Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name HDAC1P4
Plot displaying the genomic locations of a retrocopy (in chr11) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr11:114583232-114585223  UCSC
Coordinates (T2T) chr11:114593644-114595635  UCSC
Coordinates (hg19) chr11:114453954-114455945  UCSC
Strand +
Parental Sequence XM_011541309.2
Parental seq. overlap 1721 bp
Parental seq. overlap (%) 69%
Genomic Region Intragenic (NXPE2)
Intragenic (NXPE4)
Retrocopy Summary HDAC1P4, located on chr11:114583232-114585223, is a retrocopy of the parental gene HDAC1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name HDAC1
Full Name histone deacetylase 1
Also known as GON-10|HD1|KDAC1|RPD3|RPD3L1
Coordinate chr1:32292083-32333628
Strand +
Gene summary Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes LOC748850P2
Bonobo Pan paniscus HDAC1P4
Gorilla Gorilla gorilla HDAC1P4
Orangutan Pongo abelii HDAC1P4
Gibbon Nomascus leucogenys HDAC1P3
Green monkey Chlorocebus sabaeus HDAC1P1
Crab-eating macaque Macaca fascicularis HDAC1P5
Rhesus Macaca mulatta HDAC1P5
Baboon Papio anubis HDAC1P5
Golden snub-nosed monkey Rhinopithecus roxellana LOC104677352P3
Marmoset Callithrix jacchus HDAC1P2
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>HDAC1P4
GAGGGACAGGAAGTGAGCAAGATGGCGCAAAGGCAGGGCACCAGGAGGAAAGTCTGTTACTACTACGATAGGGGTGTTGGAAATTACTATTATGGACAAGCCCACCCAAGGAATCCTCACTGAATCTGCGTGACTCATAATTTGCTGCTCAACTATGGTTTCTACTGAAAAATGGAAACCCATCACCCTCACAAAGCCAATGCTGAGGAGATGACCAAGTACCACAGTGATGACTACATTAAATTCTTGTGCTCCATCTATCCAGATTACGTGTCTGAGCACAGCAAGCGGATGCAGAGATTCAACGTTAGTGAGGACTGTCCAGCATTTGATGGCCTGTTTGACTTCTGTCAGTTGTCTACTGGTGGCTCTGTGGCAAGTGCTGTGAAACTTAATGAGCAGCAGATGGACACTGCTGTGAATTGGGCTGGAGGCCTGCACCATGCAAAGAAGTTCAAGGCATCTGGCTTCTGTTATGTTAATGATACAATCTGGGCCACCTTGGAACTGCTAAAGTATCACCAGAGGGTGTTGTATGTTGACGTTGATATTCACCATGATGATGGCATGGAAGAGGCCTTCTATATTACAGGCTAGGCCAGGACTGTGTCCTTTCATAAATATGGAGAGTACTTCCCAGGAGATGGGGACTTATGGGTTATTGGGGCTGGCAAAGGCAGATATTATGCTATTAACTATCTGCTCCTAGATGGGATTGATGATGAGTCCTATGAGGCCATTTTCAAACTGGTCATGTCCAAAGTAATAGAGATGTTCCTGTCTAGTGTGGTGATCTTACAGCATGGCTCAGATGCCTTGTCTAGGGGTCACTTAGATTGCTTTAATCTGATCATCAAAGGGCATGCCAAGTGTGTGGAATCTGTCAAGAGTGTCAACCTGCCTATGTTATTGATGGCAGAAGGTGGTTACACCATTTATAATGTTGCTCAGTGCCCTGGAAATAAGAAAGAGCTGTGGCTCTGGATATGGAGATCCCTAATGAGCCTTCATACAATGATTACTTTGAATACTTTGGACCATATTTCAAGCCCTACATCAGTCCTTCCAATATGACTAACCAGAACACTAATGAGTACCTGGAGAAGATTAAACAGTGGCTGTTTGAGAACCTAGTAATGCAGGCCCATCCACCTGCAGTCCAAATGCAGGTGATTCTGAGGATGCTGTCCCTCAAGAGGGTGGCGATGAGAATGAAGAAGACCCTGACAAGCTCATCTCCATCCGTTTCTCTGACAGATGAATTACCTGTGAGGAAGAGTTCTTCGACTCTGATGAGGAGGGAGAGCGTGGCTGCAAGATCTCTCCCATCTTCAAAAAAGCCAAGAGGATTAAAACAGGATGAAAAAGAGAGACTCAGAGATGAAGAAATGTCACAGAAGAGGAGAAAAATGAAGGAGGAGAAGCCAGGAGCCAAAGAGGTCAAGGAGCAGGTCAAGCTGGCCTGAGGGAACCTCCCCTGCTCTGGCTTCCTGCCTAGTCCCCAATCTTTCTCTCCCAAACCCTCAGATTTTATGTCTTCTATTTCTCCAGGTATTCATATAAAATTTATTAAATATAAATAGTTCCAGGGACTAGACAGAAATTAAGACCCTGAGCCCAGGGCAGCTGTGCTGGGTGATCTCTTCTAGGAAATGCCTTGCCACCTATCCCTCTGCAGGTCTTAACTCTGAAGCATAAAAGGCGCCAGGTCTGGGTGAAGGGAATACTTTTGTGCAAACAGAAGACAAAATCCTGAAATGCCAAGTGCCTGCTTAGTAGCTTTGGAAAGGTGCCTTTATTGCACCTTCTAAAAGGGGTGTCTGGGTCTTCAAGGTTGCCCTGTTCTTTTCAGCTCCTAAGTAACATCAGCCATTTTTAGATTGGTTCCATTCTCATACCTTCTCACTGGCCTCAAGTGAGCCAAAAAACTCACACTGCCTGCCATCTGTCTTCCCCCAGTTCTGCAGGTGGAGGATGGTAGTCTAGTCTCCT
