAGTGTCATTTTTTTTTGTAGAGGGTGATATATACCATGTAAATGAACAAAGACATTTTAAATTTAATCACTGTTTTTATTATAAGTTCCTTAGTTCAGATATCCTTTATTAATTTATAAGatgtgtaaaactacttaattctcacaagactctatgaagtaattcttttaatctctattttataaatgaaaaaactaaggccataaatttaagaaatttgtcagtgtctcaaagctaggaaatggccatctaatcccagagcctatgctttaggtcactatgatataTACTACTCCTGTATCCTCAAGTAATGTATCATTTAGTAACACTAAGCACCCTGCTTAGTTTTCATGGatactgccaaattgccctatctcaagctttatacttgcaccatttaaagttttccacactgttggcaatatcagaagtgataaggctttgaaatgttcgccactttgataaagaggaaatgattgtttgttactgttatatacatgtatttttatcagagatgggttatgtacttttccacgtttgatagttggttgtatttctttagtgaattgatttttcttttcctttgcccatttttctgtttggatgtttgactttcttcttaatttgtaagagTATCCTATGTAGTAACAAAATCCTTTTTTAAAAATTTTTAAAGAAAAAGTATACACACAGGACTTTTTTTTTTCTAATTCAAAAAATACAAAGGCATGCAATGAAAATTAAGTCTGTTCCACTACCACATTTTCCAGTTTTTTGTGTATCTTTCTAATGATAGATACCATATGAGTATTCAAATATACATACACATACACTTAAAAAAAAAAGATGGCATATACTAACTGTTCTGTTTGGGGCTTTTTGGTGGTGGTGTTTGTTTgacagggtctcactctgcctcccaggttggagtgcaccttgaactcctggactcaagtgatccttcacctcctccttccaagtatctgacactacaggcttgcatcactatgcccagctTATACTCACCATAGTGGTTCTGTACTCCCTTAAAATATTCTGGAggccaggcatgctggctcacacctgtaatcccagcaccttgggaggccaaggtgggtggatcacctgaggtcaggagttcaagaccagcctgatcaacatggtgaaaccccatctctactaaaaatacaaaagtatccaggcgtggtagcacatacctgtaatcccagctacttgggaggctgaggtaggaaaattgtttgaacccggcagacagaggttgcagtgagccgacatcgtgccattgcactccaagcctgggcaacaagagtgaaaccgtctcacacacacacaaaaaaaaaTATTTTGGAGCTCCTTCTATATGAGTCTCTCTCTCTTATCTCTCTCAGGATGTGTGTATGTGtttgtttctctggaaaaccctgactaatacagattagctatgtattaggtaaTACATAATGCCTAATACATAACTAATATATGGACAGGAAGTTAatagactgactgtgccaccttaaaactcgtatgttgaagccctaacctccaacgtggtggtattgggagatgggccttttggaaggtaagtgtgtttgaatgaggtgaagaggttggggacttcgtgatgggattattgtccttacaagaaaagacaccagagagcttgttctgtctctttgggccatgtgaagacatggtgagaaagcagccagctgtaagccagagagtcctcaccagaacctaaccatgctggtgatatcctcatctcagacttctaacctccagaactgtgagaaaataaacttctttgtttaaacca

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