Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

Summary

Retrocopy Name PYROXD1P1
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Plot displaying the genomic locations of a retrocopy (in chr11) and its respective parental gene (in chr12). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr11:106823905-106827966  UCSC
Coordinates (T2T) chr11:106830948-106835009  UCSC
Coordinates (hg19) chr11:106694631-106698692  UCSC
Strand -
Parental Sequence NM_024854.5
Parental seq. overlap 2053 bp
Parental seq. overlap (%) 36.4%
Genomic Region Intragenic (GUCY1A2)
Retrocopy Summary PYROXD1P1, located on chr11:106823905-106827966, is a retrocopy of the parental gene PYROXD1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name PYROXD1
Full Name pyridine nucleotide-disulphide oxidoreductase domain 1
Also known as MFM8
Coordinate chr12:21437630-21471250
Strand +
Gene summary This gene encodes a nuclear-cytoplasmic pyridine nucleotide-disulphide reductase (PNDR). PNDRs are flavoproteins that catalyze the pyridine nucleotide-dependent reduction of thiol residues in other proteins. The encoded protein belongs to the class I pyridine nucleotide-disulphide oxidoreductase family but lacks the C-terminal dimerization domain found in other family members and instead has a C-terminal nitrile reductase domain. It localizes to the nucleus and to striated sarcomeric compartments. Naturally occurring mutations in this gene cause early-onset myopathy with internalized nuclei and myofibrillar disorganization. A pseudogene of this gene has been defined on chromosome 11. [provided by RefSeq, Apr 2017]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

The Genotype-Tissue Expression project - (GTEx)

Adipose SubcutaneousMuscle SkeletalArtery TibialArtery CoronaryHeart Atrial AppendageAdipose VisceralUterusVaginaBreast Mammary TissueSkin Not Sun ExposedMinor Salivary GlandBrain CortexAdrenal GlandThyroidLungSpleenPancreasEsophagus MuscularisEsophagus MucosaEsophagus Gastroesophageal JunctionStomachColon SigmoidSmall Intestine Terminal IleumColon TransverseProstateTestisNerve TibialSkin Sun ExposedHeart Left VentricleBrain CerebellumWhole BloodArtery AortaPituitaryBrain Frontal CortexBrain CaudateBrain Nucleus AccumbensBrain PutamenBrain HypothalamusBrain Spinal CordBrain HippocampusBrain Anterior Cingulate CortexOvaryBrain Cerebellar HemisphereLiverBrain Substantia NigraKidney CortexBrain AmygdalaCervix EctocervixFallopian TubeCervix EndocervixBladderKidney Medulla00.51
log10(TPM+1)

Massive Mining of Publicly Available RNA-seq Data from Human and Mouse - (ARCHS4)

AdiposeBone MarrowBreast Mammary TissueBrain CerebellumColonColon Colonic MucosaEsophagusHeartHeart VentricleKidneyLiverBrain MidbrainOvaryPancreasBrain PonsKidney CortexEye RetinaMuscle SkeletalSkinSmall IntestineBrain Spinal CordSpleenTestisThymusTracheaHeart ValveMuscle Smooth0123
log10(TPM+1)

