Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name ASS1P13
Plot displaying the genomic locations of a retrocopy (in chr11) and its respective parental gene (in chr9). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr11:107176272-107177767  UCSC
Coordinates (T2T) chr11:107183425-107184920  UCSC
Coordinates (hg19) chr11:107046998-107048493  UCSC
Strand +
Parental Sequence XM_005272200.3
Parental seq. overlap 1391 bp
Parental seq. overlap (%) 86.9%
Genomic Region Intergenic
Retrocopy Summary ASS1P13, located on chr11:107176272-107177767, is a retrocopy of the parental gene ASS1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name ASS1
Full Name argininosuccinate synthase 1
Also known as ASS|CTLN1
Coordinate chr9:130444707-130501274
Strand +
Gene summary The protein encoded by this gene catalyzes the penultimate step of the arginine biosynthetic pathway. There are approximately 10 to 14 copies of this gene including the pseudogenes scattered across the human genome, among which the one located on chromosome 9 appears to be the only functional gene for argininosuccinate synthetase. Mutations in the chromosome 9 copy of this gene cause citrullinemia. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2012]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes ASS1P10
Bonobo Pan paniscus ASS1P11
Gorilla Gorilla gorilla ASS1P10
Orangutan Pongo abelii ASS1P11
Gibbon Nomascus leucogenys ASS1P11
Green monkey Chlorocebus sabaeus ASS1P1
Crab-eating macaque Macaca fascicularis ASS1P11
Rhesus Macaca mulatta ASS1P11
Baboon Papio anubis ASS1P12
Golden snub-nosed monkey Rhinopithecus roxellana ASS1P11
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>ASS1P13
AGATTCCGGACGGTATGTCCAGCAAAGGCTCTATAGTTCTGGCCTGCAGTGGCAGCCTGGACACCTTCTGCATCCTCGTGTGGCTGAAGGAACAAGGCTATGACGTCATTGCCTACCTGGCCAGCATTGGCCAGAAGGAAGACTTCCAGGAAGCCAGGAAGAAGGCACTGAAGCCTGGGGCCAAAAAGATGTTAATTGAGGATGTCAACAGGGAGTTTGTGGAGGAGTTCATCTGGCCGGCCATGCAGTCCAGCACACTGTATGAGGACCGCTACCTCCTGGGAACCTCTCTCGCCAGGCCCTGCATCACCCACAAACAAGTGGAAGTCGCCCAGCGGGAGGGGGCCAAATATGTGTCCCACGGCACCACGGGAAAGGGGAATGATCAGGTCTGGTTTGAGCTCACCTGCTACTCGCTGGCCCCCACAGATAAAGGTCATTGCTCCCTGAAGTATGCCCGAATTCTACAACCGGTTCAAGGGCCACAGTGACCTGACGGAATATGCAAAGCAACGCGGGATTCCCACCCCGGTCACTCCCAAGAACCCGTGGAGCATGGACGAGAACCTCATGCACATCAGCTGCGAGGCTGGAATCCTGGAGAATCCCGAGAACCAAGCGCCTCCAGCTCTCTACACGAAGACCCAGGACCCGGCCAAAACCCCCAACACCCCTGACATTCTCGAGATCGAGTTCAAAAAAGGGGTCCCCGTGAAGGTGACCAACGTCAAGGATAGTGCCACCCACCAGACCTCCTTGGAGCTCTTCATGTACCTGAACGAAGTCGCGGGCAAGCACAGCGTGGGCAATATTGCCATCGTGGAGAACCGTTTCATTGGAACGAAGTCCCGAGGTATCTACCGGGCCCCAGCAGGCACCATCCTTTGCTACGCTCATTTAGACATCGAGGCCTTCACCATGTACCGGGAAGTGCACAAAATCAAACAATGCCGGGGCTTGAAATTTGCTGAGCTGGTGTATACTGGTTTCTGGCTTTCCGGCACAGCCCTGAGTGTGAATTTGTCCGCCACTGCATCGCCGAGTCCCAGGAGTGAGTGGAAGGGAAAGTGCAGGTGTCTGTCCTTAAAGGCCAGGTGTACATCCTTGGCTGGGAGTGCCCCACTGTCTACAACGAGGAGCCGGTGAGCATGAACGTGCAGGGTGATTATGAGCCAATTGATGCCACCGGGTTCATCAACATCAATTCCCTCAGGCTGAAGGAATATCATCGTCTCCAGAGCAAGGTCACTGCAAAATAGACCCCCGTACAAGGAGGAGCTGGGGCCTCCTCAATTTGCAGATCGCCCAAGTAAAGGCGCTAATTGTTGTGATAATTTGTACTTGTGACTAGTTCTCCCCGGCTGGCAGCATAGTGGGGCTGCCAGGCCCCAGCTTTGTTCCCTGGTCCCCTTGAAGCCTGCAAACGTCGTCATCGAAGGGAAGGATGGGGGGCAGCTGCGGTGGAGAGCTGTAAAATGACAAAAGATACACTAGTC
>XM_005272200.3
AGAGGGCGGACCCCGATCGCCACTCGCCGGGGACTGGGACCGAGGCAGGAGGGAAGGGGCTCCCGATGCTCAAACGCCTGGCACCGGATTCCAGACGCTATGTCCAGCAAAGGCTCCGTGGTTCTGGCCTACAGTGGCGGCCTGGACACCTCGTGCATCCTCGTGTGGCTGAAGGAACAAGGCTATGACGTCATTGCCTATCTGGCCAACATTGGCCAGAAGGAAGACTTCGAGGAAGCCAGGAAGAAGGCACTGAAGCTTGGGGCCAAAAAGGTGTTCATTGAGGATGTCAGCAGGGAGTTTGTGGAGGAGTTCATCTGGCCGGCCATCCAGTCCAGCGCACTGTATGAGGACCGCTACCTCCTGGGCACCTCTCTTGCCAGGCCCTGCATCGCCCGCAAACAAGTGGAAATCGCCCAGCGGGAGGGGGCCAAGTATGTGTCCCACGGCGCCACAGGAAAGGGGAACGATCAGGTCCGGTTTGAGCTCAGCTGCTACTCACTGGCCCCCCAGATAAAGGTCATTGCTCCCTGGAGGATGCCTGAATTCTACAACCGGTTCAAGGGCCGCAATGACCTGATGGAGTACGCAAAGCAACACGGGATTCCCATCCCGGTCACTCCCAAGAACCCGTGGAGCATGGATGAGAACCTCATGCACATCAGCTACGAGGCTGGAATCCTGGAGAACCCCAAGAACCAAGCGCCTCCAGGTCTCTACACGAAGACCCAGGACCCAGCCAAAGCCCCCAACACCCCTGACATTCTCGAGATCGAGTTCAAAAAAGGGGTCCCTGTGAAGGTGACCAACGTCAAGGATGGCACCACCCACCAGACCTCCTTGGAGCTCTTCATGTACCTGAACGAAGTCGCGGGCAAGCATGGCGTGGGCCGTATTGACATCGTGGAGAACCGCTTCATTGGAATGAAGTCCCGAGGTATCTACGAGACCCCAGCAGGCACCATCCTTTACCATGCTCATTTAGACATCGAGGCCTTCACCATGGACCGGGAAGTGCGCAAAATCAAACAAGGCCTGGGCTTGAAATTTGCTGAGCTGGTGTATACCGGTTTCTGGCACAGCCCTGAGTGTGAATTTGTCCGCCACTGCATCGCCAAGTCCCAGGAGCGAGTGGAAGGGAAAGTGCAGGTGTCCGTCCTCAAGGGCCAGGTGTACATCCTCGGCCGGGAGTCCCCACTGTCTCTCTACAATGAGGAGCTGGTGAGCATGAACGTGCAGGGTGATTATGAGCCAACTGATGCCACCGGGTTCATCAACATCAATTCCCTCAGGCTGAAGGAATATCATCGTCTCCAGAGCAAGGTCACTGCCAAATAGACCCGTGTACAATGAGGAGCTGGGGCCTCCTCAATTTGCAGATCCCCCAAGTACAGGCGCTAATTGTTGTGATAATTTGTAATTGTGACTTGTTCTCCCCGGCTGGCAGCGTAGTGGGGCTGCCAGGCCCCAGCTTTGTTCCCTGGTCCCCCTGAAGCCTGCAAACGTTGTCATCGAAGGGAAGGGTGGGGGGCAGCTGCGGTGGGGAGCTATAAAAATGACAATTAAAAGAGACACTAGTCTTTTATTTCTA

Publications

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