Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name TIMM9P1
Plot displaying the genomic locations of a retrocopy (in chr10) and its respective parental gene (in chr14). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr10:74344283-74344961  UCSC
Coordinates (T2T) chr10:75215658-75216336  UCSC
Coordinates (hg19) chr10:76104041-76104719  UCSC
Strand -
Parental Sequence NM_012460.4
Parental seq. overlap 515 bp
Parental seq. overlap (%) 40.6%
Genomic Region Intragenic (ADK)
Retrocopy Summary TIMM9P1, located on chr10:74344283-74344961, is a retrocopy of the parental gene TIMM9. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name TIMM9
Full Name translocase of inner mitochondrial membrane 9
Also known as TIM9|TIM9A
Coordinate chr14:58408494-58427531
Strand -
Gene summary TIMM9 belongs to a family of evolutionarily conserved proteins that are organized in heterooligomeric complexes in the mitochondrial intermembrane space. These proteins mediate the import and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane.[supplied by OMIM, Apr 2004]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes TIMM9P1
Bonobo Pan paniscus TIMM9P1
Gorilla Gorilla gorilla TIMM9P1
Gibbon Nomascus leucogenys TIMM9P2
Crab-eating macaque Macaca fascicularis TIMM9P2
Rhesus Macaca mulatta TIMM9P2
Baboon Papio anubis TIMM9P2
Golden snub-nosed monkey Rhinopithecus roxellana TIMM9P1
Orangutan Pongo abelii Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>TIMM9P1
ATAAATGTACCAAAAGAATATGGGTGCACAAATACCAGAATCTGATCAGATTAAACAGTTGAAGGAATTTCTTGGGACTGACAATAAACTTGCAGAAATCTGCTTTTTGGACTGTGTTAAGACTGCACAACAGATGTAAAACCTGAAGAGACCAGCCTGTTCAGAACACTTTATGGAAATATTTTTAAATGACAAAAAGAATATCCATGAGACTTCAGGAATGTAATATTCAGCAGAATGAAGCTCTGGCAGCCAAAGCAGGACTACTTGGCCAACCATGATAGAGAAGTCCTAGATTGCCAACAGCTGCTGCACTGGAAATGAGTATGCATCTGATACAATCCCCTGAAAGCAGGTGCCACCTTGTTAAGTCATCTGTCATGAGTTTTTGGCAAGTGGAAACCACTGGAGAAACCAGTGATTATTCCTATTTACCGGGAATAATCAGAATAGAAGGTCTTATTGTTCAATGAAATAATAAGGTGCAACATTTGTTGAGGCCTTAAGATTCAGCAGCATAGACACCTGATTAGAAAAATAAGCCAGCCTTGTACTGACGTCAGATGTGAGAGCCTGTGCTTAGGTAAGAAATCACGTCt
>NM_012460.4
AAGGTAGCACATTGCCGCACAAGACCGCTCTACAGTCTCATCCAAGACTTGAAGAGCTCCCGACTTGTAATACTACTTGTGTTTACCAGGGACTGTTGACACTGCTTCGCTTCCGAAGACCGTTAGGGACGTGGGATTAGATTTCCTCGCGTTATAACGAATCGGCGTCTAAGGGTTTAAGTGTCACTTGACATTACTGCTCCCACGTGTTCTTTCCCATCTGGCGGCCGCGGCTCCTGTCCAGACCCTGACCCTCCCTCCCAAGGCTCAACCGTCCCCCAACAACCCCCAGCCTTGTACTGATGTCGGATGCGAGAGCCTGTGCTTAAgtaagaatcaggccttattggagacattcaagcaaaggttggacaactacttttccagaacagaaaggaaactcatgcatcagaaaagGTGACTAATAAAGGTACCAGAAGAATATGGCTGCACAAATACCAGAATCTGATCAGATAAAACAGTTTAAGGAATTTCTGGGGACCTACAATAAACTTACAGAGACCTGCTTTTTGGACTGTGTTAAAGACTTCACAACAAGAGAAGTAAAACCTGAAGAGACCACCTGTTCAGAACATTGCTTACAGAAATATTTAAAAATGACACAAAGAATATCCATGAGATTTCAGGAATATCATATTCAGCAGAATGAAGCCCTGGCAGCCAAAGCAGGACTCCTTGGCCAACCACGATAGAGAAGTCCTGATGGATGAACTTTTGATGAAAGATTGCCAACAGCTGCTTTATTGGAAATGAGGACTCATCTGATAGAATCCCCTGAAAGCAGTAGCCACCATGTTCAACCATCTGTCATGACTGTTTGGCAAATGGAAACCGCTGGAGAAACAAAATTGCTATTTACCAGGAATAATCACAATAGAAGGTCTTATTGTTCAGTGAAATAATAAGATGCAACATTTGTTGAGGCCTTATGATTCAGCAGCTTGGTCACTTGATTAGAAAAATAAACCATTGTTTCTTCAATTGTGACTGTTAATTTTAAAGCAACTTATGTGTTCGATCATGTATGAGATAGAAAAATTTTTATTACTCAAAGTAAAATAAATGGAAATATCACTGAGCAGTTGTTTATACTGTATGGTACCATAGTATTCTCACTGGACTGTGGATACGTTGAAATGTTTTTCAATCAGGATCATCCTCCAAGCAGTCCTGTTCATTCATGTCTGCCTCAAATTGCTGGTGAATACATAAAATAGTTACTTGCTAATCA

Publications

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