Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name RPA2P2
Plot displaying the genomic locations of a retrocopy (in chr10) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr10:81136223-81137229  UCSC
Coordinates (T2T) chr10:82007674-82008680  UCSC
Coordinates (hg19) chr10:82895979-82896985  UCSC
Strand -
Parental Sequence NM_001297558.1
Parental seq. overlap 920 bp
Parental seq. overlap (%) 57%
Genomic Region Intergenic
Retrocopy Summary RPA2P2, located on chr10:81136223-81137229, is a retrocopy of the parental gene RPA2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name RPA2
Full Name replication protein A2
Also known as REPA2|RP-A p32|RP-A p34|RPA32
Coordinate chr1:27891524-27914797
Strand -
Gene summary This gene encodes a subunit of the heterotrimeric Replication Protein A (RPA) complex, which binds to single-stranded DNA (ssDNA), forming a nucleoprotein complex that plays an important role in DNA metabolism, being involved in DNA replication, repair, recombination, telomere maintenance, and co-ordinating the cellular response to DNA damage through activation of the ataxia telangiectasia and Rad3-related protein (ATR) kinase. The RPA complex protects single-stranded DNA from nucleases, prevents formation of secondary structures that would interfere with repair, and co-ordinates the recruitment and departure of different genome maintenance factors. The heterotrimeric complex has two different modes of ssDNA binding, a low-affinity and high-affinity mode, determined by which oligonucleotide/oligosaccharide-binding (OB) domains of the complex are utilized, and differing in the length of DNA bound. This subunit contains a single OB domain that participates in high-affinity DNA binding and also contains a winged helix domain at its carboxy terminus, which interacts with many genome maintenance protein. Post-translational modifications of the RPA complex also plays a role in co-ordinating different damage response pathways. [provided by RefSeq, Sep 2017]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes RPA2P1
Bonobo Pan paniscus RPA2P1
Gorilla Gorilla gorilla RPA2P1
Orangutan Pongo abelii RPA2P1
Gibbon Nomascus leucogenys RPA2P3
Marmoset Callithrix jacchus RPA2P3
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>RPA2P2
