Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name PLS1P1
Plot displaying the genomic locations of a retrocopy (in chr11) and its respective parental gene (in chr3). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr11:101765346-101769697  UCSC
Coordinates (T2T) chr11:101766449-101770800  UCSC
Coordinates (hg19) chr11:101636077-101640428  UCSC
Strand -
Parental Sequence NM_002670.3
Parental seq. overlap 1522 bp
Parental seq. overlap (%) 39.6%
Genomic Region Intergenic
Retrocopy Summary PLS1P1, located on chr11:101765346-101769697, is a retrocopy of the parental gene PLS1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name PLS1
Full Name plastin 1
Also known as DFNA76
Coordinate chr3:142596393-142713664
Strand +
Gene summary Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. The protein encoded by this gene is a third distinct plastin isoform, which is specifically expressed at high levels in the small intestine. Alternatively spliced transcript variants varying in the 5' UTR, but encoding the same protein, have been found for this gene. A pseudogene of this gene is found on chromosome 11.[provided by RefSeq, Feb 2010]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes PLS1P1
Bonobo Pan paniscus PLS1P1
Gorilla Gorilla gorilla PLS1P1
Orangutan Pongo abelii PLS1P1
Gibbon Nomascus leucogenys PLS1P1
Green monkey Chlorocebus sabaeus PLS1P1
Crab-eating macaque Macaca fascicularis PLS1P1
Rhesus Macaca mulatta PLS1P1
Baboon Papio anubis PLS1P1
Golden snub-nosed monkey Rhinopithecus roxellana PLS1P1
Marmoset Callithrix jacchus PLS1P2
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>PLS1P1
TGAATCATCATCTGGCTGATGCAGGATGGTGTACCATCAACAACTTCAGCCAAGGCAGTAAGGATTCAAGAGCCTATTTTCATCTGCTTACACAAATTGACCCTAAAGGTGACTGGGAATATGGACTTTTCAGTCCATCTTCAGGATTTCATAAGAAAAATGATTTGAAGTGTGCTGGACTTATGCTTCAAGAAGTAGATAAACTTGGCTGCAGTTTGTTACTCCTGCAGATGTGGTTTCAGGCCATCCTAAACTTAATTTAGCTTTCATAGTTAATCTGTTTAATATCTATCCATGCCTACACAAGTTAGATAATAATGACATCAATATAAACTTATTGGAGGGAGAGAGCAAAGAAGAGAGGACATTTCAGAACTGGTGCATTCCTTAGGAATCAACCCATATATTAATCATTTGTAGTTACCTTGCAGATGCTTTAGCAATCTTTCAGCTCTATGATACAATCTGAGTGTCAGTCAACTGGAGCCATGTCAACAAACCTCCTTATCCTGCCCTTGGAGGGAACATAAACATTGATAACTAACTATACAGTGGAACTTGGGAAGAATAAGGCCAAATTCTTCTTCGTTGGCATTGCTGGGCAGGACCTAAATGAAGGGAATTCAACATTTATTCTGGCATTGGTTATGGCAGCTGATGAGAGGGTACACACTGAATATGAACAAAACCAAATTCTCCTTCGTTGGCATTGCTTGGCAGGACCTAAATGAAGAGAATTCAACATTTATTCTGGCATTGGTTATGGCAGCTGATGAGAAGGTACACATTGAATATGTTATCAGATCTTGGAAAGGTTGAAAGTGCACTTTTAAAAGTACAAATAAAAATACTTTTATTTCCAGCTTCAAGATATGCCACTTCAGTTGGTTGTGAGATCAGTGCCCAGATATATGCATTGCGTGTTGACCTTGTGGAAGCGAAACCAAAAATGGTTATGTCAGTGTTTTCTTGTTTAATGGGAAAAGGACTGAACAGAATAAAATAATGAAACATTTAATATTTTTTTCTGCCACATTAAATACATTGGACGCCCCACAGTTTAAACAATTTTGAAATGCAGTGGGTATACAACTAGGGATTATTTGTGTGTTCAAAATAGTTATATATTCATTAATGAATTCAATATCCTGTTCATACTAGTTAGAACGTGTCAACCTTTTTGGATAACAGTTAATTCACCAATTGATACTGATAATAAAATATGTTCATTATCAAGCTCATACTTGATGATTAAATTATTTCTGTTTCTTGAAAATCTTATTAAAACAAGACAAATTCATTCTATTTCATGGTTCAAAAAGATGAACACAAAAAAGATTTTACAGGTTCTGCTGCAAAATATGTTTTGATTTTTTTGTTTTACATAATTTTGATCATAAATGCATTTGAACTCATAATTGAGTTTAATCCTTTTATTTTCTTTCTCCAGCTATGTAAAGTGGTCTAAAAACACTTTTCTGTAAGTTTCTATATTGTCTAAAACCTTGAAGTGACATGTATTATTCATTAATAGGAAACTTTTTTATATATGAGGACTAATTATTTAATACACTTCAAAATTCACTCTTTAGACCCAAAGTCTGTCTCGACCATTAGTTGTACAGTGGTCAACATCAGTGCACAGAATCTCAAAGAAGGAAAACCTCACTTGGTCTTAGGACTTCTCTGGCAGATCATCTAAGTTGGTCTTTTTGATGATATTGAGATTTCAAGCATCTTATACCCATGAACCTCAATGATGGCAGTATCTTCAAGTTACTTGCAGATCTCATCCTTCTTTGCAAAATGATCAATTTATTTGAACCAGATACAACTGATGAAAGAGCCATTAATAAAAAGCTCGCCGCTTTCACTCTTTCTGAAAATTTAAACCTAGTt
>NM_002670.3
AGTGTGGAATTGCTTCTTTTCTTTGGTCAAACACTAACTTTGGCAGAGGATAGACACAGCTTAGGAAGACTGAATTTTAAGTCTTCTGAATTGTTTTTCTGGACTTCCAAATCTCAAGTGATAAGACCAGCAGAAGCAGATATAAAGACCTGAAGATAGTCTTTTCTGTCCAAAGATGGAAAACAGTACTACTACCATTTCTCGGGAGGAGCTTGAAGAACTACAAGAGGCATTTAATAAAATAGATATTGACAATAGTGGGTATGTCAGTGACTATGAACTTCAAGACCTGTTTAAGGAAGCAAGCCTTCCTCTGCCTGGCTACAAGGTGCGCGAGATTGTGGAGAAAATTCTATCAGTTGCTGACAGCAACAAAGATGGCAAAATCAGTTTTGAAGAGTTTGTGTCACTAATGCAAGAATTAAAAAGCAAAGATATCAGCAAAACATTCCGAAAAATAATTAACAAGAGGGAAGGGATTACTGCTATTGGAGGAACTTCAACTATTTCCAGTGAGGGCACACAGCATTCTTATTCAGAGGAAGAAAAAGTGGCTTTTGTTAACTGGATAAACAAAGCCCTGGAGAATGACCCTGACTGTAAGCATCTTATACCCATGAATCCCAATGATGATAGTCTTTTCAAGTCACTTGCAGATGGCATCCTTCTTTGCAAAATGATCAACTTATCTGAACCAGATACAATTGATGAAAGAGCCATCAATAAGAAAAAGCTCACGCCATTCACTATTTCTgaaaatttaaacctagctctgaattctgcctcagccattggttgtacagtggtcaacattggtgcatcagatctcaaagaaggaaaaccTCACTTGGTCTTGGGACTTCTCTGGCAGATCATCAAAGTTGGCCTTTTTGCTGATATTGAGATTTCCAGGAATGAAGCTCTGATTGCATTGTTAAATGAAGGTGAGGAACTAGAGGAGCTGATGAAGCTTTCTCCCGAGGAATTACTGCTGCGATGGGTGAACTACCATCTGACCAATGCAGGATGGCATACCATCAGCAACTTCAGCCAAGACATTAAGGACTCGAGAGCCTATTTTCATCTGCTTAATCAGATTGCCCCTAAAGGTGGGGAAGATGGACCTGCCATTGCCATTGACCTTTCAGGAATTAATGAGACAAATGACCTGAAGCGTGCTGGACTCATGCTTCAAGAAGCAGATAAACTGGGCTGCAAACAGTTTGTTACTCCTGCAGATGTGGTTTCAGGCAATCCTAAACTTAATTTAGCTTTTGTAGCTAATTTGTTTAACACATACCCGTGCCTGCACAAGCCGAATAATAATGACATCGATATGAATTTACTGGAAGGAGAGAGCAAGGAAGAGAGAACATTTCGGAACTGGATGAATTCCTTGGGAGTCAACCCATACATTAATCATTTGTACAGTGACCTTGCAGATGCTTTAGTGATCTTTCAGCTCTATGAGATGATCCGAGTGCCAGTCAACTGGAGCCATGTCAACAAACCTCCTTATCCTGCCCTTGGAGGGAACATGAAGAAGATTGAAAACTGTAACTATGCAGTGGAACTTGGGAAGAACAAGGCCAAATTCTCCTTGGTTGGCATTGCTGGGCAGGACCTAAATGAAGGGAATTCAACACTTACCCTGGCATTGGTATGGCAGCTGATGAGAAGGTACACATTGAATGTGTTATCGGATCTTGGAGAGGGTGAAAAAGTAAATGATGAAATTATAATTAAATGGGTCAATCAGACTCTTAAAAGTGCAAACAAAAAGACTTCTATTTCCAGCTTCAAGGATAAATCTATAAGCACAAGTTTACCTGTCCTAGATTTAATAGATGCCATTGCACCAAATGCAGTTCGTCAAGAAATGATCAGGAGAGAAAACTTATCTGATGAGGACAAGCTGAACAATGCTAAATACGCCATTTCAGTTGCTCGAAAGATCGGTGCCCGGATATATGCATTACCTGATGACCTCGTAGAAGTGAAACCAAAGATGGTTATGACGGTGTTTGCATGCTTAATGGGAAAAGGACTGAACAGAATAAAATAATCATTTCATATGATTTTCTGCCACATTAAACATATTGTATGCCTCACAGTTTACAGGATTCTGAAATGTAGTGGGTGTAAAACCAGAGATTATTTGTATGCTCAAAATAGTTATATATTCATTAATGAATTCAATATCCTGTTCATACTAGTTAGAGCTGGTCAGCCTTTTTGGGTAACACAGTTAATTTACCAACTGATACAGATAATAGAATATATTCATAATCAAGCTGATACTTCATGATTAAATTATTTTTGTTGCTTAAAAGTCGTATTAGACAAGACTAAATCATTCTTTTTTATGGTTCAAAAAAGATGAATACAAACGTTTTTGCAGGTTCTGCTGTGAAATGTGGTTTGATTTTTTTGGTGTGTTAATTTTGATCATAAATGCATTCATACTCATAATCCAGTTTAATCCTTTTATTTGCTTCCTCCAACTATTTAAAGTGGTCCAAAAACACTTTTCTGTAAGTTTCTATACTGTCTAAAACCTTATGGTGACCAGAATTGTTTATTAATATCAAACTTTTTTATATATGAGAACTAATTCTTGAATAAACCCCAAAGTTCACTCTCTTGTTTAAGTAGCAGCAGCTTTTTACTTAAAATTTAATTTTAACTACATTGATACTTTACACATCCTAGTTTGGTAACACAGCTTTAACTATGTCATGCAACATATATATGTTGGTAGGATGTTATTAGAGAGATATGTGTGCATATATATTTTTTTGCACCTGAATCACCCAGCTTTTCATAAGTGGTATGTTTAATTGGTCATTCAGCCAACCATCAGTATTTTCCCCCCACAACATGTGTAACACTTTTCAGTCTGTGGATATCTGATACATTAAGATTTCTTTTTATAAGTATTCATTTTGAATGTGCATATAGTTATTTGACCCCTTCCAAATACTTGTAGCCAAACATTGGCTAGAACATCCCAAGATATGCTGACACTGTCCTGTTAGCTTCATATTATACTTGCTAGTTTAGGTCTCTATAGAAGCCCTATATAATTTAGAATATGCCCACTGAATATCTTTAATAGAAAGTAACATAAAGCTAGTATTCAATGTAGAGTATTTTCATATGTTTTTCACAGCCCGTTACAAATTGGCAATGTTTGGTTAATGTTTGTATTACTTGGAAATCGCTACAGCTTGGACTATTTTTTTCTAAATTTTTAGCATTAGTCCATTTCTGCTGCTAACAATTGAATCCAGAAATCTACTTTCTCCATCTTCCACTGTTAGTGCCAGTGAGCAATACTGTTGTGCAACAAAAATGTCACTTTATCTCAGTGTGAATGAGTAGTCTAAATTCCCTTTCTACCATTGATTTAAATATATATATTGGTAAGAGAGACTGCCCATGTGTTTAGAATAGAATTTTTTAAATGAAATGATCAACAGGTGGAATTTGAAATATATTCTTCTACAAAAGAGATTTCTTTCCCTTTTATATTTTGATGATTGTTTTCTTAAGATTAAGATATGTTCTTGCTCTTTTATAAGATTATTTAAATTATGTTTCCCTCTGATTTTTTTTCACCATTGTATTTACTAAGTTATTGGATTTACATGAAATCTGGCACTTTAGGGTGTTCTTTTTCTCACAGAGTATATTTAATAAAAATGCTGTGTATATAGAAA

Publications

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