Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name ACP1P3
Plot displaying the genomic locations of a retrocopy (in chr10) and its respective parental gene (in chr2). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr10:85708879-85709468  UCSC
Coordinates (T2T) chr10:86588986-86589575  UCSC
Coordinates (hg19) chr10:87468636-87469225  UCSC
Strand +
Parental Sequence NM_004300.4
Parental seq. overlap 500 bp
Parental seq. overlap (%) 33.6%
Genomic Region Intragenic (GRID1)
Retrocopy Summary ACP1P3, located on chr10:85708879-85709468, is a retrocopy of the parental gene ACP1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name ACP1
Full Name acid phosphatase 1
Also known as HAAP|LMW-PTP|LMWPTP
Coordinate chr2:264947-278283
Strand +
Gene summary The product of this gene belongs to the phosphotyrosine protein phosphatase family of proteins. It functions as an acid phosphatase and a protein tyrosine phosphatase by hydrolyzing protein tyrosine phosphate to protein tyrosine and orthophosphate. This enzyme also hydrolyzes orthophosphoric monoesters to alcohol and orthophosphate. This gene is genetically polymorphic, and three common alleles segregating at the corresponding locus give rise to six phenotypes. Each allele appears to encode at least two electrophoretically different isozymes, Bf and Bs, which are produced in allele-specific ratios. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Aug 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes ACP1P3
Bonobo Pan paniscus ACP1P3
Gorilla Gorilla gorilla ACP1P4
Orangutan Pongo abelii ACP1P3
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>ACP1P3
TTGCATGAAGAAGCATGGTATGCCCATGAATCACATGGCTCAGCAGATTATCAAAGAAGACTTTACCACATTTGATTATATACCATATATCAATGAAAGCAACTTGAGAGATTTGAATAGAAAATTTCCTCAAGTTAAAAACTGCAAAGCTAAAATTGAACTACTTGGGTGCTATGATTCACCAAAACAACTTGTTATTGAAAACCCCTGTTAAGGGAATGACCCTGACTTTGAGATGGTATACCAGCAATGTGTCAGGTGCTGCAGAGCATTCTTGGAAAAGGCCCACCGAGGCTGGGCTTATGCCCTGCTGCAGCCAACAGTGACAAGACCCCACCTGAGGTTCTGCATTTCTCAGTCAGTGTGCTAAAGTGCAATAATGTTCTACAGCTTGATACCCCAGCTCTTCCTTCAGTTGACTTACTGTTTCTTATCTTAAAAAATAATTGTAGATGGAAATCAGTTGTGTTTGGCTGAACAATAAATAAAAATATTTGATTCAGACAGTTTATGGGGTATATTAAGCATTCTTGGACTAGTTGAACCTTTCACTTTGGCCCAATTACAAGACTAGTGGAACATACAACATA
>NM_004300.4
GCCTCTGCGCGCGGGAAGATGGCGGAACAGGCTACCAAGTCCGTGCTGTTTGTGTGTCTGGGTAACATTTGTCGATCACCCATTGCAGAAGCAGTTTTCAGGAAACTTGTAACCGATCAAAACATCTCAGAGAATTGGAGGGTAGACAGCGCGGCAACTTCCGGGTATGAGATAGGGAACCCCCCTGACTACCGAGGGCAGAGCTGCATGAAGAGGCACGGCATTCCCATGAGCCACGTTGCCCGGCAGATTACCAAAGAAGATTTTGCCACATTTGATTATATACTATGTATGGATGAAAGCAATCTGAGAGATTTGAATAGAAAAAGTAATCAAGTTAAAACCTGCAAAGCTAAAATTGAACTACTTGGGAGCTATGATCCACAAAAACAACTTATTATTGAAGATCCCTATTATGGGAATGACTCTGACTTTGAGACGGTGTACCAGCAGTGTGTCAGGTGCTGCAGAGCGTTCTTGGAGAAGGCCCACTGAGGCAGGTTCGTGCCCTGCTGCGGCCAGCCTGACTAGACCCCACCCTGAGGTCCTGCATTTCTCAGTCGGTGTGTAATCACGTTCCAGGGCCCAAAGCCCAGCTCTTTGTTCAGTTGACTTACTGTTTCTTACCTTAAAAAGTAATTGTAGATGGAAATCAGTTGTGTTTGGCAGGAGAATCAATAAAAATCTTTGATTCAGACAGCTTATGGGGTATTTTAAGCATTCTTAGACTAGTTGAACATCTCACTTTGCCCCAGTTACAAAAATAGTAGAACAAGCAACATAAAACAATGAAGGAAAACCTCACTTGAAGGCCCAGGTCAACATCTAAGCCTGTTGAGACTTAGATAATCGAGTCTACCTCTTCAGTAGGTTTGTGTGGATGGCCTGGAGGGCAGGTGCCCTCTGCTCCCCAGTGCTACCTCTCTCTTCCCTAGGGCCTTTTGTGGATTGACAGTAGTCCCCTCCGTAGGAGCTCACAGTCTAGATTAGAAGTGTTTTAATTTCTACACACCCATAGTGCACACTTGTATATTGAAAAGATAGGGAAGAGAGAAACATTTATGGAATCAGTCGTTGGCACCTTCAATACTTCATGATTTTTGTCGAGTTTACTTCATGAGGAGGTCAGCCCATTGGCTCCCATCTGAACCACTTTGCCTCTGAAACTTAATTACATCCAGAAAGAAGGACACTTGTATGCTAGTCTATGGTCAGTTGAGGAATATGACTGTTTTTATATGCACATGTAACCCAAATGTCCAATATAAATTGGCTTATTTTTTAAAATAATTTTAAAAGTTGGGAAAAGTGTTATTATTTGGCATGCTTAAATATTGAATAAGTATTCTTCATCAGCATTTAATAAATGTATAGGCAGATGTAAGGTAATTTCTGTGTATTTTGAGATAATGTCAAAATCATGAATATTTCAAAATAAACTGGGGAGTTATAAAAATACAACTAGAGATATAAA

Publications

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