Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name POLR2EP1
Plot displaying the genomic locations of a retrocopy (in chr11) and its respective parental gene (in chr19). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr11:110049524-110050729  UCSC
Coordinates (T2T) chr11:110059854-110061059  UCSC
Coordinates (hg19) chr11:109920249-109921454  UCSC
Strand +
Parental Sequence NM_002695.5
Parental seq. overlap 1065 bp
Parental seq. overlap (%) 37.2%
Genomic Region Intergenic
Retrocopy Summary POLR2EP1, located on chr11:110049524-110050729, is a retrocopy of the parental gene POLR2E. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name POLR2E
Full Name RNA polymerase II, I and III subunit E
Also known as RPABC1|RPB5|XAP4|hRPB25|hsRPB5
Coordinate chr19:1086574-1095387
Strand -
Gene summary This gene encodes the fifth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases and is present in two-fold molar excess over the other polymerase subunits. An interaction between this subunit and a hepatitis virus transactivating protein has been demonstrated, suggesting that interaction between transcriptional activators and the polymerase can occur through this subunit. A pseudogene is located on chromosome 11. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes POLR2EP1
Bonobo Pan paniscus POLR2EP1
Gorilla Gorilla gorilla LOC101144214P1
Orangutan Pongo abelii POLR2EP1
Gibbon Nomascus leucogenys POLR2EP1
Green monkey Chlorocebus sabaeus POLR2EP1
Crab-eating macaque Macaca fascicularis POLR2EP1
Rhesus Macaca mulatta POLR2EP1
Golden snub-nosed monkey Rhinopithecus roxellana POLR2EP1
Baboon Papio anubis Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>POLR2EP1
GGCCATGGACGACAAGGAGGAGATGTACCAGCTCTGGAAAATCCGCAAGACCATCATGCAGCTGTGCCATGACCGTGGCTACCTAGTGACCTAGGACGAGCTTAACCAGACACTGAAGGAGTTCAAAGTCCAGTCTGGGGACAAGCCAAGTGAGGGGCAGCGGCGGCGCACGGACCTCACCGCGCTGGTGGCCCACAACGATGACCCCACCGACAAGATGTTTGTGTTCTTTCCAGAGGAGCCCAAGGTGGGCATCAAGACCCTCAACGTGTACTGCCGGCGCATGCAGCAGGAGAACATCACGCGGGTCCTCATCATGGTGCAGCAGGGCATGACGCCCTCCGCCAAGTAGTGCCTGGTCCACATGGCTCCCAAGTACATCCTGGAGCAGTTTCTGCAGCAGAAATTGCTCATCGACATCACAGAGTACGAGCTAGTCCCTGAGTACGTTGTCATGACCAAGGAGGAGGTGACAGTGCTGTTGGCCCTATATAAGCTCCGAGAGAACCAGCTGCCCAGGATCCAGGCGGGGGACGCCGTGGCGCGCTACTTTGGGATAAAGCATGGGCAGGTAGTGAAGATCATCCGGCCCAGCGAGATGGCAGGCAGGTACCTCACCTACCGGCTCATGCAGTAGCCACCTCCCTGACAGCCCCTAGAGGCAGACACACGGACAATGACCCCCGTCACCTGCAGGATGGATGCCCCTGCCCTGCCGGAGTCTAGCCCCCCAGCTCTCTCCCGGCTGCTCCTCCTCTGGGCTCCCCAAGGCAGGCAGCCTCCACTCAAGAGCTCCCATCCTGGGATGAGTCTTCCCATGGCCCAGCCCGTCCCATTCACCTGTGTATTTATGCGAGATCCAGCCTCAGGAGGTACAAGACCCCCACAGGGAGGTCACCTGGGGGCAGCTGGTGCCTGGCGTCTTCGCCCAGACTGCACTGGGTCCACAGTGTTGGGGGTTTGGGGCCCGTGTCTCCCACCAGCCACTGCTTCCTCCCGGGCTCTCAGCCTCCCACCCCTCGTCTTCCCTACCTCAGTGGCCCTGATGCGTGGTGGCCCCCACCCAGTCTTGGCTCCTTACTCCATTCACAACTGCGCAGGCTCTCAAGCCACCACGGTGTGAGATTCCAACTCAGCAGAGTTTTCGGTTGTTGTAGGAGGTTGGGTGTTTTCAAACATTAAAGACATTTTGAGTAAATAAATTTG
>NM_002695.5
