Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name COA5P1
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Plot displaying the genomic locations of a retrocopy (in chr1) and its respective parental gene (in chr2). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr1:110256753-110257401  UCSC
Coordinates (T2T) chr1:110271728-110272376  UCSC
Coordinates (hg19) chr1:110799375-110800023  UCSC
Strand +
Parental Sequence NM_001008215.3
Parental seq. overlap 604 bp
Parental seq. overlap (%) 34.1%
Genomic Region Intragenic (KCNC4)
Retrocopy Summary COA5P1, located on chr1:110256753-110257401, is a retrocopy of the parental gene COA5. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name COA5
Full Name cytochrome c oxidase assembly factor 5
Also known as 6330578E17Rik|C2orf64|CEMCOX3|MC4DN9|Pet191
Coordinate chr2:98599314-98608512
Strand -
Gene summary This gene encodes an ortholog of yeast Pet191, which in yeast is a subunit of a large oligomeric complex associated with the mitochondrial inner membrane, and required for the assembly of the cytochrome c oxidase complex. Mutations in this gene are associated with mitochondrial complex IV deficiency, a disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations, ranging from isolated myopathy to a severe disease affecting several tissues and organs. [provided by RefSeq, Dec 2011]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes COA5P1
Bonobo Pan paniscus LOC100967703P1
Gorilla Gorilla gorilla LOC101144524P1
Orangutan Pongo abelii COA5P1
Gibbon Nomascus leucogenys LOC100593539P1
Green monkey Chlorocebus sabaeus LOC103241099P1
Crab-eating macaque Macaca fascicularis LOC102143000P1
Rhesus Macaca mulatta COA5P1
Baboon Papio anubis LOC101011139P1
Golden snub-nosed monkey Rhinopithecus roxellana LOC104661478P1
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

The Genotype-Tissue Expression project - (GTEx)

Related Sequence

>COA5P1
GCTGAAGGAGGACCTGGGCGTGTGTCTGTTGCAGTCCAACTGTGTGGTCCAGGAAGGAAAATCCCCTCTGCAGTGTTTGAAGGAAGGATACTGCAAAGCTTTGAAATACTCATTTTTTGAGTATAAAAGATCAGTGTTGGATACCAGGTCAAGAATCAGAGGAAGAAAGGGATATTGATACATTATGTTGAAGCCAAGATGAAAACAACAAAGGATTTTCTCTGGTTATTAACACAAAGAAGCCAAAACAGGAAACATACTTTTTACTACATCTGTTTGGTTGGACCAGTTTTCCCCTCCATGGAACACTGAAGAAAATGAATGAGTTCTGTTTTTGAATATGTATAAAGTAAATGATTCTCTTGATCCAAGTTATTTTTAGAAGAAAAACCTAATTAAACAGTTATGGGTTGGGAGCATAATAAATGTGTTTTCAGAATTGTTCTAAAGCACAGAGAATGGAAAGATTGTTATTTGCAAACTTGACTCTTCAATTGAATTACACAATTTGTACAGGCCACTGATGTGACTGACACAGTTGATAACATGGAGCCTGTCCAGAAGACGTCAGTTGGGAAAGTTTAGGGTAAAACTTTTTCTTTAGTTCAGTCTTTCCTGTCTAGTTCTAAAATAAATTGTGTTTGATTCC
>NM_001008215.3
GCCGCTGGCTTCCGGTCCCCTGAGACTGGGGCCTCGCTCGCTCCCGACCCGGTTGCAAGTGTTGCGGTGGGAGAAAGTCGCGTCCGCATCGGAGGGGAAGCGCCGTCATGCCTAAGTATTATGAGGACAAGCCGCAGGGCGGCGCGTGCGCGGGCCTGAAGGAGGACCTGGGCGCGTGTCTGCTGCAGTCGGACTGTGTGGTCCAGGAAGGAAAATCACCTCGGCAGTGTTTGAAGGAAGGATACTGCAACTCTTTGAAGTACGCATTTTTTGAGTGTAAAAGATCAGTGTTGGATAACAGGGCAAGATTCAGAGGAAGAAAAGGATATTGATGCATTATGTTGAAGCCAACATGGAAAACAACAAATATTTTCCCTGGTCATTAACACAAAGAAGCCAAAACAGGAAACATACTTTTTACTACATCTGTTTGGTTGGACCAGATTTCCCCTCCGTGGAACACTGAAGAAAGTGGATGAGTTGTTTTCGAATATGTATAAAGTAAATGATTCTCTTGATCCAAGTTATTTTTAGAAGAAAAACCTAATTGAACAGGTATGGGTTGGGAGCATAATAAATGTGTTTTGAGAATTGTTCTAAAGCACAGAAAATGGAAAGACTGTTATTTGCAAACTTGACTCTTCAATTGAATTACCCAATTAGTACAGGCCACTGATTTGACTGACACAGTCGATAACATGCAGCCTATCCAGAAGGTGTCTGTTGGGAAAGTTTAGGATAAAACTTTTTCTTTAGTTCAGTCTTTTCCTGTCTAGTTCTAAAATGAATTGTGTTTGATTCCTTAGAGAAGAAATACTTCATTTGTGCTCTGATTCACTGAAGTAATAACCTCAGCACTTTAATAGCGTCCAcaggcatagctgatgctaggccccagattgtgttgcccaggctctttaccatcatcttcggactgtttttgtttcctggttacattttcagtctggcccgctctacataatgggccagtgtcagctccaagtccacatccttattatccatgattcaaaagggagagagagaacttcctttttcagggtccacaaatcaaatctataaaaggactctggtcttcccaggatcacctgcccttgcattggaccagtccctgtggaagaggggatgggggcctgtgatcttggccaggcctgggctatctatctgcactgtcattgctaactcctgtcagaatcacatggatgagtagtgggctgaatcccaaaaggaaaggggtTTAGAGCAAGTGGAAACAACAGATGTTCACTATAGAAAGCAAGAATGAAAACCATGAAGTGGTTGAAGATTAGCCTTACAGTAATTTTATTCTGATCACTTAATACAGTAGAGTCAAACAGGAATCCAAGTTTCCAACTTTATTATTTTTGGCACTGAAGAATTACAAAGAACTCTAGCGTCTTTATACCTCCGTGGTTCACTGGAGTTAAAGCAATCGGGGCGTTGTACAGCTCACTTGAGTTTTTAAAGGTTCTACTAAAAAGTGAGAATTCCACAGCAATATGGGTCATTGTTGCAGAATATCACAAAGGTCTGTTGTGTATACTCCTTTTCACCAGGAAAGGGACAATAATAGTTTTTTTCAATGTATATATATATAAGTGATCTAACTTTTTATTAATAAAAGTAAACAACTCTAAAATGTATATTATAAAGCCCTGTCATCTTTGTTGagtaatagctttattgagctttatttggagaaatacacataccgtaaaattcacactgaaa

Publications

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