Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name RPL15P29
Plot displaying the genomic locations of a retrocopy (in chr11) and its respective parental gene (in chr3). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr11:115949899-115950819  UCSC
Coordinates (T2T) chr11:115963014-115963934  UCSC
Coordinates (hg19) chr11:115820617-115821537  UCSC
Strand -
Parental Sequence NM_002948.5
Parental seq. overlap 806 bp
Parental seq. overlap (%) 37.1%
Genomic Region Intergenic
Retrocopy Summary RPL15P29, located on chr11:115949899-115950819, is a retrocopy of the parental gene RPL15. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name RPL15
Full Name ribosomal protein L15
Also known as DBA12|EC45|L15|RPL10|RPLY10|RPYL10
Coordinate chr3:23916545-23924631
Strand +
Gene summary Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L15E family of ribosomal proteins and a component of the 60S subunit. This gene shares sequence similarity with the yeast ribosomal protein YL10 gene. Elevated expression of this gene has been observed in esophageal tumors and gastric cancer tissues, and deletion of this gene has been observed in a Diamond-Blackfan anemia (DBA) patient. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Mar 2017]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes RPL15P11
Bonobo Pan paniscus RPL15P11
Gorilla Gorilla gorilla RPL15P10
Orangutan Pongo abelii RPL15P12
Gibbon Nomascus leucogenys RPL15P12
Green monkey Chlorocebus sabaeus RPL15P1
Crab-eating macaque Macaca fascicularis RPL15P14
Rhesus Macaca mulatta RPL15P14
Baboon Papio anubis RPL15P14
Golden snub-nosed monkey Rhinopithecus roxellana RPL15P25
Marmoset Callithrix jacchus RPL15P19
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>RPL15P29
GGTAAACCAAGATGGGTGCATACAAATACATCCAGGAGCTATGGAAGAGGCAGTCTGATGTCTTGCACTTTCTTCTGAAGGTCGGCTGTTGGCAGTACTGCTGGCTCTCTGCTCTGCACAGGAATCCCCACCCCACCTGGCCTGATAAAGCATGCCAACTGGGCTACAAGGCCAAGCAAAGTTACATTATATATAGGATTTGTATGCGCCATGGTGGCCAAAAATGCCCAGTTCCTAAGGGTGCAACTTATGGCAAGCCTGTCGACCATGATGTTAACCAGCTAGGGTTTGCTTGAAGCCTTCAGTCCACTGCAGAGGAGTAAGCTGGACACCACTGTGGAGCTTTAAGAGTCTTGAATTCTAACTGGGTTGGTGAAGATTCCACGTACAAATTTTTGGAGGTTATCCTAATTGATCCATTCCATAAAGCTATCAGAAGAAATCCTGACACCCAGTGAATCACCAAACCAGTTCGCAAGCACAGGGAGATGCATGGGTTGACATCTGCAGGCTGAAAGAGCCATGGCCTTGGAAAGGGCCATAAATTCCACCACACTCTTGGTGGTTCTCGCTGGGCAACTTGGAGAAGGCACAATACTTTCCAGCTCTACCGTTACCACTAATATAAGTAAAGTTCATAAAATTCCTACATAATAAACAACTTAGGACAGTCATGTCTGTCTACAGGTATTTGTCTTTTAAAACTAGTCTGCAGATTGTTTCATGAATGCTTTGTCAAATTATGAAAGTTAAAGTGCAGTAATGTTTGACAATGACTATAAATGATGCTGTATCTTGTTTCCAATAAGATAAACTTTTTTTGTCTTTGCTCTATCTTAGCTCTATCTTATTAGGAAGTTATATGTCAGTGTTTAAAACATATTGTGTAGTATAATAGGTTTAAAATAAATTCC