CGAGCCCAGCACATTGTACCCTGTACTATATCTAAGCTGCTTTCTGCCACTTTGATTGACGAAGTGTTTAAAATTGGGAATGTTGAGATTTCACAGGTCACTATTGTGGGGGATCATCCAACATACAGAGAAGGCTCCAACAAATATTGTTTACAAAATAGATGACATGACAACTGCACCTGTGGATGTTCGCCAGTGGGTTGACACAGATGACACCAGCAGTGAAAACACTGTCATTCCTCCAGAAAAATATGTCATTGTGGCAGGCGATTTGAGACCTCTTCAGGACAAAAAGAGCCTGGTACCCTTTAAAATCATGCCCCTGGAGGATATGAATGAGTTCACCGTACATATTCTGGAAGTGATCAATGTACACATGATACTAAGCAAAGCTAACAGGCAGCCCTCAGCAGGGAGAGCACCTATCAGCAATCCAGGAATGAGTGAAGCAGGGAAATTTGGTGGGAATAACTTCATGCCAGCAAAGGACCTACTGTGGCCCAAAACCAGGTGTTGAATTTGATTAAGCGTTGCCCAAGACCGAAAGAATTGAACTTTCAGGATCTCAAGAACCAGCTCAACCACATGTCTGTATCCTCAATCAAGCAAGCTGTGGATTTTCTGAGCAATGAGGGGCACATCTATTCTTCTGTAGATGATTATCATTTTAAATCCACAGATGCAGAATAACGGGATCTAATTGGGTACCTGAGCTATTTTACAGCTGGACCTAGTTTCACACTCTATTGTCTCCAGCTGTGCATATGTTTGGCGAGGTGGCTTCTAGGAAGTAGGTTTCATCTATATAAGGTGTCCACTGACATCCTTTTGAAACTTACTGCTCTTCTGTTTTATTTTGTTTTGATTGAAGCTCAGGGGGAGATGGGCAATTGACAGGGGTGAAATCCAAGGTGGAATTCCTTGAAGAAGTTACAAATTAGTCTGTTACAACATCAAAATAGATGGAATTGGAGGGATGCTTCCAGTAGGGTACTTAAATAATGCTT
>NM_001297558.1
GTTCTGATTGGTTGATTTCTTGCGATACCGCTCTGCCAGCCCCTTGCTTCCGCTAGTGCGGAGGGTTTTGCCCTTCGTAAAGATGGCCGCGGAGGCTTTTGGAGCCAACTGGGAGCGCAGTACGCGTTTTCTGGAGCATGGGCAGAGGAGACAGGAACAAGCGTAGCATCCGTGGATTCGAAAGCTATGGCAGCTCCTCATACGGGGGAGCCGGCGGCTACACGCAGTCCCCGGGGGGCTTTGGATCGCCCGCACCTTCTCAAGCCGAAAAGAAATCAAGAGCCCGAGCCCAGCACATTGTGCCCTGTACTATATCTCAGCTGCTTTCTGCCACTTTGGTTGATGAAGTGTTCAGAATTGGGAATGTTGAGATTTCACAGGTCACTATTGTGGGGATCATCAGACATGCAGAGAAGGCTCCAACCAACATTGTTTACAAAATAGATGACATGACAGCTGCACCCATGGACGTTCGCCAGTGGGTTGACACAGATGACACCAGCAGTGAAAACACTGTGGTTCCTCCAGAAACATATGTGAAAGTGGCAGGCCACCTGAGATCTTTTCAGAACAAAAAGAGCCTGGTAGCCTTTAAGATCATGCCCCTGGAGGATATGAATGAGTTCACCACACATATTCTGGAAGTGATCAATGCACACATGGTACTAAGCAAAGCCAACAGCCAGCCCTCAGCAGGGAGAGCACCTATCAGCAATCCAGGAATGAGTGAAGCAGGGAACTTTGGTGGGAATAGCTTCATGCCAGCAAATGGCCTCACTGTGGCCCAAAACCAGGTGTTGAATTTGATTAAGGCTTGTCCAAGACCTGAAGGGTTGAACTTTCAGGATCTCAAGAACCAGCTGAAACACATGTCTGTATCCTCAATCAAGCAAGCTGTGGATTTTCTGAGCAATGAGGGGCACATCTATTCTACTGTGGATGATGACCATTTTAAATCCACAGATGCAGAATAACTGGATCTAACTGGGTACCTGAGATATTTTACAGCTGGACCTAGTTTCACAATCTGTTGTCTCCAGCTCTGCATATGTCTGGCCAGGGGGCTTCTAGGAAGTAGGTTTCATCTATCAAATGTCTCCTCTGACTTCCTTTTGAAACTTACTGCTCTTCTGTTTTATTTTGTTTTGTTTGAAGCTCAGAGGGAGATGGGCAATTGACAGGGATGCAATCCAGGGTGGGATTTCTTGAGGAAGTTACAAATAAGCTTGTTACAACATCAAGATAGATGGAATTGGAAGGATGCTACCAGGAGAGTACTTACATAGTGCTCAGGAGTTTCTCTTCTTAAAATGTTTACTGCTGAAAGATGAGCAGGACCAGGGCGTTATAGGCAGAGCCCTAGCCGAGAAACCTGCTGGCCTCTGCCTGTTTTCATTTCCCACTTTGGTTGTGTGGCATTACTTTCAGAATTGCACTTTCCTGCTTGTCATGACTTTTTGACACACTTGCCATGACGTGTGTTTCTGTGAACATGAAGTTCTGCGGTAGTGCCTCCAGGGGCAGAGGAAAAGAAGAAGTGTTACTGCATTTTGTACAAAATAAATACAGTCATATGTTTAATAAAACAGTTCTATTGTAGTAACTTGTAAAAA

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