Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name RAB5CP1
Plot displaying the genomic locations of a retrocopy (in chr10) and its respective parental gene (in chr17). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr10:74422644-74423945  UCSC
Coordinates (T2T) chr10:75293969-75295270  UCSC
Coordinates (hg19) chr10:76182402-76183703  UCSC
Strand -
Parental Sequence NM_001252039.2
Parental seq. overlap 1131 bp
Parental seq. overlap (%) 60.8%
Genomic Region Intragenic (ADK)
Retrocopy Summary RAB5CP1, located on chr10:74422644-74423945, is a retrocopy of the parental gene RAB5C. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name RAB5C
Full Name RAB5C, member RAS oncogene family
Also known as L1880|RAB5CL|RAB5L|RABL
Coordinate chr17:42124979-42154989
Strand -
Gene summary Members of the Rab protein family are small GTPases of the Ras superfamily that are thought to ensure fidelity in the process of docking and/or fusion of vesicles with their correct acceptor compartment (Han et al., 1996 [PubMed 8646882]).[supplied by OMIM, Nov 2010]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes RAB5CP2
Bonobo Pan paniscus RAB5CP2
Gorilla Gorilla gorilla RAB5CP2
Orangutan Pongo abelii RAB5CP2
Gibbon Nomascus leucogenys RAB5CP2
Green monkey Chlorocebus sabaeus RAB5CP2
Crab-eating macaque Macaca fascicularis RAB5CP2
Rhesus Macaca mulatta RAB5CP2
Baboon Papio anubis RAB5CP2
Golden snub-nosed monkey Rhinopithecus roxellana RAB5CP2
Marmoset Callithrix jacchus RAB5CP3
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>RAB5CP1
CAAATCCAGCCTTGTCCTCCACTTTGTCAAGGGACAATTTCAAGAGTACCAGGAGAGCATAATCAGAGCAGCCTTCCTTACACAGACTGTCTGCTTAGACGACACAATAGTCAAGTTTGAGATCTGGGGCAGCGCTGGACAGGAGCGGTATCATAGCCCAGCCCCCATGTACTATGAAATCACCAAAAAAGATACATTTGCACCAGCCAAGAAATGGGTGAAGGAGCTAGAGAGGCAGGCCAGCCCCAACATTGTCACTGTACTTGTGGGTAACAAGGCAGACCTGGCCAGCAAGAAAGCCCCAGAATTCCACGAAGCACAGGACTATGCAGACGACGACAGTTGACTATGGAGACATCAGTAAAGACTGCAATGAACGTGAATGAAGTTTACACGGCGAGAGCTAAGAAGATTCCTAATAAGCCCCAGAGTGCACCTGGTGCTCCAGGCCAAAACTGAGGTACGGACCTCCAGAAGAACCACCCAGCCAGCAAGAGCCAGTGCTGCAGCAACTGAGCCCCTCTTGCCTGCCCACTGCAACTACTTCCTCTGCCTGAACGACTAGACTGGAATCCATTCTAACTAATCACACTCAGCAACTGGTGCCACCACTGGGGACAGAGGAAGGGGCCCACCATGATTTCTCCATATAATTTTGATCACAGGCCAGAGTGAGTTATTCCACCTGCATCTTTCTGTACAAATACTAATTCAATTTTAAGTCTTAGGTCACTTTTTAAATAATATTGATTTTCTGCTCTTCCCATTTCCTCCCCTTTCTATTGCTCTCCTACTTTTCCTTTGCTGGTAGCAGCCACATGCTTCTGTTCCCCTCACCCTTGTATATGAGGACGGCGTGTTTGGAGCAGCTACCCTTTCTTTCCCTCTTGCGGAACAGACTCAGCAAGAGCATCTACATCCATATCTTGTTTGGCGTGGTCTTGGGTTCAGGTGATGAGCAGCTAGGGAAGGGAGAGGTAGCTCTTCCTTCAGCTGGCTGTCATCAGGCTGCAGCCCCCTCCCCACTCCTAACTCCCAGCTGGGAAACCATAGAATTGCCACAGCATTATTGTGACAGCCATGAACCCATTGCTCACAACTCCTCCACCCTCAGTCACCCTGACCTCTGGCACTAAACCCTGTTCTGACTAAATCACAATGATGAGTACTGGGGAGCAGGTAGGTAAAGGGGGAGTGGGAAGGGATGGAACTGACTTTTTCTCTATTTTATATTGTATGTTTTCTTCAACATGTAACCTATCAGTATCTTGTCAATATAGTCAGCCCATTGATCAACCTCa
>NM_001252039.2
GGAAGTGGAGGCCGGAGCCTGGGACACCGCCGGCGGGGAGAGAAGCGGATCCCGTCCGAGCCCCGGCCCCAAGTAACGCCGCCGCCCCGGAGCCGCCAGGCTTCTAGAGATAGGCTCCTCATGTGTCTGCAATTCCAAAACTTAACAAAAACAAAAAGTTGAGCCTCTGAAGCTGTCACTAACCAAGTGATTCAGATGTCGGGACTGGAACACCAGCTGTTGGGGATGCAGGACTTGGTCTCTGCCCTCCCACACCTCCTGCCTCTTCTTTCTCTCCATCGCCCCATCTCTGCCAGTAGAGAATGGAACTGAGTTGGAGGTCCCCCTCCCCACTAAGTGCCTCTTTGCATAGCACCAGTCCCCACCCGCACGCTCTCTGGACCACTACAGCTGGACGGGCAATGGCGGGTCGGGGAGGCGCAGCACGACCCAATGGACCAGCTGCTGGGAACAAGATCTGTCAATTTAAGCTGGTTCTGCTGGGGGAGTCTGCGGTAGGCAAATCCAGCCTCGTCCTCCGCTTTGTCAAGGGACAGTTTCACGAGTACCAGGAGAGCACAATTGGAGCGGCCTTCCTCACACAGACTGTCTGCCTGGATGACACAACAGTCAAGTTTGAGATCTGGGACACAGCTGGACAGGAGCGGTATCACAGCCTGGCCCCCATGTACTATCGGGGGGCCCAGGCTGCCATCGTGGTCTATGACATCACCAACACAGATACATTTGCACGGGCCAAGAACTGGGTGAAGGAGCTACAGAGGCAGGCCAGCCCCAACATCGTCATTGCACTCGCGGGTAACAAGGCAGACCTGGCCAGCAAGAGAGCCGTGGAATTCCAGGAAGCACAAGCCTATGCAGACGACAACAGTTTGCTGTTCATGGAGACATCAGCAAAGACTGCAATGAACGTGAACGAAATCTTCATGGCAATAGCTAAGAAGCTTCCCAAGAACGAGCCCCAGAATGCAACTGGTGCTCCAGGCCGAAACCGAGGTGTGGACCTCCAGGAGAACAACCCAGCCAGCCGGAGCCAGTGCTGCAGCAACTGAGCCCCCCTTGCCTGCCCGCTGCCCCCGCCTCCTCCGCCTGAATGACCCGACTGGAATCCACTCTAACCAATCGCACTTAACGACTCGGGCCACCACTGGGGGGGCAGGGGGAGGGGTCCACCATGATTTCTCCATATAATTTTGATCATAGGCCGGAGTGAGTCATTCCACCTGCACCTTTCTGTACAAATACTAATTCAATTTTAAGTCTTAAGTCACTTTTTTAATATATATGATCTTCTGCTCTTCCCACTTCCTCCCCTTTCTACTGCTCTCCCATTTTCCCTTGCTGGGAGTAGCCACATGCTCTTGCCCCCCAACCCTTGTATATGGGGACAGTGGGGTCAGTGCAGCTACCCTTTCTTTCCCTCCTGCGGAACAGCGGACCCAGCAAGAGCATCCACATCCTCACTTTGTTCGGAGTGGTCTTTGGTTTGGGCGGTGGGGCAGACCTTGGGAAGGGGCTTAGGAAGGGAGAGGCAGCTCTTCCTTCAGCTGGCTCTCATCAGGCTGCAGCCCCCTCCCCGCTCCCACCTCCCTGCTGGGAAACCACAGCATTATCACAGCATTATTGTGACAGCCACGAACCCATTGCCCACAACCCCTCCACCCTCGGTCACCCCAACCTCTGGCTCTGAGCCCTGTTCTGACCAAATCATGATGATGAGTATTTGGGGGTGGGTGGGTAAGGGGGGGAGTGGGAGGGGACGGAACCAACTTTTTCTGTATTTTGTATTGTATGTTTTCTTCAACATGTAACCAATCAGTATCTTGTCAATATAGTCAGCCGATCGATCGACCTCA

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