>NM_002948.5
GGGAGTACAGCTCTTTCCTTTCCGTCTGGCGGCAGCCATCAGGTAAGCCAAGATGGGTGCATACAAGTACATCCAGGAGCTATGGAGAAAGAAGCAGTCTGATGTCATGCGCTTTCTTCTGAGGGTCCGCTGCTGGCAGTACCGCCAGCTCTCTGCTCTCCACAGGGCTCCCCGCCCCACCCGGCCTGATAAAGCGCGCCGACTGGGCTACAAGGCCAAGCAAGGTTACGTTATATATAGGATTCGTGTTCGCCGTGGTGGCCGAAAACGCCCAGTTCCTAAGGGTGCAACTTACGGCAAGCCTGTCCATCATGGTGTTAACCAGCTAAAGTTTGCTCGAAGCCTTCAGTCCGTTGCAGAGGAGCGAGCTGGACGCCACTGTGGGGCTCTGAGAGTCCTGAATTCTTACTGGGTTGGTGAAGATTCCACATACAAATTTTTTGAGGTTATCCTCATTGATCCATTCCATAAAGCTATCAGAAGAAATCCTGACACCCAGTGGATCACCAAACCAGTCCACAAGCACAGGGAGATGCGTGGGCTGACATCTGCAGGCCGAAAGAGCCGTGGCCTTGGAAAGGGCCACAAGTTCCACCACACTATTGGTGGCTCTCGCCGGGCAGCTTGGAGAAGGCGCAATACTCTCCAGCTCCACCGTTACCGCTAATATAAGTAAAGTTTGTAAAATTCATACTTAATAAACAATTTAGGACAGTCATGTCTGCTTACAGGTGTTATTTGTCTGTTAAAACTAGTCTGCAGATGTTTCTTGAATGCTTTGTCAAATTAAGAAAGTTAAAGTGCAATAATGTTTGAAGACAATAAGTGGTGGTGTATCTTGTTTCTAATAAGATAAACTTTTTTGTCTTTGCTTTATCTTATTAGGGAGTTGTATGTCAGTGTATAAAACATACTGTGTGGTATAACAGGCTTAATAAATTCTTTAAAAGGAGAGAACTGAAACTAGCCCTGTAGATTTGTCTGGTGCATGTGATGAAACCTGCAGCTTTATCGGAGTGATGGCAATGCTCTGCTGGTTTATTTTCAAGTGGCTGCGTTTTTTTTAGTTTGGCAGGTGTAGACTTTTTAAGTTGGGCTTTAGAAAATCTGGGTTAGCCTGAAGAAAATTGCCTCAGCCTCCACAGTACCATTTTAAATTCACATAAAAGGTGAAAGCTCCTGGTTCAGTGCCATGGCTTCATGGCATTCAGTGATTAGTGGTAATGGTAAACACTGGTGTGTTTTGAAGTTGAATGTGCGATAAAATTATTAGCCTTAAGATTGGTAAGCTAGCAATGAATGCTAGGGTGGGAAGCTGGTGAGCCAGTGGCCATTAGATAAATACCTTTCAAGTGTGAGCTTAGACGTCAACCCTAAAATACTTAACCGTAATGCTAATTGTGATCATTATGAATCCCTTCAGTCACATTAGGGGGAAAGTAGTTGGCTATAAGTACGTCATTCTTAGTCCAGTCAGTCTTAAAAACATCTTGGGTTACCCACTCTGTCCACTCCCATAGGCTACAGAAAAAGTCACAAGCGCATGGTTTCCAACCATATGTGTTTTCTGCAGTTATTTCTCTTGTTCTGGCCAAACAACCCTAAAAATCCTTACCATTCCACAAAGTTGGACCATCACTTGTGCACCCACTTTGACTATGAGTATACCACCACATTGCATTTCTGTTTGCACCATGTCTTCCAGGAGACTAGACTACTGTTGTCCAGGGTCAATTTGAGTGTAAAGAAAATGTAGACAAGGAATTGCCCAATTTTAAATTCTGACTTTGCTGACTTAATTTAAATGCTCGTTCTGAACCAATTTTCTCCTATCTTCTCTAGGGGTTTCAAAAGACTCAGTTAATTGATTTCCAGGAAGTACTCATAGCAAGTTCATAAAAGTTCTTGAGACCTAAATTTCTTCACAAAAAAAGAAAAGATCTTAAGTCATACATTTTAATTGTGTAGAGGTTGTTCAACTGAAGGAATAAATGTCTATTAAACTAAAACAAATGGACCTTCTGTTATTTTTTGTCATCTTACAGTGCTAATGTACTTTAAAGCAAACCAAATGCCCTAACCAGCAAAAAGGCATCAAAATGTGATTATAGAAATAATATAATTTGAGATAGCATAAAATGTACTTATTCTCTCA

Publications

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