Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name PGGT1BP1
Plot displaying the genomic locations of a retrocopy (in chr10) and its respective parental gene (in chr5). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr10:50721792-50727999  UCSC
Coordinates (T2T) chr10:51570366-51576574  UCSC
Coordinates (hg19) chr10:52481552-52487759  UCSC
Strand -
Parental Sequence XM_005272020.3
Parental seq. overlap 2753 bp
Parental seq. overlap (%) 20.3%
Genomic Region Intergenic
Retrocopy Summary PGGT1BP1, located on chr10:50721792-50727999, is a retrocopy of the parental gene PGGT1B. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name PGGT1B
Full Name protein geranylgeranyltransferase type I subunit beta
Also known as BGGI|GGTI
Coordinate chr5:115200247-115262887
Strand -
Gene summary Protein geranylgeranyltransferase type I (GGTase-I) transfers a geranylgeranyl group to the cysteine residue of candidate proteins containing a C-terminal CAAX motif in which 'A' is an aliphatic amino acid and 'X' is leucine (summarized by Zhang et al., 1994 [PubMed 8106351]). The enzyme is composed of a 48-kD alpha subunit (FNTA; MIM 134635) and a 43-kD beta subunit, encoded by the PGGT1B gene. The FNTA gene encodes the alpha subunit for both GGTase-I and the related enzyme farnesyltransferase.[supplied by OMIM, Mar 2010]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes PGGT1BP2
Bonobo Pan paniscus PGGT1BP1
Gorilla Gorilla gorilla PGGT1BP1
Orangutan Pongo abelii PGGT1BP1
Gibbon Nomascus leucogenys PGGT1BP1
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>PGGT1BP1
AAAAAATGCAAATATGACAGGAAATTTATAGTAATTAGTACAATCATCAGTAAAAGTAGGAAAAGGTGAAAATTAACCAAGTACCAAACACATGATTATAGTTTCTTTATAATGATCATAAAATTATTTTTGCAATTAAAACCTCTCTTCTACAACAGAAAGAGGTCTTAACAGTTTAACCAAGTCTATGAACTAGCTAATTATGAAGGAGATAGTATAAAAACTCTTCATTCGTAATTAATTTCCATTACTTGCTCAGTGACATTCAGAACTATGAGTCTAGTACTGAAATAGGGAAAGAAATCTCTTCACTAAAGGAGTTGGGTTTAAGTTAGTCTTGGTGATAATAAATGTTGAAATACAAACCTCAGTATAAAAACTAGATTACTGGTATCACTGTTTAGGAATTGTAATATTTTAAATGTTATCTTTTTTTCTAAATTAGAGAAAAAATGTTGTAAAATTACAGTCTTTCCCAAGGGAAACACTATGTACTTGGAGAAATGATTCATTTATTACTGGCATGCTTAGTTTTAAACCTGAGTTTGCCAAAGTCAACTGTATGTTTTTTAATTAGAAATAAAATAAATCTTCTGATGGTGGGGGAAAAAAATAAGCCTAATAACAGATATTATCCTTCTGTGGGTTATTCCAGTTGCTACTATTTAAATCCTGGCAGATTAAGACATCCATATCTCAAACTAAGTCATCTCTTAGACATTGGAAGTGGAAGTAGCATATACATAATGGCTTTAGGACTATATAAAAAGCCCAAATTCTTTTTTCTATATCATCAGGAAAGGTTAGAAGGTAATAAAGGTAGTAACAGTGACTGTATTCATGAATGTAAGTTAGAGAAAAATTCCAATCTAAAAGTATTTCAGAAGGCTAAATATTTTCTAACTCCTTATAATTTAATACCATAAAATTATAAATTTTAGTAAGCTTCTAATTGATATACTTGTGGGAGACTTTCTTGTGAAACTTCATGGACTAGTAAATGTTCACATTCCACAGCAACTTAATTGACCAGAAAATAGCAGGCCAGTGTGAAATGTGGAGAAACTATTTCTAACTTTTCTAACTAGTTATTTCCAAGAAAAATATTTACCGATTAAATAAATTATAAGCAATATTTCACATACATACTTTATTCCTTAGCAGGAGTGATATAATAAGGGGAAATATGAAGTCCGAAATCTCAAAAAGCTCTATTTCCTACTCCCTACTCGTCTCCTTCCCGTCCCCTAATTTTGTGGTATTTTTTTTTAGAAGGTAGGAGGAGGAGCTTTGTTTTGAGCATCTGCATACAAATAAGATTAATCAGATCATATGGCATAATTTAACCTGTTTATCATTTCAGTGTTCTTAGACTTGATCTATAATATATATGTGGTATTATATCTTTAAACATTTATATTTAATCTAAATTCATACAGAAATCTTGCTGACAGTAGTATATAATTTGAAAACTGTTGGACCTGATCATTTTTGAGAGACAGCTTTCTAGGAAGAAAACAATCTTTTTTATCTACAAGGAAAGATACTTTGTGTTTTTATTTTTAGCCATTTGAATTTTTTAATTTGTTGCCCCCAGTGTGTTAGCTGCTTTAATTTCAAACTAATACTTTTCTAATTTTTTTCAAATTAAATAAGTAAAAAAATGCAAAAACAGAACCATTCAAATAGATTCAGTGGTGCAACTCTATACATGGTCATTTTTATTCTCATATTCTCAGGTAAGTGAGAGGGAAATGTAAGCATTTAGAGGGTAAGAACCAGGCTGGATTTCTTGCGGGATCTGCACGTGCGATTTTTCCAGCGCTGCCTTGAGGATTTGCCGGAGCGCTATTCTTCACTCGAGACAAGCAGGTCCTTCCCACAGAAGGCAGATGAAATCTAAATCGCTGTGGTTTCCGAGGCTCTTCATACCTGGGTATTCCTTTCAATCCATCAAAGGCTCCTGGAACAGCTCATCCTTATGATAGTGGCCACATTGCAATGACCTACACTGGCCTTTCATGCTTAGTTATTCTTGGAGACGACTTAAGCCGAGTAAATAAAGAAGCTTGCTTAGCAGGCTTGAGAGCCCTTCAGCTGGAAGATGGGAGTTTTTGTGCAGTACCTGAAGGCAGTGAAAATGATATGCGATTTTTGTACTGTGCTTCCTGTATTTGCTATATGCTCAATAACCAGTCAGGCATGGATATGAAAAAAGCCATCTCCTATATTAAAAGAAGTATGTCCTATGACAATGGACTGGCACAGGGAGCTGGACTTGAATCTCATGGAGGATCTACTTTTTGTGGCATTGCCTCACTATGTCTGATGGGTAAACTAGAAGTTTTTTCAGAAAAAGAATTGAACACGATAAAGAGGTGGTGTATAATGGGGCAACAAAATAGTTATCATGGAAGACCTAATAAGCCTGTAGACACCCGTTATTCTTTTTGGGTGGGAGCAACTCTAAAGCTTCTAAAAATTTTCCAATACACTAACTTTGAGAAAAATAGAAATTCCATCTTATCAACTCAAGATCGCCTCGTAGGGGGATTTGCCAAGTGGCCAGTCATCCAGGTGCTTTGCATGCATACTTTGGGATCTGTGGCCTGTCACTAACAGAGGAAAGTAGAATTTGTAAAGTTCATCCTACTCTGAATGTAAGCACACGGACTTCTGAATGCCTTCTAGATCTCCATCAAAGTTGGAAAACCAAGGACTCTCAAACAATGCTCAGAGAATGTACATATCTCCACATAACTGATTTTAGATTGGGAGGGTGGGGGGATTTGTAGCATAACTGTAGCTCAAGTTTAAAAGCCATGTATAACCAAGTGTGCTCTTTTTTTAAAAGGTAGAGTCTTACAATCAAATCTCCTGCTGAGGTCACTTTGGGATATGGTCTTGAGCCAGTAATCTTTGTACTGGGTTTCAAGAAAATCTGTGTTGAAGTTTGAACCACAACTTTGTCATGGTTCTTAAATGTTTATACTGTATTTCTAAGAAGTTGTTTGAGGCAAATTAACTGTATGTGTGTAGGTTATCTTTTTAAAAACTCTTCAGTGCAAATTGTATCTTGTTATAAAATGGACACAAATCTTCAAAACAAATTTACCTTCATATAGCATTGATAATCCTCAGGTGAACACTTAGTAATCATTTAAAAAGCTCACTGCTGATGGTAGAAAATTTGCTTTAATGAATTAAGTATCTGGGATTATTCTTTGAAAACAGATGACCATAATTTTTTTAAAGAAGAGTGATTTATTTTGTCTTATTTTTAAGTAAAGTGTGCCAATTAAACCTCTGTGGCCTATATAAATGAAATTAATAACTTCATAGTAAGAATAAATAGGTTTAACTAATGTGATAGTTTTCTAAAAGGAGATTGTTTGAAGACAACTATTATGTAACTGAGGGAAAAGCAACTAACTATATGTGATTGTGAATGAGGAAGTTTTGTGCTATGTGGGTCATTTATTTAGACATTGCTGTGGTGAATACCAGTTATGTTTGATTTTATTCTCAAATCATTCGTTGCCGTCGAGGCGGACGTCGCTTCCGGAGCAGCATGGAAGCCAC
>XM_005272020.3
ATTCCGGGTCGCGGCGGACGTCGCTTCCGGAGCAGCATGGCGGCCACtgaggatgagaggctagcagggagcggtgagggagagcggCTGGATTTCTTACGGGATCGGCACGTGCGATTTTTCCAGCGCTGCCTCCAGGTTTTGCCGGAGCGCTATTCTTCACTCGAGACAAGCAGGTTGACAATTGCATTTTTTGCACTCTCCGGGCTGGATATGTTGGATTCCTTAGATGTGGTGAACAAAGATGATATAATAGAGTGGATTTATTCCCTGCAGGTCCTTCCCACAGAAGACAGATCAAATCTAAATCGCTGTGGTTTCCGAGGCTCTTCATACCTGGGTATTCCGTTCAATCCATCAAAGGCTCCTGGAACAGCTCATCCTTATGATAGTGGCCACATTGCAATGACCTACACTGGCCTCTCATGCTTAGTTATTCTTGGAGACGACTTAAGCCGAGTAAATAAAGAAGCTTGCTTAGCGGGCTTGAGAGCCCTTCAGCTGGAAGATGGGAGTTTTTGTGCAGTACCTGAAGGCAGTGAAAATGACATGCGATTTGTGTACTGTGCTTCCTGTATTTGCTATATGCTCAACAACTGGTCAGGCATGGATATGAAAAAAGCCATCACCTATATTAGAAGGAGTATGTCCTATGACAATGGACTGGCACAGGGAGCTGGACTTGAATCTCATGGAGGATCAACTTTTTGTGGCATTGCCTCACTATGTCTGATGGGTAAACTAGAAGAAGTTTTTTCAGAAAAAGAATTGAACAGGATAAAGAGGTGGTGTATAATGAGGCAACAAAATGGTTATCATGGAAGACCTAATAAGCCTGTAGACACCTGTTATTCTTTTTGGGTGGGAGCAACTCTGAAGCTTCTAAAAATTTTCCAATACACTAACTTTGAGAAAAATAGAAATTACATCTTATCAACTCAAGATCGCCTTGTAGGGGGATTTGCCAAGTGGCCAGACAGTCATCCAGATGCTTTGCATGCATACTTTGGGATCTGTGGCCTGTCACTAATGGAGGAAAGTGGAATTTGTAAAGTTCATCCTGCTCTGAATGTAAGCACACGGACTTCTGAACGCCTTCTAGATCTCCATCAAAGCTGGAAAACCAAGGACTCTAAACAATGCTCAGAGAATGTAGAGTCTTACAATCAAATCTCCTGCTGATTTCACTTTGGGATATGGTCTTGAGCCAGTAATCTTTATACTGGGTTTCAAGAAAATCTTTGTTGAAGTTTGAACCACAACTTTGTCGTGGTTCTTAAATGTTTATACTGTATTTCTAAGAAGTTGTTTGAGGCAAATTAACTGTATGTGTGTAGGTTATCTTTTTAAAAACTCTTCAGTGCAAATTGTATCTTATTATAAAATGGACACAAATTTTCAAGTTTACACTTCATATAGCATTGATAATCTTCAGGTGAACACTTAGTGATCATTTAAAAAGCTCACTGCTGATCGTAGAAAATTTGCTTTAATTAATTAAGTATCTGGGATTATTCTTTGAAAACAGATGACCATAATTTTTTTTAAAGAAGAGTGACTTATTTTGTCTTATTCTTAAGTAAAGTGTGCCAATTAAACCTGTGTGGCCTATATAAATGAAGTTAATAACTTCATAGTAAGAATAAATAGGTTTAACTAATGTGATAGTTTTCTAAAAGGAGATTGTTTGAAGACAACTATTATGTAACTGAGGGAAAAGCAACTTAACTGTATGTGATTGTGAATGAGAAAGTTTTGTGCTATGTGGGTCATTTATCTAGACATTGCTGTGGTGAATACCAGTTATGTTTGATTTTATTCTCAAATCATTAGTTGCCtttttttttttttttttttttttGCTTTCTAGGAAGAAAACAATCTTTTTTATCTAGAAGGAAAGATACTTTGTGTTTTCATTTTTAGCCATTTGAAGTTTTTAATTTATTGCCCCCAGTGTGTTAGCTGCTCTAATTTCAAACTAATACTTTTCTAATTTTTTTCAAATTAAATAAGTAAAAAATACAAAAACAGAACCATTCAAACAGATTCAGTGGTGTAACTCAATACATGGTCATTTTTATTCTCATATTTTCAGGTAAGTGAAAGGGAAATGCGACCATTTAGAGGGTAAGAAATAGGGTTTTGTTTTTGTTCATTGTTTTGTTTTAAGTCTATGAACTAGCTAATTATAAAGGAGGTAGTATAAAAACTCTTCATTAGTAATTAATTTATCAATAACTCATATCCGTTACTTGCTCAGTGACATTCAGAACTATTGCGTCTAGTACTGAAATGGGGAAAGAAATCTCTTCACTAAAGGAGTTGGCTTTAAGTTAGTCTTGGTGATAATAAATGTTGAAATACAAGTATCAGTATAAAAACTGGATTACTGGTATCACTGTTTAGGCATTGTAATACTTTAAATGTTATCTTTTTTTCTAAATCAGAGGGAAAAAAATGTTGTGAAATAACAGTCCTTCCCAAGGGAAACACTGTGTACTTGGAGAAATGATTGATTTATTATTGGCATGCTTAGTTTTAAACCTGAGTTTGCCAACTGTATGTTTTTTAATTAGAAATAAAATAAATCTTCTGATGGTGGGGGAAAAAGTAAGCTTAATAACAGATGTTATCCGTCTATGGGTTATTCCAGTTGCTACTATTTAAATCCTGGCAGATTAAGACATCCATATCTCAAACTAAGTCATCTCTTAGACATTGGAAGTTAAAGTAGCATATATATAATGGCTTTAGGACTATATAAAAAGCCCAAATTGTTTTTTCTGTATCACCAAGAAAGGTTAGAAGGCAATAAAGGTAGTAACAGTGATTTTATTCATAAATGTTAGAGAAAAATTCCAATCTAAAAGTATTTCATAAGGCTAAATATTTTCTAACTCCTGATAATTTAATACCATAAGATTATAAATTTTAGTATGCTTCTAATTGATACACTTGTGGGAGACTTTCTTGTGAAACTTTATGGACTAGTAAATGTTCACATTCCACAGCAACTGAATTGACCAGAAAATAGCAGCCCAGTGTGAATTGTGGAGAAACTATTTCTAACTTTTCTAAATAGTTATTTACAAGAAAAGCATTTATCGATTAAATAAATTATAAGCAATATTTCACATATACACTTTATTCCTTAACAGGAGCGATGTAATGAGGGAAAATACGAAGTCCGAAATCTCAAAAAGCTCTGTTACCTACTCTATACTTGTCTCCTTCCCGCCCCCTAATTTTGTGGCATTTTTTTTTTAGAAGGTAGGAGGAGGAGCTTTATTTTGAGCATCTGTGTACAAATGAGATTAATCAGATCATATGGCCTAATTTAACCTGtttatcatttcagtgtttttagatttgatctataatatatatgtgttattagatctttagttatttatatttaATCTAAATTCATATAGAAATCTTGCTGACAGTGGTATATAATTTGAAAACTGTTGGACCTGATCATTTTTgagagacagttaatgaggaggtgctctggaatcagatgacctgggtttaaatcccagatttgccagttcagcagcatgatcttggaccctaactctgccgtggataaaataagggtaaaacctaacacacagggtttaggattaaatgagataatacagataaagcacttaggatagtacctggaatacagcaaatttcaaATTATAGGTTCTTTATAATGATCATAAAATTATTTTTGTAATTAAAACCTCTCTTCTACAACAGAAAGAGGTCTTAACAGTTTAACCtcagggaaaatgatgacaacagtgttgttttctaatctccccataagaatacagagcaactaggatagccacagacactattacaacgctagatgacaaggtatctctatgaacttcaaaatacaactaagtgaggacaaaccactgaaccacatagtttcagtatctgtgggaggaagtagaaggaaggcagctggtttctgacagctctgcaaattggagaactacaacactgcccacagtttctcaactacaaagtgcagcgggccaatctaagaacagacactgaaactgggaagtgactacagaatctcatttgcagatgaatgttaaagcaatatgataaggtctgctgattgcattagagctgtctgggttttacgctgtgtacctcttgaagcttatgagacaaagcccagcactgaggacaaacttctagaattagaatccaaatgggcaggatgggtaaaataggacaaaggaaagaagatctagataagtattgggaagaaaggccaagacacagagacattatatatgtgtattttcatatatatatatattcttttaaatcactgtgaaaatgggagctctaaggctgtgaagtcatcctagagccactccttcctcctaaaagtacagaaaaactcatttcagttaaggggaaaaaaagagtaagtgagccaggattacagtccaactccagtcaaagttagtataagaaataagagaataaatagatcaacatcctcacagacaatgaaagcacaccggaaggacatgaccacaagacagataaaaacctaatatttgccaaaaAATAAAATGCAAATATGACAGGAAATTTATATTAATTAGTACAGTTATCAATAAAAGTAGGAAAAGGGGAAAATTAACCAAGTACCAAACACTTGGAGTAAaaagcaaaataaagcagaaggaaggaattaataaaagcaaaaaagaattactagtagaaaaccaaaacaatagaggcaataataaatccaagttggtgatgggtagtgcggggagttgagtcagataaactaccagctaacctatttaagaaaaaaaggaggaagcacaaatacaaaaatttaaatgacaagggggaaatagtaaaacaggaaatttgtttaaattgactattttgagcaattttacacaataaattcaaaaactattttgagaaaaatgcaaattgccaaaatttactctaggtagataaagtcacaacaaaccaattaccgtagaagaaacaaatagttaaaagtaccccttaccaaaagaagcatcaagcccagattgtttcaaggggatttctaccaaaccttttaagattaaataatcccattcttgcttaaacaattgcagagactaggaaaagaatcttgaacctcaaagtgccaaaaaaagaaaaaaaacaaataaagaaaaactcctgaattcattttataaaatgaatgtaatagcattgattcaaaaacctgacaaagatggtaccaaaaagaaaatatagagcaatctcatgaatattaataaaaagttttaatgataacattagcaaacaatccaacagcactttcaaaaggtaatcatgactaagttgggtttattgtaagaatgcaagggtagttcaatactagataatctgttactattcatattaagagttaaaaaatatcttcatctttgcagaaaagacatgatagaattgagcactcacttatgttaactatactaagtagaaattgatgaataatctattaacattgtacctctacctaaaagccagcatcttaaatttcaaagcaaaggagactttccagctgaagtcaggaacaagacatgcccactaactcctctgctacttaacaatgtgttgagagttatagccaatgaagttagacaaaataaagacgtgaattggaaaggaagaggtaaaactatttgcagatatgaatatgtatctagaaagcccaaaggaacttgttgaaaaactaaacaataaaagaacttagtaaagtagctattaaatacaatttacataaaaatatcaGTAGGCTTCAccagacacaagtgcatactttgattccatttcggtgaagttcaaaacagacagcatctatgtatggtgtcagaaatcagcaccctctttcagtcactacctctcttcccaaaggtaagtgctgtcaaaattaccatcaattagttttgtctgtttttgaattttatatgagtggaaccatatagtatacattatttttcaactggcttTAACTCAgtaggactgaaagagggtacaagggagactctgcggtgctggtaatgttctgtttcatgatctaggtgctggttacgtaggtgcattcaccttatgaatatttatcaagctgtatatgatttgtgcacttttctgtatgtataattatagctcagtaaaaatgtttactaaaaaGAGTAACAAGACtatatatatatatatatatatatatatgtatgtatatGCAAACCTAAACTAGTTAGAAGATACTTGAAGAGAAGACCACCTTTGTGATAGCAAAAGTaaaaagaaaacttaatgtgtaaatttaagacacatctaaaatctgtatgaggaaaactaaaaaaactcttgagaggcaaaaatgtagattccaccaaatggaaagatacatgatattcttagatagacaacatcaaaacatgtctttccccacttaggttcatttataaattcagtgccattccaataaaaatTATATTGTTATTTGAGAGAACATACTAGAATAACCATGGAAACTGAAAAGAATTAGAGGGGACCAGCCATATCCGACACTAAAACATACTCTAAATCCTCCATGGCAGAAGCtatcagaattttttaaagtgtgcacactttttggcccagatactctctatctatagatttagcataaagaaacatgcaaataggcaatgatacattttcaaggatctcacagccacatttttgtaattgtgaaaaataagacacaTTATGATACATTTATGTAACTCAATACTATGCAACTGTTAAAGTATGGATATTGGAAGGCATTCGTAATGTTGAATAAATGAAAagttttgtattggcacataaataggaagtccaatggaacagaagaggaattccagaaatagactcagtggcatttagaatacagtaaaggcagcatctcaagttagtgagaaaatgaacttttaagtaagtgctattgagattactggTGCTTAATTATTCAGATATTTACAATTTTAAAAAATATATAGCTTATTTCACTTTGAACCTTTTTTTAAAATGGTCATTTAGTTTTATAATTTAAAGAAAAATGATAGTTCTCTCCCCATCCCAGCCTATACTATACCCACAGCCTATACTTCCTGGAGGTAAACACCACTGTTGCATACATCTTTCAGACCTTTAATCTCTGTATATAGAGATATAGAAATAGAGAATATTCTTTAAATATCTGAACATTTAAGTATTACTCATCCCAATACAATatatacttatacaaatagatatatgtatgtatactatacataaagatctgaggtactaaatatTCCATGGTTTTTTTTCATTCAACAATGTATTATGAATGCCTTTCAATAGCCATACTTTAATAGTTGCATAGTATCACGTTGCATAAACATAttaggtcagtgcataagtaattgcactttttaccattttaatggcaaaTGAGGCACTGATTAATCAGTGCCTTatttttcacaactacaaaaatattgctgtgagatccttgaaaatgtataattgcccatttgcatgtttctttaaatttatagataaggaattactggggcaaaaagtgtgcacaatttaaatttgatgtttttgtttttgccaagctgctttttaagaaggttgtactaatgcacacttttatcTTGACACTAAGATTTTAAATATGATCAGAAAATGGGTTTCTGATAGTAAAACTGTCTACTTGTAATAATTGTGGCATTAGAAAAGACCTTTGTGGCTTCGTTCCTCAAActcatttacgaattataaatctgaattccaaatatgaattaactcacacaagataaagctttaacagttagtagcagtactgtaactagagtgcatgttttctgtctccAGAAATAACATTCTTTTTATGCCACATTTTTTTAACTGAGGTGATCATTCTCCACCCTCTTCTTTCCATGTTTTTCCATGTTTGTTCAAACTTTTCATTAAATATCTTGAGGCTCTAACTAAATTAAGGGTGGCCATTAAAATTGTATGTGGGATTCCCTGAACCAACTGGTAATGCACTACCAGCATATAAGGTGTCCTCATTAAAGCAGTTGGTGATTGGTACATGGGACCTCACTCATGTATGTTTGCATCTACTTGTGAGTCAAAAAGTTTTCTTAAAGTATAGGTGGGATCATGAAAGACATACAATTCACTGGAGAAATTGTGAAAAAGTAAAAGATTATGAATTTAGGCTCAAAGCCAATTTCCCTCTCATTTAATTCTACATGAGCAAGTCAAGGAGTTTGGTAGAGCTTTATGAAATCTCTAAAGATTGAAGGAAAACAATCACTAAAATCGATTTGATAAAGTGCAACTAAGTAGTATGCTAGCCTGTTAATGGATTTTCATCTTGTCATTTAAGTTTCAGCAATTGAGTACCACACTAGAACACCCACAAATGAGATTCTGTTACAGAGTATCTTTTTTCTACTACAGAACATACTGTAGACAGTTATTCAGTGGTTAACTTGTGGAAATAATCAGAAGATGCTTTTCACTTTTATGACTGGATATATTTTAATATTTATCATATTAAGAGAAACTTAGGTTACTTACAGCTCATAaacgttgctatgaacatcattcatttattcacttatttatttttatggtgttcctagaaagaatttcctggactaaaggatttatgctttaaaaatattggtagttactgccaagaattgccatccagaaacagtgtagccattcataaactcaacaacaaggtatgagagtgcctgtttcctcatatcctttgtgacaccggattttatcaagcttaaagttttttcattctaggtgggtgaaaatggtattccgttattgATAATGTGTGGAAATCAAGTTCTAATAAGTTTGGGGGGAGGTTAATTCTTTATATGTGCTGTATGAATTAATGCCAACTGTATGCCTTTGAGAGTGAAATCAGAATAATGTCTCTCCACTAAAGCAGGACTTAGAGcactagttttccaaatgttgtctacagatggaaacactagcatcacctgggtactcgttagaaagtgcagattctctggcggtaccttagacctcctgaattagaaactctgggggtagggttagacatttgtgttttaaacaagccctccaagtggtttcaatgcacattcaaagttgagaaccaATCACTGATAGAGAAAAAGCAGCTTGGGTAGAAACAGTTGATTATTTGCAAATTTATATTTTaaaaagataggattcttaacagtaagctctttataattcaacaatgtgatctttactcctacccccgaaaaactaatatgattttagTGTGTGGTAGCTGGATCGAAAACATAATAAATACTCAGATATGCAAAGAAAACGTTTTCTCAAATGGATTTCATTTTTATTTACCCATATCTTTGGCTATTAAGGGATGGGGGGAGGCTAAGGAAAAGGGCCATTTGAATGTGTTAGCTAACAATCTCAGTCTCTTCCGATTTCAGCAGTGTCTTTTTTTCCTGCTCCTTGCTGTCTGGGTATGTATGAGTCTTTGTGGGGCATGGGAGggtctctgttgcacactgctgctctggtctggtccctggactggtgcctactgaggtgtctgctgctagtgtggccttttgaggtgggttactgtttgcctctgatttcaattctgtggcctcttcactccggtcccaggcctctttctatccaacggatcttagtgactccatgtcGGTATCCTCTGCTCTCCCCCACTTCCCCTCCCCATGCACATTTGCTATCTGGCAAATGCAGAAACTCTTAGATCTTGTTTATGCCCgaacactgtctcctcttcctatagctacctcccttcccaccttaatgctacctggacactctggatagataagccaaaagtctgattcttttaggaccgcacacagccttttctaggctatgcctggagaagcaggtcacaaggccACcccacattaccatgtctaaattttaatttttaagttacaaataaaactagcaaattcttatgttctatatttttaggttggcaaatatatcttcataatgacaattgaaaaaatagcaaatcatatcaaataactgtgaatagcacaaattcaaaatttactgcattttccactctaggccatgatttGGCAGTGGCTGCTGCTGGGCTGGAGCAGAGTAGACAAAGGGAAGAGATTTCTCCCTGGCTTGTTGACTTGCCAGCCCTGGCTCCCTACAGTCACTGGGCATATCCACAAGATAAACATATGCTTTCTCTTCTTATAGAGGGAGCAGTGGTTTGGTCCCTTCTCTCCTGCTTAGTCTTCTCTGTCCACCTGCACCCTCTCCATCTGAGCACAGGCTTCTTTTTACTCCACCCAGCCCGACTCAGGCAATCTTCACTCAACAATATGTGCCCAGCCTCCAGCCCCCACCGACATCACCCTTTCGGGTGCTTTAAAGGAACTGGAAGTTAGAAGGCCAGGTTCCCATTTAGAAATCTTGGCCTTATAAAgttcccagcacactgctggcccttgtactcccatcccagaaccccttccatgctttgagagctcccttacatttgtgaaggaatcctaacccctttgtctgagctccatattacctccagctcccccaaactgctccttcatcataccttggacctaggggtccacatactttggcagcctaatcaaaaatgacccagggaagaagcccatgcaggttctgtaagtggactgagatagggaattccagtttctctggtatgtggggcagagtctagaaaggggCCCCACTGATTCCTTACCTTATGGACagaagcaccagaatggcatcctcttaagtgcaggagaccctcttgcccagatctaagggcagcactggcaggccaccagcctctatgttcttagtttccttcatgcctgtctagaCCTTGTTACTTCCACACATATCCTCTCCTTttcccatctttcatccttcccacactttccaggggtgggagtaggagaatttcccttcttcctttttctccatttcctgagttctctctactactgattttcattttaattggagtttaagaaacttaaaaaatcctttctcaagtgacaaagtctgactatgattcttgttttgctgcaaactcagaagctgcatatttcctcactttatccttgctgtaatattctaaacctcttaaggtaaatgaatgcctctgatggaatgggaaatgcagaggtaaaatgcacattcaaatttttcaaatttagtatcccTGCCAAattaatagaagtagggtagctaaaatgaagagggtgatgataccactgtcctctgcactgtccgggtaccacaataggttcaaggtgccacacattaaaaaggtcagagaagatcaggctttccaggagggcaaGGAGAAATAGACCATATTTTTCACAttcaaatatataaaggtctgttctctggaagaaggtttacattcagtggcaactttagaattcctgtttaggaggggcttaggggtggccatcagtaagaaagtgaagcttagagggcttgccatgaaggtgatttgcatataactgtacttcttatttattgtgtatttgaggtggcttttgagagagcaggtgaagattacaggTTAATCTTAATTGTACATCCTTCCATGGCCACACTTTGGCTTCATCAGTAACTGGACTTCTCAAAACGTTTAGCATGCACAACTAATAGTATTTGTTGAATAAAGGAATTAATAAATGAACTCATATTTAAGAACTATAAAGAACTTTCCAACTAGAGTTGCATGAGGCCGGAATGGGTAGCCACAGCAAGTTCTCCATtgctactgctgctgctgctgGAGAAGGTGAGGCTCATTCTGGAAATCAGGAAAAGAGCATGAAGACTGCAGGATTGACTCACTTTTGGTTTTGGCAGGGCAATGTTTTacacacacacacacacacacacacacacacacacacacacGATACAGCATCAACTCATTTCTCTTAAAAAAAAAAttatattgctcgttttaaagaaactgcatctgcagggaaaacaaatcatcctaatgataagggaagtttcctttttcaaaaagtctcagttcataaatggagaagcaataatggggttagaaaataactatctcacaaatgctaatagatttttaggctacaacaatcaatggatactgaaaccatcaggagaaaggttgatggagaacttaaaagtggaaggctcaagctgccaccacctgaatccactgatcaatgctgccatctctaaaagtgactcaagacattgcatgcctcctgctataatgcaatgtgaggtacacaaggtcatctataaaatatccttatcagaaagttgagactgaatctagtcagtctgatagatctaacatctagatcagggatgtccaatctttggcttgccagggccacattggaagaactgtcttggcccacacataaaatatactgatactaatgatagctgatgacctagaaaaaaaaatctcagtgttttaagaaagtttatgaatttgtgttgagccacattcaaagccatcctgggctgcatgcagctcgcaggctgtgggtttgacaaatttggtctagatctaataagtgaaatgggaacaagtaaaatgacaccatgaggaagcaatcagccatatcctaaaggcagatatgctaaagacaagtctggtttcttcaacgacttaatgacaaagaaatggaggggagtaaaggtagactgttctaaaaatgtaagagacacagcagtcaaatacaacatgttgactttgggtcctaatttgaaccaacttttgaaacacttttgagataattaagaaaatgtaaatatgacctagctattaggtattaaagaattgtttttaattgttagctgttatagtcatttctattatataagaaaattttctcatatttttagaaacattcagaatttggactggcatgatgtcatagctttacttcaaagactgtagtggaacttctacttccaaccaagatgaagtggcaggactggattttcctcccttgtaaaaaaaaaaaaaaaaaaagttaaaacctgg

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