>XM_011541309.2
CGCTGAGCGGAGCCGCGGGCGGGAGGGCGGACGGACCGACTGACGGTAGGGACGGGAGGCGAGCAAGATGGCGCAGACGCAGGGCACCCGGAGGAAAGTCTGTTACTACTACGACGGGGATGTTGGAAATTACTATTATGGACAAGGCCACCCAATGAAGCCTCACCGAATCCGCATGACTCATAATTTGCTGCTCAACTATGGTCTCTACCGAAAAATGGAAATCTATCGCCCTCACAAAGCCAATGCTGAGGAGATGACCAAGTACCACAGCGATGACTACATTAAATTCTTGCGCTCCATCCGTCCAGATAACATGTCGGAGTACAGCAAGCAGATGCAGAGATTCAACGTTGGTGAGGACTGTCCAGTATTCGATGGCCTGTTTGAGTTCTGTCAGTTGTCTACTGGTGGTTCTGTGGCAAGTGCTGTGAAACTTAATAAGCAGCAGACGGACATCGCTGTGAATTGGGCTGGGGGCCTGCACCATGCAAAGAAGTCCGAGGCATCTGGCTTCTGTTACGTCAATGATATCGTCTTGGCCATCCTGGAACTGCTAAAGTATGCCTGCCTGGCCTTGTCTCTTGGAAGAGCACCTTAGGCCAGGTTCCCATTTCCCTCTTCCCCTGGGCTTGCCTCCCTAGTTTGCTTTTCCTACCGATGTGCTGGCTAGGATGTGCTCGGTGAGTGTCTCTGGCCATCATCTCCTTGATGGGGTCTTGGTTTGATCTGAGCCACGGCATGATCAGGGGCAGATGCTGCTCAGATCCTGCCTCCAGAGTGTCCCTGTGTGGCTGGAGTTGACCCTGGCTGTAGAGTAGGAAGATCGGACTTGGTCGGCTTGGTCAGGCCTCTGGAGACACCCGGCCGCTCTTCCACCTTCCTTCAGCCAGTTTCCACGTCTCTGGTGCTTAGAGATACCTGAGGGAGGCAGCCAGCCCGGTATCACCAGAGGGTGCTGTACATTGACATTGATATTCACCATGGTGACGGCGTGGAAGAGGCCTTCTACACCACGGACCGGGTCATGACTGTGTCCTTTCATAAGTATGGAGAGTACTTCCCAGGAACTGGGGACCTACGGGATATCGGGGCTGGCAAAGGCAAGTATTATGCTGTTAACTACCCGCTCCGAGACGGGATTGATGACGAGTCCTATGAGGCCATTTTCAAGCCGGTCATGTCCAAAGTAATGGAGATGTTCCAGCCTAGTGCGGTGGTCTTACAGTGTGGCTCAGACTCCCTATCTGGGGATCGGTTAGGTTGCTTCAATCTAACTATCAAAGGACACGCCAAGTGTGTGGAATTTGTCAAGAGCTTTAACCTGCCTATGCTGATGCTGGGAGGCGGTGGTTACACCATTCGTAACGTTGCCCGGTGCTGGACATATGAGACAGCTGTGGCCCTGGATACGGAGATCCCTAATGAGCTTCCATACAATGACTACTTTGAATACTTTGGACCAGATTTCAAGCTCCACATCAGTCCTTCCAATATGACTAACCAGAACACGAATGAGTACCTGGAGAAGATCAAACAGCGACTGTTTGAGAACCTTAGAATGCTGCCGCACGCACCTGGGGTCCAAATGCAGGCGATTCCTGAGGACGCCATCCCTGAGGAGAGTGGCGATGAGGACGAAGACGACCCTGACAAGCGCATCTCGATCTGCTCCTCTGACAAACGAATTGCCTGTGAGGAAGAGTTCTCCGATTCTGAAGAGGAGGGAGAGGGGGGCCGCAAGAACTCTTCCAACTTCAAAAAAGCCAAGAGAGTCAAAACAGAGGATGAAAAAGAGAAAGACCCAGAGGAGAAGAAAGAAGTCACCGAAGAGGAGAAAACCAAGGAGGAGAAGCCAGAAGCCAAAGGGGTCAAGGAGGAGGTCAAGTTGGCCTGAATGGACCTCTCCAGCTCTGGCTTCCTGCTGAGTCCCTCACGTTTCTTCCCCAACCCCTCAGATtttatattttctatttctctgtgtatttatataaaaatttattaaatataaatatCCCCAGGGACAGAAACCAAGGCCCCGAGCTCAGGGCAGCTGTGCTGGGTGAGCTCTTCCAGGAGCCACCTTGCCACCCATTCTTCCCGTTCTTAACTTTGAACCATAAAGGGTGCCAGGTCTGGGTGAAAGGGATACTTTTATGCAACCATAAGACAAACTCCTGAAATGCCAAGTGCCTGCTTAGTAGCTTTGGAAAGGTGCCCTTATTGAACATTCTAGAAGGGGTGGCTGGGTCTTCAAGGATCTCCTGTTTTTTTCAGGCTCCTAAAGTAACATCAGCCATTTTTAGATTGGTTCTGTTTTCGTACCTTCCCACTGGCCTCAAGTGAGCCAAGAAACACTGCCTGCCCTCTGTCTGTCTTCTCCTAATTCTGCAGGTGGAGGTTGCTAGTCTAGTTTCCTTTTTGAGATACTATTTTCATTTTTGTGAGCCTCTTTGTAATAAAATGGTACATTTCTATATC

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