AGTCCGCGCGGGTTCTCGCGCGGAGAAGGGGTgcgagcggcggcggcggcggaggctgcCATGGACGACGAGGAGGAGACGTACCGGCTCTGGAAAATCCGCAAGACCATCATGCAGCTGTGCCACGACCGTGGCTATCTGGTGACCCAGGACGAGCTTGACCAGACCCTGGAGGAGTTCAAAGCCCAATCTGGGGACAAGCCGAGTGAGGGGCGGCCGCGGCGCACGGACCTCACCGTGCTGGTGGCCCACAACGATGACCCCACCGACCAGATGTTTGTGTTCTTTCCAGAGGAGCCCAAGGTGGGCATCAAGACCATCAAGGTGTACTGCCAGCGCATGCAGGAGGAGAACATCACACGGGCTCTCATCGTGGTGCAGCAGGGCATGACACCCTCCGCCAAGCAGTCCCTGGTCGACATGGCCCCCAAGTACATCCTGGAGCAGTTTCTGCAGCAGGAGCTGCTCATCAACATCACGGAGCACGAGCTAGTCCCTGAGCACGTCGTCATGACCAAGGAGGAGGTGACAGAGCTGCTGGCCCGATATAAGCTCCGAGAGAACCAGCTGCCCAGGATCCAGGCGGGGGACCCTGTGGCGCGCTACTTTGGGATAAAGCGTGGGCAGGTGGTGAAGATCATCCGGCCCAGTGAGACGGCTGGCAGGTACATCACCTACCGGCTGGTGCAGTAGCTACCGCCTGACAGCCCCTAGAGGCGGACACACAGCGACCCCCATCCCTGCAGGACAAACGCCCCTGCCCTGCCAGAATCCGGCCCCCACAGCTCTCACGGCTGCTGCTCCTCTGGACTCCCCAAGGCAGGTGGCCTCCACCCACGTTCTCCCGTCCTGGGGTGAGGCTTCCTGTGGCCCAGCCCGCCCCATTCACCTGTGGATTTGTGCGAGATGCAGCCTCAGAAGGAACAAGGCCCCCAGAGGGAGGTCACCTGGGGGCAGCTGGTGCCGGGTCTTCACCCAGACCACGCTGGGTCCCCTCTGTTGGGGGTTTGGGGTCCGGGTCTCCCACCAGCCACTGCTTCCTCCTGGGCCCTCGGCCTTCCACCCCTCGTCTTCCCTCCCTCGGGGGCCCTGATGCGTGGCGGCCCCCGCCCGGCCTCGGCTCTTTACTCCATTCACAGCCATGCACGCGCTCAAGCCACCAGGGTGCGAGATGCCAGCTCTGGAGTTCTCGGTTGTTGTAGGAGGTTGGGTGTTTTCAAATGGTAAAGATGTTTTGAGCAAATAAATTTGCTTGATACAGAAACCAGGCCGACTAACAAGGTTTCCAGCAGGTGGCCTTGCCTCACCCCAAGCACACGAGGTCAGCCTGGCAGGTGTGCCCTCCTCGCGCTGGCTTCAGGGGTCAGTGTCTCCCCAGGCCCTCGCCCTGCCCTCCCACTTCGTGCTCCTGGGTAAGGCGTGAGCGTGTCTGTCTCTTCCCTTCCCGTGAGGGTGTGGAGTTGTTCTCTGGCTTGTGCAGCTGTGGTTTGCGGCCAGTTCCTCTTACAGACGTTTGGGATCTGGCTCTACTTCCCCGTTTGCTTACTGTCTGATTTCAGAAGGCCTCGCCTGCCCAAGTTTAACCTAGCCACGTGGTTCTCTCACAGTAGCTTTATTAAGATGTAATTCACCCTCGGGCGGTCGGTGGTCTGTAACGCGCCCACTGTTCTGTGCAGCAGGGTCCCCAGATCCCCAGGCCGCGGACTGTGTGTGTGATGGGGACAGTGCTTCCCCTTCTCTCCAAATGTACTTTTTTCAAAATTGTCTTGGCCAaagcaagccagacccaaagggacaaacactgatgtcactcctaggaggtcactagagtcgtcagagactggaagtaggatgggggttcccgggactggggagttgggtggggatggggGTTCCCAGGGCTGGGGAGGAGGGAGGGGACAGAGTGTGTCATGTGCACAGTTTTAGtttgggaagatgagaaaattctggaggtggccgggcgcggtggctcacgcctgtaatcccagcactttgggaggccgaggtgggcggatcacctgaggtcgggagttcgagaccagcctgaccaacatggcaaaatcccatcactgcaaaaaatacaaaaattacctgggcgtggtggtgcatgcctgtaatcccagctacttgggagctaaggcaggagaatcacttgaacccaggaagtggaggatcgcttgagctcaggagttaaaagaccagcccgggcaacacagagaaaccccccacctctacaaaaaactttaagattacctgggcacagtggctcacacctgtaatcccaacactttgggaggctgaggcgggaggatcatttgagcccaggaggccgaggctgcagtgagctacgattgtgctcctgtactccagcctgggccacagggtcacaccctgtctcaaaaaaaaaaaaaaaTGcagttccacaggcgcatgggccacgtttccagtgcttggtggccatgtggggctgacgtgcgaaaccttagagccgggggatacgtccgtcatcgagaacgttttcctggactgccctgGGCTGCAGGTGGACGTGACGAGGTCATTCGATGCCTGACCGTCTGCACAGCCTGTGGTGAAGACCACCCGGGCTCCCACCTCGCGGGGCCCCGTGGCGGGGGGTTCCCTTCCTCACACATCCCTCCCCTAGGGGGAGGCCCAGGGCCACGCCACGGGGCTCTCTCTGTCCCCTCCCTGGCCCCTTCTTCTAAGCTTGCAGCTGCCACAGAAAATCTTCTAAGCTTGCAGCTGCCACAGAAAACACCCGATTAAAAACTTTTTATTTCAGCAAAATAAACGTGCCTGTGAAAGAACCACA

Publications

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