Related Sequence

>PYROXD1P1
ATCTACATATTTAACTTAAAGTATCACTCATTGAGCCTCTGTCAGTATAATATTGCTTTCAAAAAGATAGTTATGTCAAAAGAAAAAATATAGCTAAGTATATAAAGGCATAAAAAACTTAAGACAATTATATGGACTTATTCTCAAATATTTTACAATTAAAGGGTTTTACATAAAAATTTTTCCCTTGTTTTATACTGGAAAATTATATAATCGTGATCTCTAATTTTCAAACATTCTCAAAAGTTTAGATCTTCAGAGATAAGCTCTGAAAATATAGATCCATACATATAAAATATCTATGAAATTCTTTTAAAAACTATTGTCTAACTACAAAAATAGTGGCATATACATGCATAAACCATCTTTAATTAGAAAATTTAGTAACATTCATGTCAGGCATCATCGATTTTTCTTTTCTTAGCTCCTGTATTCTTAGAACCAGATTGCTGAAGCATGTTTGCAGCCTTCTTCTGGAAGTTGCCTGAATTTTTTTCCTCCATCTTTTTATCACCTTGTTCAGAATGACAAGTTTGAGACGATTCAGCCTACAAAAAAAAAAAATAACAAAGCAAGCACCTTGGTAAAAATCCAGCTATTCAGTTTTCTCATGAGATTAAATATTTCAAAATATTCTTTCTGTATCAGTTGGCTTTTTAAGTATACAGGGGTCTAGTTTTTTATCTACAAATTTCTATTCAAATATGAGCTCTATTTTGAATAAAAGGGGCTACATTGTGAGAGAAGTTCTAAAGACCTCAAATGTCCTTAGACACAATGGCACTTGACTTGACATGCTTTTGCAGACTTGATAGTATTTGGTTTAAAACAGTGGTTTCTAACCACTGGAACAGCAGAAACAGACTTCTCAACTATTAGTAATCACAACCAAATAAGAGCAGAGTGCATAACAAAATTAGATATTAAAACAGAGTCCTCCCATTCCAAGAAACTGGAAACCCCTAGTTTATGTTAAAAGGCCAGTCTAAATTCTTTCACTTATATCTTTACAGAAAACTATATTTTCTCTCTTCCATACCCAGAAATCTAATCAGAAAACTGACTTTTCTCATGTTCAACTGGACCTAGGGGAATATGACAGAAAAGCATCCCATAGGCTTTAATATACTTTTTAAAATATATAAAACTGAAAATTAATAGCCATTTACCCTGAAAGAGTTCTGTGTGGACTTTGTCACTTGCACAGTAATAGCATGTGCCTCATTGTTCAGAAGATTAGCTTTAGGTCCTATTTTCAAATAAGAAATGGTAGCATAAGCTGTAAAACTGTAGTCTTCTCTGCAGAAAATGCCAACAATAAGAAAGCTTTTGAAGGAATCACGGAAAACAAATTTATAAAAGCAATAACTATATGCGCAGTAATTTTTAATACATTGACTTGAAATAATAATCTACATATTTAACTTAAAGTATCACTCAGTGAGCCTCTGTCAGTGTAATATTGCTTTCAAAAAGATAGTTATGTCAAAAGAAAAAATATAGCTAAGTATATAAAGGCATAAAAAACTTAAGACAATTATATGGACTTATTCTCAAATATTTTACATTTGGCTGCTTCCTCTCCTGGAGTCCAGAGTCTCGCTGTTCCGCCGCGATATTCAGTAAACCACTGGGAGTCCGGCAGCATGAAGGCAGCGCGCCCTCCCATGACTGCAGGGAAGTTCATGGTGGTCGGCGGCGGCATCGCGGGCGTCACTTGTGCGGAGCAGTTGGCTACTCACTTTCCATCAGAAGATATTCTCTTGGTAACAGCTTCTCCTGTTATGAAAGCAGTTACAAATTTCAAGCAGATTTCTAAAATATTGGAAGAATTTGATGTTGAAGAACAATCAAGTACCATGTTAGAAAAACGCTTTCCCAACATCAAGGTTATAGAATCTGGCGTAAAGCAACTGAAGAGTGAAGAACACTGCATTGTAACAGAAGATGGCAATCAGCATGTATATAAGAAACTCTGTGTGCTGGAGCTAAACCAAAGTTGATATGTGAAGGAAATCCTTATGTATTAGGAATCCGTGATACAGACAGTGCTCAGGAATTTCAGAAACAGCTTACTAAAGCTAAAAGAATAATGATCTTAGGGAACGGTGGTATCGCACTTGAGTTAGTGTATGAAATTGAAGGCTGTGAAGTGATTTGGGCCATTAAAGATAAAGCTATAGGGAATACTTTCTTCGATGCAGGAGCAGCTGAATTCTTGACTTCAAAGCTCATTGCTGAAAAATCAGAGGCTAAAATTGCATATAAAAGAACCAGATATACAACTGAAGGAAGGAAAAAGGAAGCTAGAAGCAAATCTAAATCAGATAATGTAGGCAGTGCGTTGGGACCAGATTGGCATGAAGGCTTGAATCTTAAAGGAACAAAAGAGTTTTCTCATAAGATTCACCTTGAAGCTATGTGTGAAGTAAAGAAAATCTACCTTCAGGATGAGTTTAGAATTTTGAAGAAAAAGTCCTTCACTTTTCCAAGAGACCATACGTCAGTTACAACTAATACAGAGATGTGGCCTGTCTATGTGGAATTGACCAATGAAAAGATATATGGCTGCGATTTCATTGTCAGTGCTACAGGAGTTACACCGAATATAGAACCTTTTCTCCATGGTAACAGTTTTGATCTAGGAGAAGATGGTGGCCTGAAAGTGGATGATCATATGCACACATCCCTTCCTGATATCTATGCTGCCGGTGACATCTGTACTACATCCTGGCAGCTGAGCCCAGTCTGGCAGCAGATGAGGCTGTGGACCCAGGCTAGACAGATGGGATGGTATGCAGCAAAGTGCATGGCTGCAGCGAGTTCAGGAGACTCTATTGACATGGATTTCAGCTTTGAACTGTTTGCTCATGTGACAAAATTTTTTAACTATAAGGTTGTACTGCTGGGAAAATACAATGCACAGGGCTTAGGTTCAGATCATGAATTAATGCTGAGATGTACCAAAGGACAAGAATACATCAAAGTCGTCATGCAAAATGGACGAATGATGGGAGCTTTCTTAATTGGTGAAACTGATTTAGAAGAAACATTTGAAAACCTAATCTTAAACCAAATGAATCTTTCATCATATGGAGAAGATCTGCTAGATCCAAATATTGATATAGAAGATTATTTTGACTAAAAATGGAATTTCTTCAAGAATCATATAAAGTTCCAAATGACACCAGAAAAATCACAAGTCAATAAAATGAATGACTGTATTGAGTTAATGATGACCACACTGAAAATTACAGAAGTGATAATGATATTAGTGGAAAAATATAAAAACATAAATTCTAAGTTTGAAATCAGTTCAAAGTTTATTTATAGATATATCTTTCCAATACAACACTGACCACTTGGATAAAAATCTTAAGTTATTTATTTCTGTGTTTTAAACATAAATATGTTTACTTGTGATTTAGCTTTGGAGCAAATTTAGGTAAGTTATCTATTTAGCCAAATGTACTCTAGTAGATTAGAACCATTCTTTGTGAAATGTCAAAATATGGCTGTGGTTTCAGGAACTTTAAAATCGGTTGTATTTTACTTTAAATAGAGATGTAGCAATATCTCGTTTGCTAATATTTATATTGATGACTTACTCCTTTTTTGTTGAATTGTACTTCTGGTTTTATAACCTGAAATCATCTAc
>NM_024854.5
