Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name CACYBPP1
Plot displaying the genomic locations of a retrocopy (in chr10) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr10:84454498-84456135  UCSC
Coordinates (T2T) chr10:85333016-85334657  UCSC
Coordinates (hg19) chr10:86214254-86215891  UCSC
Strand -
Parental Sequence NM_014412.3
Parental seq. overlap 574 bp
Parental seq. overlap (%) 18.1%
Genomic Region Intragenic (CCSER2)
Retrocopy Summary CACYBPP1, located on chr10:84454498-84456135, is a retrocopy of the parental gene CACYBP. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name CACYBP
Full Name calcyclin binding protein
Also known as GIG5|PNAS-107|S100A6BP|SIP
Coordinate chr1:174999435-175012027
Strand +
Gene summary The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes CACYBPP3
Bonobo Pan paniscus CACYBPP3
Gorilla Gorilla gorilla CACYBPP3
Orangutan Pongo abelii CACYBPP2
Gibbon Nomascus leucogenys CACYBPP1
Green monkey Chlorocebus sabaeus CACYBPP2
Crab-eating macaque Macaca fascicularis CACYBPP3
Rhesus Macaca mulatta CACYBPP3
Baboon Papio anubis CACYBPP3
Golden snub-nosed monkey Rhinopithecus roxellana CACYBPP3
Marmoset Callithrix jacchus CACYBPP4
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>CACYBPP1
AGTGCAAAGAAAAAGAGAAACCCTCCTATGATACTGAAACAGATGCTAGTGAGGGATTGATGAATATTCTAAAGAAAATATATGAAGAAGGAGATAATGATATGAACCAAACCATTAATAGAGCCTGGGTGTAATCAAGAGAGAAGCACATCAAAGGAGACAGAATTTTGAGACTTAGAAGTCCTTTTGGGAAGTGTATTGTGGAAATACAGATGTTGCCAATAAGGAAATACTGGTGAGCTGCATATATAAATTTGACATCTATTTAACAGCCTTCTTCTAAGTAAAAGCAATGAATTCTTCATTTCCTATGAGAGGATTTATTTAAATAAAATATGCTTATTAAACACTTTGGAAAACACAAGGTGGGAGGGATTACCTGGCTCAGGTTGAAAAAGACTGTTTGAGGGCTCTGCATGGCGTTTCCTGTTCTCTCCCCTGTGTGGCTGCAGCTCGGGTCTTTGGCCTGACCCAGCCCGATCTAGGCTTTGGAAGAGCTACAGAAACATCTAGAAGAAGCAAAGGTGTTGCTGGAGAAGGCTACTAGGAAAGGAGTACGTGATGCCCTTACAGGTGAAAAAATCCAAAATTGAGACAGAAATCCAGAACAAGATGCAACAGAAATCATAGAAGAAAGCAGAACTTCTTGATAATGAAAAGCCAGATGCTGTGGTTGCTCCCGTTACAATGGGATATACAGTGAAAACCAGTAATTATGGATGGGATCAGTCAGATAAGTCTGTGAAAATCTACATTACCTTAACTGGAGTTCATCAAGTTCCCTCTGAGAATGTGCAGGTGCATTTTACAGAGAGGTCATTTGATCTTTTGGTAAAGAATCTAAGTGGGAGGAGTTACTCCATGACTGTGAACAATCTCCTGAAACTCATTTCTGTGGAAGGCAGTTCAAAAAAGGTCAAGACTGATACAGTTCTTATTTTATGCa
>NM_014412.3
