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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name MYL6P3
Plot displaying the genomic locations of a retrocopy (in chr10) and its respective parental gene (in chr12). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr10:65169270-65169898  UCSC
Coordinates (T2T) chr10:66029044-66029672  UCSC
Coordinates (hg19) chr10:66929028-66929656  UCSC
Strand -
Parental Sequence NM_079423.4
Parental seq. overlap 550 bp
Parental seq. overlap (%) 82.5%
Genomic Region Intergenic
Retrocopy Summary MYL6P3, located on chr10:65169270-65169898, is a retrocopy of the parental gene MYL6. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name MYL6
Full Name myosin light chain 6
Also known as ESMLC|LC17|LC17-GI|LC17-NM|LC17A|LC17B|MLC-3|MLC1SM|MLC3NM|MLC3SM
Coordinate chr12:56158359-56161579
Strand +
Gene summary Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain that is expressed in smooth muscle and non-muscle tissues. Genomic sequences representing several pseudogenes have been described and two transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes MYL6P2
Bonobo Pan paniscus MYL6P2
Gorilla Gorilla gorilla MYL6P4
Orangutan Pongo abelii MYL6P1
Gibbon Nomascus leucogenys MYL6P2
Green monkey Chlorocebus sabaeus MYL6P5
Crab-eating macaque Macaca fascicularis MYL6P6
Rhesus Macaca mulatta MYL6P6
Baboon Papio anubis MYL6P5
Golden snub-nosed monkey Rhinopithecus roxellana MYL6P3
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>MYL6P3
GACGTGTGGCTTCACTGAGGACCACACTGCAGAGTTCAAGGAGGCCTTCCAGCTGTTTGACTGAACAGGTGATGGCAAGATCCTGTACAGCCAGCGTGGGGACATGATGAGGGCCCTGGGCCAGAAATTCACCAACACTGAGGTGCCCAAAGTCCTGGGGAGCTCCAAGATGAAATGAATGTGAAGGTGCTGAACTTTGAGCACTTTCTGCCCATGCTGCAGATGGTGGTGGCCAAAAACAAGGACCAGGGCATCTATGAGGATTATGTCAAAGGACTTAGGTGTTTGACAAGGAAGGAAATGGCACGGTCATGGGTGCTGAAATCTGGCATATTCTTGTCACACTGGGTGAGAAGATGACAGAGGAAGAAGTAGACATGCTAGGGGCAGGGCACGAGGATAACATTGGTTGTATTAACTAGGAAGAGCTCATCTGCATGGTGCCAAATGGCTGAGGACCTTCCCAGTTTCCCCAGAGCCCATGTTTTTCCCTGTGTTGGATTTTTTATCTGTCCTGAAGGTTCCCTAGACTCTCTTGTCATAGCACCTTTCCCATCTTGTCTCTCTTGGATGATTTTTGCCGTCGGCATTCACCAAATAAACTTGCTGTCTGTGCCCC
>NM_079423.4
GCCATTACTGCAGGAAAAGGTCCCGGAGAGCTGAGCAGTCAAGATGTGTGACTTCACCGAAGACCAGACCGCAGAGTTCAAGGAGGCCTTCCAGCTGTTTGACCGAACAGGTGATGGCAAGATCCTGTACAGCCAGTGTGGGGATGTGATGAGGGCCCTGGGCCAGAACCCTACCAACGCCGAGGTGCTCAAGGTCCTGGGGAACCCCAAGAGTGATGAGATGAATGTGAAGGTGCTGGACTTTGAGCACTTTCTGCCCATGCTGCAGACAGTGGCCAAGAACAAGGACCAGGGCACCTATGAGGATTATGTCGAAGGACTTCGGGTGTTTGACAAGGAAGGAAATGGCACCGTCATGGGTGCTGAAATCCGGCATGTTCTTGTCACACTGGGTGAGAAGATGACAGAGGAAGAAGTAGAGATGCTGGTGGCAGGGCATGAGGACAGCAATGGTTGTATCAACTATGAAGAGCTCGTCCGCATGGTGCTGAATGGCTGAGGACCTTCCCAGTCTCCCCAGAGTCCGTGCCTTTCCCTGTGTGAATTTTGTATCTAGCCTAAAGTTTCCCTAGGCTTTCTTGTCTCAGCAACTTTCCCATCTTGTCTCTCTTGGATGATGTTTGCCGTCAGCATTCACCAAATAAACTTGCTCTCTGGGCCCTC

Publications

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