GGCTGCTTCCTCTCCTGGAGTCCAGAGTCCCGTTGCTCCGCCGCGATATTCAGTAAACCACTGGGAGTCCGGCAGCATGGAGGCAGCGCGCCCTCCCCCGACGGCAGGGAAGTTCGTGGTGGTCGGCGGCGGCATCGCGGGCGTCACTTGTGCGGAGCAGTTGGCTACTCACTTTCCATCGGAAGATATTCTCTTGGTAACAGCTTCTCCTGTTATTAAAGCAGTTACAAATTTCAAGCAGATTTCTAAAATATTGGAAGAATTCGATGTTGAAGAACAATCAAGTACCATGTTAGGAAAACGCTTTCCCAACATTAAGGTTATAGAATCTGGCGTAAAGCAACTGAAGAGTGAAGAACACTGCATTGTAACAGAAGATGGCAATCAGCACGTATATAAGAAACTCTGTCTGTGTGCTGGAGCTAAACCAAAGTTGATATGTGAAGGAAATCCTTATGTATTAGGAATCCGTGATACAGACAGTGCTCAGGAATTTCAGAAACAGCTTACTAAAGCTAAAAGAATAATGATCATAGGGAACGGTGGTATTGCACTTGAGTTAGTGTATGAAATTGAAGGCTGTGAAGTGATTTGGGCCATTAAAGATAAAGCTATAGGGAATACTTTCTTCGATGCAGGAGCAGCTGAATTCTTGACTTCAAAGCTCATTGCTGAAAAATCAGAGGCTAAAATTGCACATAAAAGAACCAGATATACAACTGAAGGAAGGAAAAAGGAAGCTAGAAGCAAATCTAAAGCAGATAATGTAGGAAGTGCATTGGGACCAGATTGGCATGAAGGCTTGAATCTTAAAGGAACAAAAGAGTTTTCTCATAAGATTCACCTTGAAACTATGTGTGAAGTAAAGAAAATCTACCTTCAGGATGAGTTTAGAATTTTGAAGAAAAAGTCCTTCACTTTTCCAAGAGACCATAAGTCAGTTACAGCTGATACAGAGATGTGGCCTGTCTATGTGGAATTGACCAATGAAAAGATATATGGCTGCGATTTCATTGTCAGTGCTACAGGAGTTACACCAAATGTAGAACCTTTTCTCCATGGTAACAGTTTTGATCTAGGAGAAGATGGTGGCCTGAAAGTGGATGATCATATGCACACATCCCTTCCTGATATCTATGCTGCCGGTGACATCTGTACTACATCCTGGCAGCTGAGCCCAGTCTGGCAGCAGATGAGGCTGTGGACCCAGGCTAGACAGATGGGATGGTATGCAGCAAAGTGCATGGCTGCAGCGAGTTCAGGAGACTCTATTGACATGGATTTCAGCTTTGAACTGTTTGCTCATGTGACAAAATTTTTTAACTATAAGGTTGTACTGCTGGGAAAATACAATGCACAGGGCTTAGGTTCAGATCATGAATTAATGCTGAGATGTACCAAAGGACGAGAATACATCAAAGTCGTCATGCAAAATGGACGAATGATGGGAGCTGTCTTAATTGGTGAAACCGATTTAGAAGAAACATTTGAAAACCTAATCTTAAACCAAATGAATCTTTCATCATATGGAGAAGATCTGCTAGATCCAAATATTGATATAGAAGATTATTTTGACTAAAAATGGAATTTCTTCAGGAATCATATAAAGTTCCAAATGACACCAGAAAAATCACAAGTCAATAAAATGAATGACTGTATTGAGTTAATGATGACCACACTGAAAATTACAGAAGTGATAATGATATTAGTGGAAAAATATAAAAACATAAATTCTAAGTTTGAAATCAGTTCAAAGTTTATTTATAGATATATCTTTCCAATACAACACTGACCGCTTAGATAAAAATCTTAAGTTATTTATTTCTGTGTTTTAAACATAAATATGTTTACTTGTGATTTAGCTTTGGAGCAAATTTAGGTAAGTTATCTACTTAGCCAAATGTACTCTAGTAGACTAGAACCATTCTTTGTGAAATGTCAAAATATGGCTATGGTTTCAGGAACTTTAAAATCGGTTGTATTTTACTTTAAATAGAGATGTAGCAATATCTCGTTTGCTAATATTTATATTGATGACTTACTCCTTTTTTGTTGAATTGTACTTCTGGTTTTATAACCTGAAATCATCTAcaagcttgtccaactctagcccacgggtctaatgcagcccagaacagctttgaatgcagcccaacacaaatctgtaaactttcttaaaacatgagatttttcttgcaatttttttttttttaagctcatcagctatcgtcagtgttagcatattttatgtgcggcccaagacaattcttcttccaatgtggctcagggaagccaaaagattggacatccctgATCTACATATTTAACTTAAAGTATCACTCAGTGAACCTCTGTCAGTATAATATTGCTTTCAAAAAGATGGTTATGTCAAAAGAAAAAATATAGCTAAGTATATAAAGGCATAAAAAACTTAAGACAATTACATGAACTTATTCTCAAATATTTTACATTTtttgtaaactttcttaaaacatgagatttttcttgcaattttttttttaagctcatcagctatcatcagtgttagcatattttatgtgcggcccaagacaattcttcttccaatgtggctcagggaagccaaaagattggacatccttgATCTACATATTTAACTTAAAGTATCACTCAGTGAGCCTCTGTCAGTATAATATTGCTTTCAAAAAGATAGTTATGTCAAAAGAAAAAATATAGCTAAGTATATAAAGGCATAAAAAACTTAAGACGATTGTATGAACTTATTCTCAAATATTTTACATTTAAAGGGTTTTACATAAAAATTTTTCCCTTGTTTTATACTGGAAAATTATATAATTCATGATCTCTAATTTTCAAACATTCTCAAAAGTTTAGATCTTCAGAGATAAGCTCTGAAAATATAGATCCATACATATAAAATATCTATGAAATTCTTTTAAAAACTATTGTCTAACTACAAAAATAATGGCATATACATGCATAAACCATCTTTAATTAGAAAATTTAGTAACATTCATATCAGGCATCATCGATTTTTCTTTTCTTAGCTCCTGTATTCTTAGAACCAGATTGCTGAAGCATGTTTGCAGCCTTCTTCTGGAAGTTGCCTGAATTTTTTTCCTCCATCTTTTTATCACCTTGTTCAGAATGACAAGTTTGAGACGATTCAGCCTACaaaaaaaaaaaaaaaacaaaGCAAGCACCTTGGTAAAAATCCAGCTATTCAGTTTTCTCATGAGATTAAATATTTCAAAATATTCTTTCTGTATCAGTTGGCTTTTTAAGTATACAGGGGTCTAGTTTTTTATCTACAAATTTCTATTCAAATATGAGCTCTATTTTGAATAAAAGGGGCTACGTTGTGAGAGAAGTTCTAAAGACCTCAAATGTCCTTAGACACAATGGCACTTGACTTGACATGCTTTTGCAGACTTGATAGTATTTGGTTTAAAACAGTGGTTTCTAACCACTGGAACAGCAGAAACAGACTTCTCAACTATTAGTAATCACAACCAAATAAGAGCAGAGTGCATAACAAAATTAGATATTCAAACGGAGTCCTCCCATTCCAAGAAACTGGAAACCCCTAGTTTATGTTAAAAGGCCAGTCTAAATTCTTTCACTTACATCTTTACAGAAAACTATATTTTCTCTCTTCCATACCCAGAAATCTAATCAGAAAACTGACTTTTCTCATGTTCAACTGGACCTAGGGGAATATGACAGAAAAGCATCCCATAGGCTTTAATATACTTTTTAAAATATATAAAACTGAAAATTAATAGCCATTTACCCTGAAAGAGTTCTGCGTGGACTTTGTCACTTGCATAGTAATAGCATGTGCCTCATTGTTCAGAAGATTAGCTTTAGGTCCTATTTTCAAATACGAAATGGTAGCATAAGCTGTAAAACTGTAGTCTTCTCTGCAGAAAATAAAGGCCAACAATAAGAAAGCTTTTGAAGGAATCACGGAAAACAAATTTATAAAAGAAATAACTATATGCGCAGTAATTCTTAACACATTGACTTGAAATAATAAAATTTACAAGAATGCAAATAAAGCCTTTAAAGAAAA

Publications

PMID - Link Title
No publications available for this retrocopy