GGCGGGCTGTGCGTGCTCGCGGTGGGCGGTGGCGGCGGCTGCCTCGCGAAGGTTCGAGATCCGTCGCGTGCGGGAGGCGGGCCGCGATCTTGCGCAGGGTCGGTGTGGGCGCAGGCTGCAGCGCCGCGACTCGTGCGGGTAGGCGTCTGCGCTCGGTTTGAGGGCTCGGCGCGGGGTTTCCTGTTCCTCCTTCTGCGCGGCTGCAGCTCGGGACTTCGGCCTGACCCAGCCCCCATGGCTTCAGAAGAGCTACAGAAAGATCTAGAAGAGGTAAAGGTGTTGCTGGAAAAGGCTACTAGGAAAAGAGTACGTGATGCCCTTACAGCTGAAAAATCCAAGATTGAGACAGAAATCAAGAACAAGATGCAACAGAAATCACAGAAGAAAGCAGAACTTCTTGATAATGAAAAACCAGCTGCTGTGGTTGCTCCCATTACAACGGGCTATACGGTGAAAATCAGTAATTATGGATGGGATCAGTCAGATAAGTTTGTGAAAATCTACATTACCTTAACTGGAGTTCATCAAGTTCCCACTGAGAATGTGCAGGTGCATTTCACAGAGAGGTCATTTGATCTTTTGGTAAAGAATCTAAATGGGAAGAGTTACTCCATGATTGTGAACAATCTCTTGAAACCCATCTCTGTGGAAGGCAGTTCAAAAAAAGTCAAGACTGATACAGTTCTTATATTGTGTAGAAAGAAAGTGGAAAACACAAGGTGGGATTACCTGACCCAGGTTGAAAAGGAGTGCAAAGAAAAAGAGAAGCCCTCCTATGACACTGAAACAGATCCTAGTGAGGGATTGATGAATGTTCTAAAGAAAATTTATGAAGATGGAGACGATGATATGAAGCGAACCATTAATAAAGCCTGGGTGGAATCAAGAGAGAAGCAAGCCAAAGGAGACACGGAATTTTGAGACTTTAAAGTCGTTTTGGGAACTGTGATGTGATGTGGAAATACTGATGTTTCCAGTAAGGGAATATTGGTGAGCTGCATATATAAATTTGACAGATAGCTATTTACATAGCCTTCTAAGTAAAGGCAATGAATTCTCCATTTCCTACTGGAGGATTTATTTAAATAAAATATGCTTATTAAACACTCCTGCAAAGATGGTTTTATTAGTACCCTGGTCATTTTGTTCAAGGAAGGGTTATATTGCATTCTCACGTGAAATATAAAAAGCAAGTCTTGCCCAATAAAAACGCTACATTGTGTGTATTTTTTGTTCAGCTAAGAATTGGAAAAGTATTTGCTTGCCTTTTAAGTTACTGACATCAGCTTCCACCAGTGTAAAAATTGAGTAAAACCTGAAGTTTTGCATAAAATGCAAATCGGTGCCTGTGCTTGAAGGTTGCTGTAGAGCATCTGACCCCTTATTACCACCTTAAGCAATGTATATGCCATGCATTACCATGCACTAATTCAATCACAGGTGTTTCTATCTAGATTTAAATATATTTGTCAATGAATGTGGAATAGAAAATCTAAACATGACAATAATAGACATATCTTTGTATGGTACCAGTTAGTTTTGCCGTGGATCAGATGGTTTATAAAAGTAATAACCATAAAGCAAAAAATAATTTGAAAGCCCGTCTATTCCTATGCTCAATAAAGTTAAGTTTTTCTTCATTAGAACAGTTTTATGATTTATTTGTCTAGGAGTATGTCAGAAAAATCAGGCTTTTAGTAGGAATTACTCCTATTCCCCCTGAAGTCAGGACCAGTGCCTGTGATCTCCATTACTTTATTTTCCTGGAGGTATTAGCCAACACAGTTAGATCAGAGAAAGCAATTGAAgccaggcatgaaggctggcgcccgtaatcccagctactaaggctggaggatcacttcagcccaggagtttaaggctgcagtgagctatgatgatgccactgtactgcagcttgggtaacagattgagaacctgtctcattaaaaaaaaaaaaaaaaaaaAAGCCGTTAGACACACAGGAAAAATCCAGAAGGGTAAACTAAACTAAAGCTACAATTAATATGGGAATTTGGAAGAAGTGGTAGGATTTAAAATACAGAAACAGTTTATGTATAGGATAGCTATAAGTAAATACTGAAACACATTATGCCTCTGTAATTGGGGTTGACACATGAACAGAATAGCAGACACAATGCATATGAAAGTTACAGAATATGGTAAAAGTGGGGTAAAGATGGGTTTTTAATGATACTAAGATAACTGAAAATAGGCATATAGATATATTCCAAGCCGCCTGACGATCTAATTGTAAAAAGTAAAGCATACAAATACTAGAAGAAAATGGAGGAAAACGACATTATATGTGACTTAAAACCTAGAAGAAATAAATAAAACTATTGATCAATTTTAACTACATAAAAATGTTTATAGgacaagaaaaaccccaccataacccaaggcaaacaatgtattgacaggattccaataattaagaatacttcatacaaaaagaaatgtaaatgacctttaacatgtaaagatgctcaccttgttcagaagagaataaaccagtgtttttacctttcacttgaaaaagaagtataaaaacaactgtattgagttgaggctgtggagaaataaggacacatatatgggaatggaatgcaaaagttaaactttggttaacaagaatatttgggcaggtgcagtggctcacacctgtaatcccaacaccttgggaggccaaggtgggcggatcacttgaggtcaggagttcaagaccatctggccaacatggtgaaaccctgtctctactgaaaataaaaaaaactagctgggcatggtggcagatgcctgtaactccagctactcgggagactgaaggacaagaatcacttgaacc

Publications

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