Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name NHP2P1
Plot displaying the genomic locations of a retrocopy (in chr10) and its respective parental gene (in chr5). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr10:92216297-92217043  UCSC
Coordinates (T2T) chr10:93098678-93099424  UCSC
Coordinates (hg19) chr10:93976054-93976800  UCSC
Strand +
Parental Sequence NM_017838.4
Parental seq. overlap 728 bp
Parental seq. overlap (%) 93.3%
Genomic Region Intragenic (CPEB3)
Retrocopy Summary NHP2P1, located on chr10:92216297-92217043, is a retrocopy of the parental gene NHP2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name NHP2
Full Name NHP2 ribonucleoprotein
Also known as DKCB2|NHP2P|NOLA2
Coordinate chr5:178149463-178153885
Strand -
Gene summary This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the DKC1, NOLA1 and NOLA3 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. The four H/ACA snoRNP proteins are also components of the telomerase complex. This gene encodes a protein related to Saccharomyces cerevisiae Nhp2p. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes NHP2P2
Bonobo Pan paniscus NHP2P2
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>NHP2P1
AGCCTCCCTGGGACTAGGTTTCAGCGGCCGCTGCGATGACCAAAATAAAGGCAGATCCCGAAGGGCCCGAGGCTCAGGCGGAGGTGTGTTCCGGGGAGCGCACCTACCAGGAGCTGCTGGTCAACCAGAACCCCATCGCGCAGCTCCTGGCTTCTCGCCGCCTCAAGCGGAAGCTCTACAAATGCATTAAGAAAGCGGTGAAGCAGAAGCAGATTCGGCGCGGGGTGAAAGAGGTTCAGAAATTTGTCAACAAAGGAGAAAAAGGGATCATGGTTTTGGCAGGAGACACACTGCCCATTGAGGTATACTGCCATCTCCCAGTTAGGTGTGAGGACCGAAATCTGCCCTATGTCTATATCCCCTCTAAGACGGACCTGGGTGCAGCCACAGGCTCCAAGCGCCCCACCTGTGTGATAATGGTCAAGCCCCACGAGGAGTACCAGGAGGCTTACGACGAGTGCCTGGAGGAGGTGCAGTCCCTGCCCCTACCCCTATGAGGAGCTCCGGTAGCACCTGGGCACCTGCCGCTGGAAGCTACTGGGCTGACGGCAGGACGACTGGCTGTCCTCCTGCCCACCCACACTGACGGCATCTTCCCAGTTCCCCAAGGCACGCCTTCTTACCAGGCAGCTCTAACAGCCCTTTCATGAAGGTAATGCTAGTCTTCTGTCCATCAGTGCCATTTCCTGTAGAACTAAAGGCTGTTCCAAGAATGTAGGGTGGAGAAAGTAAATGCTAAGACTAAAA
>NM_017838.4
AAGTGATGCCTAAAGCTGTGGACCGCGTGGGCTCGCCTCCCTGGGACTAGGTTTCAGCGGCCGCTGCGATGACCAAAATAAAGGCAGATCCCGACGGGCCCGAGGCTCAGGCGGAGGCGTGTTCCGGGGAGCGCACCTACCAGGAGCTGCTGGTCAACCAGAACCCCATCGCGCAGCCCCTGGCTTCTCGCCGCCTCACGCGGAAGCTCTACAAATGCATCAAGAAAGCGGTGAAGCAGAAGCAGATTCGGCGCGGGGTGAAAGAGGTTCAGAAATTTGTCAACAAAGGAGAAAAAGGGATCATGGTTTTGGCAGGAGACACACTGCCCATTGAGGTATACTGCCATCTCCCAGTCATGTGTGAGGACCGAAATTTGCCCTATGTCTATATCCCCTCTAAGACGGACCTGGGTGCAGCCGCAGGCTCCAAGCGCCCCACCTGTGTGATAATGGTCAAGCCCCATGAGGAGTACCAGGAGGCTTACGATGAGTGCCTGGAGGAGGTGCAGTCCCTGCCCCTACCCCTATGAGGGGCTCCGGTAGCACCTGGGCACCTGCCGCTGGAAGCTATTGGGCTGGCAGCAGGACGACTGGCTGTCCTCCTGCCCACCCACACTGACGGCATCTTCCCAGTTCCCCAAGGCACGCCTTCTTCCCAGGCAGCTCTAACAGCCCTTTCATGAAGGTAATGCTAGTCTTCTGTCCATCAGTGCCATTTCCTGTAGAACTAAAGGCTGTTCCAAGAATGTGGGGTGGGGAAAGTAAATGCTAAGACTAAAA

Publications

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